Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLD5 Gene

Aliases for PLD5 Gene

  • Phospholipase D Family, Member 5 2 3
  • Inactive Phosphatidylcholine-Hydrolyzing Phospholipase D5 3 4
  • Inactive Choline Phosphatase 5 3 4
  • Inactive PLD 5 3 4
  • PLDC 3 4
  • Inactive Phospholipase D5 3
  • CIDEC 6
  • FSP27 6
  • CIDE3 6
  • F 6

External Ids for PLD5 Gene

Previous GeneCards Identifiers for PLD5 Gene

  • GC01M238579
  • GC01M240318
  • GC01M242251
  • GC01M212711

Summaries for PLD5 Gene

GeneCards Summary for PLD5 Gene

PLD5 (Phospholipase D Family, Member 5) is a Protein Coding gene. An important paralog of this gene is PLD4.

Gene Wiki entry for PLD5 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLD5 Gene

Genomics for PLD5 Gene

Regulatory Elements for PLD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLD5 Gene

242,082,986 bp from pter
242,524,696 bp from pter
441,711 bases
Minus strand

Genomic View for PLD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLD5 Gene

Proteins for PLD5 Gene

  • Protein details for PLD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive phospholipase D5
    Protein Accession:
    Secondary Accessions:
    • A1KXV0
    • B7Z324
    • Q494U9
    • Q8NB22

    Protein attributes for PLD5 Gene

    536 amino acids
    Molecular mass:
    61312 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI01374.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI01375.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI01376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLD5 Gene


neXtProt entry for PLD5 Gene

Proteomics data for PLD5 Gene at MOPED

Post-translational modifications for PLD5 Gene

  • Ubiquitination at Lys194
  • Glycosylation at Asn121 and Asn302
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLD5 Gene

Domains for PLD5 Gene

Gene Families for PLD5 Gene

Protein Domains for PLD5 Gene

Suggested Antigen Peptide Sequences for PLD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 PLD phosphodiesterase domains.
  • Belongs to the phospholipase D family.
  • Contains 2 PLD phosphodiesterase domains.
  • Belongs to the phospholipase D family.
genes like me logo Genes that share domains with PLD5: view

Function for PLD5 Gene

Gene Ontology (GO) - Molecular Function for PLD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with PLD5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLD5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLD5 Gene

Localization for PLD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLD5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PLD5 Gene COMPARTMENTS Subcellular localization image for PLD5 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLD5: view

Pathways for PLD5 Gene

SuperPathways for PLD5 Gene

No Data Available

Interacting Proteins for PLD5 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000440896 for PLD5 Gene via STRING

Gene Ontology (GO) - Biological Process for PLD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PLD5: view

No data available for Pathways by source for PLD5 Gene

Transcripts for PLD5 Gene

Unigene Clusters for PLD5 Gene

Phospholipase D family, member 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLD5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - -
SP2: -
SP3: - -

Relevant External Links for PLD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLD5 Gene

mRNA expression in normal human tissues for PLD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLD5 Gene

This gene is overexpressed in Artery - Aorta (8.9) and Brain - Cerebellar Hemisphere (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLD5 Gene

SOURCE GeneReport for Unigene cluster for PLD5 Gene Hs.672452

genes like me logo Genes that share expressions with PLD5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for PLD5 Gene

Orthologs for PLD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLD5 35
  • 93.06 (n)
  • 95.87 (a)
PLD5 36
  • 91 (a)
(Canis familiaris)
Mammalia PLD5 35
  • 91.97 (n)
  • 95.35 (a)
PLD5 36
  • 96 (a)
(Mus musculus)
Mammalia Pld5 35
  • 88.99 (n)
  • 94.22 (a)
Pld5 16
Pld5 36
  • 94 (a)
(Pan troglodytes)
Mammalia PLD5 35
  • 99.5 (n)
  • 99.63 (a)
PLD5 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Pld5 35
  • 89.86 (n)
  • 94.78 (a)
(Monodelphis domestica)
Mammalia PLD5 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia PLD5 36
  • 78 (a)
(Gallus gallus)
Aves PLD5 35
  • 76.75 (n)
  • 78.1 (a)
PLD5 36
  • 80 (a)
(Anolis carolinensis)
Reptilia PLD5 36
  • 72 (a)
(Danio rerio)
Actinopterygii LOC100535478 35
  • 57.99 (n)
  • 52.95 (a)
CABZ01084700.1 36
  • 37 (a)
PLD5 (1 of 2) 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43345 36
  • 29 (a)
CG9248 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea T05C3.6 36
  • 24 (a)
Species with no ortholog for PLD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLD5 Gene

Gene Tree for PLD5 (if available)
Gene Tree for PLD5 (if available)

Paralogs for PLD5 Gene

Paralogs for PLD5 Gene

(2) SIMAP similar genes for PLD5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PLD5: view

Variants for PLD5 Gene

Sequence variations from dbSNP and Humsavar for PLD5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2055538 -- 242,439,214(-) actct(A/G)cgtga intron-variant
rs2083333 -- 242,284,752(+) CCCTC(C/T)GAACA intron-variant
rs2083334 -- 242,284,802(+) TATGG(C/G)GAGAA intron-variant
rs2083335 -- 242,294,090(+) GGAAT(A/G)CCTAT intron-variant
rs2055537 -- 242,439,678(-) TTCAC(A/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLD5 Gene

Variant ID Type Subtype PubMed ID
nsv873372 CNV Gain 21882294
dgv16e55 CNV Gain 17911159
nsv508703 CNV Loss 20534489
nsv468672 CNV Gain 19166990
nsv470788 CNV Gain 18288195
nsv528016 CNV Gain 19592680
esv2726296 CNV Deletion 23290073
esv2726307 CNV Deletion 23290073
esv2726318 CNV Deletion 23290073
esv1038787 CNV Insertion 17803354
esv1676362 CNV Deletion 17803354
esv998850 CNV Insertion 20482838
nsv515604 CNV Loss 19592680
esv1979417 CNV Deletion 18987734
nsv873375 CNV Gain 21882294
esv992990 CNV Insertion 20482838
esv2726329 CNV Deletion 23290073
esv998142 CNV Gain 20482838
esv25405 CNV Gain 19812545
esv2726340 CNV Deletion 23290073
esv2089690 CNV Deletion 18987734
nsv5077 CNV Loss 18451855
esv1505070 CNV Deletion 17803354
nsv873376 CNV Gain 21882294
esv2726351 CNV Deletion 23290073
esv2726363 CNV Deletion 23290073
esv2658863 CNV Deletion 23128226
esv270123 CNV Insertion 20981092
esv2658344 CNV Deletion 23128226
nsv873377 CNV Gain 21882294
nsv160878 CNV Insertion 16902084
esv1006418 CNV Insertion 20482838
esv1110378 CNV Insertion 17803354
nsv5088 CNV Loss 18451855
nsv873378 CNV Gain 21882294
nsv159213 CNV Insertion 16902084

Relevant External Links for PLD5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLD5 Gene

Disorders for PLD5 Gene

(1) OMIM Diseases for PLD5 Gene (612120)

Relevant External Links for PLD5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PLD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PLD5 Gene

Publications for PLD5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PMID: 19626040) McCauley J.L. … Haines J.L. (Genes Immun. 2009) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A genome-wide scan for common alleles affecting risk for autism. (PMID: 20663923) Anney R. … Hallmayer J. (Hum. Mol. Genet. 2010) 3 48
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PLD5 Gene

Sources for PLD5 Gene

Back to Top