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Aliases for CYP4Z1 Gene

Aliases for CYP4Z1 Gene

  • Cytochrome P450 Family 4 Subfamily Z Member 1 2 3 5
  • Cytochrome P450, Family 4, Subfamily Z, Polypeptide 1 2 3
  • CYPIVZ1 3 4
  • EC 4
  • CYP4A20 3

External Ids for CYP4Z1 Gene

Previous GeneCards Identifiers for CYP4Z1 Gene

  • GC01P046923
  • GC01P046903
  • GC01P046902
  • GC01P047245
  • GC01P047305
  • GC01P047533
  • GC01P045649

Summaries for CYP4Z1 Gene

Entrez Gene Summary for CYP4Z1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4Z1 Gene

CYP4Z1 (Cytochrome P450 Family 4 Subfamily Z Member 1) is a Protein Coding gene. Among its related pathways are cytochrome P450 and Phase II conjugation. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.

Gene Wiki entry for CYP4Z1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4Z1 Gene

Genomics for CYP4Z1 Gene

Regulatory Elements for CYP4Z1 Gene

Enhancers for CYP4Z1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP4Z1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP4Z1 Gene

47,067,448 bp from pter
47,118,320 bp from pter
50,873 bases
Plus strand

Genomic View for CYP4Z1 Gene

Genes around CYP4Z1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4Z1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4Z1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4Z1 Gene

Proteins for CYP4Z1 Gene

  • Protein details for CYP4Z1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 4Z1
    Protein Accession:
    Secondary Accessions:
    • Q5VVE4

    Protein attributes for CYP4Z1 Gene

    505 amino acids
    Molecular mass:
    59086 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP4Z1 Gene

Proteomics data for CYP4Z1 Gene at MOPED

Post-translational modifications for CYP4Z1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4Z1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CYP4Z1 Gene

Domains & Families for CYP4Z1 Gene

Gene Families for CYP4Z1 Gene

Protein Domains for CYP4Z1 Gene

Suggested Antigen Peptide Sequences for CYP4Z1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4Z1: view

Function for CYP4Z1 Gene

Molecular function for CYP4Z1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.

Enzyme Numbers (IUBMB) for CYP4Z1 Gene

Gene Ontology (GO) - Molecular Function for CYP4Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP4Z1: view

Phenotypes for CYP4Z1 Gene

genes like me logo Genes that share phenotypes with CYP4Z1: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP4Z1 Gene

Localization for CYP4Z1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4Z1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for CYP4Z1 Gene COMPARTMENTS Subcellular localization image for CYP4Z1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
golgi apparatus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CYP4Z1 Gene

Pathways & Interactions for CYP4Z1 Gene

genes like me logo Genes that share pathways with CYP4Z1: view

Pathways by source for CYP4Z1 Gene

2 BioSystems pathways for CYP4Z1 Gene

Interacting Proteins for CYP4Z1 Gene

Gene Ontology (GO) - Biological Process for CYP4Z1 Gene


No data available for SIGNOR curated interactions for CYP4Z1 Gene

Drugs & Compounds for CYP4Z1 Gene

(17) Drugs for CYP4Z1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 497
Codeine Approved, Illicit Pharma Full agonist, Agonist 69
Estradiol Approved, Investigational Pharma Sex hormone 1235
Estrone Approved Pharma Agonist Estrogenic hormone 19
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 519

(24) Additional Compounds for CYP4Z1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP4Z1: view

Transcripts for CYP4Z1 Gene

mRNA/cDNA for CYP4Z1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP4Z1 Gene

Cytochrome P450, family 4, subfamily Z, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4Z1 Gene

No ASD Table

Relevant External Links for CYP4Z1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP4Z1 Gene

mRNA expression in normal human tissues for CYP4Z1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4Z1 Gene

This gene is overexpressed in Breast - Mammary Tissue (x9.6) and Nerve - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for CYP4Z1 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP4Z1 Gene

SOURCE GeneReport for Unigene cluster for CYP4Z1 Gene Hs.176588

mRNA Expression by UniProt/SwissProt for CYP4Z1 Gene

Tissue specificity: Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.
genes like me logo Genes that share expression patterns with CYP4Z1: view

Protein tissue co-expression partners for CYP4Z1 Gene

Primer Products

Orthologs for CYP4Z1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP4Z1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC456834 35
  • 97.25 (n)
  • 95.32 (a)
CYP4Z1 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
-- 36
  • 42 (a)
(Mus musculus)
Mammalia Cyp4a12b 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
-- 36
  • 48 (a)
-- 36
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
-- 36
  • 46 (a)
-- 36
  • 49 (a)
-- 36
  • 47 (a)
Species with no ortholog for CYP4Z1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP4Z1 Gene

Gene Tree for CYP4Z1 (if available)
Gene Tree for CYP4Z1 (if available)

Paralogs for CYP4Z1 Gene

(14) SIMAP similar genes for CYP4Z1 Gene using alignment to 1 proteins: Pseudogenes for CYP4Z1 Gene

genes like me logo Genes that share paralogs with CYP4Z1: view

Variants for CYP4Z1 Gene

Sequence variations from dbSNP and Humsavar for CYP4Z1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs28463559 - 47,106,233(+) ATCAC(C/T)TTTCC reference, synonymous-codon
rs1002378 -- 47,079,640(+) AACAA(A/G)TAGAT intron-variant
rs1110425 -- 47,105,864(+) TGATA(C/T)TGGTC intron-variant
rs1295462 -- 47,109,868(-) GGCCA(C/T)GTAGA intron-variant
rs1295463 -- 47,116,574(+) GATTT(C/G/T)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4Z1 Gene

Variant ID Type Subtype PubMed ID
dgv221n71 CNV Gain 21882294
esv24824 CNV Loss 19812545

Variation tolerance for CYP4Z1 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CYP4Z1 Gene

Disorders for CYP4Z1 Gene

Relevant External Links for CYP4Z1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYP4Z1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4Z1 Gene

Publications for CYP4Z1 Gene

  1. Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. (PMID: 15059886) Rieger M.A. … Weigle B. (Cancer Res. 2004) 2 3 4 23 67
  2. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PMID: 15797250) Savas U. … Johnson E.F. (Arch. Biochem. Biophys. 2005) 3 23
  3. The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1. (PMID: 25701119) Zheng L. … Xi T. (Breast Cancer Res. Treat. 2015) 3
  4. Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. (PMID: 22841774) Yu W. … Yang J. (Toxicol. Appl. Pharmacol. 2012) 3
  5. Identification of genes associated with non-small-cell lung cancer promotion and progression. (PMID: 19473719) Bankovic J. … Tanic N. (Lung Cancer 2010) 3

Products for CYP4Z1 Gene

Sources for CYP4Z1 Gene