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Aliases for EPHA1 Gene

Aliases for EPHA1 Gene

  • EPH Receptor A1 2 3
  • Erythropoietin-Producing Hepatoma Receptor 3 4
  • Tyrosine-Protein Kinase Receptor EPH 3 4
  • Oncogene EPH 3 6
  • EC 2.7.10.1 4 64
  • HEpha1 3 4
  • EPHT1 3 4
  • EPHT 3 4
  • EPH 3 4
  • Erythropoietin-Producing Hepatoma Amplified Sequence 3
  • Ephrin Type-A Receptor 1 3
  • Soluble EPHA1 Variant 1 3
  • Soluble EPHA1 Variant 2 3
  • Eph Tyrosine Kinase 1 3
  • EPH Tyrosine Kinase 1 4
  • EPH Tyrosine Kinase 4
  • EC 2.7.10 64
  • EphA1 2

External Ids for EPHA1 Gene

Previous Symbols for EPHA1 Gene

  • EPHT
  • EPHT1

Summaries for EPHA1 Gene

Entrez Gene Summary for EPHA1 Gene

  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPHA1 Gene

EPHA1 (EPH Receptor A1) is a Protein Coding gene. Diseases associated with EPHA1 include colorectal cancer. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include protein kinase binding and transmembrane-ephrin receptor activity. An important paralog of this gene is EPHB3.

UniProtKB/Swiss-Prot for EPHA1 Gene

  • Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Gene Wiki entry for EPHA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA1 Gene

Genomics for EPHA1 Gene

Genomic Location for EPHA1 Gene

Start:
143,390,289 bp from pter
End:
143,408,892 bp from pter
Size:
18,604 bases
Orientation:
Minus strand

Genomic View for EPHA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPHA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA1 Gene

Regulatory Elements for EPHA1 Gene

Proteins for EPHA1 Gene

  • Protein details for EPHA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21709-EPHA1_HUMAN
    Recommended name:
    Ephrin type-A receptor 1
    Protein Accession:
    P21709
    Secondary Accessions:
    • A1L3V3
    • B5A966
    • B5A967
    • Q15405

    Protein attributes for EPHA1 Gene

    Size:
    976 amino acids
    Molecular mass:
    108127 Da
    Quaternary structure:
    • Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1.
    SequenceCaution:
    • Sequence=AAA36747.1; Type=Frameshift; Positions=582, 595, 601; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPHA1 Gene

    Alternative splice isoforms for EPHA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA1 Gene

Proteomics data for EPHA1 Gene at MOPED

Selected DME Specific Peptides for EPHA1 Gene

Post-translational modifications for EPHA1 Gene

Other Protein References for EPHA1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for EPHA1 Gene

Gene Families for EPHA1 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing
  • FN3 :Fibronectin type III domain containing
  • EPH :EPH receptors
IUPHAR :

UniProtKB/Swiss-Prot:

EPHA1_HUMAN
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.:
    • P21709
  • Contains 2 fibronectin type-III domains.:
    • P21709
  • Contains 1 protein kinase domain.:
    • P21709
  • Contains 1 SAM (sterile alpha motif) domain.:
    • P21709
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.:
    • P21709
genes like me logo Genes that share domains with EPHA1: view

Function for EPHA1 Gene

Molecular function for EPHA1 Gene

GENATLAS Biochemistry: EPH-related tyrosine kinase receptor 1,binding ephrin A1,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Enzyme Numbers (IUBMB) for EPHA1 Gene

Gene Ontology (GO) - Molecular Function for EPHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 12775584
GO:0004713 protein tyrosine kinase activity --
GO:0005003 ephrin receptor activity --
GO:0005005 transmembrane-ephrin receptor activity IDA 19118217
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with EPHA1: view
genes like me logo Genes that share phenotypes with EPHA1: view

miRNA for EPHA1 Gene

miRTarBase miRNAs that target EPHA1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for EPHA1 Gene

Localization for EPHA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA1 Gene COMPARTMENTS Subcellular localization image for EPHA1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EPHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 19118217
genes like me logo Genes that share ontologies with EPHA1: view

Pathways for EPHA1 Gene

genes like me logo Genes that share pathways with EPHA1: view

Pathways by source for EPHA1 Gene

1 BioSystems pathway for EPHA1 Gene
1 KEGG pathway for EPHA1 Gene

Gene Ontology (GO) - Biological Process for EPHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001954 positive regulation of cell-matrix adhesion IDA 19118217
GO:0006468 protein phosphorylation --
GO:0006469 negative regulation of protein kinase activity IDA 19118217
GO:0007166 cell surface receptor signaling pathway IDA 19118217
genes like me logo Genes that share ontologies with EPHA1: view

Compounds for EPHA1 Gene

(2) HMDB Compounds for EPHA1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(8) Novoseek inferred chemical compound relationships for EPHA1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 83 110
nitric oxide 4.08 1
ly294002 2.27 1
lipid 1.96 1
fibrinogen 0 1
genes like me logo Genes that share compounds with EPHA1: view

Transcripts for EPHA1 Gene

Unigene Clusters for EPHA1 Gene

EPH receptor A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA1 Gene

No ASD Table

Relevant External Links for EPHA1 Gene

GeneLoc Exon Structure for
EPHA1
ECgene alternative splicing isoforms for
EPHA1

Expression for EPHA1 Gene

mRNA expression in normal human tissues for EPHA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHA1 Gene

This gene is overexpressed in Esophagus - Mucosa (14.3), Vagina (5.9), Skin - Sun Exposed (Lower leg) (4.5), and Skin - Not Sun Exposed (Suprapubic) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPHA1 Gene

SOURCE GeneReport for Unigene cluster for EPHA1 Gene Hs.89839

mRNA Expression by UniProt/SwissProt for EPHA1 Gene

P21709-EPHA1_HUMAN
Tissue specificity: Overexpressed in several carcinomas
genes like me logo Genes that share expressions with EPHA1: view

Orthologs for EPHA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPHA1 36
  • 99.28 (n)
  • 99.28 (a)
EPHA1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPHA1 36
  • 86.06 (n)
  • 87.95 (a)
EPHA1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPHA1 36
  • 87.7 (n)
  • 90.27 (a)
EPHA1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epha1 36
  • 85.55 (n)
  • 88.01 (a)
Epha1 16
Epha1 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPHA1 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epha1 36
  • 85.28 (n)
  • 88.01 (a)
chicken
(Gallus gallus)
Aves EPHA1 36
  • 66.1 (n)
  • 64.19 (a)
EPHA1 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPHA1 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eph 37
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
CSA.1664 37
  • 35 (a)
ManyToMany
CSA.7809 37
  • 36 (a)
ManyToMany
Species with no ortholog for EPHA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EPHA1 Gene

ENSEMBL:
Gene Tree for EPHA1 (if available)
TreeFam:
Gene Tree for EPHA1 (if available)

Paralogs for EPHA1 Gene

Paralogs for EPHA1 Gene

Selected SIMAP similar genes for EPHA1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EPHA1: view

Variants for EPHA1 Gene

Sequence variations from dbSNP and Humsavar for EPHA1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1135752 -- 143,401,567(-) CCCCT(C/G)TACAT synonymous-codon, reference, nc-transcript-variant
rs1140683 -- 143,395,473(-) ACCCT(C/G)AGGCT synonymous-codon, reference, nc-transcript-variant
rs1804527 -- 143,391,730(-) ATCCC(A/G)TATCG reference, synonymous-codon, nc-transcript-variant
rs2242601 -- 143,396,731(-) CGCCC(C/T)GGACC intron-variant
rs3812406 -- 143,392,066(+) GTGGC(C/T)GGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPHA1 Gene

Variant ID Type Subtype PubMed ID
nsv517520 CNV Loss 19592680

Relevant External Links for EPHA1 Gene

HapMap Linkage Disequilibrium report
EPHA1

Disorders for EPHA1 Gene

(1) MalaCards Diseases for EPHA1 Gene

Search for EPHA1 Gene in MalaCards »

(14) Novoseek inferred disease relationships for EPHA1 Gene

Disease -log(P) Hits PubMed IDs
neovascularization 40.8 4
cancer 32.4 21
tumors 32.1 19
glioblastoma 26.5 1
metastasis 20.1 5

Relevant External Links for EPHA1

Genetic Association Database (GAD)
EPHA1
Human Genome Epidemiology (HuGE) Navigator
EPHA1
Tumor Gene Database (TGDB):
EPHA1
genes like me logo Genes that share disorders with EPHA1: view

No data available for UniProtKB/Swiss-Prot for EPHA1 Gene

Publications for EPHA1 Gene

  1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PMID: 9267020) (Cell 1997) 2 3 4 23
  2. Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1. (PMID: 18728013) Bocharov E.V. … Arseniev A.S. (J. Biol. Chem. 2008) 3 4 23
  3. EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. (PMID: 19118217) Yamazaki T. … Maru Y. (J. Cell Sci. 2009) 3 4 23
  4. EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma. (PMID: 20043122) Chen G. … Yu F. (Oncol. Rep. 2010) 3 4 23
  5. Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival. (PMID: 16737551) Herath N.I. … Boyd A.W. (BMC Cancer 2006) 3 23

Products for EPHA1 Gene

  • Addgene plasmids for EPHA1

Sources for EPHA1 Gene

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