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Aliases for ELK1 Gene

Aliases for ELK1 Gene

  • ELK1, ETS Transcription Factor 2 3
  • ELK1, Member Of ETS Oncogene Family 2 5

External Ids for ELK1 Gene

Previous GeneCards Identifiers for ELK1 Gene

  • GC0XM046297
  • GC0XM045755
  • GC0XM046540
  • GC0XM047252
  • GC0XM047379
  • GC0XM047494
  • GC0XM045207

Summaries for ELK1 Gene

Entrez Gene Summary for ELK1 Gene

  • This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

GeneCards Summary for ELK1 Gene

ELK1 (ELK1, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with ELK1 include prostate cancer. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELK1 Gene

  • Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).

Gene Wiki entry for ELK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELK1 Gene

Genomics for ELK1 Gene

Regulatory Elements for ELK1 Gene

Promoters for ELK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ELK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELK1 Gene

Chromosome:
X
Start:
47,635,520 bp from pter
End:
47,650,604 bp from pter
Size:
15,085 bases
Orientation:
Minus strand

Genomic View for ELK1 Gene

Genes around ELK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELK1 Gene

Proteins for ELK1 Gene

  • Protein details for ELK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19419-ELK1_HUMAN
    Recommended name:
    ETS domain-containing protein Elk-1
    Protein Accession:
    P19419
    Secondary Accessions:
    • B2R7H4
    • O75606
    • O95058
    • Q969X8
    • Q9UJM4

    Protein attributes for ELK1 Gene

    Size:
    428 amino acids
    Molecular mass:
    44888 Da
    Quaternary structure:
    • Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity (PubMed:15920481). Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9 (PubMed:17296730). Interacts with POU1F1 (PubMed:26612202).

    Three dimensional structures from OCA and Proteopedia for ELK1 Gene

    Alternative splice isoforms for ELK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELK1 Gene

Proteomics data for ELK1 Gene at MOPED

Post-translational modifications for ELK1 Gene

  • On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity).
  • Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELK1 Gene

No data available for DME Specific Peptides for ELK1 Gene

Domains & Families for ELK1 Gene

Gene Families for ELK1 Gene

Protein Domains for ELK1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELK1 Gene

Graphical View of Domain Structure for InterPro Entry

P19419

UniProtKB/Swiss-Prot:

ELK1_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELK1: view

Function for ELK1 Gene

Molecular function for ELK1 Gene

GENATLAS Biochemistry:
ets related protooncogene 1,activated by several mitogen-activated protein kinases (MAPKs),associating with a ternary complex factor 1 and SRF transcription factor and recruited to the c-fos serum response element,divergent member of the winged helix-turn-helix superfamily
UniProtKB/Swiss-Prot Function:
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).

Gene Ontology (GO) - Molecular Function for ELK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 12750007
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IDA 14970218
GO:0005515 protein binding IPI 16291755
genes like me logo Genes that share ontologies with ELK1: view
genes like me logo Genes that share phenotypes with ELK1: view

Human Phenotype Ontology for ELK1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ELK1 Gene

MGI Knock Outs for ELK1:

Animal Model Products

miRNA for ELK1 Gene

miRTarBase miRNAs that target ELK1
Targeted motifs for ELK1 Gene
HOMER Transcription Factor Regulatory Elements motif ELK1
  • Consensus sequence: HACTTCCGGY Submotif: canonical Cell Type: Hela GEO ID: GSE31477

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for ELK1 Gene

Localization for ELK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELK1 Gene COMPARTMENTS Subcellular localization image for ELK1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ELK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with ELK1: view

Pathways & Interactions for ELK1 Gene

SuperPathways for ELK1 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 IL-2 Pathway
3 Development Angiotensin activation of ERK
4 ERK Signaling
5 GPCR Pathway
genes like me logo Genes that share pathways with ELK1: view

SIGNOR curated interactions for ELK1 Gene

Gene Ontology (GO) - Biological Process for ELK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IDA 12750007
genes like me logo Genes that share ontologies with ELK1: view

Drugs & Compounds for ELK1 Gene

(19) Drugs for ELK1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(13) Additional Compounds for ELK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELK1: view

Transcripts for ELK1 Gene

Unigene Clusters for ELK1 Gene

ELK1, member of ETS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELK1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8
SP1: - - -
SP2: - - - - - - -
SP3: - - - -
SP4:
SP5: -
SP6: - -

Relevant External Links for ELK1 Gene

GeneLoc Exon Structure for
ELK1
ECgene alternative splicing isoforms for
ELK1

Expression for ELK1 Gene

mRNA expression in normal human tissues for ELK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ELK1 Gene

This gene is overexpressed in Fetal ovary (33.0), Ovary (19.7), and Blymphocyte (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ELK1 Gene



SOURCE GeneReport for Unigene cluster for ELK1 Gene Hs.181128

mRNA Expression by UniProt/SwissProt for ELK1 Gene

P19419-ELK1_HUMAN
Tissue specificity: Lung and testis.
genes like me logo Genes that share expression patterns with ELK1: view

Protein tissue co-expression partners for ELK1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ELK1 Gene

Orthologs for ELK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELK1 36
  • 75 (a)
OneToOne
ELK1 35
  • 88.94 (n)
  • 90.65 (a)
dog
(Canis familiaris)
Mammalia ELK1 35
  • 89.17 (n)
  • 91.82 (a)
ELK1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elk1 16
Elk1 36
  • 85 (a)
OneToOne
Elk1 35
  • 84.15 (n)
  • 85.48 (a)
oppossum
(Monodelphis domestica)
Mammalia ELK1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELK1 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elk1 35
  • 83.61 (n)
  • 86.18 (a)
lizard
(Anolis carolinensis)
Reptilia ELK1 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497609 35
  • 59.93 (n)
  • 58.79 (a)
zebrafish
(Danio rerio)
Actinopterygii elk1 36
  • 39 (a)
OneToOne
Species with no ortholog for ELK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELK1 Gene

ENSEMBL:
Gene Tree for ELK1 (if available)
TreeFam:
Gene Tree for ELK1 (if available)

Paralogs for ELK1 Gene

Paralogs for ELK1 Gene

(6) SIMAP similar genes for ELK1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ELK1 Gene

genes like me logo Genes that share paralogs with ELK1: view

Variants for ELK1 Gene

Sequence variations from dbSNP and Humsavar for ELK1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1997639 - 47,639,119(+) CAAAC(C/T)GCCTG intron-variant, reference, missense
rs1059579 - 47,639,001(+) CTGCA(C/T)TGGGG intron-variant, reference, missense
rs1998837 -- 47,643,466(+) tttgg(C/T)ggcaa intron-variant
rs2227996 -- 47,636,862(-) ACCCC(C/T)GTGGT reference, synonymous-codon, utr-variant-3-prime
rs2227997 -- 47,641,301(-) TGGGG(A/G)CTACG reference, synonymous-codon

Variation tolerance for ELK1 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELK1 Gene

HapMap Linkage Disequilibrium report
ELK1
Human Gene Mutation Database (HGMD)
ELK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ELK1 Gene

Disorders for ELK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ELK1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search ELK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ELK1

Genetic Association Database (GAD)
ELK1
Human Genome Epidemiology (HuGE) Navigator
ELK1
Tumor Gene Database (TGDB):
ELK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELK1
genes like me logo Genes that share disorders with ELK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELK1 Gene

Publications for ELK1 Gene

  1. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. (PMID: 2539641) Rao V.N. … Reddy E.S.P. (Science 1989) 2 3 4 67
  2. The Elk-1 and serum response factor binding sites in the major immediate-early promoter of human cytomegalovirus are required for efficient viral replication in quiescent cells and compensate for inactivation of the NF-kappaB sites in proliferating cells. (PMID: 20147408) Caposio P. … Gribaudo G. (J. Virol. 2010) 3 23
  3. Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha. (PMID: 20224786) Wang V. … Yarchoan R. (PLoS ONE 2010) 3 23
  4. SENP1 participates in the dynamic regulation of Elk-1 SUMOylation. (PMID: 20337593) Witty J. … Sharrocks A.D. (Biochem. J. 2010) 3 23
  5. Elk-1 interacts with neuronal microtubules and relocalizes to the nucleus upon phosphorylation. (PMID: 19013529) Demir O. … Kurnaz I.A. (Mol. Cell. Neurosci. 2009) 3 23

Products for ELK1 Gene

Sources for ELK1 Gene

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