Aliases for ENO1 Gene
External Ids for ENO1 Gene
Previous HGNC Symbols for ENO1 Gene
Previous GeneCards Identifiers for ENO1 Gene
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
GeneCards Summary for ENO1 Gene
ENO1 (Enolase 1) is a Protein Coding gene. Diseases associated with ENO1 include cancer-associated retinopathy and non-herpetic acute limbic encephalitis. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include poly(A) RNA binding and transcription corepressor activity. An important paralog of this gene is ENO2.
UniProtKB/Swiss-Prot for ENO1 Gene
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.
MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.