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Aliases for ERF Gene

Aliases for ERF Gene

  • Ets2 Repressor Factor 2 3 2 4
  • CRS4 3 6
  • PE-2 3 4
  • PE2 3 6
  • ETS Domain-Containing Transcription Factor ERF 3

External Ids for ERF Gene

Previous GeneCards Identifiers for ERF Gene

  • GC19M043398
  • GC19M043143
  • GC19M047427
  • GC19M047443
  • GC19M042751
  • GC19M039182

Summaries for ERF Gene

Entrez Gene Summary for ERF Gene

  • Members of the ETS family of transcription factors, such as ERF, regulate cell proliferation and differentiation. They share a highly conserved DNA-binding domain, the ETS domain, that recognizes the sequence GGAA/T (de Castro et al., 1997 [PubMed 9192842]). For further information on ETS transcription factors, see ETS1 (MIM 164720).[supplied by OMIM, Mar 2008]

GeneCards Summary for ERF Gene

ERF (Ets2 Repressor Factor) is a Protein Coding gene. Diseases associated with ERF include craniosynostosis 4 and kleeblattschaedel syndrome. Among its related pathways are Cellular Senescence and Cellular Senescence. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for ERF Gene

  • Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity).

Gene Wiki entry for ERF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERF Gene

Genomics for ERF Gene

Regulatory Elements for ERF Gene

Genomic Location for ERF Gene

Start:
42,247,565 bp from pter
End:
42,255,157 bp from pter
Size:
7,593 bases
Orientation:
Minus strand

Genomic View for ERF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERF Gene

Proteins for ERF Gene

  • Protein details for ERF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50548-ERF_HUMAN
    Recommended name:
    ETS domain-containing transcription factor ERF
    Protein Accession:
    P50548
    Secondary Accessions:
    • B2RAP1
    • B7Z4R0
    • Q59G38
    • Q9UPI7

    Protein attributes for ERF Gene

    Size:
    548 amino acids
    Molecular mass:
    58703 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92508.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for ERF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERF Gene

Proteomics data for ERF Gene at MOPED

Post-translational modifications for ERF Gene

  • Phosphorylated by multiple kinases including MAPK1/ERK2 at THR-526. Phosphorylation regulates the activity of ERF.
  • Ubiquitination at Lys105
  • Modification sites at PhosphoSitePlus

Other Protein References for ERF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ERF Gene

Domains for ERF Gene

Protein Domains for ERF Gene

Suggested Antigen Peptide Sequences for ERF Gene

Graphical View of Domain Structure for InterPro Entry

P50548

UniProtKB/Swiss-Prot:

ERF_HUMAN :
  • P50548
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ERF: view

No data available for Gene Families for ERF Gene

Function for ERF Gene

Molecular function for ERF Gene

GENATLAS Biochemistry: Ets 2 repressor factor,ubiquitously expressed with highest levels in the testis,ovary,pancreas,heart,regulated by MAPK phosphorylation during cell cycle and mitogenic stimulation,putatively involved in carcinogenesis
UniProtKB/Swiss-Prot Function: Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for ERF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0003714 transcription corepressor activity IDA 7588608
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ERF: view
genes like me logo Genes that share phenotypes with ERF: view

Animal Models for ERF Gene

MGI Knock Outs for ERF:

miRNA for ERF Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ERF Gene

Localization for ERF Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERF Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERF Gene COMPARTMENTS Subcellular localization image for ERF gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ERF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ERF: view

Pathways for ERF Gene

genes like me logo Genes that share pathways with ERF: view

Pathways by source for ERF Gene

Gene Ontology (GO) - Biological Process for ERF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 7588608
GO:0001701 in utero embryonic development --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0007049 cell cycle NAS 7588608
genes like me logo Genes that share ontologies with ERF: view

Transcripts for ERF Gene

Unigene Clusters for ERF Gene

Ets2 repressor factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERF Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for ERF Gene

GeneLoc Exon Structure for
ERF
ECgene alternative splicing isoforms for
ERF

Expression for ERF Gene

mRNA expression in normal human tissues for ERF Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERF Gene

SOURCE GeneReport for Unigene cluster for ERF Gene Hs.655969

mRNA Expression by UniProt/SwissProt for ERF Gene

P50548-ERF_HUMAN
Tissue specificity: Highest levels in testis, ovary, pancreas, and heart.
genes like me logo Genes that share expressions with ERF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ERF Gene

Orthologs for ERF Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERF 35
  • 99.27 (n)
  • 99.82 (a)
ERF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERF 35
  • 89.74 (n)
  • 95.42 (a)
ERF 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERF 35
  • 92.46 (n)
  • 99.09 (a)
ERF 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Erf 35
  • 88.44 (n)
  • 95.07 (a)
Erf 16
Erf 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERF 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Erf 35
  • 88.26 (n)
  • 95.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16754 35
tropical clawed frog
(Silurana tropicalis)
Amphibia erf 35
  • 69.5 (n)
  • 76.81 (a)
Str.1446 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13342 35
erf 35
  • 64.28 (n)
  • 67.5 (a)
erfl1 36
  • 70 (a)
OneToOne
Species with no ortholog for ERF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ERF Gene

ENSEMBL:
Gene Tree for ERF (if available)
TreeFam:
Gene Tree for ERF (if available)

Paralogs for ERF Gene

Paralogs for ERF Gene

Selected SIMAP similar genes for ERF Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ERF Gene

genes like me logo Genes that share paralogs with ERF: view

Variants for ERF Gene

Sequence variations from dbSNP and Humsavar for ERF Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1053650 -- 42,247,619(-) GAGTA(A/G)AGGGG utr-variant-3-prime
rs1053655 - 42,249,498(-) TCCCC(A/G)CGCCG missense, reference
rs1063897 -- 42,248,970(-) CCAGC(C/G)GCCCC reference, missense
rs1063898 -- 42,248,227(-) GCAAA(G/T)TGGTG utr-variant-3-prime
rs1468691 -- 42,250,285(+) ACCCC(A/G)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERF Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
nsv520239 CNV Loss 19592680
nsv911782 CNV Loss 21882294
nsv833833 CNV Loss 17160897
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
nsv833834 CNV Loss 17160897
dgv3884n71 CNV Loss 21882294
nsv911785 CNV Loss 21882294

Relevant External Links for ERF Gene

HapMap Linkage Disequilibrium report
ERF
Human Gene Mutation Database (HGMD)
ERF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERF Gene

Disorders for ERF Gene

(1) OMIM Diseases for ERF Gene (611888)

UniProtKB/Swiss-Prot

ERF_HUMAN
  • Craniosynostosis 4 (CRS4) [MIM:600775]: A primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability. {ECO:0000269 PubMed:23354439}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for ERF Gene

(1) Novoseek inferred disease relationships for ERF Gene

Disease -log(P) Hits PubMed IDs
leukemia 16.5 2
genes like me logo Genes that share disorders with ERF: view

Publications for ERF Gene

  1. ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. (PMID: 7588608) Sgouras D.N. … Mavrothalassitis G.J. (EMBO J. 1995) 2 3 4 23
  2. Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). (PMID: 9192842) de Castro C.M. … Kaufman R.E. (Genomics 1997) 2 3 4 23
  3. ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes. (PMID: 9136988) Liu D. … Mavrothalassitis G. (Oncogene 1997) 3 23
  4. Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells. (PMID: 12533699) Bain M. … Sinclair J. (J. Gen. Virol. 2003) 3 23
  5. Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS. (PMID: 17525531) Hester K.D. … Glass C.K. (Cell Cycle 2007) 3 23

Products for ERF Gene

Sources for ERF Gene

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