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Aliases for PIKFYVE Gene

Aliases for PIKFYVE Gene

  • Phosphoinositide Kinase, FYVE Finger Containing 2 3
  • PIP5K3 3 4 6
  • Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase, Type III 2 3
  • Phosphatidylinositol 3-Phosphate 5-Kinase Type III 3 4
  • Type III PIP Kinase 3 4
  • PIPkin-III 3 4
  • FYVE Finger-Containing Phosphoinositide Kinase 4
  • 1-Phosphatidylinositol 3-Phosphate 5-Kinase 3
  • 1-Phosphatidylinositol-3-Phosphate 5-Kinase 3
  • Phosphatidylinositol 3-Phosphate 5-Kinase 4
  • Zinc Finger, FYVE Domain Containing 29 3
  • Epididymis Luminal Protein 37 3
  • FYVE Domain Containing 29 2
  • EC 4
  • Zinc Finger 2
  • KIAA0981 4
  • ZFYVE29 3
  • PIKfyve 4
  • HEL37 3
  • PIP5K 3
  • FAB1 3
  • CFD 3

External Ids for PIKFYVE Gene

Previous Symbols for PIKFYVE Gene

  • PIP5K3

Summaries for PIKFYVE Gene

Entrez Gene Summary for PIKFYVE Gene

  • Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

GeneCards Summary for PIKFYVE Gene

PIKFYVE (Phosphoinositide Kinase, FYVE Finger Containing) is a Protein Coding gene. Diseases associated with PIKFYVE include corneal fleck dystrophy. Among its related pathways are Regulation of actin cytoskeleton and Hemostasis. GO annotations related to this gene include 1-phosphatidylinositol-4-phosphate 5-kinase activity and 1-phosphatidylinositol-3-phosphate 5-kinase activity. An important paralog of this gene is ZFYVE16.

UniProtKB/Swiss-Prot for PIKFYVE Gene

  • The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.

Gene Wiki entry for PIKFYVE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIKFYVE Gene

Genomics for PIKFYVE Gene

Genomic Location for PIKFYVE Gene

208,266,267 bp from pter
208,358,751 bp from pter
92,485 bases
Plus strand

Genomic View for PIKFYVE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIKFYVE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIKFYVE Gene

Regulatory Elements for PIKFYVE Gene

Proteins for PIKFYVE Gene

  • Protein details for PIKFYVE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    1-phosphatidylinositol 3-phosphate 5-kinase
    Protein Accession:
    Secondary Accessions:
    • Q08AR7
    • Q08AR8
    • Q53ST3
    • Q53T36
    • Q8N5H0
    • Q8NB67

    Protein attributes for PIKFYVE Gene

    2098 amino acids
    Molecular mass:
    237136 Da
    Quaternary structure:
    • Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold.
    • Sequence=BAC03674.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PIKFYVE Gene


neXtProt entry for PIKFYVE Gene

Proteomics data for PIKFYVE Gene at MOPED

Post-translational modifications for PIKFYVE Gene

  • Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIKFYVE Gene

No data available for DME Specific Peptides for PIKFYVE Gene

Domains for PIKFYVE Gene

Gene Families for PIKFYVE Gene

  • ZFYVE :Zinc fingers, FYVE domain containing


  • Contains 1 DEP domain.:
    • Q9Y2I7
  • Contains 1 PIPK domain.:
    • Q9Y2I7
  • Contains 1 FYVE-type zinc finger.:
    • Q9Y2I7
genes like me logo Genes that share domains with PIKFYVE: view

Function for PIKFYVE Gene

Molecular function for PIKFYVE Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
UniProtKB/Swiss-Prot Function: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.

Enzyme Numbers (IUBMB) for PIKFYVE Gene

Gene Ontology (GO) - Molecular Function for PIKFYVE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity IEA --
GO:0005515 protein binding IPI 15046600
GO:0005524 ATP binding IEA --
GO:0016307 phosphatidylinositol phosphate kinase activity --
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity TAS 15046600
genes like me logo Genes that share ontologies with PIKFYVE: view
genes like me logo Genes that share phenotypes with PIKFYVE: view

Animal Models for PIKFYVE Gene

MGI Knock Outs for PIKFYVE:

miRNA for PIKFYVE Gene

No data available for Transcription Factor Targeting and HOMER Transcription for PIKFYVE Gene

Localization for PIKFYVE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIKFYVE Gene

Endosome membrane. Note=Mainly associated with membranes of the late endocytic pathway.

Subcellular locations from

Jensen Localization Image for PIKFYVE Gene COMPARTMENTS Subcellular localization image for PIKFYVE gene
Compartment Confidence
endosome 5
golgi apparatus 4
cytosol 3
nucleus 3
lysosome 2
vacuole 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PIKFYVE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005829 cytosol IEA --
GO:0005911 cell-cell junction IEA --
GO:0010008 endosome membrane IDA 17556371
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with PIKFYVE: view

Pathways for PIKFYVE Gene

genes like me logo Genes that share pathways with PIKFYVE: view

Gene Ontology (GO) - Biological Process for PIKFYVE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006898 NOT receptor-mediated endocytosis IMP 14551253
GO:0032288 myelin assembly IEA --
GO:0034504 protein localization to nucleus IMP 17909029
genes like me logo Genes that share ontologies with PIKFYVE: view

Compounds for PIKFYVE Gene

(3) HMDB Compounds for PIKFYVE Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure

(19) Novoseek inferred chemical compound relationships for PIKFYVE Gene

Compound -log(P) Hits PubMed IDs
phosphoinositide 81.5 10
ptdins(3)p 80.4 3
phosphatidylinositol 68 13
pip2 67.2 2
lipid 46.6 11
genes like me logo Genes that share compounds with PIKFYVE: view

Transcripts for PIKFYVE Gene

Unigene Clusters for PIKFYVE Gene

Phosphoinositide kinase, FYVE finger containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIKFYVE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^
SP1: -
SP2: - -
SP3: - -
SP4: - -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42

Relevant External Links for PIKFYVE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIKFYVE Gene

mRNA expression in normal human tissues for PIKFYVE Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIKFYVE Gene

SOURCE GeneReport for Unigene cluster for PIKFYVE Gene Hs.744997

genes like me logo Genes that share expressions with PIKFYVE: view

Orthologs for PIKFYVE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIKFYVE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIKFYVE 36
  • 99.76 (n)
  • 99.67 (a)
  • 100 (a)
(Bos Taurus)
Mammalia PIKFYVE 36
  • 91.36 (n)
  • 94.76 (a)
  • 95 (a)
(Canis familiaris)
Mammalia PIKFYVE 36
  • 91.99 (n)
  • 95.28 (a)
  • 95 (a)
(Mus musculus)
Mammalia Pikfyve 36
  • 85.94 (n)
  • 87.9 (a)
Pikfyve 16
Pikfyve 37
  • 93 (a)
(Monodelphis domestica)
Mammalia PIKFYVE 37
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 83 (a)
-- 37
  • 94 (a)
-- 37
  • 91 (a)
-- 37
  • 84 (a)
-- 37
  • 87 (a)
(Rattus norvegicus)
Mammalia Pikfyve 36
  • 89.64 (n)
  • 93.42 (a)
(Gallus gallus)
  • 77.8 (n)
  • 87 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia PIKFYVE 37
  • 83 (a)
(Danio rerio)
Actinopterygii pikfyve 36
  • 67.92 (n)
  • 75.04 (a)
pikfyve 37
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005216 36
  • 47.18 (n)
  • 39.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta fab1 36
  • 49.13 (n)
  • 41.36 (a)
fab1 37
  • 36 (a)
(Caenorhabditis elegans)
Secernentea ppk-3 37
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAB1 37
  • 19 (a)
FAB1 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2672 37
  • 35 (a)
Species with no ortholog for PIKFYVE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIKFYVE Gene

Gene Tree for PIKFYVE (if available)
Gene Tree for PIKFYVE (if available)

Paralogs for PIKFYVE Gene

Paralogs for PIKFYVE Gene

genes like me logo Genes that share paralogs with PIKFYVE: view

Variants for PIKFYVE Gene

Sequence variations from dbSNP and Humsavar for PIKFYVE Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs893253 - 208,325,804(-) GCAAA(C/G)TCTCT reference, missense
rs893254 - 208,325,795(-) CTGGC(A/T)GCTCG reference, missense
rs893255 -- 208,325,188(-) CTTAA(C/T)ATCTG intron-variant
rs893256 -- 208,304,129(-) TCAAT(A/G)GCAAC intron-variant
rs934712 -- 208,320,120(-) ATATA(C/T)TCTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PIKFYVE Gene

Variant ID Type Subtype PubMed ID
nsv834517 CNV Loss 17160897
nsv875752 CNV Loss 21882294
nsv819526 CNV Loss 19587683
nsv3137 CNV Insertion 18451855
nsv437315 CNV Loss 16327808
nsv460055 CNV Loss 19166990

Relevant External Links for PIKFYVE Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for PIKFYVE Gene

(1) OMIM Diseases for PIKFYVE Gene (609414)


  • Corneal dystrophy, fleck (CFD) [MIM:121850]: A form of stromal corneal dystrophy characterized by numerous small white flecks scattered in all levels of the stroma, with configurations varying from semicircular to wreath-like, curvilinear, or punctate. Although CFD may occasionally cause mild photophobia, patients are typically asymptomatic and have normal vision. {ECO:0000269 PubMed:15902656}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) MalaCards Diseases for PIKFYVE Gene

Search for PIKFYVE Gene in MalaCards »

(1) Novoseek inferred disease relationships for PIKFYVE Gene

Disease -log(P) Hits PubMed IDs
carcinoma 0 1

Relevant External Links for PIKFYVE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PIKFYVE: view

Publications for PIKFYVE Gene

  1. Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve endomembrane localization. (PMID: 11706043) Sbrissa D. … Shisheva A. (J. Biol. Chem. 2002) 3 4 23
  2. Core protein machinery for mammalian phosphatidylinositol 3,5- bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. (PMID: 17556371) Sbrissa D. … Shisheva A. (J. Biol. Chem. 2007) 3 4 23
  3. ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality. (PMID: 18950639) Sbrissa D. … Shisheva A. (J. Mol. Biol. 2008) 3 4 23
  4. Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin. (PMID: 19056739) Ikonomov O.C. … Shisheva A. (J. Biol. Chem. 2009) 3 23
  5. PIKfyve-dependent regulation of the Cl- channel ClC-2. (PMID: 19232516) Klaus F. … Lang F. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for PIKFYVE Gene

Sources for PIKFYVE Gene

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