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Aliases for HTR3D Gene

Aliases for HTR3D Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 3D, Ionotropic 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 3 Family Member D 2 3
  • Serotonin Receptor 3D 3 4
  • 5-Hydroxytryptamine Receptor 3 Subunit D 3
  • 5-Hydroxytryptamine Receptor 3D 3
  • Serotonin 5-HT-3D Receptor 3
  • 5-HT3-D 4
  • 5-HT3D 4
  • 5HT3D 3

External Ids for HTR3D Gene

Summaries for HTR3D Gene

Entrez Gene Summary for HTR3D Gene

  • The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for HTR3D Gene

HTR3D (5-Hydroxytryptamine (Serotonin) Receptor 3D, Ionotropic) is a Protein Coding gene. Diseases associated with HTR3D include migraine. Among its related pathways are CREB Pathway and Circadian entrainment. GO annotations related to this gene include extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for HTR3D Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel

Tocris Summary for HTR3D Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.

Gene Wiki entry for HTR3D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3D Gene

Genomics for HTR3D Gene

Genomic Location for HTR3D Gene

184,031,544 bp from pter
184,039,369 bp from pter
7,826 bases
Plus strand

Genomic View for HTR3D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3D Gene

Regulatory Elements for HTR3D Gene

Proteins for HTR3D Gene

  • Protein details for HTR3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-hydroxytryptamine receptor 3D
    Protein Accession:
    Secondary Accessions:
    • C9J2I6
    • J3QT78
    • Q495N5
    • Q495N6
    • Q7Z6B3

    Protein attributes for HTR3D Gene

    454 amino acids
    Molecular mass:
    50191 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

    Alternative splice isoforms for HTR3D Gene


neXtProt entry for HTR3D Gene

Proteomics data for HTR3D Gene at MOPED

Post-translational modifications for HTR3D Gene

Other Protein References for HTR3D Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR3D Gene

Domains for HTR3D Gene

Gene Families for HTR3D Gene

  • HTR :5-HT (serotonin) receptors
  • HTR3 :Ligand-gated ion channels / 5-HT (serotonin) receptors, ionotropic

Protein Domains for HTR3D Gene


  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily.:
    • Q70Z44
genes like me logo Genes that share domains with HTR3D: view

Function for HTR3D Gene

Molecular function for HTR3D Gene

UniProtKB/Swiss-Prot Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel

Gene Ontology (GO) - Molecular Function for HTR3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004993 serotonin receptor activity IDA 17392525
GO:0005230 extracellular ligand-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with HTR3D: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HTR3D Gene

Localization for HTR3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3D Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

Jensen Localization Image for HTR3D Gene COMPARTMENTS Subcellular localization image for HTR3D gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for HTR3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR3D: view

Pathways for HTR3D Gene

genes like me logo Genes that share pathways with HTR3D: view

Pathways by source for HTR3D Gene

1 KEGG pathway for HTR3D Gene

Interacting Proteins for HTR3D Gene

Gene Ontology (GO) - Biological Process for HTR3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0007210 serotonin receptor signaling pathway IDA 17392525
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with HTR3D: view

Compounds for HTR3D Gene

(5) Tocris Compounds for HTR3D Gene

Compound Action Cas Number
Granisetron hydrochloride 5-HT3 antagonist [107007-99-8]
Ondansetron hydrochloride Selective 5-HT3 antagonist [103639-04-9]
SR 57227 hydrochloride Potent, selective 5-HT3 agonist [77145-61-0]
Tropisetron hydrochloride Potent 5-HT3 receptor antagonist; orally active [105826-92-4]
Zacopride hydrochloride Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist [90182-92-6]
genes like me logo Genes that share compounds with HTR3D: view

Transcripts for HTR3D Gene

mRNA/cDNA for HTR3D Gene

(3) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3D Gene

No ASD Table

Relevant External Links for HTR3D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTR3D Gene

mRNA expression in normal human tissues for HTR3D Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HTR3D Gene

SOURCE GeneReport for Unigene cluster for HTR3D Gene Hs.448004

mRNA Expression by UniProt/SwissProt for HTR3D Gene

Tissue specificity: Expressed in liver, as well as fetal and adult colon and kidney.
genes like me logo Genes that share expressions with HTR3D: view

Orthologs for HTR3D Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HTR3D 37
  • 85 (a)
(Bos Taurus)
Mammalia HTR3D 37
  • 53 (a)
(Canis familiaris)
Mammalia HTR3D 37
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 50 (a)
-- 37
  • 47 (a)
(Danio rerio)
Actinopterygii CU207281.1 37
  • 38 (a)
CU207281.2 37
  • 25 (a)
Species with no ortholog for HTR3D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3D Gene

Gene Tree for HTR3D (if available)
Gene Tree for HTR3D (if available)

Paralogs for HTR3D Gene

Paralogs for HTR3D Gene

Selected SIMAP similar genes for HTR3D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HTR3D: view

Variants for HTR3D Gene

Sequence variations from dbSNP and Humsavar for HTR3D Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs939334 -- 184,031,943(-) AAGCC(A/G)TCAGT intron-variant, upstream-variant-2KB
rs1000952 - 184,038,034(-) ACCTG(C/T)GCCTG missense, reference
rs1467257 -- 184,037,743(+) TCCAC(A/C)GTCTT intron-variant
rs2014046 -- 184,032,149(-) AGGCA(C/T)GGTGG intron-variant, upstream-variant-2KB
rs2090720 -- 184,032,217(-) CAGGC(A/G)TTCAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HTR3D Gene

Variant ID Type Subtype PubMed ID
nsv4145 CNV Insertion 18451855

Relevant External Links for HTR3D Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

Disorders for HTR3D Gene

(1) MalaCards Diseases for HTR3D Gene

Search for HTR3D Gene in MalaCards »

(1) University of Copenhagen DISEASES for HTR3D Gene

Relevant External Links for HTR3D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HTR3D: view

No data available for UniProtKB/Swiss-Prot for HTR3D Gene

Publications for HTR3D Gene

  1. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PMID: 12801637) Niesler B. … Rappold G.A. (Gene 2003) 2 3 4
  2. Characterization of the novel human serotonin receptor subunits 5- HT3C, 5-HT3D, and 5-HT3E. (PMID: 17392525) Niesler B. … Bruess M. (Mol. Pharmacol. 2007) 3 4
  3. Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia. (PMID: 19794330) Schuhmacher A. … Maier W. (Pharmacogenet. Genomics 2009) 3 49
  4. Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (PMID: 20021265) Goecke T.W. … Fasching P.A. (Acta Obstet Gynecol Scand 2010) 3 49
  5. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PMID: 20538960) Larkin E.K. … Redline S. (Am. J. Respir. Crit. Care Med. 2010) 3 49

Products for HTR3D Gene

Sources for HTR3D Gene

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