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Aliases for DHRSX Gene

Aliases for DHRSX Gene

  • Dehydrogenase/Reductase X-Linked 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 46C Member 1 3 4
  • Short Chain Dehydrogenase/Reductase Family 7C Member 6 3 4
  • Dehydrogenase/Reductase (SDR Family) X Chromosome 2 3
  • Dehydrogenase/Reductase (SDR Family) Y-Linked 2 3
  • CXorf11 3 4
  • SDR46C1 3 4
  • DHRS5X 3 4
  • DHRSXY 3 4
  • SDR7C6 3 4
  • Dehydrogenase/Reductase SDR Family Member On Chromosome X 3
  • Short Chain Dehydrogenase/Reductase Family 46C, Member 1 2
  • Short Chain Dehydrogenase/Reductase Family 7C, Member 6 2
  • Dehydrogenase/Reductase (SDR Family) X-Linked 3
  • EC 1.1.-.- 4
  • DHRS5Y 3
  • DHRSY 3

External Ids for DHRSX Gene

Previous GeneCards Identifiers for DHRSX Gene

  • GC0XM001605
  • GC0YU900009
  • GC00U921559
  • GC0XM000082

Summaries for DHRSX Gene

GeneCards Summary for DHRSX Gene

DHRSX (Dehydrogenase/Reductase X-Linked) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH14.

UniProtKB/Swiss-Prot for DHRSX Gene

  • Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851).

Gene Wiki entry for DHRSX Gene

Additional gene information for DHRSX Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRSX Gene

Genomics for DHRSX Gene

Regulatory Elements for DHRSX Gene

Enhancers for DHRSX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH002703 1.6 FANTOM5 Ensembl dbSUPER 1.9 -204.4 -204396 8 PKNOX1 FOXA2 ARID4B SIN3A ZNF143 FOS ATF7 RUNX3 JUNB NFIL3 ZBED1 CD99 DHRSX ARSD XG
GH0XH002695 1.4 FANTOM5 Ensembl dbSUPER 1.4 -194.0 -193997 2.4 PKNOX1 JUN EBF1 ZBTB40 BATF FOSL1 ZNF121 CTBP1 GATA3 EED CD99 ZBED1 DHRSX XG
GH0XH002430 0.7 FANTOM5 Ensembl 2.2 +72.4 72355 0.5 POLR2A ZBED1 DHRSX DHRSX-IT1
GH0XH002324 1.1 FANTOM5 Ensembl 1.3 +177.5 177458 1.1 ZNF76 ZBTB40 YY1 IKZF2 CREM ZNF680 HCFC1 YY2 ZBTB11 ZEB2 DHRSX ZBED1 LOC101928070 DHRSX-IT1
GH0XH002767 1 FANTOM5 Ensembl 1.3 -264.8 -264803 1.2 HDAC1 ZNF687 KLF1 RFX1 HLF MAX RFX5 NFIL3 CTBP1 GATA3 CD99 ZBED1 DHRSX XG GYG2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHRSX on UCSC Golden Path with GeneCards custom track

Genomic Locations for DHRSX Gene

Genomic Locations for DHRSX Gene
283,300 bases
Minus strand

Genomic View for DHRSX Gene

Genes around DHRSX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRSX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRSX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRSX Gene

Proteins for DHRSX Gene

  • Protein details for DHRSX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member on chromosome X
    Protein Accession:
    Secondary Accessions:
    • Q6UWC7
    • Q8WUS4
    • Q96GR8
    • Q9NTF6

    Protein attributes for DHRSX Gene

    330 amino acids
    Molecular mass:
    36443 Da
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

neXtProt entry for DHRSX Gene

Post-translational modifications for DHRSX Gene

No Post-translational modifications

Other Protein References for DHRSX Gene

No data available for DME Specific Peptides for DHRSX Gene

Domains & Families for DHRSX Gene

Gene Families for DHRSX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for DHRSX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRSX: view

Function for DHRSX Gene

Molecular function for DHRSX Gene

UniProtKB/Swiss-Prot Function:
Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851).

Enzyme Numbers (IUBMB) for DHRSX Gene

Gene Ontology (GO) - Molecular Function for DHRSX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRSX: view
genes like me logo Genes that share phenotypes with DHRSX: view

Animal Model Products

miRNA for DHRSX Gene

miRTarBase miRNAs that target DHRSX

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHRSX Gene

Localization for DHRSX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRSX Gene

Secreted. Note=Secreted in a non-classical form. A signal peptide sequence at position 1-31 is predicted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRSX gene
Compartment Confidence
extracellular 5
cytoskeleton 2
mitochondrion 2
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHRSX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 25076851
genes like me logo Genes that share ontologies with DHRSX: view

Pathways & Interactions for DHRSX Gene

SuperPathways for DHRSX Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRSX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010508 positive regulation of autophagy IMP 25076851
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRSX: view

No data available for Pathways by source and SIGNOR curated interactions for DHRSX Gene

Drugs & Compounds for DHRSX Gene

No Compound Related Data Available

Transcripts for DHRSX Gene

mRNA/cDNA for DHRSX Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRSX Gene

Dehydrogenase/reductase (SDR family) X-linked:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRSX Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - -
SP3: -
SP4: -

Relevant External Links for DHRSX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRSX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRSX Gene

Protein differential expression in normal tissues from HIPED for DHRSX Gene

This gene is overexpressed in Nasal epithelium (54.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHRSX Gene

NURSA nuclear receptor signaling pathways regulating expression of DHRSX Gene:


SOURCE GeneReport for Unigene cluster for DHRSX Gene:


mRNA Expression by UniProt/SwissProt for DHRSX Gene:

Tissue specificity: Widely expressed. Highly expressed in the pancreas.

Evidence on tissue expression from TISSUES for DHRSX Gene

  • Nervous system(4.5)
  • Intestine(4.3)
  • Pancreas(3.5)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with DHRSX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRSX Gene

Orthologs for DHRSX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRSX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHRSX 34
  • 96 (a)
(Canis familiaris)
Mammalia DHRSX 33 34
  • 79.87 (n)
(Bos Taurus)
Mammalia DHRSX 33
  • 77.6 (n)
MGC152281 34
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia DHRSX 34
  • 74 (a)
(Monodelphis domestica)
Mammalia DHRSX 34
  • 67 (a)
(Mus musculus)
Mammalia Dhrsx 33 16
  • 63.27 (n)
CAAA01118383.1 34
  • 56 (a)
(Rattus norvegicus)
Mammalia Dhrsx 33
  • 59.62 (n)
(Gallus gallus)
Aves DHRSX 33 34
  • 71.28 (n)
(Anolis carolinensis)
Reptilia DHRSX 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrsx 33
  • 66.67 (n)
(Danio rerio)
Actinopterygii dhrsx 33 34
  • 60.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011810 33
  • 51.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11200 33 34
  • 51.02 (n)
(Caenorhabditis elegans)
Secernentea dhs-1 34
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV9 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
Species where no ortholog for DHRSX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRSX Gene

Gene Tree for DHRSX (if available)
Gene Tree for DHRSX (if available)

Paralogs for DHRSX Gene

Paralogs for DHRSX Gene

(9) SIMAP similar genes for DHRSX Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHRSX: view

Variants for DHRSX Gene

Sequence variations from dbSNP and Humsavar for DHRSX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1127915 --
rs12010 --
rs3210910 --

Structural Variations from Database of Genomic Variants (DGV) for DHRSX Gene

Variant ID Type Subtype PubMed ID
nsv9930 CNV gain 18304495
nsv9929 CNV gain 18304495
nsv953726 CNV deletion 24416366
nsv953725 CNV deletion 24416366
nsv953397 CNV deletion 24416366
nsv953396 CNV deletion 24416366
nsv1153600 CNV duplication 26484159
nsv1152788 CNV duplication 26484159
nsv1152521 CNV duplication 26484159
nsv1147379 CNV duplication 26484159
nsv1146767 CNV duplication 26484159
nsv1145280 CNV deletion 24896259
nsv1141661 CNV duplication 24896259
nsv1140091 CNV duplication 24896259
nsv1140090 CNV duplication 24896259
nsv1140010 CNV duplication 24896259
nsv1137685 CNV deletion 24896259
nsv1132750 CNV duplication 24896259
nsv1125146 CNV duplication 24896259
nsv1122259 CNV deletion 24896259
nsv1078665 CNV duplication 25765185
nsv1078149 CNV duplication 25765185
nsv1078103 CNV duplication 25765185
nsv1077257 CNV deletion 25765185
nsv1076739 CNV duplication 25765185
nsv1076241 CNV deletion 25765185
nsv1075707 CNV deletion 25765185
nsv1075303 CNV deletion 25765185
nsv10010 CNV gain 18304495
nsv10009 CNV gain 18304495
esv3558533 CNV deletion 23714750
esv3558531 CNV deletion 23714750
esv3558530 CNV deletion 23714750
esv3558528 CNV deletion 23714750
esv3558526 CNV deletion 23714750
esv3336612 CNV duplication 20981092
esv29996 CNV loss 17803354
esv2982198 CNV insertion 24192839
esv2758855 CNV gain 17122850
esv2741137 CNV deletion 23290073
esv2739865 CNV deletion 23290073
esv2739864 CNV deletion 23290073
esv2739863 CNV deletion 23290073
esv2739861 CNV deletion 23290073
esv2739860 CNV deletion 23290073
esv2739859 CNV deletion 23290073
esv2739858 CNV deletion 23290073
esv2739857 CNV deletion 23290073
esv2739856 CNV deletion 23290073
esv2739855 CNV deletion 23290073
esv2739854 CNV deletion 23290073
esv2739853 CNV deletion 23290073
esv2739852 CNV deletion 23290073
esv2739850 CNV deletion 23290073
esv2739849 CNV deletion 23290073
esv2739848 CNV deletion 23290073
esv2739847 CNV deletion 23290073
esv2739846 CNV deletion 23290073
esv2739845 CNV deletion 23290073
esv2739843 CNV deletion 23290073
esv2739841 CNV deletion 23290073
esv2739838 CNV deletion 23290073
esv2739837 CNV deletion 23290073
esv2739835 CNV deletion 23290073
esv2739834 CNV deletion 23290073
esv2739833 CNV deletion 23290073
esv2678233 CNV deletion 23128226
esv2676100 CNV deletion 23128226
esv2674998 CNV deletion 23128226
esv2674467 CNV deletion 23128226
esv2673036 CNV deletion 23128226
esv2669209 CNV deletion 23128226
esv2666881 CNV deletion 23128226
esv2664729 CNV deletion 23128226
esv2663710 CNV deletion 23128226
esv2663505 CNV deletion 23128226
esv2663112 CNV deletion 23128226
esv2660086 CNV deletion 23128226
esv2659495 CNV deletion 23128226
esv2658918 CNV deletion 23128226
esv25220 CNV loss 19812545
esv2356582 CNV deletion 18987734
esv23482 CNV loss 19812545
esv22584 CNV gain 19812545
esv2159685 CNV deletion 18987734
esv1991441 CNV deletion 18987734
dgv4337n106 CNV deletion 24896259
dgv4336n106 CNV deletion 24896259
dgv1309e201 CNV deletion 23290073

Variation tolerance for DHRSX Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.62; 89.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRSX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRSX Gene

Disorders for DHRSX Gene

Relevant External Links for DHRSX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DHRSX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRSX Gene

Publications for DHRSX Gene

  1. Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. (PMID: 11731500) Gianfrancesco F … D'Urso M (Genome research 2001) 2 3 4 22 60
  2. DHRSX, a novel non-classical secretory protein associated with starvation induced autophagy. (PMID: 25076851) Zhang G … Wang L (International journal of medical sciences 2014) 3 4 60
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60

Products for DHRSX Gene

Sources for DHRSX Gene

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