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Aliases for MUC20 Gene

Aliases for MUC20 Gene

  • Mucin 20, Cell Surface Associated 2 3 5
  • MUC-20 3 4
  • Transmembrane Mucin MUC20S 3
  • KIAA1359 4

External Ids for MUC20 Gene

Previous GeneCards Identifiers for MUC20 Gene

  • GC03P196775
  • GC03P196937
  • GC03P195447
  • GC03P192723
  • GC03P195343

Summaries for MUC20 Gene

Entrez Gene Summary for MUC20 Gene

  • This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]

GeneCards Summary for MUC20 Gene

MUC20 (Mucin 20, Cell Surface Associated) is a Protein Coding gene. Among its related pathways are Diseases associated with O-glycosylation of proteins and Defective GALNT12 causes colorectal cancer 1 (CRCS1).

UniProtKB/Swiss-Prot for MUC20 Gene

  • May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.

Gene Wiki entry for MUC20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC20 Gene

Genomics for MUC20 Gene

Regulatory Elements for MUC20 Gene

Enhancers for MUC20 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MUC20 on UCSC Golden Path with GeneCards custom track

Genomic Location for MUC20 Gene

195,720,882 bp from pter
195,741,123 bp from pter
20,242 bases
Plus strand

Genomic View for MUC20 Gene

Genes around MUC20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MUC20 Gene

  • Protein details for MUC20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6UX97
    • Q76I83
    • Q76I85
    • Q86ST8
    • Q8NBY6
    • Q96KA1
    • Q9P2I8

    Protein attributes for MUC20 Gene

    709 amino acids
    Molecular mass:
    71982 Da
    Quaternary structure:
    • Interacts with MET; oligomerization increases affinity for MET.
    • Sequence=AAQ88814.1; Type=Frameshift; Positions=638; Evidence={ECO:0000305}; Sequence=BAA92597.1; Type=Miscellaneous discrepancy; Note=Dubious isoform. Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for MUC20 Gene


neXtProt entry for MUC20 Gene

Proteomics data for MUC20 Gene at MOPED

Post-translational modifications for MUC20 Gene

  • Glycosylation at Thr 70, Asn 423, Ser 547, Asn 616, Asn 622, and Thr 652
  • Modification sites at PhosphoSitePlus

Other Protein References for MUC20 Gene

No data available for DME Specific Peptides for MUC20 Gene

Domains & Families for MUC20 Gene

Gene Families for MUC20 Gene


Protein Domains for MUC20 Gene


Suggested Antigen Peptide Sequences for MUC20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC20: view

No data available for UniProtKB/Swiss-Prot for MUC20 Gene

Function for MUC20 Gene

Molecular function for MUC20 Gene

UniProtKB/Swiss-Prot Function:
May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.

Phenotypes for MUC20 Gene

GenomeRNAi human phenotypes for MUC20:
genes like me logo Genes that share phenotypes with MUC20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MUC20

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC20 Gene

Localization for MUC20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC20 Gene

Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane.

Subcellular locations from

Jensen Localization Image for MUC20 Gene COMPARTMENTS Subcellular localization image for MUC20 gene
Compartment Confidence
plasma membrane 5
extracellular 4
golgi apparatus 4
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MUC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with MUC20: view

Pathways & Interactions for MUC20 Gene

genes like me logo Genes that share pathways with MUC20: view

Gene Ontology (GO) - Biological Process for MUC20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048012 hepatocyte growth factor receptor signaling pathway IBA --
GO:0051260 protein homooligomerization IDA 15314156
genes like me logo Genes that share ontologies with MUC20: view

No data available for SIGNOR curated interactions for MUC20 Gene

Drugs & Compounds for MUC20 Gene

No Compound Related Data Available

Transcripts for MUC20 Gene

Unigene Clusters for MUC20 Gene

Mucin 20, cell surface associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC20 Gene

No ASD Table

Relevant External Links for MUC20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUC20 Gene

mRNA expression in normal human tissues for MUC20 Gene

mRNA differential expression in normal tissues according to GTEx for MUC20 Gene

This gene is overexpressed in Kidney - Cortex (x5.1), Esophagus - Mucosa (x4.3), and Minor Salivary Gland (x4.3).

Protein differential expression in normal tissues from HIPED for MUC20 Gene

This gene is overexpressed in Urine (35.4) and Milk (33.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC20 Gene

SOURCE GeneReport for Unigene cluster for MUC20 Gene Hs.308992

mRNA Expression by UniProt/SwissProt for MUC20 Gene

Tissue specificity: Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis.
genes like me logo Genes that share expression patterns with MUC20: view

Protein tissue co-expression partners for MUC20 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MUC20 Gene

Orthologs for MUC20 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MUC20 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MUC20 35
  • 72.9 (n)
  • 58.66 (a)
MUC20 36
  • 51 (a)
(Mus musculus)
Mammalia Muc20 35
  • 63.39 (n)
  • 45.45 (a)
Muc20 16
Muc20 36
  • 32 (a)
(Pan troglodytes)
Mammalia LOC750356 35
  • 95.51 (n)
  • 92.24 (a)
(Rattus norvegicus)
Mammalia Muc20 35
  • 63.92 (n)
  • 47.87 (a)
(Bos Taurus)
Mammalia MUC20 36
  • 45 (a)
(Monodelphis domestica)
Mammalia MUC20 36
  • 18 (a)
Species with no ortholog for MUC20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC20 Gene

Gene Tree for MUC20 (if available)
Gene Tree for MUC20 (if available)

Paralogs for MUC20 Gene

genes like me logo Genes that share paralogs with MUC20: view

No data available for Paralogs for MUC20 Gene

Variants for MUC20 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUC20 Gene

The region encoding the tandem repeats is highly polymorphic. Divergence of the number of tandem repeats was seen in different cDNA libraries.

Sequence variations from dbSNP and Humsavar for MUC20 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_038536 -
VAR_038537 -
rs2550232 - 195,725,928(+) AGACA(C/T)AGATC reference, missense
rs3828408 - 195,726,372(-) TGGTC(A/G)GTGTC reference, missense
rs11923495 - 195,729,674(+) TCCTG(C/T)GGCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MUC20 Gene

Variant ID Type Subtype PubMed ID
nsv878138 CNV Gain 21882294
dgv1549e1 CNV Complex 17122850
nsv428430 CNV Gain+Loss 18775914
nsv878146 CNV Loss 21882294
dgv5366n71 CNV Gain 21882294
nsv820189 CNV Gain 19587683
esv2726477 CNV Deletion 23290073
nsv822408 CNV Gain 20364138
dgv905e199 CNV Deletion 23128226
essv12347 CNV CNV 17122850
dgv1551e1 CNV Complex 17122850
dgv1552e1 CNV Complex 17122850
dgv1553e1 CNV Complex 17122850
esv22821 CNV Gain+Loss 19812545
nsv878154 CNV Loss 21882294
dgv1554e1 CNV Complex 17122850
dgv5368n71 CNV Gain 21882294
esv2429380 CNV Gain 19546169
nsv469606 CNV Complex 16826518
nsv471621 CNV Gain+Loss 15918152
esv32809 CNV Gain+Loss 17666407
nsv829825 CNV Loss 17160897
dgv5369n71 CNV Loss 21882294
nsv436932 CNV Loss 16327808
nsv878159 CNV Gain 21882294
dgv1555e1 CNV Complex 17122850
esv2751988 CNV Gain 17911159
nsv822410 CNV Loss 20364138
nsv436752 CNV Insertion 17901297
nsv878160 CNV Gain 21882294
nsv471428 CNV Duplication 19718026
esv2726488 CNV Deletion 23290073
nsv237976 CNV Loss 16902084
nsv236267 CNV Loss 16902084
esv2726489 CNV Deletion 23290073
dgv850n67 CNV Loss 20364138
nsv820762 CNV Duplication 20802225
nsv819699 CNV Loss 19587683
nsv822413 CNV Gain 20364138
nsv821242 CNV Duplication 20802225
dgv906e199 CNV Deletion 23128226
esv2726490 CNV Deletion 23290073
nsv878161 CNV Loss 21882294

Variation tolerance for MUC20 Gene

Gene Damage Index Score: 9.29; 88.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for MUC20 Gene

Disorders for MUC20 Gene

Relevant External Links for MUC20

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MUC20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MUC20 Gene

Publications for MUC20 Gene

  1. Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy. (PMID: 16508246) Li G. … Wang H. (Am. J. Nephrol. 2006) 3 4 48 67
  2. Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney. (PMID: 14565953) Higuchi T. … Nakamura M. (J. Biol. Chem. 2004) 2 3
  3. MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. (PMID: 15314156) Higuchi T. … Nakamura M. (Mol. Cell. Biol. 2004) 3 23
  4. Expression analysis of the transmembrane mucin MUC20 in human corneal and conjunctival epithelia. (PMID: 25168902) Woodward A.M. … ArgA1eso P. (Invest. Ophthalmol. Vis. Sci. 2014) 3
  5. Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways. (PMID: 22929560) Kesimer M. … Pickles R.J. (Mucosal Immunol 2013) 3

Products for MUC20 Gene

Sources for MUC20 Gene