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Aliases for CRTC2 Gene

Aliases for CRTC2 Gene

  • CREB Regulated Transcription Coactivator 2 2 3
  • TORC2 3 4 6
  • TORC-2 3 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 2 3
  • Transducer Of Regulated CAMP Response Element-Binding Protein 2 4
  • CREB-Regulated Transcription Coactivator 2 3
  • Transducer Of CREB Protein 2 4

External Ids for CRTC2 Gene

Previous GeneCards Identifiers for CRTC2 Gene

  • GC01M150734
  • GC01M152186
  • GC01M125282

Summaries for CRTC2 Gene

Entrez Gene Summary for CRTC2 Gene

  • This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]

GeneCards Summary for CRTC2 Gene

CRTC2 (CREB Regulated Transcription Coactivator 2) is a Protein Coding gene. Diseases associated with CRTC2 include human t-cell leukemia virus type 1. Among its related pathways are PI3K-Akt signaling pathway and Glucose / Energy Metabolism. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC3.

UniProtKB/Swiss-Prot for CRTC2 Gene

  • Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene Wiki entry for CRTC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTC2 Gene

Genomics for CRTC2 Gene

Regulatory Elements for CRTC2 Gene

Genomic Location for CRTC2 Gene

Start:
153,947,669 bp from pter
End:
153,958,656 bp from pter
Size:
10,988 bases
Orientation:
Minus strand

Genomic View for CRTC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRTC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTC2 Gene

Proteins for CRTC2 Gene

  • Protein details for CRTC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53ET0-CRTC2_HUMAN
    Recommended name:
    CREB-regulated transcription coactivator 2
    Protein Accession:
    Q53ET0
    Secondary Accessions:
    • Q6UUV8
    • Q7Z3X7
    • Q8N332

    Protein attributes for CRTC2 Gene

    Size:
    693 amino acids
    Molecular mass:
    73302 Da
    Quaternary structure:
    • Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. Arg-314 in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (By similarity). Interacts with PPP3CA/calcineurin alpha, SIK2 and 14-3-3 proteins, YWHAB and YWHAG. Interaction with the human T-cell leukemia virus type 1 (HTLV-1) Tax protein is essential for optimal transcription activation by Tax. Interaction with RFWD2/COP1 mediates nuclear export and degradation of CRTC2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CRTC2 Gene

neXtProt entry for CRTC2 Gene

Proteomics data for CRTC2 Gene at MOPED

Post-translational modifications for CRTC2 Gene

  • Asymmetric dimethylation of arginine resisues by PRMT6 enhances the association of CRTC2 with CREB on the promoters of gluconeogenic genes.
  • Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs (SIK1 and SIK2) by LKB1. Both insulin and AMPK increase this phosphorylation of CRTC2 while glucagon suppresses it. Phosphorylation at Ser-274 by MARK2 is induced under low glucose conditions and dephosphorylated in response to glucose influx. Phosphorylation at Ser-274 promotes interaction with 14-3-3 proteins and translocation to the cytoplasm.
  • Ubiquitination at Lys156
  • Modification sites at PhosphoSitePlus

Other Protein References for CRTC2 Gene

No data available for DME Specific Peptides for CRTC2 Gene

Domains for CRTC2 Gene

Protein Domains for CRTC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRTC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q53ET0

UniProtKB/Swiss-Prot:

CRTC2_HUMAN :
  • Q53ET0
Family:
  • Belongs to the TORC family.
genes like me logo Genes that share domains with CRTC2: view

No data available for Gene Families for CRTC2 Gene

Function for CRTC2 Gene

Molecular function for CRTC2 Gene

UniProtKB/Swiss-Prot Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene Ontology (GO) - Molecular Function for CRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19164291
GO:0008140 cAMP response element binding protein binding IBA --
genes like me logo Genes that share ontologies with CRTC2: view

Phenotypes for CRTC2 Gene

genes like me logo Genes that share phenotypes with CRTC2: view

Animal Models for CRTC2 Gene

MGI Knock Outs for CRTC2:

miRNA for CRTC2 Gene

miRTarBase miRNAs that target CRTC2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRTC2 Gene

Localization for CRTC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTC2 Gene

Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRTC2 Gene COMPARTMENTS Subcellular localization image for CRTC2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CRTC2: view

Pathways for CRTC2 Gene

genes like me logo Genes that share pathways with CRTC2: view

Pathways by source for CRTC2 Gene

1 Cell Signaling Technology pathway for CRTC2 Gene
2 BioSystems pathways for CRTC2 Gene
1 PharmGKB pathway for CRTC2 Gene
2 KEGG pathways for CRTC2 Gene

Gene Ontology (GO) - Biological Process for CRTC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0016032 viral process IEA --
GO:0032793 positive regulation of CREB transcription factor activity ISS --
GO:0042593 glucose homeostasis ISS --
genes like me logo Genes that share ontologies with CRTC2: view

Compounds for CRTC2 Gene

(2) HMDB Compounds for CRTC2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with CRTC2: view

Transcripts for CRTC2 Gene

Unigene Clusters for CRTC2 Gene

CREB regulated transcription coactivator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRTC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for CRTC2 Gene

GeneLoc Exon Structure for
CRTC2
ECgene alternative splicing isoforms for
CRTC2

Expression for CRTC2 Gene

mRNA expression in normal human tissues for CRTC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRTC2 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRTC2 Gene

SOURCE GeneReport for Unigene cluster for CRTC2 Gene Hs.406392

mRNA Expression by UniProt/SwissProt for CRTC2 Gene

Q53ET0-CRTC2_HUMAN
Tissue specificity: Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.
genes like me logo Genes that share expressions with CRTC2: view

Orthologs for CRTC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRTC2 35
  • 96.64 (n)
  • 94.7 (a)
CRTC2 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
OneToMany
CRTC2 35
  • 91.2 (n)
  • 92.64 (a)
CRTC2 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CRTC2 35
  • 87.97 (n)
  • 89.32 (a)
CRTC2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crtc2 35
  • 90.3 (n)
  • 92.47 (a)
Crtc2 16
Crtc2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRTC2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crtc2 35
  • 89.92 (n)
  • 92.33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crtc2 35
  • 67.51 (n)
  • 66.54 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01081897.1 36
  • 54 (a)
OneToMany
CRTC2 (1 of 2) 36
  • 27 (a)
OneToMany
Species with no ortholog for CRTC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTC2 Gene

ENSEMBL:
Gene Tree for CRTC2 (if available)
TreeFam:
Gene Tree for CRTC2 (if available)

Paralogs for CRTC2 Gene

Paralogs for CRTC2 Gene

Selected SIMAP similar genes for CRTC2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CRTC2 Gene

genes like me logo Genes that share paralogs with CRTC2: view

Variants for CRTC2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CRTC2 Gene

Q53ET0-CRTC2_HUMAN
Variant Cys-379, under a dominant model, linked to a recessive mutation in LKB1, may be associated with susceptibility to type II or non-insulin-dependent diabetes mellitus (NIDDM)

Sequence variations from dbSNP and Humsavar for CRTC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1934434 -- 153,955,167(-) TCTCA(G/T)TTACA splice-acceptor-variant
rs1934435 -- 153,955,050(-) CCCCA(G/T)CCAGG intron-variant
rs1934436 -- 153,951,625(-) CCTCC(A/C)TAAGC missense, reference
rs1934437 -- 153,951,598(-) CTTCC(A/C)TGAGC missense, reference
rs10127983 -- 153,950,800(+) GGAGA(C/T)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRTC2 Gene

Variant ID Type Subtype PubMed ID
nsv872450 CNV Loss 21882294

Relevant External Links for CRTC2 Gene

HapMap Linkage Disequilibrium report
CRTC2

Disorders for CRTC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CRTC2 Gene including...

Search for CRTC2 Gene in MalaCards »

Relevant External Links for CRTC2

Genetic Association Database (GAD)
CRTC2
Human Genome Epidemiology (HuGE) Navigator
CRTC2
genes like me logo Genes that share disorders with CRTC2: view

No data available for UniProtKB/Swiss-Prot for CRTC2 Gene

Publications for CRTC2 Gene

  1. Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes. (PMID: 17950019) Keshavarz P. … Itakura M. (Mol. Genet. Metab. 2008) 3 4 23 48
  2. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PMID: 15454081) Screaton R.A. … Montminy M. (Cell 2004) 3 4 23
  3. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PMID: 14506290) Iourgenko V. … Labow M.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  4. TORCs: transducers of regulated CREB activity. (PMID: 14536081) Conkright M.D. … Montminy M. (Mol. Cell 2003) 2 3 4
  5. Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2. (PMID: 18626018) Jansson D. … Screaton R.A. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 23

Products for CRTC2 Gene

Sources for CRTC2 Gene

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