Aliases for SPRED2 Gene
External Ids for SPRED2 Gene
Previous GeneCards Identifiers for SPRED2 Gene
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SPRED2 Gene
SPRED2 (Sprouty-Related, EVH1 Domain Containing 2) is a Protein Coding gene. Diseases associated with SPRED2 include legius syndrome. Among its related pathways are Kit Receptor Signaling Pathway and Kit Receptor Signaling Pathway. GO annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is SPRED1.
UniProtKB/Swiss-Prot for SPRED2 Gene
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase