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Aliases for EPS8 Gene

Aliases for EPS8 Gene

  • Epidermal Growth Factor Receptor Pathway Substrate 8 2 3 5
  • Epidermal Growth Factor Receptor Kinase Substrate 8 3
  • DFNB102 3

External Ids for EPS8 Gene

Previous GeneCards Identifiers for EPS8 Gene

  • GC12M015512
  • GC12M015917
  • GC12M015673

Summaries for EPS8 Gene

Entrez Gene Summary for EPS8 Gene

  • This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPS8 Gene

EPS8 (Epidermal Growth Factor Receptor Pathway Substrate 8) is a Protein Coding gene. Diseases associated with EPS8 include Deafness, Autosomal Recessive 102 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are G-protein signaling RAC1 in cellular process and Development ERBB-family signaling. GO annotations related to this gene include actin binding and Rac GTPase binding. An important paralog of this gene is EPS8L2.

UniProtKB/Swiss-Prot for EPS8 Gene

  • Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.

Gene Wiki entry for EPS8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPS8 Gene

Genomics for EPS8 Gene

Regulatory Elements for EPS8 Gene

Enhancers for EPS8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G015698 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +181.5 181454 5.3 HDGF FOXA2 RAD21 GATA2 ZNF366 RELB FOS ETV6 IKZF2 CREM EPS8 RNU6-251P STRAP ENSG00000256564 GC12M015672 ENSG00000255565
GH12G015635 1.6 Ensembl ENCODE dbSUPER 12.1 +245.0 244968 3.3 SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF143 ZNF207 FOS ZNF263 SP3 RNU6-251P EPS8 ENSG00000261324 GC12M015672 LOC105369672
GH12G015710 1.5 Ensembl ENCODE dbSUPER 12.2 +169.9 169884 3.3 HNRNPUL1 FOXA2 ATF1 ZFP64 YY1 KLF7 ZNF263 ZNF202 SP5 MXD4 SUPT16HP1 WBP11 HIST4H4 ENSG00000261324 RNU6-251P EPS8 ENSG00000256564 GC12M015672 ENSG00000255565
GH12G015707 1.1 ENCODE dbSUPER 15.9 +173.6 173598 3.2 FOXA2 THRB RAD21 YY1 RARA CREM THAP11 MIXL1 MXD4 CEBPB EPS8 RNU6-251P GC12M015672 ENSG00000255565
GH12G015727 1.5 Ensembl ENCODE dbSUPER 11.3 +153.9 153916 1.8 PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF143 ZNF207 RNU6-251P EPS8 ENSG00000255565 GC12M015672
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EPS8 on UCSC Golden Path with GeneCards custom track

Promoters for EPS8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000049300 -272 2400 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for EPS8 Gene

Chromosome:
12
Start:
15,620,141 bp from pter
End:
15,882,329 bp from pter
Size:
262,189 bases
Orientation:
Minus strand

Genomic View for EPS8 Gene

Genes around EPS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPS8 Gene

Proteins for EPS8 Gene

  • Protein details for EPS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12929-EPS8_HUMAN
    Recommended name:
    Epidermal growth factor receptor kinase substrate 8
    Protein Accession:
    Q12929
    Secondary Accessions:
    • A6NMC3
    • A8K6W2
    • A8KA66
    • B4DX66
    • Q8N6J0

    Protein attributes for EPS8 Gene

    Size:
    822 amino acids
    Molecular mass:
    91882 Da
    Quaternary structure:
    • Homodimer. Part of a complex consisting of ABI1, EPS8 and SOS1. Interacts with MYO15A and WHRN. Interacts with LANCL1 (By similarity). Interacts with EGFR; mediates EPS8 phosphorylation (By similarity). Interacts with BAIAP2. Interacts with SHB.

    Three dimensional structures from OCA and Proteopedia for EPS8 Gene

    Alternative splice isoforms for EPS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPS8 Gene

Post-translational modifications for EPS8 Gene

  • Phosphorylation at Ser-625 and Thr-629 by MAPK following BDNF treatment promotes removal from actin and filopodia formation (By similarity). Phosphorylated by several receptor tyrosine kinases.
  • Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during G2 phase, leading to its transient degradation and subsequent cell shape changes required to allow mitotic progression. Reappears at the midzone of dividing cells (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EPS8 (EPS8)

No data available for DME Specific Peptides for EPS8 Gene

Domains & Families for EPS8 Gene

Graphical View of Domain Structure for InterPro Entry

Q12929

UniProtKB/Swiss-Prot:

EPS8_HUMAN :
  • The effector region is required for activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. It mediates both barbed-end actin capping and actin bundling activities. The capping activity is mediated by an amphipathic helix that binds within the hydrophobic pocket at the barbed ends of actin blocking further addition of actin monomers, while the bundling activity is mediated by a compact 4 helix bundle, which contacts 3 actin subunits along the filament (By similarity).
  • Belongs to the EPS8 family.
Domain:
  • The effector region is required for activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. It mediates both barbed-end actin capping and actin bundling activities. The capping activity is mediated by an amphipathic helix that binds within the hydrophobic pocket at the barbed ends of actin blocking further addition of actin monomers, while the bundling activity is mediated by a compact 4 helix bundle, which contacts 3 actin subunits along the filament (By similarity).
  • The SH3 domain mediates interaction with SHB.
Family:
  • Belongs to the EPS8 family.
genes like me logo Genes that share domains with EPS8: view

No data available for Gene Families for EPS8 Gene

Function for EPS8 Gene

Molecular function for EPS8 Gene

GENATLAS Biochemistry:
epidermal growth factor receptor (EGFR) substrate,complexing with SSH3BP1 and putatively mediating the transfer of signals from Ras to Racs
UniProtKB/Swiss-Prot Function:
Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.

Gene Ontology (GO) - Molecular Function for EPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0005070 SH3/SH2 adaptor activity TAS 8084614
GO:0005515 protein binding IPI 15289329
GO:0035591 signaling adaptor activity IEA --
GO:0048365 Rac GTPase binding ISS --
genes like me logo Genes that share ontologies with EPS8: view
genes like me logo Genes that share phenotypes with EPS8: view

Human Phenotype Ontology for EPS8 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EPS8 Gene

MGI Knock Outs for EPS8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for EPS8 Gene

Localization for EPS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPS8 Gene

Cytoplasm, cell cortex. Cell projection, ruffle membrane. Cell projection, growth cone. Cell projection, stereocilium. Cell junction, synapse, synaptosome. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells (By similarity). Localizes to the midzone of dividing cells. {ECO:0000250, ECO:0000250 UniProtKB:Q08509}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPS8 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 3
golgi apparatus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for EPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0005903 brush border IEA --
GO:0005938 cell cortex ISS --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with EPS8: view

Pathways & Interactions for EPS8 Gene

genes like me logo Genes that share pathways with EPS8: view

Pathways by source for EPS8 Gene

1 Cell Signaling Technology pathway for EPS8 Gene
2 GeneGo (Thomson Reuters) pathways for EPS8 Gene
1 Qiagen pathway for EPS8 Gene

Gene Ontology (GO) - Biological Process for EPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8084614
GO:0007173 epidermal growth factor receptor signaling pathway TAS 8084614
GO:0008283 cell proliferation TAS 8084614
GO:0008344 adult locomotory behavior IEA --
GO:0008360 regulation of cell shape ISS --
genes like me logo Genes that share ontologies with EPS8: view

No data available for SIGNOR curated interactions for EPS8 Gene

Drugs & Compounds for EPS8 Gene

(1) Drugs for EPS8 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for EPS8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EPS8: view

Transcripts for EPS8 Gene

Unigene Clusters for EPS8 Gene

Epidermal growth factor receptor pathway substrate 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPS8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - -
SP2: - - - - -
SP3: -
SP4:
SP5:
SP6:

ExUns: 19 ^ 20a · 20b ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for EPS8 Gene

GeneLoc Exon Structure for
EPS8
ECgene alternative splicing isoforms for
EPS8

Expression for EPS8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EPS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EPS8 Gene

This gene is overexpressed in Bone marrow stromal cell (15.8), Urine (12.1), and Gallbladder (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPS8 Gene



NURSA nuclear receptor signaling pathways regulating expression of EPS8 Gene:

EPS8

SOURCE GeneReport for Unigene cluster for EPS8 Gene:

Hs.591160

mRNA Expression by UniProt/SwissProt for EPS8 Gene:

Q12929-EPS8_HUMAN
Tissue specificity: Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.

Evidence on tissue expression from TISSUES for EPS8 Gene

  • Nervous system(4.8)
  • Liver(4.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for EPS8 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • head
  • inner ear
  • middle ear
  • outer ear
  • skull
General:
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with EPS8: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for EPS8 Gene

Orthologs for EPS8 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPS8 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia EPS8 34 35
  • 92.61 (n)
cow
(Bos Taurus)
Mammalia EPS8 34 35
  • 89.67 (n)
oppossum
(Monodelphis domestica)
Mammalia EPS8 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eps8 34 16 35
  • 84.49 (n)
rat
(Rattus norvegicus)
Mammalia Eps8 34
  • 84.06 (n)
chicken
(Gallus gallus)
Aves EPS8 34 35
  • 77.99 (n)
lizard
(Anolis carolinensis)
Reptilia EPS8 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eps8 34
  • 67.73 (n)
Str.19077 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11312 34
zebrafish
(Danio rerio)
Actinopterygii eps8 34 35
  • 63.22 (n)
zgc56041 34
fruit fly
(Drosophila melanogaster)
Insecta aru 36 35
  • 46 (a)
CG8907 35
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea eps-8 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for EPS8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPS8 Gene

ENSEMBL:
Gene Tree for EPS8 (if available)
TreeFam:
Gene Tree for EPS8 (if available)

Paralogs for EPS8 Gene

Paralogs for EPS8 Gene

genes like me logo Genes that share paralogs with EPS8: view

Variants for EPS8 Gene

Sequence variations from dbSNP and Humsavar for EPS8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs587777691 Pathogenic 15,681,274(+) CGTCT(A/G)GGAAA reference, stop-gained
rs139258361 Uncertain significance 15,650,927(+) CATAA(A/G)GTTCA reference, missense
rs1000002784 -- 15,631,331(+) AAGTA(C/G)CATGC intron-variant
rs1000026198 -- 15,730,216(+) AGTCA(C/T)TTACC intron-variant
rs1000030290 -- 15,684,707(+) TGGAA(C/G)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPS8 Gene

Variant ID Type Subtype PubMed ID
esv2135886 CNV deletion 18987734
esv2663867 CNV deletion 23128226
esv2760899 CNV gain 21179565
esv3580159 CNV loss 25503493
esv3628677 CNV loss 21293372
nsv1045663 CNV loss 25217958
nsv1138109 CNV deletion 24896259
nsv557615 CNV loss 21841781

Variation tolerance for EPS8 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPS8 Gene

Human Gene Mutation Database (HGMD)
EPS8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPS8 Gene

Disorders for EPS8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EPS8 Gene - From: OMIM, ClinVar, Orphanet, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 102
  • autosomal recessive nonsyndromic deafness 102
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
- elite association - COSMIC cancer census association via MalaCards
Search EPS8 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EPS8_HUMAN
  • Deafness, autosomal recessive, 102 (DFNB102) [MIM:615974]: A form of non-syndromic deafness characterized by profound hearing loss affecting all frequencies. Vestibular function is unaffected. {ECO:0000269 PubMed:24741995}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Defects in EPS8 are associated with some cancers, such as pancreatic, oral squamous cell carcinomas or pituitary cancers. Contributes to cell transformation in response to growth factor treatment and is overexpressed in a number of tumors, indicating that EPS8 levels must be tightly regulated. {ECO:0000269 PubMed:11244499, ECO:0000269 PubMed:18566210, ECO:0000269 PubMed:19008210, ECO:0000269 PubMed:19116338, ECO:0000269 PubMed:19448673}.

Relevant External Links for EPS8

Genetic Association Database (GAD)
EPS8
Human Genome Epidemiology (HuGE) Navigator
EPS8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPS8
genes like me logo Genes that share disorders with EPS8: view

No data available for Genatlas for EPS8 Gene

Publications for EPS8 Gene

  1. Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24. (PMID: 8084614) Wong W.T. … di Fiore P.P. (Oncogene 1994) 2 3 4 22 64
  2. Epidermal growth factor receptor pathway substrate 8 is overexpressed in human pituitary tumors: role in proliferation and survival. (PMID: 19116338) Xu M. … Wierman M.E. (Endocrinology 2009) 3 4 22 64
  3. Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation. (PMID: 19448673) Yap L.F. … Paterson I.C. (Oncogene 2009) 3 4 22 64
  4. Eps8 decreases chemosensitivity and affects survival of cervical cancer patients. (PMID: 18566210) Chen Y.J. … Leu T.H. (Mol. Cancer Ther. 2008) 3 4 22 64
  5. Regulation of cell shape by Cdc42 is mediated by the synergic actin- bundling activity of the Eps8-IRSp53 complex. (PMID: 17115031) Disanza A. … Scita G. (Nat. Cell Biol. 2006) 3 4 22 64

Products for EPS8 Gene

Sources for EPS8 Gene

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