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Aliases for EPHB2 Gene

Aliases for EPHB2 Gene

  • EPH Receptor B2 2 3
  • EPHT3 3 4 6
  • ERK 3 4 6
  • DRT 3 4 6
  • Developmentally-Regulated Eph-Related Tyrosine Kinase 3 4
  • Tyrosine-Protein Kinase Receptor EPH-3 3 4
  • Renal Carcinoma Antigen NY-REN-47 3 4
  • Tyrosine-Protein Kinase TYRO5 3 4
  • EPH-Like Kinase 5 3 4
  • EC 2.7.10.1 4 64
  • Tyro5 3 4
  • CAPB 3 6
  • Hek5 3 4
  • PCBC 3 6
  • EK5 3 4
  • Protein-Tyrosine Kinase HEK5 3
  • Elk-Related Tyrosine Kinase 3
  • ELK-Related Tyrosine Kinase 4
  • Ephrin Type-B Receptor 2 3
  • Eph Tyrosine Kinase 3 3
  • EPH Tyrosine Kinase 3 4
  • EC 2.7.10 64
  • EphB2 2
  • EPTH3 4

External Ids for EPHB2 Gene

Previous Symbols for EPHB2 Gene

  • DRT
  • ERK
  • EPHT3

Summaries for EPHB2 Gene

Entrez Gene Summary for EPHB2 Gene

  • Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPHB2 Gene

EPHB2 (EPH Receptor B2) is a Protein Coding gene. Diseases associated with EPHB2 include prostate cancer/brain cancer susceptibility, somatic and prostate cancer. Among its related pathways are GPCR Pathway and L1CAM interactions. GO annotations related to this gene include receptor binding and transmembrane-ephrin receptor activity. An important paralog of this gene is EPHB3.

UniProtKB/Swiss-Prot for EPHB2 Gene

  • Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Gene Wiki entry for EPHB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHB2 Gene

Genomics for EPHB2 Gene

Genomic Location for EPHB2 Gene

Start:
22,710,770 bp from pter
End:
22,915,330 bp from pter
Size:
204,561 bases
Orientation:
Plus strand

Genomic View for EPHB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPHB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHB2 Gene

Regulatory Elements for EPHB2 Gene

Proteins for EPHB2 Gene

  • Protein details for EPHB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29323-EPHB2_HUMAN
    Recommended name:
    Ephrin type-B receptor 2
    Protein Accession:
    P29323
    Secondary Accessions:
    • O43477
    • Q5T0U6
    • Q5T0U7
    • Q5T0U8

    Protein attributes for EPHB2 Gene

    Size:
    1055 amino acids
    Molecular mass:
    117493 Da
    Quaternary structure:
    • Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph production in the inner ear.

    Three dimensional structures from OCA and Proteopedia for EPHB2 Gene

    Alternative splice isoforms for EPHB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHB2 Gene

Proteomics data for EPHB2 Gene at MOPED

Post-translational modifications for EPHB2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn265, Asn336, Asn428, and Asn482

Other Protein References for EPHB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for EPHB2 Gene

Gene Families for EPHB2 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing
  • FN3 :Fibronectin type III domain containing
  • EPH :EPH receptors
IUPHAR :

UniProtKB/Swiss-Prot:

EPHB2_HUMAN
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.:
    • P29323
  • Contains 2 fibronectin type-III domains.:
    • P29323
  • Contains 1 protein kinase domain.:
    • P29323
  • Contains 1 SAM (sterile alpha motif) domain.:
    • P29323
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.:
    • P29323
genes like me logo Genes that share domains with EPHB2: view

Function for EPHB2 Gene

Molecular function for EPHB2 Gene

GENATLAS Biochemistry: EPH-related tyrosine kinase receptor,binding ephrins B,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance,developmentally regulated,expressed in brain,and other tissues,likely involved in neurogenesis and oncogenesis (neuroblastoma,SCLC),phosphorylating and interacting with RRAS to control integrin activity
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Enzyme Numbers (IUBMB) for EPHB2 Gene

Gene Ontology (GO) - Molecular Function for EPHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity ISS --
GO:0004872 receptor activity --
GO:0005003 ephrin receptor activity --
GO:0005005 transmembrane-ephrin receptor activity TAS 8589679
genes like me logo Genes that share ontologies with EPHB2: view
genes like me logo Genes that share phenotypes with EPHB2: view

Animal Models for EPHB2 Gene

MGI Knock Outs for EPHB2:

miRNA for EPHB2 Gene

miRTarBase miRNAs that target EPHB2

No data available for Transcription Factor Targeting and HOMER Transcription for EPHB2 Gene

Localization for EPHB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHB2 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHB2 Gene COMPARTMENTS Subcellular localization image for EPHB2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for EPHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with EPHB2: view

Pathways for EPHB2 Gene

genes like me logo Genes that share pathways with EPHB2: view

Pathways by source for EPHB2 Gene

Gene Ontology (GO) - Biological Process for EPHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0001525 angiogenesis ISS --
GO:0001655 urogenital system development ISS --
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway --
genes like me logo Genes that share ontologies with EPHB2: view

Compounds for EPHB2 Gene

(2) HMDB Compounds for EPHB2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Drugbank Compounds for EPHB2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Phosphoaminophosphonic Acid-Adenylate Ester
target

(15) Novoseek inferred chemical compound relationships for EPHB2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 73.7 52
pd 98,059 46.9 5
n-formylmethionyl-leucylphenylalanine 44.9 2
sb 203580 40.4 1
phosphatidylinositol 30.8 4
genes like me logo Genes that share compounds with EPHB2: view

Transcripts for EPHB2 Gene

Unigene Clusters for EPHB2 Gene

EPH receptor B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for EPHB2 Gene

GeneLoc Exon Structure for
EPHB2
ECgene alternative splicing isoforms for
EPHB2

Expression for EPHB2 Gene

mRNA expression in normal human tissues for EPHB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHB2 Gene

This gene is overexpressed in Colon - Transverse (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPHB2 Gene

SOURCE GeneReport for Unigene cluster for EPHB2 Gene Hs.523329

mRNA Expression by UniProt/SwissProt for EPHB2 Gene

P29323-EPHB2_HUMAN
Tissue specificity: Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain
genes like me logo Genes that share expressions with EPHB2: view

Orthologs for EPHB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPHB2 36
  • 99.65 (n)
  • 100 (a)
EPHB2 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPHB2 36
  • 92.52 (n)
  • 99.06 (a)
EPHB2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPHB2 36
  • 93.46 (n)
  • 99.69 (a)
EPHB2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ephb2 36
  • 90.94 (n)
  • 99.49 (a)
Ephb2 16
Ephb2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPHB2 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ephb2 36
  • 91.21 (n)
  • 98.88 (a)
chicken
(Gallus gallus)
Aves EPHB2 36
  • 84.64 (n)
  • 96.07 (a)
EPHB2 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 93 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.506 36
zebrafish
(Danio rerio)
Actinopterygii ephb2 36
  • 77.65 (n)
  • 86.78 (a)
ephb2a 37
  • 83 (a)
OneToMany
ephb2b 37
  • 88 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eph 37
  • 39 (a)
OneToMany
Eph 38
  • 42 (a)
hop 38
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
CSA.1664 37
  • 40 (a)
ManyToMany
CSA.7809 37
  • 41 (a)
ManyToMany
Species with no ortholog for EPHB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHB2 Gene

ENSEMBL:
Gene Tree for EPHB2 (if available)
TreeFam:
Gene Tree for EPHB2 (if available)

Paralogs for EPHB2 Gene

Paralogs for EPHB2 Gene

genes like me logo Genes that share paralogs with EPHB2: view

Variants for EPHB2 Gene

Sequence variations from dbSNP and Humsavar for EPHB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs116119 -- 22,892,694(+) CCTAC(C/T)TTTGT intron-variant
rs170129 -- 22,883,069(-) accta(C/T)ggctt intron-variant
rs172417 -- 22,714,438(+) TAGCA(G/T)GTCTA intron-variant
rs172635 -- 22,881,312(-) caagc(A/G)attct intron-variant
rs177927 -- 22,881,677(-) gcaga(A/G)gtttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPHB2 Gene

Variant ID Type Subtype PubMed ID
esv34161 CNV Loss 18971310
nsv870805 CNV Gain 21882294
esv2538911 CNV Insertion 19546169
nsv512725 CNV Insertion 21212237
nsv469829 CNV Loss 16826518
nsv871487 CNV Loss 21882294
nsv870618 CNV Loss 21882294
nsv509036 CNV Insertion 20534489
esv1389294 CNV Deletion 17803354
nsv528926 CNV Loss 19592680
nsv6409 CNV Insertion 18451855

Relevant External Links for EPHB2 Gene

HapMap Linkage Disequilibrium report
EPHB2
Human Gene Mutation Database (HGMD)
EPHB2

Disorders for EPHB2 Gene

(1) OMIM Diseases for EPHB2 Gene (600997)

UniProtKB/Swiss-Prot

EPHB2_HUMAN
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:15300251, ECO:0000269 PubMed:16155194}. Note=The gene represented in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.

(2) University of Copenhagen DISEASES for EPHB2 Gene

(20) Novoseek inferred disease relationships for EPHB2 Gene

Disease -log(P) Hits PubMed IDs
tumors 31.3 23
colorectal tumors 30.3 3
teratocarcinoma 29.7 1
glioblastoma 27.1 5
adenoma 23 7

Relevant External Links for EPHB2

Genetic Association Database (GAD)
EPHB2
Human Genome Epidemiology (HuGE) Navigator
EPHB2
genes like me logo Genes that share disorders with EPHB2: view

Publications for EPHB2 Gene

  1. eek and erk, new members of the eph subclass of receptor protein- tyrosine kinases. (PMID: 1648701) Chan J. … Watt V.M. (Oncogene 1991) 2 3 4 23
  2. A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. (PMID: 16155194) Kittles R.A. … Carpten J.D. (J. Med. Genet. 2006) 3 4 23 49
  3. A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals. (PMID: 9696046) Tang X.X. … Ikegaki N. (Oncogene 1998) 3 4 23
  4. Oligomeric structure of the human EphB2 receptor SAM domain. (PMID: 9933164) Thanos C.D. … Bowie J.U. (Science 1999) 3 4 23
  5. Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer. (PMID: 7688222) Iwase T. … Kino I. (Biochem. Biophys. Res. Commun. 1993) 3 4 23

Products for EPHB2 Gene

Sources for EPHB2 Gene

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