Aliases for EPRS Gene
Aliases for EPRS Gene
- Glutamyl-Prolyl-TRNA Synthetase 2 3 5
- Cell Proliferation-Inducing Gene 32 Protein 3 4
- Bifunctional Aminoacyl-TRNA Synthetase 3 4
- Glutamatyl-Prolyl-TRNA Synthetase 3 4
- Glutamate TRNA Ligase 2 3
- QARS 3 4
- QPRS 3 4
- PARS 3 4
- Bifunctional Glutamate/Proline--TRNA Ligase 3
- Proliferation-Inducing Gene 32 Protein 3
- Proliferation-Inducing Protein 32 3
- Glutaminyl-TRNA Synthetase 3
External Ids for EPRS Gene
- HGNC: 3418
- Entrez Gene: 2058
- Ensembl: ENSG00000136628
- OMIM: 138295
- UniProtKB: P07814
Previous HGNC Symbols for EPRS Gene
- QPRS
- QARS
Previous GeneCards Identifiers for EPRS Gene
- GC01M218738
- GC01M215985
- GC01M216688
- GC01M217198
- GC01M216530
- GC01M218208
- GC01M220141
- GC01M190816
Summaries for EPRS Gene
-
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for EPRS Gene
EPRS (Glutamyl-Prolyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with EPRS include Aqueous Misdirection and Deafness, Autosomal Recessive 98. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include nucleotide binding and GTPase binding.
UniProtKB/Swiss-Prot for EPRS Gene
-
Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (PubMed:1756734, PubMed:24100331, PubMed:23263184). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPRS Gene
Genomics for EPRS Gene
GeneHancer (GH) Regulatory Elements for EPRS Gene
Promoters and enhancers for EPRS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around EPRS on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for EPRS Gene
Genomic Locations for EPRS Gene
- chr1:219,968,600-220,046,658
- (GRCh38/hg38)
- Size:
- 78,059 bases
- Orientation:
- Minus strand
- chr1:220,141,942-220,220,000
- (GRCh37/hg19)
Genomic View for EPRS Gene
Genes around EPRS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q41 by Ensembl
- 1q41 by Entrez Gene
- 1q41 by HGNC
EPRS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EPRS Gene
Proteins for EPRS Gene
-
Protein details for EPRS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07814-SYEP_HUMAN
- Recommended name:
- Bifunctional glutamate/proline--tRNA ligase
- Protein Accession:
- P07814
- A0AVA9
- B9EGH3
- Q05BP6
- Q05DF8
- Q5DSM1
- Q5H9S5
- Q6PD57
- Q86X73
Protein attributes for EPRS Gene
- Size:
- 1512 amino acids
- Molecular mass:
- 170591 Da
- Quaternary structure:
-
- Homodimer (PubMed:24100331, PubMed:23263184). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464). Forms a linear complex that contains MARS, EEF1E1, EPRS and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928). Interacts with DUS2L (PubMed:15994936). Component of the GAIT complex; in humans the complex assembly seems to be a two-step process in which EPRS first associates with SYNCRIP to form a pre-GAIT complex which is deficient in GAIT element binding (PubMed:15479637).
- SequenceCaution:
-
- Sequence=AAH15494.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH34797.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH46156.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58921.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAS72877.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA30354.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=CAA38224.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for EPRS Gene
Selected DME Specific Peptides for EPRS Gene
- P07814:
-
- EFLWQEGH
- RFDDTNP
- WELKGVP
- RRDTGEK
- DDTNPEKE
- VDGWDDPR
- KTEKEKFAG
- LRAKIDM
Post-translational modifications for EPRS Gene
- Phosphorylated at Ser-886 by CDK5 and at Ser-999 by an unknown kinase in a IFN-gamma-dependent manner in monocytes; these sequential phosphorylations are causing release from the multisynthetase complex, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition. Phosphorylation at Ser-999 is specifically required for the interaction of GAIT complex-associated RPL13A with eIF4G.
- Ubiquitination at posLast=229229, posLast=435435, Lys472, posLast=535535, Lys782, Lys861, posLast=943943, posLast=11321132, Lys1143, Lys1375, Lys1435, and Lys1503
Other Protein References for EPRS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for EPRS
- Novus Biologicals Antibodies for EPRS
-
Abcam antibodies for EPRS
-
Cloud-Clone Corp. Antibodies for EPRS
- Invitrogen Antibodies for EPRS
- GeneTex EPRS antibody for EPRS
-
Santa Cruz Biotechnology (SCBT) Antibodies for EPRS
Protein Products
-
OriGene Purified Proteins for EPRS
- Search Origene for MassSpec and Protein Over-expression Lysates for EPRS
- Origene Custom Protein Services for EPRS
- Novus Biologicals proteins for EPRS
-
Cloud-Clone Corp. Proteins for EPRS
- antibodies-online: Search results for 6 available EPRS Proteins ranked by validation data
- Compare Top EPRS Proteins
-
Quality Products:
- Search GeneTex for Proteins for EPRS
Assay Products
- antibodies-online: Search results for 2 available EPRS Elisa Kits ranked by validation data
- Compare Top EPRS Elisa Kits
-
Quality Products:
Domains & Families for EPRS Gene
Gene Families for EPRS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EPRS Gene
- InterPro:
-
- Glutathione-S-Trfase_C_sf
- GST_C
- Rossmann-like_a/b/a_fold
- S15_NS1_RNA-bd
- Anticodon-bd_dom_sf
- aa-tRNA-synth_II
- Glu/Gln-tRNA-synth
- aa-tRNA-synth_I_CS
- Glu/Gln-tRNA-synth_Ib_cat-dom
- Glu/Gln-tRNA-synth_Ib_a-bdl
- aa-tRNA-synt_IIb
- Pro-tRNA_ligase_II_C
- Pro-tRNA_synth_II
- Ribosomal_L25/Gln-tRNA_synth
- Rbsml_L25/Gln-tRNA_synth_N
- Glu-tRNA-synth_arc/euk
- Glu/Gln-tRNA-synth_Ib_codon-bd
- WHEP-TRS_dom
- Pro-tRNA-ligase_IIa_arc-type
- ProRS_core_arch_euk
- Anticodon-bd
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EPRS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07814UniProtKB/Swiss-Prot:
SYEP_HUMAN :- The WHEP-TRS domain is involved in RNA binding.
- In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
- Domain:
-
- The WHEP-TRS domain is involved in RNA binding.
- Family:
-
- In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
- In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
Function for EPRS Gene
Molecular function for EPRS Gene
- GENATLAS Biochemistry:
- glutamyl-prolyl-tRNA synthetase
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by halofuginone.
- UniProtKB/Swiss-Prot Function:
- Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (PubMed:1756734, PubMed:24100331, PubMed:23263184). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
Enzyme Numbers (IUBMB) for EPRS Gene
Phenotypes From GWAS Catalog for EPRS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004812 | aminoacyl-tRNA ligase activity | IEA | -- |
| GO:0004818 | glutamate-tRNA ligase activity | TAS,IEA | -- |
| GO:0004827 | proline-tRNA ligase activity | TAS | -- |
Phenotypes for EPRS Gene
- MGI mutant phenotypes for EPRS:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for EPRS:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Synthetic lethal with Ras
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- Increased HPV18 LCR reporter activity
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance
- Decreased influenza A virus infection
- Decreased viability after ionizing radiation
Animal Models for EPRS Gene
- MGI Knock Outs for EPRS:
-
- Eprs tm1b(EUCOMM)Hmgu
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPRS
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EPRS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPRS gene
- Search ViGene Biosciences for EPRS
CRISPR Products
-
OriGene CRISPR knockouts for EPRS
- genomics-online: gRNA clones - Search results for 66 available EPRS gene related products
- Overview of 66 available EPRS gene related products
- Applied Biological Materials CRISPR for EPRS
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPRS
- GenScript: Design CRISPR guide RNA sequences for EPRS
miRNA for EPRS Gene
- miRTarBase miRNAs that target EPRS
miRNA Products
- Search ViGene Biosciences for EPRS
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EPRS
- Browse OriGene Inhibitory RNA Products For EPRS
- genomics-online: shRNA clones - Search results for 66 available EPRS gene related products
- Overview of 66 available EPRS gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EPRS gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EPRS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPRS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for EPRS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for EPRS gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EPRS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPRS gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPRS Gene
Localization for EPRS Gene
Subcellular locations from UniProtKB/Swiss-Prot for EPRS Gene
- Cytoplasm, cytosol.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA,IEA | 10791971 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | HDA,IDA | 19946888 |
| GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex | IEA,IDA | 10791971 |
| GO:0030529 | intracellular ribonucleoprotein complex | IDA | 15479637 |
Pathways & Interactions for EPRS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | tRNA Aminoacylation | ||
| 2 | Metabolism |
.37
|
|
| 3 | Viral mRNA Translation | ||
| 4 | tRNA processing |
.55
|
|
| 5 | Porphyrin and chlorophyll metabolism | ||
Pathways by source for EPRS Gene
2 BioSystems pathways for EPRS Gene
9 Reactome pathways for EPRS Gene
3 KEGG pathways for EPRS Gene
1 Qiagen pathway for EPRS Gene
Interacting Proteins for EPRS Gene
Selected Interacting proteins:
ENSP00000355890
P07814-SYEP_HUMAN
for EPRS Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | IEA | -- |
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0006418 | tRNA aminoacylation for protein translation | TAS,IEA | -- |
| GO:0006424 | glutamyl-tRNA aminoacylation | IEA,IBA | -- |
| GO:0006433 | prolyl-tRNA aminoacylation | IDA | 24100331 |
Drugs & Compounds for EPRS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutamic Acid | Approved | Nutra | Full agonist, Agonist, Target | 251 | ||
| L-Proline | Approved | Nutra | Target | 0 | ||
| Famotidine | Approved | Pharma | Histamine H2-receptor antagonist | 64 | ||
| Phosphoric acid | Approved | Pharma | 0 | |||
| Adenosine monophosphate | Approved, Investigational | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for EPRS Gene
mRNA/cDNA for EPRS Gene
- (2) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (564) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EPRS Gene
CRISPR Products
-
OriGene CRISPR knockouts for EPRS
- genomics-online: gRNA clones - Search results for 66 available EPRS gene related products
- Overview of 66 available EPRS gene related products
- Applied Biological Materials CRISPR for EPRS
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPRS
- GenScript: Design CRISPR guide RNA sequences for EPRS
miRNA Products
- Search ViGene Biosciences for EPRS
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EPRS
- Browse OriGene Inhibitory RNA Products For EPRS
- genomics-online: shRNA clones - Search results for 66 available EPRS gene related products
- Overview of 66 available EPRS gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EPRS gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EPRS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPRS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for EPRS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27a | · | 27b | ^ | 28a | · | 28b | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 35b | ^ | 36a | · | 36b |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: | |||||
| SP13: | |||||
| SP14: | |||||
| SP15: | |||||
| SP16: | |||||
| SP17: |
Expression for EPRS Gene
This gene is overexpressed in Lymph node (9.0) and Salivary gland (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPRS Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of EPRS Gene:
EPRSSOURCE GeneReport for Unigene cluster for EPRS Gene:
Hs.497788Evidence on tissue expression from TISSUES for EPRS Gene
- Nervous system(4.9)
- Intestine(4.8)
- Lung(4.8)
- Liver(4.7)
- Eye(4.6)
- Bone marrow(4.2)
- Heart(3.5)
- Pancreas(3.5)
- Kidney(3.3)
- Blood(2.8)
- Muscle(2.8)
- Stomach(2.8)
- Gall bladder(2)
- Skin(2)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for EPRS
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPRS Gene
Orthologs for EPRS Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EPRS 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | EPRS 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | EPRS 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Eprs 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Eprs 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EPRS 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EPRS 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | EPRS 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | eprs 33 |
|
||
| Str.1851 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21378 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | eprs 33 34 |
|
||
| wufb06c03 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.14111 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Aats-glupro 35 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | prs-1 35 |
|
|
|
| ers-2 35 |
|
|
|||
| ears-1 34 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GUS1 33 34 |
|
||
| -- 36 |
|
|
|||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A00682g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR264W 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G26710 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.5281 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0271200 33 |
|
||
| Os.6059 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.4312 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.3156 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11263 34 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC17A5.15c 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU08894 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.14752 33 |
|
- Species where no ortholog for EPRS was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EPRS Gene
(1) SIMAP similar genes for EPRS Gene using alignment to 4 proteins:
No data available for Paralogs for EPRS Gene
Variants for EPRS Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005479 | -- | 219,984,604(-) | G/A | intron_variant | |
| rs1000050882 | -- | 220,028,019(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000165503 | -- | 220,035,214(-) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000172801 | -- | 220,002,514(-) | A/G | intron_variant | |
| rs1000210519 | -- | 219,990,985(-) | G/A/C | intron_variant |
Residual Variation Intolerance Score:
2.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.75;
73.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EPRS Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- EPRS
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPRS Gene
Disorders for EPRS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| aqueous misdirection |
|
|
| deafness, autosomal recessive 98 |
|
|
| separation anxiety disorder |
|
|
Search EPRS in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EPRS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for EPRS Gene
Publications for EPRS Gene
- Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity. (PMID: 19647514) Arif A … Fox PL (Molecular cell 2009) 3 4 22 58
- A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. (PMID: 15994936) Kato T … Nakamura Y (Cancer research 2005) 3 4 22 58
- Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. (PMID: 15479637) Sampath P … Fox PL (Cell 2004) 3 4 22 58
- Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats. (PMID: 11123902) Jeong EJ … Kim KS (Biochemistry 2000) 3 4 22 58
- The primary structure of human glutaminyl-tRNA synthetase. A highly conserved core, amino acid repeat regions, and homologies with translation elongation factors. (PMID: 1988429) Fett R … Knippers R (The Journal of biological chemistry 1991) 2 3 4 58
Products for EPRS Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for EPRS
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for EPRS
- Search Origene for MassSpec and Protein Over-expression Lysates for EPRS
- Origene Custom Protein Services for EPRS
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPRS
- Browse OriGene Inhibitory RNA Products For EPRS
- OriGene qPCR primer pairs for EPRS
- OriGene CRISPR knockouts for EPRS
- OriGene ORF clones in human for EPRS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EPRS
- GenScript: Next-day shipping of latest version cDNA ORF clones for EPRS in any vector
- GenScript Custom Purified and Recombinant Proteins Services for EPRS
- GenScript Custom Assay Services for EPRS
- GenScript Custom overexpressing Cell Line Services for EPRS
- GenScript: Design CRISPR guide RNA sequences for EPRS
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for EPRS
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for EPRS
- Novus Biologicals proteins for EPRS
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for EPRS
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for EPRS
- Cloud-Clone Corp. Proteins for EPRS
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for EPRS
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPRS
- VectorBuilder custom plasmid, inducible vectors for EPRS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPRS
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 41 available EPRS Antibodies ranked by validation data
- Compare Top EPRS Antibodies
- antibodies-online: Search results for 2 available EPRS Elisa Kits ranked by validation data
- Compare Top EPRS Elisa Kits
- Quality Products:
- antibodies-online: Search results for 6 available EPRS Proteins ranked by validation data
- Compare Top EPRS Proteins
- Quality Products:
- GeneTex EPRS antibody for EPRS
- Search GeneTex for Proteins for EPRS
- ViGene Biosciences adenoviral particle packaged cDNA for EPRS gene
- ViGene Biosciences lentiviral particle packaged cDNA for EPRS gene
- ViGene Biosciences ready-to-package AAV shRNAs for EPRS gene
- Search ViGene Biosciences for EPRS
- Santa Cruz Biotechnology (SCBT) Antibodies for EPRS
- Search Santa Cruz Biotechnology (SCBT) for EPRS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EPRS
- genomics-online: cdna clones - Search results for 66 available EPRS gene related products
- Overview of 66 available EPRS gene related products
- orf clones - Search results for 66 available EPRS gene related products
- Overview of 66 available EPRS gene related products
- genomics-online: gRNA clones - Search results for 66 available EPRS gene related products
- Overview of 66 available EPRS gene related products
- genomics-online: primer clones - Search results for 66 available EPRS gene related products
- Overview of 66 available EPRS gene related products
- genomics-online: shRNA clones - Search results for 66 available EPRS gene related products
- Overview of 66 available EPRS gene related products
Sources for EPRS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew