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Aliases for ELK1 Gene

Aliases for ELK1 Gene

  • ELK1, Member Of ETS Oncogene Family 2 3

External Ids for ELK1 Gene

Summaries for ELK1 Gene

Entrez Gene Summary for ELK1 Gene

  • This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

GeneCards Summary for ELK1 Gene

ELK1 (ELK1, Member Of ETS Oncogene Family) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELK1 Gene

  • Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element

Gene Wiki entry for ELK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELK1 Gene

Genomics for ELK1 Gene

Genomic Location for ELK1 Gene

Start:
47,635,520 bp from pter
End:
47,650,604 bp from pter
Size:
15,085 bases
Orientation:
Minus strand

Genomic View for ELK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELK1 Gene

Regulatory Elements for ELK1 Gene

Proteins for ELK1 Gene

  • Protein details for ELK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19419-ELK1_HUMAN
    Recommended name:
    ETS domain-containing protein Elk-1
    Protein Accession:
    P19419
    Secondary Accessions:
    • B2R7H4
    • O75606
    • O95058
    • Q969X8
    • Q9UJM4

    Protein attributes for ELK1 Gene

    Size:
    428 amino acids
    Molecular mass:
    44888 Da
    Quaternary structure:
    • Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9.

    Three dimensional structures from OCA and Proteopedia for ELK1 Gene

    Alternative splice isoforms for ELK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELK1 Gene

Proteomics data for ELK1 Gene at MOPED

Post-translational modifications for ELK1 Gene

  • On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14.
  • Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELK1 Gene

No data available for DME Specific Peptides for ELK1 Gene

Domains for ELK1 Gene

Protein Domains for ELK1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ELK1_HUMAN
Domain:
  • Contains 1 ETS DNA-binding domain.:
    • P19419
Family:
  • Belongs to the ETS family.:
    • P19419
genes like me logo Genes that share domains with ELK1: view

No data available for Gene Families for ELK1 Gene

Function for ELK1 Gene

Molecular function for ELK1 Gene

GENATLAS Biochemistry: ets related protooncogene 1,activated by several mitogen-activated protein kinases (MAPKs),associating with a ternary complex factor 1 and SRF transcription factor and recruited to the c-fos serum response element,divergent member of the winged helix-turn-helix superfamily
UniProtKB/Swiss-Prot Function: Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element

Gene Ontology (GO) - Molecular Function for ELK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12750007
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001047 core promoter binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 12750007
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with ELK1: view
genes like me logo Genes that share phenotypes with ELK1: view

Animal Models for ELK1 Gene

MGI Knock Outs for ELK1:

miRNA for ELK1 Gene

miRTarBase miRNAs that target ELK1
Targeting motifs for ELK1 Gene
HOMER Transcription Factor Regulatory Elements motif ELK1
  • Consensus sequence: HACTTCCGGY Submotif: canonical Cell Type: Hela GeoId: GSE31477

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for ELK1 Gene

Localization for ELK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELK1 Gene COMPARTMENTS Subcellular localization image for ELK1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ELK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20018936
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with ELK1: view

Pathways for ELK1 Gene

genes like me logo Genes that share pathways with ELK1: view

Gene Ontology (GO) - Biological Process for ELK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ELK1: view

Compounds for ELK1 Gene

(32) Novoseek inferred chemical compound relationships for ELK1 Gene

Compound -log(P) Hits PubMed IDs
pd 98,059 73.1 9
sp 600125 57 2
sb 203580 51.2 2
phosphatidylinositol 43 3
anisomycin 41.6 5
genes like me logo Genes that share compounds with ELK1: view

Transcripts for ELK1 Gene

Unigene Clusters for ELK1 Gene

ELK1, member of ETS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELK1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8
SP1: - - -
SP2: - - - - - - -
SP3: - - - -
SP4:
SP5: -
SP6: - -

Relevant External Links for ELK1 Gene

GeneLoc Exon Structure for
ELK1
ECgene alternative splicing isoforms for
ELK1

Expression for ELK1 Gene

mRNA expression in normal human tissues for ELK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ELK1 Gene

SOURCE GeneReport for Unigene cluster for ELK1 Gene Hs.181128

mRNA Expression by UniProt/SwissProt for ELK1 Gene

P19419-ELK1_HUMAN
Tissue specificity: Lung and testis
genes like me logo Genes that share expressions with ELK1: view

Orthologs for ELK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELK1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELK1 36
  • 88.94 (n)
  • 90.65 (a)
ELK1 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELK1 36
  • 89.17 (n)
  • 91.82 (a)
ELK1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elk1 36
  • 84.15 (n)
  • 85.48 (a)
Elk1 16
Elk1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELK1 37
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELK1 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elk1 36
  • 83.61 (n)
  • 86.18 (a)
lizard
(Anolis carolinensis)
Reptilia ELK1 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497609 36
  • 59.93 (n)
  • 58.79 (a)
zebrafish
(Danio rerio)
Actinopterygii elk1 37
  • 39 (a)
OneToOne
Species with no ortholog for ELK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELK1 Gene

ENSEMBL:
Gene Tree for ELK1 (if available)
TreeFam:
Gene Tree for ELK1 (if available)

Paralogs for ELK1 Gene

Paralogs for ELK1 Gene

Selected SIMAP similar genes for ELK1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ELK1 Gene

genes like me logo Genes that share paralogs with ELK1: view

Variants for ELK1 Gene

Sequence variations from dbSNP and Humsavar for ELK1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs13907 -- 47,635,636(+) GCACT(A/G)TCCCC utr-variant-3-prime
rs1059579 - 47,639,001(+) CTGCA(C/T)TGGGG missense, reference, intron-variant
rs1059587 -- 47,635,895(-) CTGCC(G/T)CCTCC utr-variant-3-prime
rs1059608 -- 47,635,577(-) TTTTT(C/T)TAAAG utr-variant-3-prime
rs1997639 - 47,639,119(+) CAAAC(C/T)GCCTG missense, reference, intron-variant

Relevant External Links for ELK1 Gene

HapMap Linkage Disequilibrium report
ELK1
Human Gene Mutation Database (HGMD)
ELK1
Locus Specific Mutation Databases (LSDB)
ELK1

No data available for Structural Variations from Database of Genomic Variants (DGV) for ELK1 Gene

Disorders for ELK1 Gene

(13) Novoseek inferred disease relationships for ELK1 Gene

Disease -log(P) Hits PubMed IDs
prostate carcinoma 37.5 1
tumors 24.2 6
prostate cancer 16.2 1
necrosis 10.7 2
breast cancer 9.31 6

Relevant External Links for ELK1

Genetic Association Database (GAD)
ELK1
Human Genome Epidemiology (HuGE) Navigator
ELK1
Tumor Gene Database (TGDB):
ELK1
genes like me logo Genes that share disorders with ELK1: view

No data available for UniProtKB/Swiss-Prot for ELK1 Gene

Publications for ELK1 Gene

  1. Elk-1 protein domains required for direct and SRF-assisted DNA- binding. (PMID: 1630903) Janknecht R. … Nordheim A. (Nucleic Acids Res. 1992) 3 4 23
  2. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. (PMID: 7889942) Gille H. … Shaw P.E. (EMBO J. 1995) 3 4 23
  3. Structural organization of the human ELK1 gene and its processed pseudogene ELK2 genes. (PMID: 10231026) Yamauchi T. … Isobe M. (DNA Res. 1999) 3 4 23
  4. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. (PMID: 12887893) Yang S.-H. … Sharrocks A.D. (Mol. Cell 2003) 3 4 23
  5. SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. (PMID: 15210726) Salinas S. … Hipskind R.A. (J. Cell Biol. 2004) 3 4 23

Products for ELK1 Gene

  • Addgene plasmids for ELK1

Sources for ELK1 Gene

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