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Aliases for EPHB1 Gene

Aliases for EPHB1 Gene

  • EPH Receptor B1 2 3
  • EPHT2 3 4 6
  • NET 3 4 6
  • Neuronally-Expressed EPH-Related Tyrosine Kinase 3 4
  • Tyrosine-Protein Kinase Receptor EPH-2 3 4
  • EPH-Like Kinase 6 3 4
  • EC 2.7.10.1 4 63
  • Hek6 3 4
  • EK6 3 4
  • ELK 3 4
  • Ephrin Type-B Receptor 1 3
  • Soluble EPHB1 Variant 1 3
  • Eph Tyrosine Kinase 2 3
  • EPH Tyrosine Kinase 2 4
  • EC 2.7.10 63
  • EphB1 2

External Ids for EPHB1 Gene

Previous HGNC Symbols for EPHB1 Gene

  • EPHT2

Previous GeneCards Identifiers for EPHB1 Gene

  • GC03M131897
  • GC03P135607
  • GC03P135795
  • GC03P135835
  • GC03P135996
  • GC03P134316
  • GC03P131890

Summaries for EPHB1 Gene

Entrez Gene Summary for EPHB1 Gene

  • Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPHB1 Gene

EPHB1 (EPH Receptor B1) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include transmembrane-ephrin receptor activity and axon guidance receptor activity. An important paralog of this gene is EPHB3.

UniProtKB/Swiss-Prot for EPHB1 Gene

  • Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

Gene Wiki entry for EPHB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHB1 Gene

Genomics for EPHB1 Gene

Regulatory Elements for EPHB1 Gene

Genomic Location for EPHB1 Gene

Start:
134,597,801 bp from pter
End:
135,260,467 bp from pter
Size:
662,667 bases
Orientation:
Plus strand

Genomic View for EPHB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPHB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHB1 Gene

Proteins for EPHB1 Gene

  • Protein details for EPHB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54762-EPHB1_HUMAN
    Recommended name:
    Ephrin type-B receptor 1
    Protein Accession:
    P54762
    Secondary Accessions:
    • A8K593
    • B3KTB2
    • B5A969
    • O43569
    • O95142
    • O95143
    • Q0VG87

    Protein attributes for EPHB1 Gene

    Size:
    984 amino acids
    Molecular mass:
    109885 Da
    Quaternary structure:
    • Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts with EPHB6; transphosphorylates EPHB6 to form an active signaling complex. Interacts with PICK1 (By similarity). Interacts (through Tyr-594) with NCK1 (via SH2 domain); activates the JUN cascade to regulate cell adhesion (By similarity). The ligand-activated form interacts (through Tyr-928) with GRB7 and GRB10 (via SH2 domains). The ligand-activated form interacts (residues within the catalytic domain) with GRB2 (via SH2 domain). Interacts with GRB2, SHC1 and SRC; activates the MAPK/ERK cascade to regulate cell migration. Interacts with CBL; regulates receptor degradation through ubiquitination. Interacts with ACP1.
    SequenceCaution:
    • Sequence=AAB94627.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries.; Evidence={ECO:0000305}; Sequence=AAB94628.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries.; Evidence={ECO:0000305}; Sequence=AAD02031.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPHB1 Gene

    Alternative splice isoforms for EPHB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHB1 Gene

Proteomics data for EPHB1 Gene at MOPED

Post-translational modifications for EPHB1 Gene

  • Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL.
  • Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation.
  • Glycosylation at Asn334, Asn426, and Asn480
  • Modification sites at PhosphoSitePlus

Domains for EPHB1 Gene

Gene Families for EPHB1 Gene

HGNC:
  • EPH :EPH receptors
  • FN3 :Fibronectin type III domain containing
  • SAMD :Sterile alpha motif (SAM) domain containing
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P54762

UniProtKB/Swiss-Prot:

EPHB1_HUMAN :
  • P54762
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHB1: view

Function for EPHB1 Gene

Molecular function for EPHB1 Gene

GENATLAS Biochemistry: EPH-related tyrosine kinase receptor,binding ephrins B1,B2,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

Enzyme Numbers (IUBMB) for EPHB1 Gene

Gene Ontology (GO) - Molecular Function for EPHB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0005003 ephrin receptor activity --
GO:0005005 transmembrane-ephrin receptor activity IDA 18034775
GO:0005515 protein binding IPI 12223469
genes like me logo Genes that share ontologies with EPHB1: view
genes like me logo Genes that share phenotypes with EPHB1: view

Animal Models for EPHB1 Gene

MGI Knock Outs for EPHB1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for EPHB1 Gene

Localization for EPHB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHB1 Gene

Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHB1 Gene COMPARTMENTS Subcellular localization image for EPHB1 gene
Compartment Confidence
endosome 5
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for EPHB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 18034775
genes like me logo Genes that share ontologies with EPHB1: view

Pathways for EPHB1 Gene

genes like me logo Genes that share pathways with EPHB1: view

Pathways by source for EPHB1 Gene

2 Cell Signaling Technology pathways for EPHB1 Gene
1 KEGG pathway for EPHB1 Gene

Gene Ontology (GO) - Biological Process for EPHB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 9499402
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway --
GO:0007411 axon guidance TAS --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with EPHB1: view

Compounds for EPHB1 Gene

(2) HMDB Compounds for EPHB1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Novoseek inferred chemical compound relationships for EPHB1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 57.8 11
phosphotyrosine 41.6 1
genes like me logo Genes that share compounds with EPHB1: view

Transcripts for EPHB1 Gene

Unigene Clusters for EPHB1 Gene

EPH receptor B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHB1 Gene

No ASD Table

Relevant External Links for EPHB1 Gene

GeneLoc Exon Structure for
EPHB1
ECgene alternative splicing isoforms for
EPHB1

Expression for EPHB1 Gene

mRNA expression in normal human tissues for EPHB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHB1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.0) and Brain - Cerebellum (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EPHB1 Gene

SOURCE GeneReport for Unigene cluster for EPHB1 Gene Hs.116092

mRNA Expression by UniProt/SwissProt for EPHB1 Gene

P54762-EPHB1_HUMAN
Tissue specificity: Preferentially expressed in brain
genes like me logo Genes that share expressions with EPHB1: view

Orthologs for EPHB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPHB1 35
  • 99.73 (n)
  • 99.9 (a)
EPHB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPHB1 35
  • 93.09 (n)
  • 99.19 (a)
EPHB1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPHB1 35
  • 92.92 (n)
  • 98.68 (a)
EPHB1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ephb1 35
  • 91.33 (n)
  • 98.88 (a)
Ephb1 16
Ephb1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPHB1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ephb1 35
  • 91.57 (n)
  • 98.88 (a)
chicken
(Gallus gallus)
Aves EPHB1 35
  • 84.42 (n)
  • 94.92 (a)
EPHB1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPHB1 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1028 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ephb1 35
  • 78.8 (n)
  • 91.73 (a)
Str.11068 35
zebrafish
(Danio rerio)
Actinopterygii ephb1 35
  • 76.68 (n)
  • 87.32 (a)
EPHB1 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000489 35
  • 54.65 (n)
  • 48.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta Eph 35
  • 49.39 (n)
  • 46.9 (a)
Eph 36
  • 40 (a)
OneToMany
Eph 37
  • 42 (a)
hop 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea F59A3.8 37
  • 33 (a)
old-2 37
  • 33 (a)
T25B9.5 37
  • 34 (a)
old-1 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
CSA.1664 36
  • 39 (a)
ManyToMany
CSA.7809 36
  • 43 (a)
ManyToMany
Species with no ortholog for EPHB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPHB1 Gene

ENSEMBL:
Gene Tree for EPHB1 (if available)
TreeFam:
Gene Tree for EPHB1 (if available)

Paralogs for EPHB1 Gene

Paralogs for EPHB1 Gene

genes like me logo Genes that share paralogs with EPHB1: view

Variants for EPHB1 Gene

Sequence variations from dbSNP and Humsavar for EPHB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10608 -- 135,260,327(+) TCCTT(A/G)TTGTA utr-variant-3-prime
rs28211 -- 135,011,819(-) ATGCA(C/G)TGGAA intron-variant
rs28223 -- 135,011,416(+) AATTC(A/C)AGAAG intron-variant
rs28338 -- 135,020,932(-) CTACG(A/T)CAATT intron-variant
rs36037 -- 135,034,787(-) TACAG(G/T)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPHB1 Gene

Variant ID Type Subtype PubMed ID
nsv877515 CNV Gain 21882294
nsv508956 CNV Insertion 20534489
nsv822262 CNV Loss 20364138
nsv460859 CNV Loss 19166990
esv29010 CNV Gain 19812545
nsv513075 CNV Loss 21212237
esv2490314 CNV Deletion 19546169
esv2309200 CNV Deletion 18987734
esv2725955 CNV Deletion 23290073
esv2660214 CNV Deletion 23128226
esv991539 CNV Deletion 20482838
esv2663866 CNV Deletion 23128226
nsv877516 CNV Gain 21882294
nsv877517 CNV Loss 21882294
nsv829731 CNV Loss 17160897
nsv818168 CNV Loss 17921354
nsv436394 CNV Deletion 17901297
nsv520932 CNV Loss 19592680
esv2677066 CNV Deletion 23128226
esv22232 CNV Loss 19812545
esv2421444 CNV Deletion 20811451
nsv441840 CNV CNV 18776908
nsv519871 CNV Loss 19592680
nsv514169 CNV Loss 21397061
nsv4020 CNV Insertion 18451855

Relevant External Links for EPHB1 Gene

HapMap Linkage Disequilibrium report
EPHB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHB1 Gene

Disorders for EPHB1 Gene

(2) Novoseek inferred disease relationships for EPHB1 Gene

Disease -log(P) Hits PubMed IDs
metastasis 0 2
tumors 0 1

Relevant External Links for EPHB1

Genetic Association Database (GAD)
EPHB1
Human Genome Epidemiology (HuGE) Navigator
EPHB1
genes like me logo Genes that share disorders with EPHB1: view

No data available for UniProtKB/Swiss-Prot for EPHB1 Gene

Publications for EPHB1 Gene

  1. cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein- tyrosine kinase gene preferentially expressed in brain. (PMID: 8666391) Tang X.X. … Ikegaki N. (Genomics 1995) 2 3 4 23
  2. EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. (PMID: 12925710) Vindis C. … Huynh-Do U. (J. Cell Biol. 2003) 3 4 23
  3. Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. (PMID: 18034775) Fasen K. … Huynh-Do U. (Traffic 2008) 3 4 23
  4. The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. (PMID: 11713248) Freywald A. … Roifman C.M. (J. Biol. Chem. 2002) 3 4 23
  5. Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. (PMID: 8798570) Stein E. … Daniel T.O. (J. Biol. Chem. 1996) 3 4

Products for EPHB1 Gene

  • Addgene plasmids for EPHB1

Sources for EPHB1 Gene

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