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Aliases for EPHB6 Gene

Aliases for EPHB6 Gene

  • EPH Receptor B6 2 3 5
  • Tyrosine-Protein Kinase-Defective Receptor EPH-6 3 4
  • HEP 3 4
  • Human Kinase-Defective Eph-Family Receptor Protein 3
  • EC 2.7.10.1 63
  • EphB6 2

External Ids for EPHB6 Gene

Previous GeneCards Identifiers for EPHB6 Gene

  • GC07P140878
  • GC07P141946
  • GC07P142023
  • GC07P142069
  • GC07P142262
  • GC07P142552
  • GC07P136891
  • GC07P142859
  • GC07P142920

Summaries for EPHB6 Gene

Entrez Gene Summary for EPHB6 Gene

  • This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for EPHB6 Gene

EPHB6 (EPH Receptor B6) is a Protein Coding gene. Diseases associated with EPHB6 include Good Syndrome. Among its related pathways are Axon guidance and EphB-EphrinB Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA3.

UniProtKB/Swiss-Prot for EPHB6 Gene

  • Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

Tocris Summary for EPHB6 Gene

  • Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.

Gene Wiki entry for EPHB6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHB6 Gene

Genomics for EPHB6 Gene

Regulatory Elements for EPHB6 Gene

Enhancers for EPHB6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EPHB6 on UCSC Golden Path with GeneCards custom track

Promoters for EPHB6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EPHB6 on UCSC Golden Path with GeneCards custom track

Genomic Location for EPHB6 Gene

Chromosome:
7
Start:
142,854,643 bp from pter
End:
142,871,094 bp from pter
Size:
16,452 bases
Orientation:
Plus strand

Genomic View for EPHB6 Gene

Genes around EPHB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHB6 Gene

Proteins for EPHB6 Gene

  • Protein details for EPHB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15197-EPHB6_HUMAN
    Recommended name:
    Ephrin type-B receptor 6
    Protein Accession:
    O15197
    Secondary Accessions:
    • A4D2I7
    • A8CDT5
    • D3DXD3
    • Q2TB23
    • Q2TB24

    Protein attributes for EPHB6 Gene

    Size:
    1021 amino acids
    Molecular mass:
    110700 Da
    Quaternary structure:
    • Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner.
    SequenceCaution:
    • Sequence=AAD03058.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI10608.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP20939.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA21560.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL23775.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW51902.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for EPHB6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHB6 Gene

Proteomics data for EPHB6 Gene at MOPED

Selected DME Specific Peptides for EPHB6 Gene

Post-translational modifications for EPHB6 Gene

  • Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
  • Glycosylation at Asn 480
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EPHB6 (EphB6)

Domains & Families for EPHB6 Gene

Suggested Antigen Peptide Sequences for EPHB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15197

UniProtKB/Swiss-Prot:

EPHB6_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2.
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHB6: view

Function for EPHB6 Gene

Molecular function for EPHB6 Gene

GENATLAS Biochemistry:
EPH-related tyrosine kinase receptor,135kDa,binding ephrin B6,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance
UniProtKB/Swiss-Prot Function:
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

Enzyme Numbers (IUBMB) for EPHB6 Gene

Gene Ontology (GO) - Molecular Function for EPHB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005003 ephrin receptor activity IEA --
genes like me logo Genes that share ontologies with EPHB6: view
genes like me logo Genes that share phenotypes with EPHB6: view

Animal Models for EPHB6 Gene

MGI Knock Outs for EPHB6:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EPHB6 Gene

Localization for EPHB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHB6 Gene

Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHB6 Gene COMPARTMENTS Subcellular localization image for EPHB6 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for EPHB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with EPHB6: view

Pathways & Interactions for EPHB6 Gene

genes like me logo Genes that share pathways with EPHB6: view

Interacting Proteins for EPHB6 Gene

Gene Ontology (GO) - Biological Process for EPHB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002456 T cell mediated immunity IEA --
GO:0048013 ephrin receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with EPHB6: view

No data available for SIGNOR curated interactions for EPHB6 Gene

Drugs & Compounds for EPHB6 Gene

(2) Drugs for EPHB6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for EPHB6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EPHB6: view

Transcripts for EPHB6 Gene

mRNA/cDNA for EPHB6 Gene

(14) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPHB6 Gene

EPH receptor B6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHB6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for EPHB6 Gene

GeneLoc Exon Structure for
EPHB6
ECgene alternative splicing isoforms for
EPHB6

Expression for EPHB6 Gene

mRNA expression in normal human tissues for EPHB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHB6 Gene

This gene is overexpressed in Brain - Cortex (x5.2), Skin - Not Sun Exposed (Suprapubic) (x4.5), and Skin - Sun Exposed (Lower leg) (x4.3).

Protein differential expression in normal tissues from HIPED for EPHB6 Gene

This gene is overexpressed in Urine (17.8), Platelet (10.3), Liver (9.9), and Frontal cortex (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EPHB6 Gene



SOURCE GeneReport for Unigene cluster for EPHB6 Gene Hs.380089

mRNA Expression by UniProt/SwissProt for EPHB6 Gene

O15197-EPHB6_HUMAN
Tissue specificity: Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
genes like me logo Genes that share expression patterns with EPHB6: view

Protein tissue co-expression partners for EPHB6 Gene

Primer Products

Orthologs for EPHB6 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHB6 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia EPHB6 35
  • 88.83 (n)
  • 92.89 (a)
EPHB6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ephb6 35
  • 86.74 (n)
  • 92.6 (a)
Ephb6 16
Ephb6 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EPHB6 35
  • 99.54 (n)
  • 99.51 (a)
EPHB6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ephb6 35
  • 86.25 (n)
  • 92.1 (a)
oppossum
(Monodelphis domestica)
Mammalia EPHB6 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPHB6 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPHB6 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-26c10.6 35
  • 55.76 (n)
  • 51.06 (a)
EPHB6 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eph 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
CSA.1664 36
  • 34 (a)
ManyToMany
CSA.7809 36
  • 35 (a)
ManyToMany
Species with no ortholog for EPHB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHB6 Gene

ENSEMBL:
Gene Tree for EPHB6 (if available)
TreeFam:
Gene Tree for EPHB6 (if available)

Paralogs for EPHB6 Gene

Paralogs for EPHB6 Gene

genes like me logo Genes that share paralogs with EPHB6: view

Variants for EPHB6 Gene

Sequence variations from dbSNP and Humsavar for EPHB6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs8177173 - 142,864,164(+) GCGGC(A/G)GCACC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs8177143 - 142,864,648(+) CCCCC(A/C/G)CAGGC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs8177146 - 142,865,498(+) ATAAG(G/T)CTTCT nc-transcript-variant, reference, missense
rs8177175 - 142,866,517(+) GAGCC(A/G)GGCAT nc-transcript-variant, reference, missense
VAR_036091 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for EPHB6 Gene

Variant ID Type Subtype PubMed ID
nsv428187 CNV Loss 18775914
dgv2145e1 CNV Complex 17122850
nsv889274 CNV Loss 21882294
nsv831168 CNV Gain 17160897
dgv7504n71 CNV Loss 21882294
nsv526015 CNV Gain 19592680
nsv520735 CNV Loss 19592680

Variation tolerance for EPHB6 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.50; 88.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHB6 Gene

Human Gene Mutation Database (HGMD)
EPHB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHB6 Gene

Disorders for EPHB6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EPHB6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
good syndrome
  • thymoma with hypogammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards
Search EPHB6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EPHB6

Human Genome Epidemiology (HuGE) Navigator
EPHB6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPHB6
genes like me logo Genes that share disorders with EPHB6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPHB6 Gene

Publications for EPHB6 Gene

  1. Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. (PMID: 15955811) Matsuoka H. … Nakamoto M. (J. Biol. Chem. 2005) 3 4 23 67
  2. DNA-based assay for EPHB6 expression in breast carcinoma cells as a potential diagnostic test for detecting tumor cells in circulation. (PMID: 20181626) Fox B.P. … Kandpal R.P. (Cancer Genomics Proteomics 2010) 3 23
  3. Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells. (PMID: 18819711) Alonso-C L.M. … Zapata A.G. (Leuk. Res. 2009) 3 23
  4. The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma. (PMID: 19513565) Yu J. … MA1ller-Tidow C. (Int. J. Oncol. 2009) 3 23
  5. Loss of EphB6 expression in metastatic melanoma. (PMID: 14612926) Hafner C. … Vogt T. (Int. J. Oncol. 2003) 3 23

Products for EPHB6 Gene

Sources for EPHB6 Gene

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