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Aliases for EPHB2 Gene

Aliases for EPHB2 Gene

  • EPH Receptor B2 2 3
  • Developmentally-Regulated Eph-Related Tyrosine Kinase 3 4
  • Tyrosine-Protein Kinase Receptor EPH-3 3 4
  • Renal Carcinoma Antigen NY-REN-47 3 4
  • Tyrosine-Protein Kinase TYRO5 3 4
  • EPH-Like Kinase 5 3 4
  • EC 2.7.10.1 4 63
  • Tyro5 3 4
  • EPHT3 3 4
  • Hek5 3 4
  • ERK 3 4
  • DRT 3 4
  • EK5 3 4
  • Protein-Tyrosine Kinase HEK5 3
  • Elk-Related Tyrosine Kinase 3
  • ELK-Related Tyrosine Kinase 4
  • Eph Tyrosine Kinase 3 3
  • EPH Tyrosine Kinase 3 4
  • EC 2.7.10 63
  • EphB2 2
  • EPTH3 4
  • CAPB 3
  • PCBC 3

External Ids for EPHB2 Gene

Previous HGNC Symbols for EPHB2 Gene

  • DRT
  • ERK
  • EPHT3

Previous GeneCards Identifiers for EPHB2 Gene

  • GC01P022677
  • GC01P022143
  • GC01P022506
  • GC01P022782
  • GC01P022910
  • GC01P023037
  • GC01P021351

Summaries for EPHB2 Gene

Entrez Gene Summary for EPHB2 Gene

  • This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

GeneCards Summary for EPHB2 Gene

EPHB2 (EPH Receptor B2) is a Protein Coding gene. Diseases associated with EPHB2 include prostate cancer/brain cancer susceptibility, somatic and sclerosing liposarcoma. Among its related pathways are GPCR Pathway and Developmental Biology. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHB3.

UniProtKB/Swiss-Prot for EPHB2 Gene

  • Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Gene Wiki entry for EPHB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHB2 Gene

Genomics for EPHB2 Gene

Regulatory Elements for EPHB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EPHB2 Gene

Chromosome:
1
Start:
22,710,770 bp from pter
End:
22,921,500 bp from pter
Size:
210,731 bases
Orientation:
Plus strand

Genomic View for EPHB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for EPHB2 Gene

Proteins for EPHB2 Gene

  • Protein details for EPHB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29323-EPHB2_HUMAN
    Recommended name:
    Ephrin type-B receptor 2
    Protein Accession:
    P29323
    Secondary Accessions:
    • O43477
    • Q5T0U6
    • Q5T0U7
    • Q5T0U8

    Protein attributes for EPHB2 Gene

    Size:
    1055 amino acids
    Molecular mass:
    117493 Da
    Quaternary structure:
    • Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph production in the inner ear.

    Three dimensional structures from OCA and Proteopedia for EPHB2 Gene

    Alternative splice isoforms for EPHB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHB2 Gene

Proteomics data for EPHB2 Gene at MOPED

Post-translational modifications for EPHB2 Gene

  • Glycosylation at Asn 265, Asn 336, Asn 428, and Asn 482
  • Modification sites at PhosphoSitePlus

Other Protein References for EPHB2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EPHB2 (EphB2)

Domains & Families for EPHB2 Gene

Suggested Antigen Peptide Sequences for EPHB2 Gene

Graphical View of Domain Structure for InterPro Entry

P29323

UniProtKB/Swiss-Prot:

EPHB2_HUMAN :
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHB2: view

Function for EPHB2 Gene

Molecular function for EPHB2 Gene

GENATLAS Biochemistry:
EPH-related tyrosine kinase receptor,binding ephrins B,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance,developmentally regulated,expressed in brain,and other tissues,likely involved in neurogenesis and oncogenesis (neuroblastoma,SCLC),phosphorylating and interacting with RRAS to control integrin activity
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Enzyme Numbers (IUBMB) for EPHB2 Gene

Gene Ontology (GO) - Molecular Function for EPHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity ISS --
GO:0005003 ephrin receptor activity --
GO:0005005 transmembrane-ephrin receptor activity TAS 8589679
GO:0005515 protein binding IPI 17255949
genes like me logo Genes that share ontologies with EPHB2: view
genes like me logo Genes that share phenotypes with EPHB2: view

Animal Models for EPHB2 Gene

MGI Knock Outs for EPHB2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPHB2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for EPHB2 Gene

Localization for EPHB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHB2 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHB2 Gene COMPARTMENTS Subcellular localization image for EPHB2 gene
Compartment Confidence
cytosol 4
extracellular 4
plasma membrane 4
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EPHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with EPHB2: view

Pathways & Interactions for EPHB2 Gene

genes like me logo Genes that share pathways with EPHB2: view

PCR Array Products

SIGNOR curated interactions for EPHB2 Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EPHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0001655 urogenital system development ISS --
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway --
GO:0007399 nervous system development TAS 8589679
genes like me logo Genes that share ontologies with EPHB2: view

Drugs & Compounds for EPHB2 Gene

(10) Drugs for EPHB2 Gene - From: HMDB, NovoSeek, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Isoproterenol Approved Pharma Full agonist, Agonist 15
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
NMDA Pharma Full agonist, Agonist 0
SB 203580 Pharma P38 MAP kinase inhibitor, Selective inhibitor of p38 MAPK 0

(8) Additional Compounds for EPHB2 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
FMLP
N-FORMYLMETHIONYL-LEUCYLPHENYLALANINE
PD 98,059
Phosphatidylinositol
genes like me logo Genes that share compounds with EPHB2: view

Transcripts for EPHB2 Gene

Unigene Clusters for EPHB2 Gene

EPH receptor B2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPHB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPHB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for EPHB2 Gene

GeneLoc Exon Structure for
EPHB2
ECgene alternative splicing isoforms for
EPHB2

Expression for EPHB2 Gene

mRNA expression in normal human tissues for EPHB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHB2 Gene

This gene is overexpressed in Colon - Transverse (x6.7).

Protein differential expression in normal tissues from HIPED for EPHB2 Gene

This gene is overexpressed in Fetal Brain (37.6) and Ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPHB2 Gene



SOURCE GeneReport for Unigene cluster for EPHB2 Gene Hs.523329

mRNA Expression by UniProt/SwissProt for EPHB2 Gene

P29323-EPHB2_HUMAN
Tissue specificity: Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain
genes like me logo Genes that share expression patterns with EPHB2: view

Protein tissue co-expression partners for EPHB2 Gene

Primer Products

In Situ Assay Products

Orthologs for EPHB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EPHB2 35
  • 92.52 (n)
  • 99.06 (a)
EPHB2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPHB2 35
  • 93.46 (n)
  • 99.69 (a)
EPHB2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ephb2 35
  • 90.94 (n)
  • 99.49 (a)
Ephb2 16
Ephb2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EPHB2 35
  • 99.65 (n)
  • 100 (a)
EPHB2 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ephb2 35
  • 91.21 (n)
  • 98.88 (a)
oppossum
(Monodelphis domestica)
Mammalia EPHB2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPHB2 35
  • 84.64 (n)
  • 96.07 (a)
EPHB2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.506 35
zebrafish
(Danio rerio)
Actinopterygii ephb2 35
  • 77.65 (n)
  • 86.78 (a)
ephb2a 36
  • 83 (a)
OneToMany
ephb2b 36
  • 88 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eph 37
  • 42 (a)
hop 37
  • 39 (a)
Eph 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
CSA.1664 36
  • 40 (a)
ManyToMany
CSA.7809 36
  • 41 (a)
ManyToMany
Species with no ortholog for EPHB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHB2 Gene

ENSEMBL:
Gene Tree for EPHB2 (if available)
TreeFam:
Gene Tree for EPHB2 (if available)

Paralogs for EPHB2 Gene

Paralogs for EPHB2 Gene

genes like me logo Genes that share paralogs with EPHB2: view

Variants for EPHB2 Gene

Sequence variations from dbSNP and Humsavar for EPHB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs116119 -- 22,892,694(+) CCTAC(C/T)TTTGT intron-variant
rs172417 -- 22,714,438(+) TAGCA(G/T)GTCTA intron-variant
rs172635 -- 22,881,312(-) caagc(A/G)attct intron-variant, upstream-variant-2KB
rs7541752 -- 22,808,405(+) TGGCA(A/G)GTGAG intron-variant
rs10799760 -- 22,728,553(+) TGGCA(C/T)GAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPHB2 Gene

Variant ID Type Subtype PubMed ID
esv34161 CNV Loss 18971310
nsv870805 CNV Gain 21882294
esv2538911 CNV Insertion 19546169
nsv512725 CNV Insertion 21212237
nsv469829 CNV Loss 16826518
nsv871487 CNV Loss 21882294
nsv870618 CNV Loss 21882294
nsv509036 CNV Insertion 20534489
esv1389294 CNV Deletion 17803354
nsv528926 CNV Loss 19592680
nsv6409 CNV Insertion 18451855

Variation tolerance for EPHB2 Gene

Residual Variation Intolerance Score: 2.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHB2 Gene

HapMap Linkage Disequilibrium report
EPHB2
Human Gene Mutation Database (HGMD)
EPHB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHB2 Gene

Disorders for EPHB2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for EPHB2 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

- elite association
Search EPHB2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EPHB2_HUMAN
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:15300251, ECO:0000269 PubMed:16155194}. Note=The gene represented in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.

Relevant External Links for EPHB2

Genetic Association Database (GAD)
EPHB2
Human Genome Epidemiology (HuGE) Navigator
EPHB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPHB2
genes like me logo Genes that share disorders with EPHB2: view

No data available for Genatlas for EPHB2 Gene

Publications for EPHB2 Gene

  1. eek and erk, new members of the eph subclass of receptor protein- tyrosine kinases. (PMID: 1648701) Chan J. … Watt V.M. (Oncogene 1991) 2 23 67
  2. Four novel RET germline variants in exons 8 and 11 display an oncogenic potential in vitro. (PMID: 20103606) Muzza M. … Fugazzola L. (Eur. J. Endocrinol. 2010) 23 67
  3. The EphB2 tumor suppressor induces autophagic cell death via concomitant activation of the ERK1/2 and PI3K pathways. (PMID: 20046096) Kandouz M. … Batist G. (Cell Cycle 2010) 23 67
  4. Melanin-concentrating hormone-1 receptor binding activity of pheophorbides isolated from Morus alba leaves. (PMID: 20013814) Oh B.K. … Lee B.H. (Phytother Res 2010) 23 67
  5. Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment. (PMID: 20338920) Das A. … Shah V.H. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010) 23 67

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