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Aliases for NR2F6 Gene

Aliases for NR2F6 Gene

  • Nuclear Receptor Subfamily 2 Group F Member 6 2 3 5
  • V-ErbA-Related Protein 2 3 4
  • ERBAL2 3 4
  • EAR-2 3 4
  • EAR2 3 4
  • V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 2 3
  • Nuclear Receptor Subfamily 2, Group F, Member 6 2
  • Nuclear Receptor V-ErbA-Related 3
  • ERBA-Related Gene-2 3

External Ids for NR2F6 Gene

Previous HGNC Symbols for NR2F6 Gene

  • ERBAL2

Previous GeneCards Identifiers for NR2F6 Gene

  • GC19M017836
  • GC19M017734
  • GC19M017187
  • GC19M017203
  • GC19M017342
  • GC19M016910

Summaries for NR2F6 Gene

GeneCards Summary for NR2F6 Gene

NR2F6 (Nuclear Receptor Subfamily 2 Group F Member 6) is a Protein Coding gene. Among its related pathways are Gene Expression and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is NR2F1.

UniProtKB/Swiss-Prot for NR2F6 Gene

  • Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5-AGGTCA-3 direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

Gene Wiki entry for NR2F6 Gene

Additional gene information for NR2F6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2F6 Gene

Genomics for NR2F6 Gene

GeneHancer (GH) Regulatory Elements for NR2F6 Gene

Promoters and enhancers for NR2F6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I017239 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 568.5 +0.9 924 10.4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 NR2F6 GC19M017243 CHERP ENSG00000267904 MVB12A GTPBP3 C19orf44 ENSG00000268087 OCEL1 ENSG00000268743
GH19I017336 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.2 -91.4 -91416 2.5 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 GTPBP3 CHERP ENSG00000269578 ENSG00000268743 IQCN COLGALT1 C19orf44 SIN3B HAUS8 MVB12A
GH19I017234 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +10.1 10082 3.2 HDGF ATF1 SIN3A ZNF2 YY1 POLR2B ZNF766 GLIS2 ZNF207 ZNF143 OCEL1 NR2F6 MVB12A BST2 GTPBP3 GC19M017243 ENSG00000269095
GH19I016323 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 +917.9 917938 9.1 PKNOX1 SIN3A ZNF121 GLIS2 ZNF213 ATF7 FOS REST MAFF GLIS1 KLF2 C19orf44 SIN3B CHERP ENSG00000269578 ENSG00000268743 EPS15L1 MED26 TMEM38A NR2F6
GH19I017159 Enhancer 0.9 ENCODE dbSUPER 11.5 +86.1 86070 1.1 USF1 SAP130 MAX ARID4B EBF1 RAD21 ZBTB40 RARA ZNF7 POLR2A MYO9B NR2F6 CPAMD8 ENSG00000268056 GC19M017123
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NR2F6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NR2F6 gene promoter:

Genomic Locations for NR2F6 Gene

Genomic Locations for NR2F6 Gene
chr19:17,231,883-17,245,940
(GRCh38/hg38)
Size:
14,058 bases
Orientation:
Minus strand
chr19:17,342,692-17,356,749
(GRCh37/hg19)

Genomic View for NR2F6 Gene

Genes around NR2F6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR2F6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR2F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2F6 Gene

Proteins for NR2F6 Gene

  • Protein details for NR2F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10588-NR2F6_HUMAN
    Recommended name:
    Nuclear receptor subfamily 2 group F member 6
    Protein Accession:
    P10588
    Secondary Accessions:
    • B2RC68
    • Q5XGA0
    • Q6P586
    • Q9BUE8

    Protein attributes for NR2F6 Gene

    Size:
    404 amino acids
    Molecular mass:
    42979 Da
    Quaternary structure:
    • Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1 (By similarity). Interacts with THRB.

neXtProt entry for NR2F6 Gene

Post-translational modifications for NR2F6 Gene

No Post-translational modifications

Other Protein References for NR2F6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NR2F6 Gene

Domains & Families for NR2F6 Gene

Gene Families for NR2F6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

P10588

UniProtKB/Swiss-Prot:

NR2F6_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with NR2F6: view

Function for NR2F6 Gene

Molecular function for NR2F6 Gene

GENATLAS Biochemistry:
nuclear receptor subfamily 2,group F,member 6,steroid/thyroid receptor superfamily
UniProtKB/Swiss-Prot Function:
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5-AGGTCA-3 direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
UniProtKB/Swiss-Prot Induction:
Inhibited by gonadotropin in granulosa cells.

Phenotypes From GWAS Catalog for NR2F6 Gene

Gene Ontology (GO) - Molecular Function for NR2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA,TAS 2905047
GO:0003700 DNA binding transcription factor activity IDA 10644740
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with NR2F6: view
genes like me logo Genes that share phenotypes with NR2F6: view

Animal Models for NR2F6 Gene

MGI Knock Outs for NR2F6:

Animal Model Products

CRISPR Products

miRNA for NR2F6 Gene

miRTarBase miRNAs that target NR2F6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NR2F6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NR2F6 Gene

Localization for NR2F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2F6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR2F6 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NR2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10644740
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with NR2F6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NR2F6 Gene

Pathways & Interactions for NR2F6 Gene

genes like me logo Genes that share pathways with NR2F6: view

Pathways by source for NR2F6 Gene

SIGNOR curated interactions for NR2F6 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NR2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 10644740
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007165 signal transduction TAS 2905047
genes like me logo Genes that share ontologies with NR2F6: view

Drugs & Compounds for NR2F6 Gene

No Compound Related Data Available

Transcripts for NR2F6 Gene

mRNA/cDNA for NR2F6 Gene

Unigene Clusters for NR2F6 Gene

Nuclear receptor subfamily 2, group F, member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NR2F6

Alternative Splicing Database (ASD) splice patterns (SP) for NR2F6 Gene

No ASD Table

Relevant External Links for NR2F6 Gene

GeneLoc Exon Structure for
NR2F6
ECgene alternative splicing isoforms for
NR2F6

Expression for NR2F6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR2F6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR2F6 Gene

This gene is overexpressed in Liver (x4.3).

Protein differential expression in normal tissues from HIPED for NR2F6 Gene

This gene is overexpressed in Breast (51.5) and Retina (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NR2F6 Gene



NURSA nuclear receptor signaling pathways regulating expression of NR2F6 Gene:

NR2F6

SOURCE GeneReport for Unigene cluster for NR2F6 Gene:

Hs.466148

mRNA Expression by UniProt/SwissProt for NR2F6 Gene:

P10588-NR2F6_HUMAN
Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for NR2F6 Gene

  • Lung(4.5)
  • Liver(4.4)
  • Kidney(4.3)
  • Pancreas(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with NR2F6: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2F6 Gene

Orthologs for NR2F6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2F6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2F6 33 34
  • 99.01 (n)
dog
(Canis familiaris)
Mammalia NR2F6 33 34
  • 94.19 (n)
cow
(Bos Taurus)
Mammalia NR2F6 33 34
  • 92.29 (n)
mouse
(Mus musculus)
Mammalia Nr2f6 33 16 34
  • 87.06 (n)
rat
(Rattus norvegicus)
Mammalia Nr2f6 33
  • 87.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NR2F6 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR2F6 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR2F6 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nr2f6 33
  • 70.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia nr2f6-prov 33
zebrafish
(Danio rerio)
Actinopterygii nr2f6b 34
  • 75 (a)
OneToMany
nr2f6a 34 33
  • 71.91 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dsf 35
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-55 35 34
  • 34 (a)
Species where no ortholog for NR2F6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR2F6 Gene

ENSEMBL:
Gene Tree for NR2F6 (if available)
TreeFam:
Gene Tree for NR2F6 (if available)

Paralogs for NR2F6 Gene

Paralogs for NR2F6 Gene

genes like me logo Genes that share paralogs with NR2F6: view

Variants for NR2F6 Gene

Sequence variations from dbSNP and Humsavar for NR2F6 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000144965 -- 17,246,105(-) G/C upstream_transcript_variant
rs1000229357 -- 17,232,278(-) T/A 3_prime_UTR_variant
rs1000298473 -- 17,237,414(-) T/C intron_variant
rs1000412418 -- 17,237,569(-) G/A intron_variant
rs1000622758 -- 17,236,324(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NR2F6 Gene

Variant ID Type Subtype PubMed ID
esv29611 CNV loss 19812545
nsv1071513 CNV deletion 25765185
nsv1118819 CNV deletion 24896259
nsv1118820 CNV deletion 24896259
nsv470129 CNV loss 18288195

Variation tolerance for NR2F6 Gene

Gene Damage Index Score: 2.23; 40.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NR2F6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR2F6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2F6 Gene

Disorders for NR2F6 Gene

Additional Disease Information for NR2F6

No disorders were found for NR2F6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NR2F6 Gene

Publications for NR2F6 Gene

  1. The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. (PMID: 10713182) Zhu XG … Cheng SY (Molecular and cellular biology 2000) 3 4 22 58
  2. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (PMID: 2905047) Miyajima N … Yamamoto T (Nucleic acids research 1988) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. (PMID: 11682620) Zhang Y … Dufau ML (Molecular endocrinology (Baltimore, Md.) 2001) 4 22 58
  5. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PMID: 10644740) Zhang Y … Dufau ML (The Journal of biological chemistry 2000) 3 4 58

Products for NR2F6 Gene

Sources for NR2F6 Gene

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