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Aliases for SLC29A1 Gene

Aliases for SLC29A1 Gene

  • Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 1 2 3
  • ENT1 3 4 6
  • Equilibrative Nitrobenzylmercaptopurine Riboside-Sensitive Nucleoside Transporter 3 4
  • Solute Carrier Family 29 (Nucleoside Transporters), Member 1 2 3
  • Equilibrative NBMPR-Sensitive Nucleoside Transporter 3 4
  • Solute Carrier Family 29 Member 1 3 4
  • Nucleoside Transporter, Es-Type 3 4
  • Equilibrative Nitrobenzylmercaptopurine Riboside (NBMPR)-Sensitive Nucleoside Transporter 3
  • Equilibrative Nucleoside Transporter 1 3
  • Solute Carrier Family 29, Member 1 3

External Ids for SLC29A1 Gene

Previous HGNC Symbols for SLC29A1 Gene

  • ENT1

Previous GeneCards Identifiers for SLC29A1 Gene

  • GC06P044189
  • GC06P044234
  • GC06P044295
  • GC06P044187
  • GC06P043909

Summaries for SLC29A1 Gene

Entrez Gene Summary for SLC29A1 Gene

  • This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC29A1 Gene

SLC29A1 (Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC29A1 include pancreas adenocarcinoma and pancreatic cancer. Among its related pathways are RNA Polymerase I Promoter Opening and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include nucleoside transmembrane transporter activity. An important paralog of this gene is SLC29A3.

UniProtKB/Swiss-Prot for SLC29A1 Gene

  • Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs)

Tocris Summary for SLC29A1 Gene

  • Nucleoside transporters are divided into two families; the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1-3) display subtype-selective expression patterns; CNT1 is localized primarily to epithelial tissue whereas CNT2 and CNT3 have more widespread distributions. SLC29 family transporters (ENT1-4) are glycosylated proteins, localized to the plasma and mitochondrial membranes. They are expressed in the heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. They mediate nucleoside influx and efflux and exhibit highest affinity for adenosine. CNT and ENT transporters play critical roles in nucleoside salvage pathways where they mediate the first step of nucleotide biosynthesis. In addition, these transporters work in concert to terminate adenosine signaling and are vital determinants in the response to a variety of anticancer and antiviral treatments, as they modulate the entry of these nucleoside analogs into target tissues.

Gene Wiki entry for SLC29A1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC29A1 Gene

Genomics for SLC29A1 Gene

Regulatory Elements for SLC29A1 Gene

Transcription factor binding sites by QIAGEN in the SLC29A1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC29A1 Gene

Start:
44,219,505 bp from pter
End:
44,234,151 bp from pter
Size:
14,647 bases
Orientation:
Plus strand

Genomic View for SLC29A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC29A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC29A1 Gene

Proteins for SLC29A1 Gene

  • Protein details for SLC29A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99808-S29A1_HUMAN
    Recommended name:
    Equilibrative nucleoside transporter 1
    Protein Accession:
    Q99808
    Secondary Accessions:
    • B3KQV7
    • B3KQY5
    • Q5T9W9
    • Q9UJY2

    Protein attributes for SLC29A1 Gene

    Size:
    456 amino acids
    Molecular mass:
    50219 Da
    Quaternary structure:
    • Identified in a complex with STOM.

    Alternative splice isoforms for SLC29A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC29A1 Gene

Proteomics data for SLC29A1 Gene at MOPED

Post-translational modifications for SLC29A1 Gene

Antibody Products

No data available for DME Specific Peptides for SLC29A1 Gene

Domains for SLC29A1 Gene

Gene Families for SLC29A1 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q99808

UniProtKB/Swiss-Prot:

S29A1_HUMAN :
  • Q99808
Family:
  • Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
genes like me logo Genes that share domains with SLC29A1: view

Function for SLC29A1 Gene

Molecular function for SLC29A1 Gene

GENATLAS Biochemistry: solute carrier family 29,member A1,equilibrative nucleoside transporter,widely distributed
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.62 mM for adenosine {ECO:0000269 PubMed:12527552}; Note=Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.;
UniProtKB/Swiss-Prot Function: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs)

Gene Ontology (GO) - Molecular Function for SLC29A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005337 nucleoside transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC29A1: view

Phenotypes for SLC29A1 Gene

genes like me logo Genes that share phenotypes with SLC29A1: view

Animal Models for SLC29A1 Gene

MGI Knock Outs for SLC29A1:

Animal Model Products

CRISPR Products

miRNA for SLC29A1 Gene

miRTarBase miRNAs that target SLC29A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC29A1 Gene

Localization for SLC29A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC29A1 Gene

Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC29A1 Gene COMPARTMENTS Subcellular localization image for SLC29A1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 4
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLC29A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IDA 12527552
genes like me logo Genes that share ontologies with SLC29A1: view

Pathways for SLC29A1 Gene

genes like me logo Genes that share pathways with SLC29A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLC29A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 8986748
GO:0006810 transport --
GO:0007595 lactation IEA --
GO:0015858 nucleoside transport IDA 12527552
GO:0015862 uridine transport IEA --
genes like me logo Genes that share ontologies with SLC29A1: view

Compounds for SLC29A1 Gene

(4) Tocris Compounds for SLC29A1 Gene

Compound Action Cas Number
Decynium 22 PMAT inhibitor [977-96-8]
Dilazep dihydrochloride Adenosine uptake inhibitor [20153-98-4]
Dipyridamole Adenosine transport inhibitor [58-32-2]
NBMPR Equilibrative nucleoside transporter 1 (ENT1) inhibitor [38048-32-7]

(1) HMDB Compounds for SLC29A1 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(11) Drugbank Compounds for SLC29A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cytarabine
  • Ara-C
147-94-4 transporter substrate
Didanosine
  • DDI
69655-05-6 transporter
Fludarabine
  • FAMP
75607-67-9 transporter substrate
Fluorouracil
  • 5-Fluorouracil
51-21-8 transporter substrate
Gemcitabine
  • dFdC
95058-81-4 transporter substrate

(8) IUPHAR Ligand for SLC29A1 Gene

Ligand Type Action Affinity Pubmed IDs
NBTI Inhibitor Inhibition 9.7
draflazine Inhibitor Inhibition 9.5
KF24345 Inhibitor Inhibition 9.4
NBTGR Inhibitor Inhibition 9.3
[3H]NBTI None None 9.3
dilazep Inhibitor Inhibition 9
dipyridamole Inhibitor Inhibition 8.5
[14C]adenosine None None

(29) Novoseek inferred chemical compound relationships for SLC29A1 Gene

Compound -log(P) Hits PubMed IDs
nitrobenzylthioinosine 95.3 9
5-(saenta-x8)fluorescein 93.7 3
nucleoside 93.5 150
draflazine 90.6 2
soluflazine 89.6 2

(2) PharmGKB related drug/compound annotations for SLC29A1 Gene

Drug/compound Annotation
gemcitabine CA
paclitaxel CA
genes like me logo Genes that share compounds with SLC29A1: view

Transcripts for SLC29A1 Gene

Unigene Clusters for SLC29A1 Gene

Solute carrier family 29 (nucleoside transporters), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC29A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC29A1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12a ·
SP1: - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - -
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - - -
SP16: - - - - - - - - -
SP17: - - - -
SP18:
SP19: - - - - - - - - - - - - - - - - -
SP20:
SP21:
SP22:
SP23: - - - - - - - - - - - - -
SP24: - - - - - - - - - - - -
SP25: - - - - - - - - - - -
SP26: - - - - - - - - - - - -
SP27: - - - - - - - - - - -
SP28: - - - - - - - -
SP29: - - - - - - - -
SP30: - - - - - -
SP31: - - - - - -
SP32:

ExUns: 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - -
SP11: - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14:
SP15:
SP16: - - - - - -
SP17:
SP18: - - -
SP19: - - - - - - - - - - -
SP20:
SP21:
SP22:
SP23: - - - - - -
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:

Relevant External Links for SLC29A1 Gene

GeneLoc Exon Structure for
SLC29A1
ECgene alternative splicing isoforms for
SLC29A1

Expression for SLC29A1 Gene

mRNA expression in normal human tissues for SLC29A1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC29A1 Gene

SOURCE GeneReport for Unigene cluster for SLC29A1 Gene Hs.25450

mRNA Expression by UniProt/SwissProt for SLC29A1 Gene

Q99808-S29A1_HUMAN
Tissue specificity: Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen.
genes like me logo Genes that share expressions with SLC29A1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC29A1 Gene

Orthologs for SLC29A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC29A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC29A1 35
  • 99.56 (n)
  • 99.78 (a)
SLC29A1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC29A1 35
  • 87.57 (n)
  • 86.84 (a)
SLC29A1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC29A1 35
  • 89.55 (n)
  • 87.5 (a)
mouse
(Mus musculus)
Mammalia Slc29a1 35
  • 82.38 (n)
  • 80.04 (a)
Slc29a1 16
Slc29a1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC29A1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc29a1 35
  • 81.8 (n)
  • 78.29 (a)
chicken
(Gallus gallus)
Aves SLC29A1 35
  • 68.09 (n)
  • 61.8 (a)
SLC29A1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC29A1 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68732 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC107853 35
  • 64.41 (n)
  • 63.06 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.290 35
zebrafish
(Danio rerio)
Actinopterygii LOC100331439 35
  • 67.92 (n)
  • 69.72 (a)
SLC29A1 (2 of 2) 36
  • 65 (a)
OneToMany
slc29a1a 36
  • 65 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009114 35
  • 50.54 (n)
  • 39.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ent1 35
  • 47.39 (n)
  • 35.18 (a)
Ent1 36
  • 29 (a)
OneToMany
CG11907 37
  • 32 (a)
BEST:LD04971 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea ent-2 36
  • 26 (a)
ManyToMany
K02E11.1 37
  • 26 (a)
K09A9.3 37
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FUN26 35
  • 43.22 (n)
  • 26.13 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15862g 35
  • 42.47 (n)
  • 28.76 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00356 35
  • 45.6 (n)
  • 31.07 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for SLC29A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC29A1 Gene

ENSEMBL:
Gene Tree for SLC29A1 (if available)
TreeFam:
Gene Tree for SLC29A1 (if available)

Paralogs for SLC29A1 Gene

Paralogs for SLC29A1 Gene

Selected SIMAP similar genes for SLC29A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC29A1: view

Variants for SLC29A1 Gene

Sequence variations from dbSNP and Humsavar for SLC29A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14623 -- 44,233,970(+) CCTGC(A/G)CCTCC utr-variant-3-prime
rs70914 -- 44,226,264(+) TCAGT(A/G)CACAT intron-variant, upstream-variant-2KB
rs186556 -- 44,231,465(+) ATGTA(C/T)GTAGG intron-variant
rs324148 -- 44,228,841(+) GAAAA(C/T)GGCTC intron-variant
rs324149 -- 44,229,258(+) GCAAA(C/T)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC29A1 Gene

Variant ID Type Subtype PubMed ID
nsv885851 CNV Loss 21882294
nsv5282 CNV Insertion 18451855
nsv885852 CNV Loss 21882294
nsv462936 CNV Loss 19166990
dgv6843n71 CNV Loss 21882294
nsv524398 CNV Loss 19592680

Relevant External Links for SLC29A1 Gene

HapMap Linkage Disequilibrium report
SLC29A1
Human Gene Mutation Database (HGMD)
SLC29A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC29A1 Gene

Disorders for SLC29A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for SLC29A1 Gene including...

Search for SLC29A1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLC29A1 Gene

(14) Novoseek inferred disease relationships for SLC29A1 Gene

Disease -log(P) Hits PubMed IDs
pancreatic cancer 59.3 6
diabetes gestational 43.8 9
leukemia 41.4 2
adenocarcinoma 27.8 4
acute leukemia 23 1

Relevant External Links for SLC29A1

Genetic Association Database (GAD)
SLC29A1
Human Genome Epidemiology (HuGE) Navigator
SLC29A1
genes like me logo Genes that share disorders with SLC29A1: view

No data available for UniProtKB/Swiss-Prot for SLC29A1 Gene

Publications for SLC29A1 Gene

  1. Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. (PMID: 8986748) Griffiths M. … Baldwin S.A. (Nat. Med. 1997) 2 3 4
  2. Characterization of ribavirin uptake systems in human hepatocytes. (PMID: 20185188) Fukuchi Y. … Chiba K. (J. Hepatol. 2010) 3 23 25
  3. Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma. (PMID: 16818276) MarcAc S. … Colomer D. (Haematologica 2006) 3 23 25
  4. Assignment of the human equilibrative nucleoside transporter (hENT1) to 6p21.1-p21.2. (PMID: 9344680) Coe I.R. … Cass C.E. (Genomics 1997) 2 3
  5. Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles. (PMID: 10755314) Lum P.Y. … Unadkat J.D. (Cancer Chemother. Pharmacol. 2000) 3 4

Products for SLC29A1 Gene

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