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Aliases for NRK Gene

Aliases for NRK Gene

  • Nik Related Kinase 2 3
  • EC 2.7.11.1 4 63
  • EC 2.7.11 63
  • NESK 3

External Ids for NRK Gene

Previous GeneCards Identifiers for NRK Gene

  • GC0XP103839
  • GC0XP104872
  • GC0XP105067
  • GC0XP094691

Summaries for NRK Gene

Entrez Gene Summary for NRK Gene

  • The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]

GeneCards Summary for NRK Gene

NRK (Nik Related Kinase) is a Protein Coding gene. Diseases associated with NRK include sotos syndrome 1. Among its related pathways are TNF signaling (REACTOME). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for NRK Gene

  • May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).

Gene Wiki entry for NRK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRK Gene

Genomics for NRK Gene

Regulatory Elements for NRK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NRK Gene

Chromosome:
X
Start:
105,821,856 bp from pter
End:
105,958,612 bp from pter
Size:
136,757 bases
Orientation:
Plus strand

Genomic View for NRK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRK Gene

Proteins for NRK Gene

  • Protein details for NRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2Y5-NRK_HUMAN
    Recommended name:
    Nik-related protein kinase
    Protein Accession:
    Q7Z2Y5
    Secondary Accessions:
    • Q32ND6
    • Q5H9K2
    • Q6ZMP2

    Protein attributes for NRK Gene

    Size:
    1582 amino acids
    Molecular mass:
    178479 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRK Gene

Proteomics data for NRK Gene at MOPED

Selected DME Specific Peptides for NRK Gene

Post-translational modifications for NRK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRK Gene

Domains & Families for NRK Gene

Gene Families for NRK Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z2Y5

UniProtKB/Swiss-Prot:

NRK_HUMAN :
  • Contains 1 CNH domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 CNH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with NRK: view

Function for NRK Gene

Molecular function for NRK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).

Enzyme Numbers (IUBMB) for NRK Gene

Gene Ontology (GO) - Molecular Function for NRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0005524 ATP binding IEA --
GO:0008349 NOT MAP kinase kinase kinase kinase activity IBA --
genes like me logo Genes that share ontologies with NRK: view
genes like me logo Genes that share phenotypes with NRK: view

Animal Models for NRK Gene

MGI Knock Outs for NRK:

Animal Model Products

miRNA for NRK Gene

miRTarBase miRNAs that target NRK

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRK

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for NRK Gene

Localization for NRK Gene

Gene Ontology (GO) - Cellular Components for NRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with NRK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NRK Gene

Pathways & Interactions for NRK Gene

SuperPathways for NRK Gene

Superpath Contained pathways
1 TNF signaling (REACTOME)
genes like me logo Genes that share pathways with NRK: view

Pathways by source for NRK Gene

1 BioSystems pathway for NRK Gene

Gene Ontology (GO) - Biological Process for NRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IBA --
GO:0006468 protein phosphorylation --
GO:0007256 activation of JNKK activity IEA --
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0007567 parturition IEA --
genes like me logo Genes that share ontologies with NRK: view

No data available for SIGNOR curated interactions for NRK Gene

Drugs & Compounds for NRK Gene

No Compound Related Data Available

Transcripts for NRK Gene

Unigene Clusters for NRK Gene

Nik related kinase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRK Gene

No ASD Table

Relevant External Links for NRK Gene

GeneLoc Exon Structure for
NRK
ECgene alternative splicing isoforms for
NRK

Expression for NRK Gene

mRNA expression in normal human tissues for NRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRK Gene

This gene is overexpressed in Ovary (x16.2) and Adrenal Gland (x10.2).

Protein differential expression in normal tissues from HIPED for NRK Gene

This gene is overexpressed in Plasma (57.9) and Placenta (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRK Gene



SOURCE GeneReport for Unigene cluster for NRK Gene Hs.209527

genes like me logo Genes that share expression patterns with NRK: view

Protein tissue co-expression partners for NRK Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NRK Gene

Orthologs for NRK Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRK 35
  • 89.26 (n)
  • 86.08 (a)
NRK 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRK 35
  • 90.42 (n)
  • 88.49 (a)
NRK 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrk 35
  • 79.03 (n)
  • 71.03 (a)
Nrk 16
Nrk 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NRK 35
  • 99.55 (n)
  • 99.33 (a)
NRK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrk 35
  • 76.46 (n)
  • 64.08 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 18 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NRK 36
  • 19 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-81j8.6 36
  • 16 (a)
ManyToMany
Species with no ortholog for NRK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRK Gene

ENSEMBL:
Gene Tree for NRK (if available)
TreeFam:
Gene Tree for NRK (if available)

Paralogs for NRK Gene

genes like me logo Genes that share paralogs with NRK: view

Variants for NRK Gene

Sequence variations from dbSNP and Humsavar for NRK Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs103026 -- 105,844,015(+) TGTGT(C/G)TGTCT intron-variant
rs169674 -- 105,923,634(+) TTTAA(A/G)TTGTT intron-variant
rs169675 -- 105,916,702(-) CGACC(A/G)TGACA intron-variant
rs184092 -- 105,933,824(+) TCAAA(C/T)TCTGC intron-variant
rs209078 -- 105,921,858(+) ACCAA(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRK Gene

Variant ID Type Subtype PubMed ID
esv2752312 CNV Gain 17911159
esv2676289 CNV Deletion 23128226
nsv521259 CNV Gain 19592680
esv2636339 CNV Deletion 19546169
esv2140378 CNV Deletion 18987734
esv4419 CNV Deletion 18987735
esv2740368 CNV Deletion 23290073
esv2660063 CNV Deletion 23128226
esv2482028 CNV Deletion 19546169

Variation tolerance for NRK Gene

Residual Variation Intolerance Score: 66.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRK Gene

HapMap Linkage Disequilibrium report
NRK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRK Gene

Disorders for NRK Gene

MalaCards: The human disease database

(1) MalaCards diseases for NRK Gene - From: DISEASES

Disorder Aliases PubMed IDs
sotos syndrome 1
  • sotos syndrome
- elite association
Search NRK in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRK
genes like me logo Genes that share disorders with NRK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRK Gene

Publications for NRK Gene

  1. Confirmation of region-specific patterns of gene expression in the human brain. (PMID: 17375343) Ernst C. … Turecki G. (Neurogenetics 2007) 23 67
  2. Computational and experimental studies on human misshapen/NIK-related kinase MINK-1. (PMID: 15032605) Qu K. … Xu D. (Curr. Med. Chem. 2004) 23 67
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67
  4. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C. … Stratton M.R. (Nature 2007) 67
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67

Products for NRK Gene

Sources for NRK Gene

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