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Aliases for ELK4 Gene

Aliases for ELK4 Gene

  • ELK4, ETS-Domain Protein (SRF Accessory Protein 1) 2 3
  • SAP1 3 4 6
  • Serum Response Factor Accessory Protein 1 3 4
  • SAP-1 3 4
  • ETS Domain-Containing Protein Elk-4 3
  • SRF Accessory Protein 1 4

External Ids for ELK4 Gene

Summaries for ELK4 Gene

Entrez Gene Summary for ELK4 Gene

  • This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELK4 Gene

ELK4 (ELK4, ETS-Domain Protein (SRF Accessory Protein 1)) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Akt Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELK4 Gene

  • Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at Lys-18 (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5side of SRF, but does not bind DNA autonomously.

Gene Wiki entry for ELK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELK4 Gene

Genomics for ELK4 Gene

Genomic Location for ELK4 Gene

Start:
205,597,556 bp from pter
End:
205,633,829 bp from pter
Size:
36,274 bases
Orientation:
Minus strand

Genomic View for ELK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELK4 Gene

Regulatory Elements for ELK4 Gene

Proteins for ELK4 Gene

  • Protein details for ELK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28324-ELK4_HUMAN
    Recommended name:
    ETS domain-containing protein Elk-4
    Protein Accession:
    P28324
    Secondary Accessions:
    • P28323
    • Q6GSJ2

    Protein attributes for ELK4 Gene

    Size:
    431 amino acids
    Molecular mass:
    46900 Da
    Quaternary structure:
    • Interacts with SIRT7.

    Three dimensional structures from OCA and Proteopedia for ELK4 Gene

    Alternative splice isoforms for ELK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELK4 Gene

Proteomics data for ELK4 Gene at MOPED

Post-translational modifications for ELK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELK4 Gene

No data available for DME Specific Peptides for ELK4 Gene

Domains for ELK4 Gene

Protein Domains for ELK4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ELK4_HUMAN
Domain:
  • Contains 1 ETS DNA-binding domain.:
    • P28324
Family:
  • Belongs to the ETS family.:
    • P28324
genes like me logo Genes that share domains with ELK4: view

No data available for Gene Families for ELK4 Gene

Function for ELK4 Gene

Molecular function for ELK4 Gene

GENATLAS Biochemistry: ets related protooncogene 4,homologous to murine Sap1,ubiquitously expressed,associating with a ternary complex factor 1 and SRF transcription factor and recruited to the c-fos serum response element,divergent member of the winged helix-turn-helix superfamily
UniProtKB/Swiss-Prot Function: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at Lys-18 (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5side of SRF, but does not bind DNA autonomously.

Gene Ontology (GO) - Molecular Function for ELK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001047 core promoter binding TAS 22722849
GO:0003677 DNA binding TAS 1339307
GO:0003682 chromatin binding IDA 22722849
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 7851904
genes like me logo Genes that share ontologies with ELK4: view
genes like me logo Genes that share phenotypes with ELK4: view

Animal Models for ELK4 Gene

MGI Knock Outs for ELK4:

miRNA for ELK4 Gene

miRTarBase miRNAs that target ELK4
Targeting motifs for ELK4 Gene
HOMER Transcription Factor Regulatory Elements motif ELK4
  • Consensus sequence: NRYTTCCGGY Submotif: canonical Cell Type: Hela GeoId: GSE31477

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for ELK4 Gene

Localization for ELK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELK4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELK4 Gene COMPARTMENTS Subcellular localization image for ELK4 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ELK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ELK4: view

Pathways for ELK4 Gene

genes like me logo Genes that share pathways with ELK4: view

Gene Ontology (GO) - Biological Process for ELK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 22722849
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0030154 cell differentiation IBA --
GO:0070932 histone H3 deacetylation IDA 22722849
genes like me logo Genes that share ontologies with ELK4: view

Transcripts for ELK4 Gene

Unigene Clusters for ELK4 Gene

ELK4, ETS-domain protein (SRF accessory protein 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELK4 Gene

No ASD Table

Relevant External Links for ELK4 Gene

GeneLoc Exon Structure for
ELK4
ECgene alternative splicing isoforms for
ELK4

Expression for ELK4 Gene

mRNA expression in normal human tissues for ELK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ELK4 Gene

SOURCE GeneReport for Unigene cluster for ELK4 Gene Hs.497520

genes like me logo Genes that share expressions with ELK4: view

Orthologs for ELK4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELK4 36
  • 99.69 (n)
  • 99.07 (a)
ELK4 37
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELK4 36
  • 89.4 (n)
  • 90.26 (a)
ELK4 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELK4 36
  • 84.11 (n)
  • 84.65 (a)
ELK4 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elk4 36
  • 85.63 (n)
  • 87.41 (a)
Elk4 16
Elk4 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELK4 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELK4 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elk4 36
  • 84.93 (n)
  • 86.71 (a)
chicken
(Gallus gallus)
Aves ELK4 36
  • 75.66 (n)
  • 79.07 (a)
ELK4 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELK4 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia elk4-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia elk4 36
  • 65.23 (n)
  • 66.58 (a)
zebrafish
(Danio rerio)
Actinopterygii elk4 36
  • 58.8 (n)
  • 60.24 (a)
elk4 37
  • 55 (a)
OneToOne
Species with no ortholog for ELK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELK4 Gene

ENSEMBL:
Gene Tree for ELK4 (if available)
TreeFam:
Gene Tree for ELK4 (if available)

Paralogs for ELK4 Gene

Paralogs for ELK4 Gene

Selected SIMAP similar genes for ELK4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ELK4: view

Variants for ELK4 Gene

Sequence variations from dbSNP and Humsavar for ELK4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13757 -- 205,632,071(-) GCAGA(C/T)GCGGC utr-variant-5-prime, intron-variant, nc-transcript-variant
rs1064406 -- 205,620,446(-) CCACC(A/G)GTTGA synonymous-codon, reference, nc-transcript-variant
rs1064407 -- 205,620,155(-) TTGTC(A/T)CTGGA reference, synonymous-codon, nc-transcript-variant
rs2226161 -- 205,611,999(-) ATTTA(G/T)AATTA utr-variant-3-prime, intron-variant
rs2867891 -- 205,629,851(+) AGTTC(A/G)CGACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ELK4 Gene

Variant ID Type Subtype PubMed ID
nsv4188 CNV Insertion 18451855

Relevant External Links for ELK4 Gene

HapMap Linkage Disequilibrium report
ELK4

Disorders for ELK4 Gene

No disorders were found for ELK4 Gene.

No data available for UniProtKB/Swiss-Prot for ELK4 Gene

Publications for ELK4 Gene

  1. Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. (PMID: 7851904) Shipley J. … Patel K. (Genomics 1994) 2 3 23
  2. Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. (PMID: 9734357) Mo Y. … Marmorstein R. (Mol. Cell 1998) 3 4 23
  3. c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. (PMID: 11313879) Chai Y. … Rao V.N. (Oncogene 2001) 3 23
  4. Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex. (PMID: 11846562) Mo Y. … Marmorstein R. (J. Mol. Biol. 2001) 3 23
  5. Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. (PMID: 8293474) Dalton S. … Treisman R. (Cell 1994) 3 4

Products for ELK4 Gene

Sources for ELK4 Gene

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