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Aliases for ALG14 Gene

Aliases for ALG14 Gene

  • ALG14, UDP-N-Acetylglucosaminyltransferase Subunit 2 3 5
  • Asparagine-Linked Glycosylation 14 Homolog (S. Cerevisiae) 2
  • Asparagine-Linked Glycosylation 14 Homolog (Yeast) 2
  • CMS15 3

External Ids for ALG14 Gene

Previous GeneCards Identifiers for ALG14 Gene

  • GC01M095161
  • GC01M095449
  • GC01M093570

Summaries for ALG14 Gene

Entrez Gene Summary for ALG14 Gene

  • This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

GeneCards Summary for ALG14 Gene

ALG14 (ALG14, UDP-N-Acetylglucosaminyltransferase Subunit) is a Protein Coding gene. Diseases associated with ALG14 include Myasthenic Syndrome, Congenital, 15, Without Tubular Aggregates and Congenital Myasthenic Syndromes With Glycosylation Defect. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism.

UniProtKB/Swiss-Prot for ALG14 Gene

  • May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER.

Gene Wiki entry for ALG14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG14 Gene

Genomics for ALG14 Gene

Regulatory Elements for ALG14 Gene

Enhancers for ALG14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALG14 on UCSC Golden Path with GeneCards custom track

Promoters for ALG14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALG14 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALG14 Gene

94,974,407 bp from pter
95,072,964 bp from pter
98,558 bases
Minus strand

Genomic View for ALG14 Gene

Genes around ALG14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALG14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALG14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG14 Gene

Proteins for ALG14 Gene

  • Protein details for ALG14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-N-acetylglucosamine transferase subunit ALG14 homolog
    Protein Accession:
    Secondary Accessions:
    • A8K030

    Protein attributes for ALG14 Gene

    216 amino acids
    Molecular mass:
    24151 Da
    Quaternary structure:
    • Heterodimer with ALG13 isoform 2 to form a functional enzyme.

neXtProt entry for ALG14 Gene

Proteomics data for ALG14 Gene at MOPED

Post-translational modifications for ALG14 Gene

  • Ubiquitination at Lys 99
  • Modification sites at PhosphoSitePlus

Other Protein References for ALG14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ALG14 Gene

Domains & Families for ALG14 Gene

Gene Families for ALG14 Gene

Protein Domains for ALG14 Gene

Suggested Antigen Peptide Sequences for ALG14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ALG14 family.
  • Belongs to the ALG14 family.
genes like me logo Genes that share domains with ALG14: view

Function for ALG14 Gene

Molecular function for ALG14 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER.
genes like me logo Genes that share phenotypes with ALG14: view

Human Phenotype Ontology for ALG14 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for ALG14 Gene

miRTarBase miRNAs that target ALG14

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ALG14 Gene

Localization for ALG14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG14 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ALG14 Gene COMPARTMENTS Subcellular localization image for ALG14 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
plasma membrane 3
cytosol 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ALG14 Gene

Pathways & Interactions for ALG14 Gene

genes like me logo Genes that share pathways with ALG14: view

Interacting Proteins for ALG14 Gene

Gene Ontology (GO) - Biological Process for ALG14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ALG14: view

No data available for SIGNOR curated interactions for ALG14 Gene

Drugs & Compounds for ALG14 Gene

No Compound Related Data Available

Transcripts for ALG14 Gene

Unigene Clusters for ALG14 Gene

ALG14, UDP-N-acetylglucosaminyltransferase subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALG14 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - - -

Relevant External Links for ALG14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALG14 Gene

mRNA expression in normal human tissues for ALG14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ALG14 Gene

This gene is overexpressed in Nasal epithelium (66.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALG14 Gene

SOURCE GeneReport for Unigene cluster for ALG14 Gene Hs.408927

genes like me logo Genes that share expression patterns with ALG14: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ALG14 Gene

Orthologs for ALG14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG14 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ALG14 35
  • 89.53 (n)
  • 89.53 (a)
ALG14 36
  • 88 (a)
(Mus musculus)
Mammalia Alg14 35
  • 81.33 (n)
  • 79.5 (a)
Alg14 16
Alg14 36
  • 76 (a)
(Pan troglodytes)
Mammalia ALG14 35
  • 98.3 (n)
  • 97.67 (a)
ALG14 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Alg14 35
  • 81.33 (n)
  • 80.09 (a)
(Bos Taurus)
Mammalia ALG14 36
  • 80 (a)
(Monodelphis domestica)
Mammalia ALG14 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia ALG14 36
  • 81 (a)
(Gallus gallus)
Aves ALG14 35
  • 74.01 (n)
  • 72.88 (a)
ALG14 36
  • 61 (a)
(Anolis carolinensis)
Reptilia ALG14 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia alg14 35
  • 67.69 (n)
  • 67.86 (a)
(Danio rerio)
Actinopterygii alg14 35
  • 62.93 (n)
  • 63.78 (a)
alg14 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003461 35
  • 52.15 (n)
  • 49.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6308 35
  • 48.21 (n)
  • 47.62 (a)
CG6308 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea hpo-16 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG14 36
  • 30 (a)
ALG14 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18230 35
  • 52.05 (n)
  • 47.59 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alg14 35
  • 51.3 (n)
  • 49.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for ALG14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALG14 Gene

Gene Tree for ALG14 (if available)
Gene Tree for ALG14 (if available)

Paralogs for ALG14 Gene

No data available for Paralogs for ALG14 Gene

Variants for ALG14 Gene

Sequence variations from dbSNP and Humsavar for ALG14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11165298 - 95,072,859(+) CGCCA(C/G/T)AGCTC nc-transcript-variant, reference, missense
VAR_073331 Myasthenic syndrome, congenital, 15 (CMS15)
rs1122028 -- 94,994,712(+) GCTGA(C/G)GCCTG intron-variant
rs1342888 -- 95,015,624(-) AAACC(C/T)GCCCC intron-variant
rs1557176 -- 94,986,521(+) aggct(A/G)tagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALG14 Gene

Variant ID Type Subtype PubMed ID
nsv830636 CNV Loss 17160897
esv993631 CNV Insertion 20482838
esv1116942 CNV Insertion 17803354
esv5799 CNV Loss 19470904
esv2670670 CNV Deletion 23128226
nsv498675 CNV Loss 21111241
dgv57n67 CNV Loss 20364138
nsv513994 CNV Loss 21397061

Variation tolerance for ALG14 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALG14 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG14 Gene

Disorders for ALG14 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ALG14 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ALG14 in MalaCards View complete list of genes associated with diseases


  • Myasthenic syndrome, congenital, 15 (CMS15) [MIM:616227]: A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. {ECO:0000269 PubMed:23404334}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ALG14

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ALG14: view

No data available for Genatlas for ALG14 Gene

Publications for ALG14 Gene

  1. Congenital myasthenic syndromes due to mutations in ALG2 and ALG14. (PMID: 23404334) Cossins J. … Beeson D. (Brain 2013) 3 4 67
  2. Two proteins homologous to the N- and C-terminal domains of the bacterial glycosyltransferase Murg are required for the second step of dolichyl-linked oligosaccharide synthesis in Saccharomyces cerevisiae. (PMID: 15615718) Chantret I. … Moore S.E. (J. Biol. Chem. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3
  5. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3

Products for ALG14 Gene

Sources for ALG14 Gene