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Aliases for NR2F6 Gene

Aliases for NR2F6 Gene

  • Nuclear Receptor Subfamily 2, Group F, Member 6 2 3
  • ERBAL2 3 4 6
  • EAR2 3 4 6
  • V-ErbA-Related Protein 2 3 4
  • EAR-2 3 4
  • V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 2 3
  • Nuclear Receptor Subfamily 2 Group F Member 6 3
  • Nuclear Receptor V-ErbA-Related 3
  • ERBA-Related Gene-2 3

External Ids for NR2F6 Gene

Previous HGNC Symbols for NR2F6 Gene

  • ERBAL2

Previous GeneCards Identifiers for NR2F6 Gene

  • GC19M017836
  • GC19M017734
  • GC19M017187
  • GC19M017203
  • GC19M017342
  • GC19M016910

Summaries for NR2F6 Gene

GeneCards Summary for NR2F6 Gene

NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6) is a Protein Coding gene. Diseases associated with NR2F6 include chronic purulent otitis media. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and steroid hormone receptor activity. An important paralog of this gene is RXRG.

UniProtKB/Swiss-Prot for NR2F6 Gene

  • Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5-AGGTCA-3 direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

Gene Wiki entry for NR2F6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2F6 Gene

Genomics for NR2F6 Gene

Regulatory Elements for NR2F6 Gene

Genomic Location for NR2F6 Gene

Start:
17,231,883 bp from pter
End:
17,245,940 bp from pter
Size:
14,058 bases
Orientation:
Minus strand

Genomic View for NR2F6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NR2F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2F6 Gene

Proteins for NR2F6 Gene

  • Protein details for NR2F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10588-NR2F6_HUMAN
    Recommended name:
    Nuclear receptor subfamily 2 group F member 6
    Protein Accession:
    P10588
    Secondary Accessions:
    • B2RC68
    • Q5XGA0
    • Q6P586
    • Q9BUE8

    Protein attributes for NR2F6 Gene

    Size:
    404 amino acids
    Molecular mass:
    42979 Da
    Quaternary structure:
    • Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1 (By similarity). Interacts with THRB.

neXtProt entry for NR2F6 Gene

Proteomics data for NR2F6 Gene at MOPED

Post-translational modifications for NR2F6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR2F6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NR2F6 Gene

Domains for NR2F6 Gene

Gene Families for NR2F6 Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P10588

UniProtKB/Swiss-Prot:

NR2F6_HUMAN :
  • P10588
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with NR2F6: view

Function for NR2F6 Gene

Molecular function for NR2F6 Gene

GENATLAS Biochemistry: nuclear receptor subfamily 2,group F,member 6,steroid/thyroid receptor superfamily
UniProtKB/Swiss-Prot Function: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5-AGGTCA-3 direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
UniProtKB/Swiss-Prot Induction: Inhibited by gonadotropin in granulosa cells.

Gene Ontology (GO) - Molecular Function for NR2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding TAS 2905047
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 10644740
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with NR2F6: view
genes like me logo Genes that share phenotypes with NR2F6: view

Animal Models for NR2F6 Gene

MGI Knock Outs for NR2F6:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NR2F6 Gene

Localization for NR2F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2F6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR2F6 Gene COMPARTMENTS Subcellular localization image for NR2F6 gene
Compartment Confidence
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for NR2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10644740
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with NR2F6: view

Pathways for NR2F6 Gene

genes like me logo Genes that share pathways with NR2F6: view

Pathways by source for NR2F6 Gene

1 BioSystems pathway for NR2F6 Gene

Gene Ontology (GO) - Biological Process for NR2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 10644740
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007165 signal transduction TAS 2905047
genes like me logo Genes that share ontologies with NR2F6: view

Transcripts for NR2F6 Gene

mRNA/cDNA for NR2F6 Gene

Unigene Clusters for NR2F6 Gene

Nuclear receptor subfamily 2, group F, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NR2F6 Gene

No ASD Table

Relevant External Links for NR2F6 Gene

GeneLoc Exon Structure for
NR2F6
ECgene alternative splicing isoforms for
NR2F6

Expression for NR2F6 Gene

mRNA expression in normal human tissues for NR2F6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR2F6 Gene

This gene is overexpressed in Liver (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NR2F6 Gene

SOURCE GeneReport for Unigene cluster for NR2F6 Gene Hs.466148

mRNA Expression by UniProt/SwissProt for NR2F6 Gene

P10588-NR2F6_HUMAN
Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with NR2F6: view

Orthologs for NR2F6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2F6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2F6 35
  • 99.01 (n)
  • 99.75 (a)
NR2F6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NR2F6 35
  • 92.29 (n)
  • 97.76 (a)
NR2F6 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR2F6 35
  • 94.19 (n)
  • 97.95 (a)
NR2F6 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr2f6 35
  • 87.06 (n)
  • 93.83 (a)
Nr2f6 16
Nr2f6 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR2F6 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR2F6 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr2f6 35
  • 87.06 (n)
  • 92.29 (a)
chicken
(Gallus gallus)
Aves NR2F6 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia nr2f6-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nr2f6 35
  • 70.18 (n)
  • 82.01 (a)
zebrafish
(Danio rerio)
Actinopterygii nr2f6a 35
  • 71.91 (n)
  • 77.41 (a)
nr2f6a 36
  • 74 (a)
OneToMany
nr2f6b 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dsf 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-55 36
  • 37 (a)
OneToOne
unc-55 37
  • 34 (a)
Species with no ortholog for NR2F6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR2F6 Gene

ENSEMBL:
Gene Tree for NR2F6 (if available)
TreeFam:
Gene Tree for NR2F6 (if available)

Paralogs for NR2F6 Gene

Paralogs for NR2F6 Gene

genes like me logo Genes that share paralogs with NR2F6: view

Variants for NR2F6 Gene

Sequence variations from dbSNP and Humsavar for NR2F6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs751010 -- 17,231,507(+) acagc(A/G)aaact downstream-variant-500B
rs891205 -- 17,243,777(-) GAGTG(G/T)CCCCA intron-variant
rs1056989 -- 17,232,266(+) GGGCC(C/G)CGGGA utr-variant-3-prime
rs1056991 -- 17,232,273(+) GGGAG(C/G)CCCCT utr-variant-3-prime
rs1057060 -- 17,235,730(+) GCTCA(G/T)GCGCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for NR2F6 Gene

Variant ID Type Subtype PubMed ID
dgv3756n71 CNV Loss 21882294
dgv3757n71 CNV Loss 21882294
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
nsv911185 CNV Loss 21882294
nsv911186 CNV Gain 21882294
nsv911188 CNV Loss 21882294
nsv911189 CNV Loss 21882294
dgv3759n71 CNV Loss 21882294
dgv3760n71 CNV Loss 21882294
esv29611 CNV Loss 19812545

Relevant External Links for NR2F6 Gene

HapMap Linkage Disequilibrium report
NR2F6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2F6 Gene

Disorders for NR2F6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NR2F6 Gene including...

Search for NR2F6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NR2F6 Gene

genes like me logo Genes that share disorders with NR2F6: view

No data available for UniProtKB/Swiss-Prot for NR2F6 Gene

Publications for NR2F6 Gene

  1. The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. (PMID: 10713182) Zhu X.G. … Cheng S.Y. (Mol. Cell. Biol. 2000) 3 4 23
  2. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (PMID: 2905047) Miyajima N. … Yamamoto T. (Nucleic Acids Res. 1988) 2 3 4
  3. EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. (PMID: 11682620) Zhang Y. … Dufau M.L. (Mol. Endocrinol. 2001) 4 23
  4. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PMID: 10644740) Zhang Y. … Dufau M.L. (J. Biol. Chem. 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NR2F6 Gene

Sources for NR2F6 Gene

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