Aliases for EPHB6 Gene
External Ids for EPHB6 Gene
Previous GeneCards Identifiers for EPHB6 Gene
This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for EPHB6 Gene
EPHB6 (EPH Receptor B6) is a Protein Coding gene. Diseases associated with EPHB6 include familial colorectal cancer and gliosarcoma. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include receptor activity and ephrin receptor activity. An important paralog of this gene is EPHB3.
UniProtKB/Swiss-Prot for EPHB6 Gene
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.