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Aliases for ESRRG Gene

Aliases for ESRRG Gene

  • Estrogen-Related Receptor Gamma 2 3
  • Nuclear Receptor Subfamily 3 Group B Member 3 3 4
  • Estrogen Receptor-Related Protein 3 3 4
  • ERR Gamma-2 3 4
  • NR3B3 3 4
  • ERR3 3 4
  • ERRgamma 3
  • KIAA0832 4
  • ERRG2 4

External Ids for ESRRG Gene

Previous GeneCards Identifiers for ESRRG Gene

  • GC01M215342
  • GC01M212521
  • GC01M213280
  • GC01M213733
  • GC01M213064
  • GC01M214743
  • GC01M216676
  • GC01M187351

Summaries for ESRRG Gene

Entrez Gene Summary for ESRRG Gene

  • This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]

GeneCards Summary for ESRRG Gene

ESRRG (Estrogen-Related Receptor Gamma) is a Protein Coding gene. Diseases associated with ESRRG include vaginal cancer and breast cancer. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding and steroid binding. An important paralog of this gene is AR.

UniProtKB/Swiss-Prot for ESRRG Gene

  • Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.

Gene Wiki entry for ESRRG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESRRG Gene

Genomics for ESRRG Gene

Regulatory Elements for ESRRG Gene

Genomic Location for ESRRG Gene

Start:
216,503,246 bp from pter
End:
217,137,755 bp from pter
Size:
634,510 bases
Orientation:
Minus strand

Genomic View for ESRRG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ESRRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESRRG Gene

Proteins for ESRRG Gene

  • Protein details for ESRRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62508-ERR3_HUMAN
    Recommended name:
    Estrogen-related receptor gamma
    Protein Accession:
    P62508
    Secondary Accessions:
    • A8K4I0
    • A8K6I2
    • B3KY84
    • E9PGB7
    • F8W8J3
    • O75454
    • O96021
    • Q68DA0
    • Q6P274
    • Q6PK28
    • Q6TS38
    • Q9R1F3
    • Q9UNJ4

    Protein attributes for ESRRG Gene

    Size:
    458 amino acids
    Molecular mass:
    51306 Da
    Quaternary structure:
    • Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2.
    Miscellaneous:
    • No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG
    SequenceCaution:
    • Sequence=AAH08218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA74855.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ESRRG Gene

    Alternative splice isoforms for ESRRG Gene

neXtProt entry for ESRRG Gene

Proteomics data for ESRRG Gene at MOPED

Post-translational modifications for ESRRG Gene

  • Acetylated by PCAF/KAT2 (in vitro).
  • Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.
  • Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ESRRG Gene

Domains for ESRRG Gene

Gene Families for ESRRG Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

Suggested Antigen Peptide Sequences for ESRRG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62508

UniProtKB/Swiss-Prot:

ERR3_HUMAN :
  • P62508
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.
genes like me logo Genes that share domains with ESRRG: view

Function for ESRRG Gene

Molecular function for ESRRG Gene

GENATLAS Biochemistry: estrogen-related receptor G,orphan receptor family,steroid/thyroid hormone receptor superfamily,expressed in brain,lung,bone marrow,adrenal gland,trachea,spinal cord,thyroid
UniProtKB/Swiss-Prot Function: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.

Gene Ontology (GO) - Molecular Function for ESRRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0003707 steroid hormone receptor activity IEA --
GO:0003708 retinoic acid receptor activity IEA --
genes like me logo Genes that share ontologies with ESRRG: view
genes like me logo Genes that share phenotypes with ESRRG: view

Animal Models for ESRRG Gene

MGI Knock Outs for ESRRG:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ESRRG Gene

Localization for ESRRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESRRG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ESRRG Gene COMPARTMENTS Subcellular localization image for ESRRG gene
Compartment Confidence
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for ESRRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ESRRG: view

Pathways for ESRRG Gene

genes like me logo Genes that share pathways with ESRRG: view

Pathways by source for ESRRG Gene

Gene Ontology (GO) - Biological Process for ESRRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated IDA 23836911
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0043401 steroid hormone mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with ESRRG: view

Compounds for ESRRG Gene

(7) Drugbank Compounds for ESRRG Gene

(7) IUPHAR Ligand for ESRRG Gene

Ligand Type Action Affinity Pubmed IDs
4-hydroxy?aetamoxifen Antagonist Antagonist 7.5
DY131 Agonist Agonist 6.2
GSK4716 Agonist Agonist 5.7
diethylstilbestrol Antagonist Antagonist 5.3
genistein Activator None
7,4-dihydroxyisoflavone Activator None
5,7-dihydroxy-4-methoxyisoflavone Agonist Agonist

(7) Novoseek inferred chemical compound relationships for ESRRG Gene

Compound -log(P) Hits PubMed IDs
4-hydroxytamoxifen 87.9 4
bisphenol a 78.8 8
diethylstilbestrol 72.7 3
estrogen 69 40
estradiol 20.4 1
genes like me logo Genes that share compounds with ESRRG: view

Transcripts for ESRRG Gene

Unigene Clusters for ESRRG Gene

Estrogen-related receptor gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ESRRG Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - -
SP6: - -
SP7: - -
SP8: - - - - - - - - - - - - - - - - -
SP9: - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - -
SP13: - -
SP14:
SP15: - - - -
SP16: - - - - - - - - - - - - - - - - -
SP17: - - -
SP18: - - -
SP19: - - - - - - -

ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d · 18e · 18f · 18g · 18h · 18i · 18j ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7: - - - -
SP8: - -
SP9:
SP10: - -
SP11: - -
SP12: - -
SP13: - -
SP14:
SP15:
SP16: - -
SP17: - -
SP18: - -
SP19:

Relevant External Links for ESRRG Gene

GeneLoc Exon Structure for
ESRRG
ECgene alternative splicing isoforms for
ESRRG

Expression for ESRRG Gene

mRNA expression in normal human tissues for ESRRG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ESRRG Gene

This gene is overexpressed in Stomach (8.3) and Heart - Left Ventricle (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ESRRG Gene

SOURCE GeneReport for Unigene cluster for ESRRG Gene Hs.444225

mRNA Expression by UniProt/SwissProt for ESRRG Gene

P62508-ERR3_HUMAN
Tissue specificity: Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
genes like me logo Genes that share expressions with ESRRG: view

Orthologs for ESRRG Gene

This gene was present in the common ancestor of animals.

Orthologs for ESRRG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ESRRG 35
  • 99.36 (n)
  • 100 (a)
ESRRG 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ESRRG 35
  • 95.29 (n)
  • 98.65 (a)
ESRRG 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ESRRG 35
  • 95.44 (n)
  • 98.65 (a)
ESRRG 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Esrrg 35
  • 92.53 (n)
  • 98.65 (a)
Esrrg 16
Esrrg 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ESRRG 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ESRRG 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Esrrg 35
  • 91.8 (n)
  • 99.77 (a)
chicken
(Gallus gallus)
Aves ESRRG 35
  • 88.05 (n)
  • 97.47 (a)
ESRRG 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ESRRG 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia esrrg 35
  • 84.9 (n)
  • 95.4 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.27648 35
esrrga 35
  • 79.23 (n)
  • 91.95 (a)
esrrga 36
  • 81 (a)
OneToMany
esrrgb 36
  • 68 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001743 35
  • 52.54 (n)
  • 49.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta ERR 35
  • 52.57 (n)
  • 49.24 (a)
ERR 36
  • 34 (a)
OneToMany
ERR 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for ESRRG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ESRRG Gene

ENSEMBL:
Gene Tree for ESRRG (if available)
TreeFam:
Gene Tree for ESRRG (if available)

Paralogs for ESRRG Gene

Paralogs for ESRRG Gene

genes like me logo Genes that share paralogs with ESRRG: view

Variants for ESRRG Gene

Sequence variations from dbSNP and Humsavar for ESRRG Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs700041 -- 217,080,219(+) TATAT(C/G)TTAAA intron-variant, upstream-variant-2KB
rs700042 -- 217,069,458(-) ATAGG(A/T)GCTAT intron-variant
rs730968 -- 216,655,482(-) CCCCA(A/G)TGTAG intron-variant
rs766158 -- 216,814,119(+) CATGG(A/G)AAAAA intron-variant
rs766159 -- 216,813,951(+) ATTCA(C/T)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ESRRG Gene

Variant ID Type Subtype PubMed ID
nsv873178 CNV Loss 21882294
nsv4565 CNV Loss 18451855
nsv520098 CNV Loss 19592680
nsv468138 CNV Loss 19166990
nsv508694 CNV Loss 20534489
nsv512757 CNV Insertion 21212237
esv1607878 CNV Insertion 17803354
nsv519715 CNV Loss 19592680
esv269200 CNV Insertion 20981092
dgv529n71 CNV Loss 21882294
dgv58e201 CNV Deletion 23290073
nsv520457 CNV Loss 19592680
nsv521019 CNV Loss 19592680
esv2722851 CNV Deletion 23290073
nsv160531 CNV Loss 16902084
esv2722862 CNV Deletion 23290073
nsv525040 CNV Loss 19592680
esv2664498 CNV Deletion 23128226
nsv441737 CNV CNV 18776908
nsv514044 CNV Loss 21397061

Relevant External Links for ESRRG Gene

HapMap Linkage Disequilibrium report
ESRRG
Human Gene Mutation Database (HGMD)
ESRRG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESRRG Gene

Disorders for ESRRG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ESRRG Gene including...

Search for ESRRG Gene in MalaCards »

(1) University of Copenhagen DISEASES for ESRRG Gene

(1) Novoseek inferred disease relationships for ESRRG Gene

Disease -log(P) Hits PubMed IDs
breast cancer 4.75 1

Relevant External Links for ESRRG

Genetic Association Database (GAD)
ESRRG
Human Genome Epidemiology (HuGE) Navigator
ESRRG
genes like me logo Genes that share disorders with ESRRG: view

No data available for UniProtKB/Swiss-Prot for ESRRG Gene

Publications for ESRRG Gene

  1. Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. (PMID: 11864604) Greschik H. … Renaud J.-P. (Mol. Cell 2002) 3 4 23
  2. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PMID: 14651967) Hentschke M. … Borgmeyer U. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  3. X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. (PMID: 16990259) Wang L. … Nolte R.T. (J. Biol. Chem. 2006) 3 4 23
  4. Association with replication between estrogen-related receptor gamma (ESRRgamma) polymorphisms and bone phenotypes in women of European ancestry. (PMID: 19821770) Elfassihi L. … Rousseau F. (J. Bone Miner. Res. 2010) 3 23 48
  5. Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR. (PMID: 10072763) Chen F. … Caskey C.T. (Gene 1999) 2 3 4

Products for ESRRG Gene

Sources for ESRRG Gene

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