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Aliases for STX2 Gene

Aliases for STX2 Gene

  • Syntaxin 2 2 3
  • Epimorphin 2 3 4
  • STX2A 3 4 6
  • STX2B 3 4 6
  • STX2C 3 4 6
  • EPIM 3 4 6
  • Syntaxin-2 3
  • EPM 3

External Ids for STX2 Gene

Previous HGNC Symbols for STX2 Gene

  • STX2B
  • STX2C
  • STX2A
  • EPIM

Previous GeneCards Identifiers for STX2 Gene

  • GC12M129840
  • GC12M131274
  • GC12M128256

Summaries for STX2 Gene

Entrez Gene Summary for STX2 Gene

  • The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for STX2 Gene

STX2 (Syntaxin 2) is a Protein Coding gene. Among its related pathways are Disease and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include calcium-dependent protein binding and SNAP receptor activity. An important paralog of this gene is STX4.

UniProtKB/Swiss-Prot for STX2 Gene

  • Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm

Gene Wiki entry for STX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX2 Gene

Genomics for STX2 Gene

Regulatory Elements for STX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STX2 Gene

Start:
130,789,600 bp from pter
End:
130,839,274 bp from pter
Size:
49,675 bases
Orientation:
Minus strand

Genomic View for STX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX2 Gene

Proteins for STX2 Gene

  • Protein details for STX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32856-STX2_HUMAN
    Recommended name:
    Syntaxin-2
    Protein Accession:
    P32856
    Secondary Accessions:
    • Q86VW8

    Protein attributes for STX2 Gene

    Size:
    288 amino acids
    Molecular mass:
    33341 Da
    Quaternary structure:
    • Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent.
    SequenceCaution:
    • Sequence=BAA03436.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for STX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX2 Gene

Proteomics data for STX2 Gene at MOPED

Post-translational modifications for STX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STX2 Gene

Antibody Products

  • R&D Systems Antibodies for STX2 (Epimorphin/Syntaxin 2)

No data available for DME Specific Peptides for STX2 Gene

Domains for STX2 Gene

Protein Domains for STX2 Gene

Suggested Antigen Peptide Sequences for STX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32856

UniProtKB/Swiss-Prot:

STX2_HUMAN :
  • P32856
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX2: view

No data available for Gene Families for STX2 Gene

Function for STX2 Gene

Molecular function for STX2 Gene

UniProtKB/Swiss-Prot Function:
Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm

Gene Ontology (GO) - Molecular Function for STX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 12773094
GO:0046983 protein dimerization activity IDA 22226963
GO:0048306 calcium-dependent protein binding ISS --
genes like me logo Genes that share ontologies with STX2: view
genes like me logo Genes that share phenotypes with STX2: view

Animal Model Products

miRNA for STX2 Gene

miRTarBase miRNAs that target STX2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STX2 Gene

Localization for STX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX2 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX2 Gene COMPARTMENTS Subcellular localization image for STX2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22226963
GO:0005886 plasma membrane IDA 21720706
GO:0005911 cell-cell junction IEA --
GO:0008021 synaptic vesicle IBA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with STX2: view

Pathways for STX2 Gene

genes like me logo Genes that share pathways with STX2: view

Pathways by source for STX2 Gene

1 Qiagen pathway for STX2 Gene
1 BioSystems pathway for STX2 Gene
2 Reactome pathways for STX2 Gene

Gene Ontology (GO) - Biological Process for STX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0007165 signal transduction TAS 1581962
GO:0007340 acrosome reaction ISS --
GO:0007398 ectoderm development TAS 8466509
GO:0009887 organ morphogenesis TAS 1581962
genes like me logo Genes that share ontologies with STX2: view

Compounds for STX2 Gene

(4) Novoseek inferred chemical compound relationships for STX2 Gene

Compound -log(P) Hits PubMed IDs
neurotoxin c 85.5 2
n-ethylmaleimide 60.1 3
atp 0 1
calcium 0 2
genes like me logo Genes that share compounds with STX2: view

Transcripts for STX2 Gene

Unigene Clusters for STX2 Gene

Syntaxin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX2 Gene

No ASD Table

Relevant External Links for STX2 Gene

GeneLoc Exon Structure for
STX2
ECgene alternative splicing isoforms for
STX2

Expression for STX2 Gene

mRNA expression in normal human tissues for STX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for STX2 Gene

This gene is overexpressed in Spinal cord (20.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX2 Gene

SOURCE GeneReport for Unigene cluster for STX2 Gene Hs.437585

genes like me logo Genes that share expressions with STX2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for STX2 Gene

Orthologs for STX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STX2 35
  • 88.54 (n)
  • 93.75 (a)
STX2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX2 35
  • 87.78 (n)
  • 91.46 (a)
STX2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stx2 35
  • 84.95 (n)
  • 89.58 (a)
Stx2 16
Stx2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STX2 35
  • 99.65 (n)
  • 99.65 (a)
STX2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx2 35
  • 84.37 (n)
  • 88.54 (a)
oppossum
(Monodelphis domestica)
Mammalia STX2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX2 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves STX2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15965 35
stx2 35
  • 73.05 (n)
  • 73.52 (a)
zebrafish
(Danio rerio)
Actinopterygii stx2b 35
  • 65.04 (n)
  • 64.81 (a)
stx2b 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syx1A 36
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-64 36
  • 52 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4995 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for STX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX2 Gene

ENSEMBL:
Gene Tree for STX2 (if available)
TreeFam:
Gene Tree for STX2 (if available)

Paralogs for STX2 Gene

Paralogs for STX2 Gene

Selected SIMAP similar genes for STX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STX2: view

Variants for STX2 Gene

Sequence variations from dbSNP and Humsavar for STX2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1236 -- 130,789,849(+) TCTAA(A/T)TACAA utr-variant-3-prime
rs8579 -- 130,790,045(-) CTCCA(C/G/T)GCCTC utr-variant-3-prime
rs13155 -- 130,790,939(-) ATTGG(C/T)TGCAA utr-variant-3-prime
rs13696 -- 130,789,900(-) CCTAC(A/T)GAAAT utr-variant-3-prime
rs17564 -- 130,821,769(-) AAACA(C/G)TATTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for STX2 Gene

Variant ID Type Subtype PubMed ID
nsv939 CNV Insertion 18451855
nsv527536 CNV Loss 19592680

Relevant External Links for STX2 Gene

HapMap Linkage Disequilibrium report
STX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX2 Gene

Disorders for STX2 Gene

(3) University of Copenhagen DISEASES for STX2 Gene

(2) Novoseek inferred disease relationships for STX2 Gene

Disease -log(P) Hits PubMed IDs
colitis ulcerative 3.23 1
inflammatory bowel diseases 0.74 2

Relevant External Links for STX2

Human Genome Epidemiology (HuGE) Navigator
STX2
genes like me logo Genes that share disorders with STX2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for STX2 Gene

Publications for STX2 Gene

  1. Molecular cloning of human epimorphin: identification of isoforms and their unique properties. (PMID: 8466509) Hirai Y. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  2. The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12. (PMID: 8938452) Zha H. … Wilder R.L. (Genomics 1996) 2 3 23
  3. Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments. (PMID: 15943887) Band A.M. … Kuismanen E. (BMC Cell Biol. 2005) 2 3 23
  4. Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. (PMID: 9045631) Tellam J.T. … James D.E. (J. Biol. Chem. 1997) 3 23
  5. SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane. (PMID: 17485553) Flaumenhaft R. … Dvorak A.M. (Blood 2007) 3 23

Products for STX2 Gene

Sources for STX2 Gene

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