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Aliases for DHRSX Gene

Aliases for DHRSX Gene

  • Dehydrogenase/Reductase (SDR Family) X-Linked 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 46C Member 1 3 4
  • Short Chain Dehydrogenase/Reductase Family 7C Member 6 3 4
  • Dehydrogenase/Reductase (SDR Family) X Chromosome 2 3
  • Dehydrogenase/Reductase (SDR Family) Y-Linked 2 3
  • CXorf11 3 4
  • SDR46C1 3 4
  • DHRS5X 3 4
  • DHRSXY 3 4
  • SDR7C6 3 4
  • Short Chain Dehydrogenase/Reductase Family 46C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 7C, Member 6 3
  • Short Chain Dehydrogenase/Reductase Family 46C 2
  • Short Chain Dehydrogenase/Reductase Family 7C 2
  • EC 1.1.-.- 4
  • Member 1 2
  • Member 6 2
  • DHRS5Y 3
  • DHRSY 3

External Ids for DHRSX Gene

Previous GeneCards Identifiers for DHRSX Gene

  • GC0XM001605
  • GC0YU900009
  • GC00U921559
  • GC0XM000082

Summaries for DHRSX Gene

GeneCards Summary for DHRSX Gene

DHRSX (Dehydrogenase/Reductase (SDR Family) X-Linked) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH14.

Gene Wiki entry for DHRSX Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRSX Gene

Genomics for DHRSX Gene

Regulatory Elements for DHRSX Gene

Enhancers for DHRSX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DHRSX on UCSC Golden Path with GeneCards custom track

Genomic Location for DHRSX Gene

2,219,506 bp from pter
2,502,805 bp from pter
283,300 bases
Minus strand

Genomic View for DHRSX Gene

Genes around DHRSX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRSX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRSX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRSX Gene

Proteins for DHRSX Gene

  • Protein details for DHRSX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member on chromosome X
    Protein Accession:
    Secondary Accessions:
    • Q6UWC7
    • Q8WUS4
    • Q96GR8
    • Q9NTF6

    Protein attributes for DHRSX Gene

    330 amino acids
    Molecular mass:
    36443 Da
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

neXtProt entry for DHRSX Gene

Proteomics data for DHRSX Gene at MOPED

Post-translational modifications for DHRSX Gene

No Post-translational modifications

Other Protein References for DHRSX Gene

No data available for DME Specific Peptides for DHRSX Gene

Domains & Families for DHRSX Gene

Gene Families for DHRSX Gene

Suggested Antigen Peptide Sequences for DHRSX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRSX: view

Function for DHRSX Gene

Enzyme Numbers (IUBMB) for DHRSX Gene

Phenotypes for DHRSX Gene

genes like me logo Genes that share phenotypes with DHRSX: view

miRNA for DHRSX Gene

miRTarBase miRNAs that target DHRSX

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHRSX Gene

Localization for DHRSX Gene

Subcellular locations from

Jensen Localization Image for DHRSX Gene COMPARTMENTS Subcellular localization image for DHRSX gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DHRSX Gene

Pathways & Interactions for DHRSX Gene

SuperPathways for DHRSX Gene

No Data Available

Interacting Proteins for DHRSX Gene

Gene Ontology (GO) - Biological Process for DHRSX Gene


No data available for Pathways by source and SIGNOR curated interactions for DHRSX Gene

Drugs & Compounds for DHRSX Gene

No Compound Related Data Available

Transcripts for DHRSX Gene

mRNA/cDNA for DHRSX Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRSX Gene

Dehydrogenase/reductase (SDR family) X-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHRSX Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - -
SP3: -
SP4: -

Relevant External Links for DHRSX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRSX Gene

mRNA expression in normal human tissues for DHRSX Gene

Protein differential expression in normal tissues from HIPED for DHRSX Gene

This gene is overexpressed in Nasal epithelium (54.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHRSX Gene

SOURCE GeneReport for Unigene cluster for DHRSX Gene Hs.131452

mRNA Expression by UniProt/SwissProt for DHRSX Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with DHRSX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for DHRSX Gene

Orthologs for DHRSX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRSX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHRSX 35
  • 77.6 (n)
  • 74.22 (a)
MGC152281 36
  • 32 (a)
(Canis familiaris)
Mammalia DHRSX 35
  • 79.87 (n)
  • 80.86 (a)
  • 80 (a)
(Mus musculus)
Mammalia Dhrsx 35
  • 63.27 (n)
  • 57.41 (a)
Dhrsx 16
CAAA01118383.1 36
  • 56 (a)
(Rattus norvegicus)
Mammalia Dhrsx 35
  • 59.62 (n)
  • 54.29 (a)
(Monodelphis domestica)
Mammalia DHRSX 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia DHRSX 36
  • 74 (a)
(Pan troglodytes)
Mammalia DHRSX 36
  • 96 (a)
(Gallus gallus)
Aves DHRSX 35
  • 71.28 (n)
  • 71.15 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia DHRSX 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrsx 35
  • 66.67 (n)
  • 66.77 (a)
(Danio rerio)
Actinopterygii dhrsx 35
  • 60.9 (n)
  • 55.77 (a)
dhrsx 36
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011810 35
  • 51.79 (n)
  • 40.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11200 35
  • 51.02 (n)
  • 40.07 (a)
CG11200 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea dhs-1 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV9 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for DHRSX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRSX Gene

Gene Tree for DHRSX (if available)
Gene Tree for DHRSX (if available)

Paralogs for DHRSX Gene

Paralogs for DHRSX Gene

(9) SIMAP similar genes for DHRSX Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHRSX: view

Variants for DHRSX Gene

Sequence variations from dbSNP and Humsavar for DHRSX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_016100 -
VAR_055354 -
VAR_055355 -

Structural Variations from Database of Genomic Variants (DGV) for DHRSX Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
dgv2432e1 CNV Complex 17122850
esv2666881 CNV Deletion 23128226
esv2739833 CNV Deletion 23290073
esv2739834 CNV Deletion 23290073
esv2658918 CNV Deletion 23128226
esv2663710 CNV Deletion 23128226
esv2739835 CNV Deletion 23290073
esv2741137 CNV Deletion 23290073
dgv1367e201 CNV Deletion 23290073
esv2739837 CNV Deletion 23290073
esv2739838 CNV Deletion 23290073
esv2739841 CNV Deletion 23290073
esv2739843 CNV Deletion 23290073
esv2739845 CNV Deletion 23290073
esv1991441 CNV Deletion 18987734
esv2739846 CNV Deletion 23290073
esv2739847 CNV Deletion 23290073
esv2676100 CNV Deletion 23128226
esv2660086 CNV Deletion 23128226
esv2678233 CNV Deletion 23128226
esv2739848 CNV Deletion 23290073
esv2673036 CNV Deletion 23128226
esv2739849 CNV Deletion 23290073
esv25220 CNV Loss 19812545
nsv9929 CNV Gain 18304495
esv2659495 CNV Deletion 23128226
esv2739850 CNV Deletion 23290073
esv2739852 CNV Deletion 23290073
esv2663505 CNV Deletion 23128226
esv2739853 CNV Deletion 23290073
esv2739854 CNV Deletion 23290073
esv2739855 CNV Deletion 23290073
esv22584 CNV Gain 19812545
esv2739856 CNV Deletion 23290073
esv2739857 CNV Deletion 23290073
esv2669209 CNV Deletion 23128226
esv2674467 CNV Deletion 23128226
esv23482 CNV Loss 19812545
esv2663112 CNV Deletion 23128226
esv2739858 CNV Deletion 23290073
esv2739859 CNV Deletion 23290073
esv2674998 CNV Deletion 23128226
esv2356582 CNV Deletion 18987734
esv2739860 CNV Deletion 23290073
esv2664729 CNV Deletion 23128226
esv2739861 CNV Deletion 23290073
esv2739863 CNV Deletion 23290073
esv2159685 CNV Deletion 18987734
esv2739864 CNV Deletion 23290073
esv2739865 CNV Deletion 23290073
nsv9930 CNV Gain 18304495
nsv10009 CNV Gain 18304495
nsv10010 CNV Gain 18304495

Variation tolerance for DHRSX Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.62; 89.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DHRSX Gene

Disorders for DHRSX Gene

Relevant External Links for DHRSX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHRSX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRSX Gene

Publications for DHRSX Gene

  1. Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. (PMID: 11731500) Gianfrancesco F. … D'Urso M. (Genome Res. 2001) 2 3 4 23 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. DHRSX, a novel non-classical secretory protein associated with starvation induced autophagy. (PMID: 25076851) Zhang G. … Wang L. (Int J Med Sci 2014) 3
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3

Products for DHRSX Gene

Sources for DHRSX Gene