Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TIGD1 Gene

Aliases for TIGD1 Gene

  • Tigger Transposable Element Derived 1 2 3
  • Tigger Transposable Element-Derived Protein 1 3
  • EEYORE 3

External Ids for TIGD1 Gene

Previous GeneCards Identifiers for TIGD1 Gene

  • GC02M231469
  • GC02M232142
  • GC02M233376
  • GC02M233615
  • GC02M233238
  • GC02M233121
  • GC02M225263

Summaries for TIGD1 Gene

Entrez Gene Summary for TIGD1 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD1 Gene

TIGD1 (Tigger Transposable Element Derived 1) is a Protein Coding gene. An important paralog of this gene is TIGD5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD1 Gene

Genomics for TIGD1 Gene

Regulatory Elements for TIGD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIGD1 Gene

Start:
232,547,968 bp from pter
End:
232,550,592 bp from pter
Size:
2,625 bases
Orientation:
Minus strand

Genomic View for TIGD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIGD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD1 Gene

Proteins for TIGD1 Gene

  • Protein details for TIGD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MW7-TIGD1_HUMAN
    Recommended name:
    Tigger transposable element-derived protein 1
    Protein Accession:
    Q96MW7
    Secondary Accessions:
    • Q6P4D2
    • Q6PIF9

    Protein attributes for TIGD1 Gene

    Size:
    591 amino acids
    Molecular mass:
    67299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD1 Gene

Proteomics data for TIGD1 Gene at MOPED

Post-translational modifications for TIGD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD1 Gene

Domains for TIGD1 Gene

Protein Domains for TIGD1 Gene

Suggested Antigen Peptide Sequences for TIGD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MW7

UniProtKB/Swiss-Prot:

TIGD1_HUMAN :
  • Q96MW7
Domain:
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD1: view

No data available for Gene Families for TIGD1 Gene

Function for TIGD1 Gene

Gene Ontology (GO) - Molecular Function for TIGD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD1: view

Phenotypes for TIGD1 Gene

GenomeRNAi human phenotypes for TIGD1:
genes like me logo Genes that share phenotypes with TIGD1: view

Animal Model Products

CRISPR Products

miRNA for TIGD1 Gene

miRTarBase miRNAs that target TIGD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIGD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIGD1 Gene

Localization for TIGD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIGD1 Gene COMPARTMENTS Subcellular localization image for TIGD1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TIGD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD1: view

Pathways for TIGD1 Gene

SuperPathways for TIGD1 Gene

No Data Available

Interacting Proteins for TIGD1 Gene

Gene Ontology (GO) - Biological Process for TIGD1 Gene

None

No data available for Pathways by source for TIGD1 Gene

Transcripts for TIGD1 Gene

mRNA/cDNA for TIGD1 Gene

(84) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD1 Gene

Tigger transposable element derived 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIGD1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD1 Gene

No ASD Table

Relevant External Links for TIGD1 Gene

GeneLoc Exon Structure for
TIGD1
ECgene alternative splicing isoforms for
TIGD1

Expression for TIGD1 Gene

mRNA expression in normal human tissues for TIGD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIGD1 Gene

SOURCE GeneReport for Unigene cluster for TIGD1 Gene Hs.211823

genes like me logo Genes that share expressions with TIGD1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIGD1 Gene

Orthologs for TIGD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIGD1 35
  • 99.27 (n)
  • 99.32 (a)
TIGD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC101902808 35
  • 89.69 (n)
  • 87.29 (a)
dog
(Canis familiaris)
Mammalia TIGD1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TIGD1 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIGD1 36
  • 53 (a)
OneToOne
Species with no ortholog for TIGD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD1 Gene

ENSEMBL:
Gene Tree for TIGD1 (if available)
TreeFam:
Gene Tree for TIGD1 (if available)

Paralogs for TIGD1 Gene

Paralogs for TIGD1 Gene

Selected SIMAP similar genes for TIGD1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TIGD1 Gene

genes like me logo Genes that share paralogs with TIGD1: view

Variants for TIGD1 Gene

Sequence variations from dbSNP and Humsavar for TIGD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs112969708 -- 232,547,573(+) AGTTC(A/G)TATTA downstream-variant-500B
rs113546674 -- 232,547,634(+) AGAGC(A/T)GAGTC downstream-variant-500B
rs146398054 -- 232,548,037(+) TGCAA(C/T)AGCAT downstream-variant-500B
rs187560207 -- 232,547,675(+) GAGTG(A/G)GGGAG downstream-variant-500B
rs527564448 -- 232,547,600(+) TCTGT(C/G)TCTGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TIGD1 Gene

Variant ID Type Subtype PubMed ID
nsv821918 CNV Gain 20364138
nsv875977 CNV Loss 21882294
nsv875998 CNV Loss 21882294
nsv876000 CNV Gain 21882294
dgv4454n71 CNV Loss 21882294
nsv3212 CNV Loss 18451855

Relevant External Links for TIGD1 Gene

HapMap Linkage Disequilibrium report
TIGD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD1 Gene

Disorders for TIGD1 Gene

(1) University of Copenhagen DISEASES for TIGD1 Gene

genes like me logo Genes that share disorders with TIGD1: view

No data available for UniProtKB/Swiss-Prot for TIGD1 Gene

Publications for TIGD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for TIGD1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TIGD1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TIGD1
    • Block miRNA regulation of TIGD1 using miScript Target Protectors

    Sources for TIGD1 Gene

    Back to Top

    Content