Aliases for ERV3-1 Gene
- Endogenous Retrovirus Group 3 Member 1, Envelope 2 3
- HERV-R_7q21.2 Provirus Ancestral Env Polyprotein 3 4
- Endogenous Retrovirus Group 3, Member 1 2 3
- Endogenous Retrovirus Group 3 Member 1 2 5
- Endogenous Retroviral Sequence 3 2 3
- ERV3-1 Envelope Protein 3 4
- HERV-R Envelope Protein 3 4
- ERV-R Envelope Protein 3 4
- ERV3 3 4
- Endogenous Retroviral Sequence 3 (Includes Zinc Finger Protein H-Plk/HPF9) 2
External Ids for ERV3-1 Gene
Previous HGNC Symbols for ERV3-1 Gene
Previous GeneCards Identifiers for ERV3-1 Gene
This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This protein is overexpressed in colorectal and other cancers. [provided by RefSeq, Jan 2017]
GeneCards Summary for ERV3-1 Gene
ERV3-1 (Endogenous Retrovirus Group 3 Member 1, Envelope) is a Protein Coding gene. Diseases associated with ERV3-1 include Choriocarcinoma.
UniProtKB/Swiss-Prot for ERV3-1 Gene
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro.
SU mediates receptor recognition.
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).