Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ETF1 Gene

Aliases for ETF1 Gene

  • Eukaryotic Translation Termination Factor 1 2 3
  • Sup45 (Yeast Omnipotent Suppressor 45) Homolog-Like 1 2 3
  • Polypeptide Chain Release Factor 1 2 3
  • Protein Cl1 3 4
  • SUP45L1 3 4
  • TB3-1 3 4
  • ERF1 3 4
  • RF1 3 4
  • Eukaryotic Release Factor 1 4
  • D5S1995 3
  • ERF 3

External Ids for ETF1 Gene

Previous HGNC Symbols for ETF1 Gene

  • SUP45L1
  • ERF1
  • ERF

Previous GeneCards Identifiers for ETF1 Gene

  • GC05M137716
  • GC05M137872
  • GC05M137918
  • GC05M137869
  • GC05M133032
  • GC05M137843

Summaries for ETF1 Gene

Entrez Gene Summary for ETF1 Gene

  • This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

GeneCards Summary for ETF1 Gene

ETF1 (Eukaryotic Translation Termination Factor 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Cellular Senescence. GO annotations related to this gene include poly(A) RNA binding and ribosome binding.

UniProtKB/Swiss-Prot for ETF1 Gene

  • Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Wiki entry for ETF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETF1 Gene

Genomics for ETF1 Gene

Regulatory Elements for ETF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ETF1 Gene

Chromosome:
5
Start:
138,506,093 bp from pter
End:
138,543,300 bp from pter
Size:
37,208 bases
Orientation:
Minus strand

Genomic View for ETF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ETF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETF1 Gene

Proteins for ETF1 Gene

  • Protein details for ETF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62495-ERF1_HUMAN
    Recommended name:
    Eukaryotic peptide chain release factor subunit 1
    Protein Accession:
    P62495
    Secondary Accessions:
    • B2R6B4
    • D3DQC1
    • P46055
    • Q5M7Z7
    • Q96CG1

    Protein attributes for ETF1 Gene

    Size:
    437 amino acids
    Molecular mass:
    49031 Da
    Quaternary structure:
    • Heterodimer of two subunits, one of which binds GTP. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.

    Three dimensional structures from OCA and Proteopedia for ETF1 Gene

    Alternative splice isoforms for ETF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETF1 Gene

Proteomics data for ETF1 Gene at MOPED

Post-translational modifications for ETF1 Gene

  • Ubiquitination at Lys 171, Lys 384, and Lys 404
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ETF1 (ETF1)

No data available for DME Specific Peptides for ETF1 Gene

Domains & Families for ETF1 Gene

Suggested Antigen Peptide Sequences for ETF1 Gene

Graphical View of Domain Structure for InterPro Entry

P62495

UniProtKB/Swiss-Prot:

ERF1_HUMAN :
  • Belongs to the eukaryotic release factor 1 family.
Family:
  • Belongs to the eukaryotic release factor 1 family.
genes like me logo Genes that share domains with ETF1: view

No data available for Gene Families for ETF1 Gene

Function for ETF1 Gene

Molecular function for ETF1 Gene

GENATLAS Biochemistry:
eukaryotic translation termination factor 1,associating with the catalytic subunit of protein phosphatase 2A
UniProtKB/Swiss-Prot Function:
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Ontology (GO) - Molecular Function for ETF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7990965
GO:0003747 translation release factor activity TAS 15326224
GO:0005515 protein binding IPI 9620853
GO:0008079 translation termination factor activity TAS 10413110
GO:0016149 translation release factor activity, codon specific IBA --
genes like me logo Genes that share ontologies with ETF1: view
genes like me logo Genes that share phenotypes with ETF1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ETF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ETF1 Gene

Localization for ETF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETF1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETF1 Gene COMPARTMENTS Subcellular localization image for ETF1 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for ETF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA 12426392
GO:0005829 cytosol TAS --
GO:0018444 translation release factor complex IBA --
genes like me logo Genes that share ontologies with ETF1: view

Pathways & Interactions for ETF1 Gene

genes like me logo Genes that share pathways with ETF1: view

Pathways by source for ETF1 Gene

1 Cell Signaling Technology pathway for ETF1 Gene
1 BioSystems pathway for ETF1 Gene

Gene Ontology (GO) - Biological Process for ETF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006415 translational termination TAS --
GO:0006449 regulation of translational termination TAS 7990965
GO:0006479 protein methylation IDA 18539146
genes like me logo Genes that share ontologies with ETF1: view

No data available for SIGNOR curated interactions for ETF1 Gene

Drugs & Compounds for ETF1 Gene

(5) Drugs for ETF1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0
puromycin Experimental Pharma 0
Selenocysteine Experimental Pharma 0
histidine Nutra 31

(9) Additional Compounds for ETF1 Gene - From: NovoSeek

genes like me logo Genes that share compounds with ETF1: view

Transcripts for ETF1 Gene

Unigene Clusters for ETF1 Gene

Eukaryotic translation termination factor 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ETF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ETF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6: - - - -
SP7:

Relevant External Links for ETF1 Gene

GeneLoc Exon Structure for
ETF1
ECgene alternative splicing isoforms for
ETF1

Expression for ETF1 Gene

mRNA expression in normal human tissues for ETF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ETF1 Gene



SOURCE GeneReport for Unigene cluster for ETF1 Gene Hs.483494

genes like me logo Genes that share expression patterns with ETF1: view

Protein tissue co-expression partners for ETF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ETF1 Gene

Orthologs for ETF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ETF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ETF1 35
  • 96.57 (n)
  • 100 (a)
ETF1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETF1 35
  • 96.64 (n)
  • 99.77 (a)
ETF1 36
  • 100 (a)
OneToMany
ETF1 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Etf1 35
  • 94.97 (n)
  • 100 (a)
Etf1 16
Etf1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ETF1 35
  • 100 (n)
  • 100 (a)
ETF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etf1 35
  • 95.04 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia ETF1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETF1 35
  • 88.86 (n)
  • 100 (a)
ETF1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETF1 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia etf1 35
  • 84.36 (n)
  • 98.86 (a)
MGC75958 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3333 35
zebrafish
(Danio rerio)
Actinopterygii etf1 35
etf1 35
  • 79.1 (n)
  • 97.25 (a)
etf1 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta eRF1 37
  • 84 (a)
eRF1 35
  • 71.02 (n)
  • 85.78 (a)
eRF1 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010310 35
  • 71.25 (n)
  • 85.78 (a)
worm
(Caenorhabditis elegans)
Secernentea T05H4.6a 37
  • 80 (a)
T05H4.6b 37
  • 80 (a)
etf-1 35
  • 71.93 (n)
  • 81.07 (a)
etf-1 36
  • 61 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER028C 35
  • 63.57 (n)
  • 68.84 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11231g 35
  • 67.06 (n)
  • 72.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUP45 35
  • 66.04 (n)
  • 68.71 (a)
SUP45 36
  • 67 (a)
OneToOne
SUP45 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ERF1-1 35
  • 65.65 (n)
  • 72.47 (a)
soybean
(Glycine max)
eudicotyledons Gma.18085 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8098 35
barley
(Hordeum vulgare)
Liliopsida Hv.3060 35
rice
(Oryza sativa)
Liliopsida Os.7009 35
Os01g0939500 35
  • 66.74 (n)
  • 73.95 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5741 35
corn
(Zea mays)
Liliopsida Zm.13318 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4884 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00410 35
  • 66.12 (n)
  • 74.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sup45 35
  • 61.97 (n)
  • 66.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7901 36
  • 84 (a)
OneToOne
Species with no ortholog for ETF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ETF1 Gene

ENSEMBL:
Gene Tree for ETF1 (if available)
TreeFam:
Gene Tree for ETF1 (if available)

Paralogs for ETF1 Gene

Pseudogenes.org Pseudogenes for ETF1 Gene

genes like me logo Genes that share paralogs with ETF1: view

No data available for Paralogs for ETF1 Gene

Variants for ETF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ETF1 Gene

Variant ID Type Subtype PubMed ID
nsv329728 CNV Loss 16902084
esv2669716 CNV Deletion 23128226
esv2677157 CNV Deletion 23128226

Variation tolerance for ETF1 Gene

Residual Variation Intolerance Score: 24.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETF1 Gene

HapMap Linkage Disequilibrium report
ETF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ETF1 Gene

Disorders for ETF1 Gene

Relevant External Links for ETF1

Genetic Association Database (GAD)
ETF1
Human Genome Epidemiology (HuGE) Navigator
ETF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETF1
genes like me logo Genes that share disorders with ETF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETF1 Gene

Publications for ETF1 Gene

  1. A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor. (PMID: 7990965) Frolova L. … Kisselev L. (Nature 1994) 2 23 67
  2. Molecular mapping and candidate gene identification of the Rf2 gene for pollen fertility restoration in sorghum [Sorghum bicolor (L.) Moench]. (PMID: 20091293) Jordan D.R. … Klein R.R. (Theor. Appl. Genet. 2010) 23 67
  3. Autoregulatory systems controlling translation factor expression: thermostat-like control of translational accuracy. (PMID: 20185543) Betney R. … Stansfield I. (RNA 2010) 23 67
  4. Eukaryotic release factor 1-2 affects Arabidopsis responses to glucose and phytohormones during germination and early seedling development. (PMID: 19939886) Zhou X. … Li L. (J. Exp. Bot. 2010) 23 67
  5. GTP-dependent structural rearrangement of the eRF1:eRF3 complex and eRF3 sequence motifs essential for PABP binding. (PMID: 19906736) Kononenko A.V. … Hauryliuk V. (Nucleic Acids Res. 2010) 23 67

Products for ETF1 Gene

Sources for ETF1 Gene

Back to Top

Content