Aliases for EPHA1 Gene
Aliases for EPHA1 Gene
External Ids for EPHA1 Gene
- HGNC: 3385
- Entrez Gene: 2041
- Ensembl: ENSG00000146904
- OMIM: 179610
- UniProtKB: P21709
Previous HGNC Symbols for EPHA1 Gene
- EPHT
- EPHT1
Previous GeneCards Identifiers for EPHA1 Gene
- GC07M141414
- GC07M142482
- GC07M142559
- GC07M142605
- GC07M142798
- GC07M143087
- GC07M137425
Summaries for EPHA1 Gene
-
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for EPHA1 Gene
EPHA1 (EPH Receptor A1) is a Protein Coding gene. Diseases associated with EPHA1 include Placenta Praevia and Craniofrontonasal Dysplasia. Among its related pathways are GPCR Pathway and MAPK-Erk Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA2.
UniProtKB/Swiss-Prot for EPHA1 Gene
-
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
-
Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA1 Gene
Genomics for EPHA1 Gene
Regulatory Elements for EPHA1 Gene
Enhancers for EPHA1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around EPHA1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the EPHA1 gene promoter:
Regulatory Element Products
Genomic Location for EPHA1 Gene
- Chromosome:
- 7
- Start:
- 143,390,289 bp from pter
- End:
- 143,408,892 bp from pter
- Size:
- 18,604 bases
- Orientation:
- Minus strand
Genomic View for EPHA1 Gene
Genes around EPHA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q35 by Ensembl
- 7q34-q35 by Entrez Gene
- 7q34-q35 by HGNC
EPHA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EPHA1 Gene
Proteins for EPHA1 Gene
-
Protein details for EPHA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P21709-EPHA1_HUMAN
- Recommended name:
- Ephrin type-A receptor 1
- Protein Accession:
- P21709
- A1L3V3
- B5A966
- B5A967
- Q15405
Protein attributes for EPHA1 Gene
- Size:
- 976 amino acids
- Molecular mass:
- 108127 Da
- Quaternary structure:
-
- Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1.
- SequenceCaution:
-
- Sequence=AAA36747.1; Type=Frameshift; Positions=582, 595, 601; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for EPHA1 Gene
Protein Expression for EPHA1 Gene
Selected DME Specific Peptides for EPHA1 Gene
- P21709:
-
- RDLAARN
- RWTAPEAI
- LAQFPDT
- CKETFNL
- YVHRDLAARNILVN
- ALVSVRV
- LPGHQKRI
- TEFMENG
Post-translational modifications for EPHA1 Gene
- Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.
- Ubiquitinated.
- Glycosylation at Asn414
- Modification sites at PhosphoSitePlus
Other Protein References for EPHA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for EPHA1 (EphA1)
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-
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- Novus Biologicals Antibodies for EPHA1
-
Cloud-Clone Corp. Antibodies for EPHA1
- Invitrogen Antibodies for EPHA1
- antibodies-online Antibodies for EPHA1: See all 127
- GeneTex EPHA1 antibody for EPHA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for EPHA1
Protein Products
- R&D Systems Proteins and Enzymes for EPHA1 (EphA1)
- Search Origene for MassSpec and Protein Over-expression Lysates for EPHA1
- Origene Custom Protein Services for EPHA1
- Novus Biologicals proteins for EPHA1
- Sino Biological Recombinant Proteins for EPHA1
- Sino Biological Cell Lysates for EPHA1
-
Cloud-Clone Corp. Proteins for EPHA1
- antibodies-online Proteins for EPHA1: See all 14
- Search antibodies-online for peptides
- Search GeneTex for Proteins for EPHA1
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for EPHA1 (EphA1)
-
Cloud-Clone Corp Assay Kits for EPHA1
- antibodies-online Kits for EPHA1: See all 16
Domains & Families for EPHA1 Gene
Gene Families for EPHA1 Gene
Protein Domains for EPHA1 Gene
- InterPro:
-
- Ig-like_fold
- Prot_kinase_dom
- Kinase-like_dom
- Protein_kinase_ATP_BS
- Tyr_kinase_AS
- Ser-Thr/Tyr_kinase_cat_dom
- FN3_dom
- Tyr_kinase_cat_dom
- Growth_fac_rcpt_
- Galactose-bd-like
- SAM
- SAM/pointed
- Tyr-kin_ephrin_A/B_rcpt-like
- Ephrin_rcpt_lig-bd_dom
- Eph_TM
- Tyr_kinase_rcpt_V_CS
- EphA1_rcpt_lig-bd
- Tyr_kinase_ephrin_rcpt
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EPHA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P21709UniProtKB/Swiss-Prot:
EPHA1_HUMAN :- Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Function for EPHA1 Gene
Molecular function for EPHA1 Gene
- GENATLAS Biochemistry:
- EPH-related tyrosine kinase receptor 1,binding ephrin A1,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot Function:
- Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Enzyme Numbers (IUBMB) for EPHA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IDA | 12775584 |
| GO:0004713 | protein tyrosine kinase activity | IEA | -- |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA | -- |
| GO:0005003 | ephrin receptor activity | IEA | -- |
| GO:0005005 | transmembrane-ephrin receptor activity | IDA | 19118217 |
Phenotypes for EPHA1 Gene
- MGI mutant phenotypes for EPHA1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for EPHA1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased substrate adherent cell growth
- Decreased viability of wild-type and TP53 knockout cells
- Condensed cis-Golgi
- Synthetic lethal with gemcitabine
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Models for EPHA1 Gene
- MGI Knock Outs for EPHA1:
-
- Epha1 tm1Sld
Animal Model Products
-
Taconic Biosciences Mouse Models for EPHA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPHA1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EPHA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPHA1 gene
- Search ViGene Biosciences for EPHA1
CRISPR Products
-
OriGene CRISPR knockouts for EPHA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPHA1
- GenScript: Design CRISPR guide RNA sequences for EPHA1
miRNA for EPHA1 Gene
- miRTarBase miRNAs that target EPHA1
-
- hsa-mir-335-5p (MIRT017674)
- hsa-mir-297 (MIRT551875)
- hsa-mir-3924 (MIRT551876)
- hsa-mir-190a-3p (MIRT551877)
- hsa-mir-524-5p (MIRT551878)
- hsa-mir-520d-5p (MIRT551879)
- hsa-mir-223-5p (MIRT551880)
- hsa-mir-567 (MIRT551881)
- hsa-mir-511-3p (MIRT551882)
- hsa-mir-656-3p (MIRT551883)
- hsa-mir-5011-5p (MIRT551884)
- hsa-mir-1277-5p (MIRT551885)
miRNA Products
- Search ViGene Biosciences for EPHA1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EPHA1
- Browse OriGene Inhibitory RNA Products For EPHA1
-
ViGene Biosciences ready-to-package AAV shRNAs for EPHA1 gene
Clone Products
- Sino Biological Human cDNA Clone for EPHA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EPHA1
- VectorBuilder custom plasmid, inducible vectors for EPHA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPHA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for EPHA1 (EphA1)
Cell Line Products
-
Horizon Cell Lines for EPHA1
-
ViGene Biosciences adenoviral particle packaged cDNA for EPHA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EPHA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPHA1 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPHA1 Gene
Localization for EPHA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EPHA1 Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 19118217 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for EPHA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | GPCR Pathway |
.73
.62
|
.55
|
| 2 | ERK Signaling |
.61
.58
|
.49
|
| 3 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 4 | Actin Nucleation by ARP-WASP Complex |
.41
.35
|
|
| 5 | MAPK-Erk Pathway |
.38
|
|
Pathways by source for EPHA1 Gene
3 Sino Biological pathways for EPHA1 Gene
1 Cell Signaling Technology pathway for EPHA1 Gene
1 BioSystems pathway for EPHA1 Gene
7 Reactome pathways for EPHA1 Gene
1 KEGG pathway for EPHA1 Gene
3 GeneGo (Thomson Reuters) pathways for EPHA1 Gene
Interacting Proteins for EPHA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001954 | positive regulation of cell-matrix adhesion | IDA | 19118217 |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006469 | negative regulation of protein kinase activity | IDA | 19118217 |
| GO:0007155 | cell adhesion | IEA | -- |
Drugs & Compounds for EPHA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for EPHA1 Gene
mRNA/cDNA for EPHA1 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (74) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for EPHA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPHA1
- GenScript: Design CRISPR guide RNA sequences for EPHA1
miRNA Products
- Search ViGene Biosciences for EPHA1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EPHA1
- Browse OriGene Inhibitory RNA Products For EPHA1
-
ViGene Biosciences ready-to-package AAV shRNAs for EPHA1 gene
Clone Products
- Sino Biological Human cDNA Clone for EPHA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EPHA1
- VectorBuilder custom plasmid, inducible vectors for EPHA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPHA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for EPHA1 (EphA1)
Expression for EPHA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Eye (Sensory Organs)
- Epiblast (Early Embryonic Tissues)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for EPHA1 Gene
This gene is overexpressed in Esophagus - Mucosa (x14.3), Vagina (x5.9), Skin - Sun Exposed (Lower leg) (x4.5), and Skin - Not Sun Exposed (Suprapubic) (x4.4).
This gene is overexpressed in Serum (32.6) and Urine (26.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPHA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of EPHA1 Gene:
EPHA1SOURCE GeneReport for Unigene cluster for EPHA1 Gene:
Hs.89839mRNA Expression by UniProt/SwissProt for EPHA1 Gene:
P21709-EPHA1_HUMAN
Tissue specificity:
Overexpressed in several carcinomas.
Evidence on tissue expression from TISSUES for EPHA1 Gene
- Nervous system(4.5)
- Heart(2.3)
- Blood(2.2)
- Lung(2.2)
- Skin(2.2)
- Muscle(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for EPHA1
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for EPHA1 Gene
Orthologs for EPHA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EPHA1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | EPHA1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | EPHA1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Epha1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Epha1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EPHA1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EPHA1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | EPHA1 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Eph 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| CSA.7809 35 |
|
ManyToMany | |||
| CSA.1664 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany |
- Species where no ortholog for EPHA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for EPHA1 Gene
Paralogs for EPHA1 Gene
(15) SIMAP similar genes for EPHA1 Gene using alignment to 4 proteins:
Variants for EPHA1 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_042119 | A breast pleomorphic lobular carcinoma sample | ||||
| rs1000056958 | -- | 143,401,247(+) | TCTCT(C/G)CAACC | intron-variant | |
| rs1000282912 | -- | 143,392,928(+) | CAGAG(C/T)AAGAC | intron-variant | |
| rs1000399540 | -- | 143,400,786(+) | GTCAC(G/T)ATTTT | intron-variant | |
| rs1000411029 | -- | 143,392,736(+) | CAGGA(G/T)TTCGA | intron-variant |
Residual Variation Intolerance Score:
56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.05;
75.16% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for EPHA1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA1 Gene
Disorders for EPHA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| placenta praevia |
|
|
| craniofrontonasal dysplasia |
|
|
| rh isoimmunization |
|
|
| placenta disease |
|
|
| uterine disease |
|
|
Search EPHA1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for EPHA1
No data available for UniProtKB/Swiss-Prot and Genatlas for EPHA1 Gene
Publications for EPHA1 Gene
- Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PMID: 9267020) (Cell 1997) 2 3 4 22 64
- EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma. (PMID: 20043122) Chen G. … Yu F. (Oncol. Rep. 2010) 3 4 22 64
- EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. (PMID: 19118217) Yamazaki T. … Maru Y. (J. Cell Sci. 2009) 3 4 22 64
- Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1. (PMID: 18728013) Bocharov E.V. … Arseniev A.S. (J. Biol. Chem. 2008) 3 4 22 64
- Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. (PMID: 21460841) Naj A.C. … Schellenberg G.D. (Nat. Genet. 2011) 3 46 64
Products for EPHA1 Gene
- R&D Systems Antibodies for EPHA1 (EphA1)
- R&D Systems Proteins and Enzymes for EPHA1 (EphA1)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for EPHA1 (EphA1)
- R&D Systems cDNA Clones for EPHA1 (EphA1)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Custom Antibody ServicesOriGene Antibodies for EPHA1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for EPHA1
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EPHA1
- Browse OriGene Inhibitory RNA Products For EPHA1
- OriGene qPCR primer pairs for EPHA1
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- OriGene ORF clones in human for EPHA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for EPHA1 in any vector
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- GenScript: Design CRISPR guide RNA sequences for EPHA1
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- CloneReady with Over 120,000 Genes
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- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for EPHA1
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- Cloud-Clone Corp. Antibodies for EPHA1
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- Taconic Biosciences Mouse Models for EPHA1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for EPHA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EPHA1
- antibodies-online Antibodies for EPHA1: See all 127
- antibodies-online Kits for EPHA1: See all 16
- antibodies-online Proteins for EPHA1: See all 14
- Search antibodies-online for peptides
- GeneTex EPHA1 antibody for EPHA1
- Search GeneTex for Proteins for EPHA1
- ViGene Biosciences adenoviral particle packaged cDNA for EPHA1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EPHA1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EPHA1 gene
- Search ViGene Biosciences for EPHA1
- Santa Cruz Biotechnology (SCBT) Antibodies for EPHA1
- Search Santa Cruz Biotechnology (SCBT) for EPHA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EPHA1
- Horizon Cell Lines for EPHA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPHA1
- VectorBuilder custom plasmid, inducible vectors for EPHA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPHA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for EPHA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer