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Aliases for TXLNA Gene

Aliases for TXLNA Gene

  • Taxilin Alpha 2 3 5
  • TXLN 3 4
  • Interleukin 14 3
  • Alpha-Taxilin 3
  • IL14 3

External Ids for TXLNA Gene

Previous GeneCards Identifiers for TXLNA Gene

  • GC01P032315
  • GC01P032417
  • GC01P032645
  • GC01P030761

Summaries for TXLNA Gene

GeneCards Summary for TXLNA Gene

TXLNA (Taxilin Alpha) is a Protein Coding gene. Diseases associated with TXLNA include Inclusion Conjunctivitis and Amyotrophic Lateral Sclerosis Type 10. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. GO annotations related to this gene include cytokine activity and high molecular weight B cell growth factor receptor binding. An important paralog of this gene is TXLNG.

UniProtKB/Swiss-Prot for TXLNA Gene

  • May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

Gene Wiki entry for TXLNA Gene

Additional gene information for TXLNA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXLNA Gene

Genomics for TXLNA Gene

Regulatory Elements for TXLNA Gene

Enhancers for TXLNA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H031924 2.1 FANTOM5 Ensembl ENCODE dbSUPER 114.8 -243.9 -243854 22 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B PUM1 EIF3I
GH01H032262 1.8 FANTOM5 Ensembl ENCODE dbSUPER 82.5 +85.7 85702 4 ZNF493 ZFP64 RARA SCRT2 ZNF654 ZNF680 ZC3H11A CEBPB OVOL3 REST TXLNA RBBP4 KHDRBS1 SNRNP40 TMEM39B ZBTB8A ZNF362 DCDC2B TSSK3 S100PBP
GH01H031951 2.1 FANTOM5 Ensembl ENCODE dbSUPER 40.9 -223.6 -223616 9 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 YBX1 YY1 ZNF766 SNRNP40 KHDRBS1 RBBP4 TMEM39B TXLNA ZBTB8A IQCC ENSG00000224066 TSSK3 MTMR9LP
GH01H032813 1.7 FANTOM5 ENCODE dbSUPER 47.5 +637.6 637556 7 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A RBBP4 KHDRBS1 ZBTB8A TXLNA TMEM39B S100PBP KPNA6 ZSCAN20 TSSK3 FAM229A
GH01H032289 1.2 ENCODE 65.7 +111.6 111634 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SNRNP40 RBBP4 KHDRBS1 TXLNA TSSK3 TMEM39B S100PBP ZBTB8A FAM229A DCDC2B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TXLNA on UCSC Golden Path with GeneCards custom track

Promoters for TXLNA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004326 614 1801 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B

Genomic Location for TXLNA Gene

Chromosome:
1
Start:
32,179,686 bp from pter
End:
32,198,285 bp from pter
Size:
18,600 bases
Orientation:
Plus strand

Genomic View for TXLNA Gene

Genes around TXLNA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXLNA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXLNA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXLNA Gene

Proteins for TXLNA Gene

  • Protein details for TXLNA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40222-TXLNA_HUMAN
    Recommended name:
    Alpha-taxilin
    Protein Accession:
    P40222
    Secondary Accessions:
    • D3DPP6
    • Q5TFJ6
    • Q66K62
    • Q86T54
    • Q86T85
    • Q86T86
    • Q86Y86
    • Q86YW3
    • Q8N2Y3

    Protein attributes for TXLNA Gene

    Size:
    546 amino acids
    Molecular mass:
    61891 Da
    Quaternary structure:
    • Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.
    SequenceCaution:
    • Sequence=AAH46565.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TXLNA Gene

Post-translational modifications for TXLNA Gene

  • Ubiquitination at posLast=403403
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for TXLNA (alpha-Taxilin)

No data available for DME Specific Peptides for TXLNA Gene

Domains & Families for TXLNA Gene

Gene Families for TXLNA Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for TXLNA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TXLNA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40222

UniProtKB/Swiss-Prot:

TXLNA_HUMAN :
  • Belongs to the taxilin family.
Family:
  • Belongs to the taxilin family.
genes like me logo Genes that share domains with TXLNA: view

Function for TXLNA Gene

Molecular function for TXLNA Gene

UniProtKB/Swiss-Prot Function:
May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

Gene Ontology (GO) - Molecular Function for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 8327514
GO:0005515 protein binding IPI 21903422
GO:0019905 syntaxin binding IEA --
GO:0030372 high molecular weight B cell growth factor receptor binding NAS 8327514
genes like me logo Genes that share ontologies with TXLNA: view
genes like me logo Genes that share phenotypes with TXLNA: view

Animal Model Products

CRISPR Products

miRNA for TXLNA Gene

miRTarBase miRNAs that target TXLNA

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TXLNA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXLNA Gene

Localization for TXLNA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXLNA gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 3
cytoskeleton 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TXLNA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TXLNA Gene

Pathways & Interactions for TXLNA Gene

genes like me logo Genes that share pathways with TXLNA: view

Pathways by source for TXLNA Gene

Gene Ontology (GO) - Biological Process for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0008283 cell proliferation NAS 8327514
GO:0042113 B cell activation IEA --
genes like me logo Genes that share ontologies with TXLNA: view

No data available for SIGNOR curated interactions for TXLNA Gene

Drugs & Compounds for TXLNA Gene

(1) Drugs for TXLNA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with TXLNA: view

Transcripts for TXLNA Gene

Unigene Clusters for TXLNA Gene

Taxilin alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TXLNA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TXLNA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - -
SP5: -

Relevant External Links for TXLNA Gene

GeneLoc Exon Structure for
TXLNA
ECgene alternative splicing isoforms for
TXLNA

Expression for TXLNA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXLNA Gene

Protein differential expression in normal tissues from HIPED for TXLNA Gene

This gene is overexpressed in Breast (25.6), Urine (8.0), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXLNA Gene



Protein tissue co-expression partners for TXLNA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TXLNA Gene:

TXLNA

SOURCE GeneReport for Unigene cluster for TXLNA Gene:

Hs.17987

mRNA Expression by UniProt/SwissProt for TXLNA Gene:

P40222-TXLNA_HUMAN
Tissue specificity: Ubiquitous, with much higher expression in heart, kidney, liver and pancreas.

Evidence on tissue expression from TISSUES for TXLNA Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TXLNA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXLNA Gene

Orthologs for TXLNA Gene

This gene was present in the common ancestor of animals.

Orthologs for TXLNA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXLNA 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia TXLNA 33 34
  • 90.15 (n)
cow
(Bos Taurus)
Mammalia TXLNA 33 34
  • 89.54 (n)
mouse
(Mus musculus)
Mammalia Txlna 33 16 34
  • 87.39 (n)
rat
(Rattus norvegicus)
Mammalia Txlna 33
  • 87.34 (n)
oppossum
(Monodelphis domestica)
Mammalia TXLNA 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TXLNA 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXLNA 33 34
  • 73.69 (n)
lizard
(Anolis carolinensis)
Reptilia TXLNA 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1214 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7529 33
zebrafish
(Danio rerio)
Actinopterygii txlna 33 34
  • 70.88 (n)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009667 33
  • 55.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5886 33 34
  • 53.64 (n)
worm
(Caenorhabditis elegans)
Secernentea T22C1.6 33 34
  • 43.64 (n)
Species where no ortholog for TXLNA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXLNA Gene

ENSEMBL:
Gene Tree for TXLNA (if available)
TreeFam:
Gene Tree for TXLNA (if available)

Paralogs for TXLNA Gene

Paralogs for TXLNA Gene

(5) SIMAP similar genes for TXLNA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TXLNA: view

Variants for TXLNA Gene

Sequence variations from dbSNP and Humsavar for TXLNA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000056294 -- 32,186,268(+) TGGCT(A/G)TGGTA intron-variant
rs1000089966 -- 32,185,830(+) AGTAG(C/T)TGGGA intron-variant
rs1000119851 -- 32,190,702(+) TTTGT(A/G)GAATT intron-variant
rs1000374182 -- 32,197,781(+) CTTCA(C/T)GTCCA utr-variant-3-prime
rs1000464886 -- 32,183,782(+) ACCAA(C/G)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXLNA Gene

Variant ID Type Subtype PubMed ID
nsv7745 CNV insertion 18451855

Variation tolerance for TXLNA Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXLNA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXLNA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXLNA Gene

Disorders for TXLNA Gene

MalaCards: The human disease database

(2) MalaCards diseases for TXLNA Gene - From: DISEASES

Disorder Aliases PubMed IDs
inclusion conjunctivitis
  • adult inclusion conjunctivitis
amyotrophic lateral sclerosis type 10
  • als10
- elite association - COSMIC cancer census association via MalaCards
Search TXLNA in MalaCards View complete list of genes associated with diseases

Relevant External Links for TXLNA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXLNA
genes like me logo Genes that share disorders with TXLNA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXLNA Gene

Publications for TXLNA Gene

  1. Identification and characterization of taxilin isoforms. (PMID: 15184072) Nogami S … Shirataki H (Biochemical and biophysical research communications 2004) 2 3 22 60
  2. Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells. (PMID: 12558796) Nogami S … Shirataki H (Genes to cells : devoted to molecular & cellular mechanisms 2003) 3 4 22 60
  3. Interaction of taxilin with syntaxin which does not form the SNARE complex. (PMID: 14623251) Nogami S … Shirataki H (Biochemical and biophysical research communications 2003) 2 3 4 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for TXLNA Gene

Sources for TXLNA Gene

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