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Aliases for PLD5 Gene

Aliases for PLD5 Gene

  • Phospholipase D Family Member 5 2 3 5
  • Inactive Phosphatidylcholine-Hydrolyzing Phospholipase D5 3 4
  • Phospholipase D Family, Member 5 2 3
  • Inactive Choline Phosphatase 5 3 4
  • Inactive PLD 5 3 4
  • PLDC 3 4

External Ids for PLD5 Gene

Previous GeneCards Identifiers for PLD5 Gene

  • GC01M238579
  • GC01M240318
  • GC01M242251
  • GC01M212711

Summaries for PLD5 Gene

GeneCards Summary for PLD5 Gene

PLD5 (Phospholipase D Family Member 5) is a Protein Coding gene. Diseases associated with PLD5 include uterine benign neoplasm. An important paralog of this gene is PLD3.

Gene Wiki entry for PLD5 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLD5 Gene

Genomics for PLD5 Gene

Regulatory Elements for PLD5 Gene

Enhancers for PLD5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLD5 Gene

Chromosome:
1
Start:
242,082,986 bp from pter
End:
242,530,544 bp from pter
Size:
447,559 bases
Orientation:
Minus strand

Genomic View for PLD5 Gene

Genes around PLD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLD5 Gene

Proteins for PLD5 Gene

  • Protein details for PLD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7P1-PLD5_HUMAN
    Recommended name:
    Inactive phospholipase D5
    Protein Accession:
    Q8N7P1
    Secondary Accessions:
    • A1KXV0
    • B7Z324
    • Q494U9
    • Q8NB22

    Protein attributes for PLD5 Gene

    Size:
    536 amino acids
    Molecular mass:
    61312 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01374.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI01375.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI01376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLD5 Gene

Proteomics data for PLD5 Gene at MOPED

Post-translational modifications for PLD5 Gene

  • Glycosylation at Asn 121 and Asn 302
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLD5 Gene

Domains & Families for PLD5 Gene

Gene Families for PLD5 Gene

Protein Domains for PLD5 Gene

Suggested Antigen Peptide Sequences for PLD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7P1

UniProtKB/Swiss-Prot:

PLD5_HUMAN :
  • Contains 2 PLD phosphodiesterase domains.
  • Belongs to the phospholipase D family.
Domain:
  • Contains 2 PLD phosphodiesterase domains.
Family:
  • Belongs to the phospholipase D family.
genes like me logo Genes that share domains with PLD5: view

Function for PLD5 Gene

genes like me logo Genes that share phenotypes with PLD5: view

Animal Models for PLD5 Gene

MGI Knock Outs for PLD5:
  • Pld5 tm1b(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for PLD5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLD5 Gene

Localization for PLD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLD5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLD5 Gene COMPARTMENTS Subcellular localization image for PLD5 gene
Compartment Confidence
cytosol 4
mitochondrion 3
nucleus 2
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PLD5 Gene

Pathways & Interactions for PLD5 Gene

SuperPathways for PLD5 Gene

No Data Available

Interacting Proteins for PLD5 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000440896%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000365895%0d%0a9606.ENSP00000429473%0d%0a9606.ENSP00000259241%0d%0a
Selected Interacting proteins: ENSP00000440896 for PLD5 Gene via STRING

Gene Ontology (GO) - Biological Process for PLD5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLD5 Gene

Drugs & Compounds for PLD5 Gene

No Compound Related Data Available

Transcripts for PLD5 Gene

Unigene Clusters for PLD5 Gene

Phospholipase D family, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for PLD5 Gene

GeneLoc Exon Structure for
PLD5
ECgene alternative splicing isoforms for
PLD5

Expression for PLD5 Gene

mRNA expression in normal human tissues for PLD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLD5 Gene

This gene is overexpressed in Artery - Aorta (x8.9) and Brain - Cerebellar Hemisphere (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLD5 Gene



SOURCE GeneReport for Unigene cluster for PLD5 Gene Hs.672452

genes like me logo Genes that share expression patterns with PLD5: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PLD5 Gene

Orthologs for PLD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLD5 35
  • 93.06 (n)
  • 95.87 (a)
PLD5 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLD5 35
  • 91.97 (n)
  • 95.35 (a)
PLD5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pld5 35
  • 88.99 (n)
  • 94.22 (a)
Pld5 16
Pld5 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLD5 35
  • 99.5 (n)
  • 99.63 (a)
PLD5 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pld5 35
  • 89.86 (n)
  • 94.78 (a)
oppossum
(Monodelphis domestica)
Mammalia PLD5 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLD5 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLD5 35
  • 76.75 (n)
  • 78.1 (a)
PLD5 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLD5 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100535478 35
  • 57.99 (n)
  • 52.95 (a)
CABZ01084700.1 36
  • 37 (a)
OneToMany
PLD5 (1 of 2) 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43345 36
  • 29 (a)
ManyToMany
CG9248 36
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T05C3.6 36
  • 24 (a)
ManyToMany
Species with no ortholog for PLD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLD5 Gene

ENSEMBL:
Gene Tree for PLD5 (if available)
TreeFam:
Gene Tree for PLD5 (if available)

Paralogs for PLD5 Gene

Paralogs for PLD5 Gene

(2) SIMAP similar genes for PLD5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PLD5: view

Variants for PLD5 Gene

Sequence variations from dbSNP and Humsavar for PLD5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs316839 -- 242,158,783(+) ctcct(A/G)ttttt intron-variant
rs316840 -- 242,159,227(+) gatat(A/G)gaaag intron-variant
rs316841 -- 242,159,352(+) agaca(C/T)ggttt intron-variant
rs316842 -- 242,159,592(+) GATCC(C/T)GCCCC intron-variant
rs316843 -- 242,160,751(+) gtggt(G/T)gcaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLD5 Gene

Variant ID Type Subtype PubMed ID
nsv873372 CNV Gain 21882294
dgv16e55 CNV Gain 17911159
nsv508703 CNV Loss 20534489
nsv468672 CNV Gain 19166990
nsv470788 CNV Gain 18288195
nsv528016 CNV Gain 19592680
esv2726296 CNV Deletion 23290073
esv2726307 CNV Deletion 23290073
esv2726318 CNV Deletion 23290073
esv1038787 CNV Insertion 17803354
esv1676362 CNV Deletion 17803354
esv998850 CNV Insertion 20482838
nsv515604 CNV Loss 19592680
esv1979417 CNV Deletion 18987734
nsv873375 CNV Gain 21882294
esv992990 CNV Insertion 20482838
esv2726329 CNV Deletion 23290073
esv998142 CNV Gain 20482838
esv25405 CNV Gain 19812545
esv2726340 CNV Deletion 23290073
esv2089690 CNV Deletion 18987734
nsv5077 CNV Loss 18451855
esv1505070 CNV Deletion 17803354
nsv873376 CNV Gain 21882294
esv2726351 CNV Deletion 23290073
esv2726363 CNV Deletion 23290073
esv2658863 CNV Deletion 23128226
esv270123 CNV Insertion 20981092
esv2658344 CNV Deletion 23128226
nsv873377 CNV Gain 21882294
nsv160878 CNV Insertion 16902084
esv1006418 CNV Insertion 20482838
esv1110378 CNV Insertion 17803354
nsv5088 CNV Loss 18451855
nsv873378 CNV Gain 21882294
nsv159213 CNV Insertion 16902084

Variation tolerance for PLD5 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 14.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLD5 Gene

HapMap Linkage Disequilibrium report
PLD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLD5 Gene

Disorders for PLD5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLD5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
uterine benign neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search PLD5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLD5

Genetic Association Database (GAD)
PLD5
Human Genome Epidemiology (HuGE) Navigator
PLD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLD5
genes like me logo Genes that share disorders with PLD5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLD5 Gene

Publications for PLD5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. (PMID: 24057671) Chimusa E.R. … Hoal E.G. (Hum. Mol. Genet. 2014) 3
  3. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L. … Wang L. (BMC Genomics 2014) 3
  4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  5. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski M.K. … Reilly M.P. (BMC Med. Genet. 2013) 3

Products for PLD5 Gene

Sources for PLD5 Gene

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