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Aliases for CYP4Z1 Gene

Aliases for CYP4Z1 Gene

  • Cytochrome P450, Family 4, Subfamily Z, Polypeptide 1 2 3
  • CYPIVZ1 3 4
  • Cytochrome P450 4Z1 3
  • EC 1.14.14.1 4
  • CYP4A20 3

External Ids for CYP4Z1 Gene

Previous GeneCards Identifiers for CYP4Z1 Gene

  • GC01P046923
  • GC01P046903
  • GC01P046902
  • GC01P047245
  • GC01P047305
  • GC01P047533
  • GC01P045649

Summaries for CYP4Z1 Gene

Entrez Gene Summary for CYP4Z1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4Z1 Gene

CYP4Z1 (Cytochrome P450, Family 4, Subfamily Z, Polypeptide 1) is a Protein Coding gene. Among its related pathways are Biological oxidations and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F12.

Gene Wiki entry for CYP4Z1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4Z1 Gene

Genomics for CYP4Z1 Gene

Regulatory Elements for CYP4Z1 Gene

Genomic Location for CYP4Z1 Gene

Start:
47,067,488 bp from pter
End:
47,118,320 bp from pter
Size:
50,833 bases
Orientation:
Plus strand

Genomic View for CYP4Z1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP4Z1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4Z1 Gene

Proteins for CYP4Z1 Gene

  • Protein details for CYP4Z1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W10-CP4Z1_HUMAN
    Recommended name:
    Cytochrome P450 4Z1
    Protein Accession:
    Q86W10
    Secondary Accessions:
    • Q5VVE4

    Protein attributes for CYP4Z1 Gene

    Size:
    505 amino acids
    Molecular mass:
    59086 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP4Z1 Gene

Proteomics data for CYP4Z1 Gene at MOPED

Post-translational modifications for CYP4Z1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4Z1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP4Z1 Gene

Domains for CYP4Z1 Gene

Gene Families for CYP4Z1 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP4Z1 Gene

Suggested Antigen Peptide Sequences for CYP4Z1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W10

UniProtKB/Swiss-Prot:

CP4Z1_HUMAN :
  • Q86W10
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4Z1: view

Function for CYP4Z1 Gene

Molecular function for CYP4Z1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Enzyme Numbers (IUBMB) for CYP4Z1 Gene

Gene Ontology (GO) - Molecular Function for CYP4Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0020037 heme binding IEA --
GO:0070330 aromatase activity IEA --
genes like me logo Genes that share ontologies with CYP4Z1: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP4Z1 Gene

Localization for CYP4Z1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4Z1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4Z1 Gene COMPARTMENTS Subcellular localization image for CYP4Z1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP4Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP4Z1: view

Pathways for CYP4Z1 Gene

genes like me logo Genes that share pathways with CYP4Z1: view

Pathways by source for CYP4Z1 Gene

2 BioSystems pathways for CYP4Z1 Gene

Interacting Proteins for CYP4Z1 Gene

Gene Ontology (GO) - Biological Process for CYP4Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4Z1: view

Compounds for CYP4Z1 Gene

(49) HMDB Compounds for CYP4Z1 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9
genes like me logo Genes that share compounds with CYP4Z1: view

Transcripts for CYP4Z1 Gene

mRNA/cDNA for CYP4Z1 Gene

(22) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP4Z1 Gene

Cytochrome P450, family 4, subfamily Z, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4Z1 Gene

No ASD Table

Relevant External Links for CYP4Z1 Gene

GeneLoc Exon Structure for
CYP4Z1
ECgene alternative splicing isoforms for
CYP4Z1

Expression for CYP4Z1 Gene

mRNA expression in normal human tissues for CYP4Z1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4Z1 Gene

This gene is overexpressed in Breast - Mammary Tissue (9.6) and Nerve - Tibial (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP4Z1 Gene

SOURCE GeneReport for Unigene cluster for CYP4Z1 Gene Hs.176588

mRNA Expression by UniProt/SwissProt for CYP4Z1 Gene

Q86W10-CP4Z1_HUMAN
Tissue specificity: Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.
genes like me logo Genes that share expressions with CYP4Z1: view

Orthologs for CYP4Z1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP4Z1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP4Z1 36
  • 97 (a)
OneToOne
LOC456834 35
  • 97.25 (n)
  • 95.32 (a)
mouse
(Mus musculus)
Mammalia Cyp4a12b 36
  • 49 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
Species with no ortholog for CYP4Z1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP4Z1 Gene

ENSEMBL:
Gene Tree for CYP4Z1 (if available)
TreeFam:
Gene Tree for CYP4Z1 (if available)

Paralogs for CYP4Z1 Gene

Selected SIMAP similar genes for CYP4Z1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CYP4Z1 Gene

genes like me logo Genes that share paralogs with CYP4Z1: view

Variants for CYP4Z1 Gene

Sequence variations from dbSNP and Humsavar for CYP4Z1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1002378 -- 47,079,640(+) AACAA(A/G)TAGAT intron-variant
rs1110425 -- 47,105,864(+) TGATA(C/T)TGGTC intron-variant
rs1295462 -- 47,109,868(-) GGCCA(C/T)GTAGA intron-variant
rs1295463 -- 47,116,574(+) GATTT(C/T)GTTTT intron-variant
rs1393665 -- 47,082,819(+) GGAAA(C/G)ACTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4Z1 Gene

Variant ID Type Subtype PubMed ID
dgv221n71 CNV Gain 21882294
esv24824 CNV Loss 19812545

Relevant External Links for CYP4Z1 Gene

HapMap Linkage Disequilibrium report
CYP4Z1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4Z1 Gene

Disorders for CYP4Z1 Gene

No disorders were found for CYP4Z1 Gene.

No data available for UniProtKB/Swiss-Prot for CYP4Z1 Gene

Publications for CYP4Z1 Gene

  1. Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. (PMID: 15059886) Rieger M.A. … Weigle B. (Cancer Res. 2004) 2 3 4 23
  2. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PMID: 15797250) Savas U. … Johnson E.F. (Arch. Biochem. Biophys. 2005) 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PMID: 15128046) Nelson D.R. … Nebert D.W. (Pharmacogenetics 2004) 3
  5. Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid. (PMID: 19090726) ZAPllner A. … Bureik M. (Biol. Chem. 2009) 3

Products for CYP4Z1 Gene

Sources for CYP4Z1 Gene

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