Aliases for EMD Gene
External Ids for EMD Gene
Previous GeneCards Identifiers for EMD Gene
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for EMD Gene
EMD (Emerin) is a Protein Coding gene. Diseases associated with EMD include Emery-Dreifuss Muscular Dystrophy 1, X-Linked and Emery-Dreifuss Muscular Dystrophy, X-Linked. Among its related pathways are Nuclear Envelope Reassembly and Arrhythmogenic right ventricular cardiomyopathy (ARVC). GO annotations related to this gene include actin binding and beta-tubulin binding.
UniProtKB/Swiss-Prot for EMD Gene
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.