Aliases for ERG Gene
- V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2 3 5
- V-Ets Avian Erythroblastosis Virus E26 Oncogene Related 2 2 3
- Transcriptional Regulator ERG (Transforming Protein ERG) 2 3
- V-Ets Erythroblastosis Virus E26 Oncogene Like 2 3
- Erythroblast Transformation-Specific Transcription Factor ERG Variant 10 3
- V-Ets Erythroblastosis Virus E26 Oncogene Homolog 3
- TMPRSS2-ERG Prostate Cancer Specific 2
External Ids for ERG Gene
Previous GeneCards Identifiers for ERG Gene
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
GeneCards Summary for ERG Gene
ERG (V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog) is a Protein Coding gene. Diseases associated with ERG include ewing sarcoma and extraskeletal ewing sarcoma. Among its related pathways are Prostate Cancer and Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and signal transducer activity. An important paralog of this gene is ETS2.
UniProtKB/Swiss-Prot for ERG Gene
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.