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Aliases for ELF2 Gene

Aliases for ELF2 Gene

  • E74 Like ETS Transcription Factor 2 2 3 5
  • E74-Like Factor 2 (Ets Domain Transcription Factor) 2 3
  • NERF 3 4
  • ETS-Related Transcription Factor Elf-2 3
  • Ets Family Transcription Factor ELF2C 3
  • New Ets-Related Factor 3
  • New ETS-Related Factor 4
  • E74-Like Factor 2 4
  • NERF-1a,B 3
  • NERF-1A 3
  • NERF-1B 3
  • NERF-2 3
  • EU32 3

External Ids for ELF2 Gene

Previous GeneCards Identifiers for ELF2 Gene

  • GC04M140884
  • GC04M140278
  • GC04M140445
  • GC04M140556
  • GC04M140336
  • GC04M140198
  • GC04M139978
  • GC04M135708

Summaries for ELF2 Gene

GeneCards Summary for ELF2 Gene

ELF2 (E74 Like ETS Transcription Factor 2) is a Protein Coding gene. Diseases associated with ELF2 include Carpal Tunnel Syndrome, Familial and Nerve Compression Syndrome. Among its related pathways are Immune response IL-23 signaling pathway and ADP signalling through P2Y purinoceptor 12. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ELF1.

UniProtKB/Swiss-Prot for ELF2 Gene

  • Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.

  • Isoform 2 may function in repression of RUNX1-mediated transactivation.

Gene Wiki entry for ELF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELF2 Gene

Genomics for ELF2 Gene

Regulatory Elements for ELF2 Gene

Enhancers for ELF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G139081 1.6 FANTOM5 ENCODE 28.8 +93.5 93472 4.4 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF548 SP3 NFYC TBX21 ELF2 NAA15 NOCT LOC105377448 MGARP RAB33B H3F3AP6 GC04P139099 RNU6-531P
GH04G139175 1.7 FANTOM5 ENCODE dbSUPER 17.3 -0.1 -146 3.8 PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ELF2 NOCT NDUFC1 RAB33B GC04P139186
GH04G139207 1.4 Ensembl ENCODE dbSUPER 17.4 -31.2 -31156 2.3 ATF1 BMI1 RFX5 ZNF766 ZNF366 FOS IKZF2 CREM ZNF362 CAVIN1 ELF2 RNU6-1074P MGARP GC04P139211 ENSG00000207384
GH04G139151 1.2 ENCODE dbSUPER 17.9 +23.3 23274 4.1 FOXA2 ATF1 TCF12 ZNF121 ZNF766 GATA2 NCOA1 REST SMARCA4 PBX2 ELF2 RNU6-1074P MGARP NOCT LOC105377448 ENSG00000276396 PPP1R14BP3
GH04G139213 1.5 Ensembl ENCODE dbSUPER 12.2 -37.1 -37117 1.6 PKNOX1 ATF1 SIN3A ZNF766 GATA2 GTF2B NCOA1 PPARG ZNF518A ZNF592 RNU6-1074P ELF2 MGARP MAML3 RAB33B GC04P139211 RNU6-506P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELF2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ELF2 gene promoter:

Genomic Location for ELF2 Gene

Chromosome:
4
Start:
139,028,112 bp from pter
End:
139,177,218 bp from pter
Size:
149,107 bases
Orientation:
Minus strand

Genomic View for ELF2 Gene

Genes around ELF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELF2 Gene

Proteins for ELF2 Gene

  • Protein details for ELF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15723-ELF2_HUMAN
    Recommended name:
    ETS-related transcription factor Elf-2
    Protein Accession:
    Q15723
    Secondary Accessions:
    • E9PCX3
    • Q15724
    • Q15725
    • Q6P1K5

    Protein attributes for ELF2 Gene

    Size:
    593 amino acids
    Molecular mass:
    63967 Da
    Quaternary structure:
    • Interacts with the LIM domains of LMO2 (By similarity). Interacts via its N-terminal region with RUNX1.
    SequenceCaution:
    • Sequence=AAH65025.1; Type=Frameshift; Positions=541; Evidence={ECO:0000305};

    Alternative splice isoforms for ELF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELF2 Gene

Post-translational modifications for ELF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ELF2 Gene

Domains & Families for ELF2 Gene

Gene Families for ELF2 Gene

Protein Domains for ELF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15723

UniProtKB/Swiss-Prot:

ELF2_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELF2: view

Function for ELF2 Gene

Molecular function for ELF2 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.
UniProtKB/Swiss-Prot Function:
Isoform 2 may function in repression of RUNX1-mediated transactivation.

Gene Ontology (GO) - Molecular Function for ELF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 14970218
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ELF2: view
genes like me logo Genes that share phenotypes with ELF2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELF2 Gene

Localization for ELF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELF2 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for ELF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IC 14970218
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with ELF2: view

Pathways & Interactions for ELF2 Gene

genes like me logo Genes that share pathways with ELF2: view

Pathways by source for ELF2 Gene

1 BioSystems pathway for ELF2 Gene
1 PharmGKB pathway for ELF2 Gene
1 GeneGo (Thomson Reuters) pathway for ELF2 Gene

Interacting Proteins for ELF2 Gene

Gene Ontology (GO) - Biological Process for ELF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 8756667
GO:0030154 cell differentiation IBA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 8756667
genes like me logo Genes that share ontologies with ELF2: view

No data available for SIGNOR curated interactions for ELF2 Gene

Transcripts for ELF2 Gene

Unigene Clusters for ELF2 Gene

E74-like factor 2 (ets domain transcription factor):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1:
SP2: - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for ELF2 Gene

GeneLoc Exon Structure for
ELF2
ECgene alternative splicing isoforms for
ELF2

Expression for ELF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELF2 Gene

Protein differential expression in normal tissues from HIPED for ELF2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (48.2) and Heart (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ELF2 Gene



Protein tissue co-expression partners for ELF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ELF2 Gene:

ELF2

SOURCE GeneReport for Unigene cluster for ELF2 Gene:

Hs.634040

mRNA Expression by UniProt/SwissProt for ELF2 Gene:

Q15723-ELF2_HUMAN
Tissue specificity: Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung, skeletal muscle, spleen, thymus, testis and ovary. Moderate expression in prostate, small intestine, kidney, liver and pancreas, and weak expression in colon, brain and peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for ELF2 Gene

  • Liver(4.2)
  • Nervous system(2.5)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ELF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELF2 Gene

Orthologs for ELF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELF2 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia ELF2 34 35
  • 94.76 (n)
cow
(Bos Taurus)
Mammalia ELF2 34 35
  • 94.66 (n)
rat
(Rattus norvegicus)
Mammalia Elf2 34
  • 89.69 (n)
mouse
(Mus musculus)
Mammalia Elf2 34 16 35
  • 88.54 (n)
oppossum
(Monodelphis domestica)
Mammalia ELF2 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELF2 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELF2 35 34
  • 80.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELF2 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17593 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19357 34
zebrafish
(Danio rerio)
Actinopterygii elf2b 34 35
  • 61.61 (n)
elf2a 35
  • 49 (a)
OneToMany
elf2 34
fruit fly
(Drosophila melanogaster)
Insecta Eip74EF 36
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea C24A1.2 36
  • 56 (a)
ets-8 35
  • 34 (a)
ManyToMany
elf-1 35
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for ELF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELF2 Gene

ENSEMBL:
Gene Tree for ELF2 (if available)
TreeFam:
Gene Tree for ELF2 (if available)

Paralogs for ELF2 Gene

Paralogs for ELF2 Gene

(8) SIMAP similar genes for ELF2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ELF2 Gene

genes like me logo Genes that share paralogs with ELF2: view

Variants for ELF2 Gene

Sequence variations from dbSNP and Humsavar for ELF2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000005012 -- 139,168,788(+) GTCTC(A/C)AACTC intron-variant
rs1000005855 -- 139,124,130(+) GCCCC(A/G)GTCTC intron-variant
rs1000022125 -- 139,072,550(+) TTACA(A/G)ACAAG intron-variant
rs10001095 -- 139,152,885(+) ATAGT(C/G)TCATA intron-variant
rs1000128786 -- 139,075,652(+) TTGAA(C/G)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELF2 Gene

Variant ID Type Subtype PubMed ID
esv275286 CNV gain+loss 21479260
nsv1020743 CNV loss 25217958
nsv1028153 CNV loss 25217958
nsv1131828 CNV deletion 24896259
nsv964098 CNV duplication 23825009
nsv980260 CNV duplication 23825009

Variation tolerance for ELF2 Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELF2 Gene

Disorders for ELF2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ELF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
carpal tunnel syndrome, familial
  • carpal tunnel syndrome
nerve compression syndrome
  • compression neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search ELF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ELF2

Genetic Association Database (GAD)
ELF2
Human Genome Epidemiology (HuGE) Navigator
ELF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELF2
genes like me logo Genes that share disorders with ELF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELF2 Gene

Publications for ELF2 Gene

  1. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. (PMID: 8756667) Oettgen P. … Libermann T.A. (Mol. Cell. Biol. 1996) 2 3 4 22 64
  2. Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. (PMID: 14970218) Cho J.-Y. … Libermann T.A. (J. Biol. Chem. 2004) 3 4 22 64
  3. E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth. (PMID: 18544453) Qiu Y. … Aozasa K. (Exp. Mol. Pathol. 2008) 3 22 64
  4. E74-like factor 2 regulates valosin-containing protein expression. (PMID: 17368566) Zhang B. … Aozasa K. (Biochem. Biophys. Res. Commun. 2007) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ELF2 Gene

Sources for ELF2 Gene

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