Aliases for ERF Gene
External Ids for ERF Gene
Previous GeneCards Identifiers for ERF Gene
Members of the ETS family of transcription factors, such as ERF, regulate cell proliferation and differentiation. They share a highly conserved DNA-binding domain, the ETS domain, that recognizes the sequence GGAA/T (de Castro et al., 1997 [PubMed 9192842]). For further information on ETS transcription factors, see ETS1 (MIM 164720).[supplied by OMIM, Mar 2008]
GeneCards Summary for ERF Gene
ERF (Ets2 Repressor Factor) is a Protein Coding gene. Diseases associated with ERF include craniosynostosis 4 and kleeblattschaedel syndrome. Among its related pathways are Cellular Senescence and Cellular Senescence. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ETV2.
UniProtKB/Swiss-Prot for ERF Gene
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity).