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Aliases for ELAVL4 Gene

Aliases for ELAVL4 Gene

  • ELAV Like Neuron-Specific RNA Binding Protein 4 2 3 5
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D) 2 3
  • Paraneoplastic Encephalomyelitis Antigen HuD 3 4
  • Hu Antigen D 2 3
  • PNEM 3 4
  • HUD 3 4
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 2
  • Hu-Antigen D 4

External Ids for ELAVL4 Gene

Previous HGNC Symbols for ELAVL4 Gene

  • HUD

Previous GeneCards Identifiers for ELAVL4 Gene

  • GC01P050199
  • GC01P049460
  • GC01P049928
  • GC01P049941
  • GC01P050283
  • GC01P050347
  • GC01P050513
  • GC01P048632

Summaries for ELAVL4 Gene

GeneCards Summary for ELAVL4 Gene

ELAVL4 (ELAV Like Neuron-Specific RNA Binding Protein 4) is a Protein Coding gene. Diseases associated with ELAVL4 include hallucinogen abuse and paraneoplastic neurologic disorders. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC1L2A.

UniProtKB/Swiss-Prot for ELAVL4 Gene

  • May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.

Gene Wiki entry for ELAVL4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL4 Gene

Genomics for ELAVL4 Gene

Regulatory Elements for ELAVL4 Gene

Enhancers for ELAVL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ELAVL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELAVL4 Gene

Chromosome:
1
Start:
50,048,014 bp from pter
End:
50,203,786 bp from pter
Size:
155,773 bases
Orientation:
Plus strand

Genomic View for ELAVL4 Gene

Genes around ELAVL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAVL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAVL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL4 Gene

Proteins for ELAVL4 Gene

  • Protein details for ELAVL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26378-ELAV4_HUMAN
    Recommended name:
    ELAV-like protein 4
    Protein Accession:
    P26378
    Secondary Accessions:
    • B1APY6
    • B1APY7
    • B7Z4G7
    • Q8IYD4
    • Q96J74
    • Q96J75
    • Q9UD24

    Protein attributes for ELAVL4 Gene

    Size:
    380 amino acids
    Molecular mass:
    41770 Da
    Quaternary structure:
    • Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP.

    Three dimensional structures from OCA and Proteopedia for ELAVL4 Gene

    Alternative splice isoforms for ELAVL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELAVL4 Gene

Proteomics data for ELAVL4 Gene at MOPED

Post-translational modifications for ELAVL4 Gene

  • Methylation at Arg-243 by CARM1 weakens protective binding to the 3-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ELAVL4 Gene

Domains & Families for ELAVL4 Gene

Gene Families for ELAVL4 Gene

Graphical View of Domain Structure for InterPro Entry

P26378

UniProtKB/Swiss-Prot:

ELAV4_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the RRM elav family.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL4: view

Function for ELAVL4 Gene

Molecular function for ELAVL4 Gene

GENATLAS Biochemistry:
Drosophila Elav-like 4 (embryonic,lethal,abnormal vision),neural specific,expressed in brain,identified using sera from patients with a paraplastic multifocal neurologic disorder,homologous to HD,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded
UniProtKB/Swiss-Prot Function:
May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.

Gene Ontology (GO) - Molecular Function for ELAVL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,TAS 1655278
GO:0017091 AU-rich element binding IDA 10710437
genes like me logo Genes that share ontologies with ELAVL4: view
genes like me logo Genes that share phenotypes with ELAVL4: view

Animal Models for ELAVL4 Gene

MGI Knock Outs for ELAVL4:

Animal Model Products

CRISPR Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELAVL4 Gene

Localization for ELAVL4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELAVL4 Gene COMPARTMENTS Subcellular localization image for ELAVL4 gene
Compartment Confidence
nucleus 4
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ELAVL4 Gene

Pathways & Interactions for ELAVL4 Gene

SuperPathways for ELAVL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELAVL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing TAS 10348344
GO:0007612 learning IEA --
genes like me logo Genes that share ontologies with ELAVL4: view

No data available for Pathways by source and SIGNOR curated interactions for ELAVL4 Gene

Drugs & Compounds for ELAVL4 Gene

(2) Additional Compounds for ELAVL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELAVL4: view

Transcripts for ELAVL4 Gene

Unigene Clusters for ELAVL4 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: -
SP7: - -
SP8:
SP9: - - -
SP10:

Relevant External Links for ELAVL4 Gene

GeneLoc Exon Structure for
ELAVL4
ECgene alternative splicing isoforms for
ELAVL4

Expression for ELAVL4 Gene

mRNA expression in normal human tissues for ELAVL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELAVL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x11.3), Brain - Anterior cingulate cortex (BA24) (x8.6), Brain - Cortex (x6.5), Brain - Hypothalamus (x5.2), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for ELAVL4 Gene

This gene is overexpressed in Brain (39.1) and Fetal Brain (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ELAVL4 Gene



SOURCE GeneReport for Unigene cluster for ELAVL4 Gene Hs.213050

mRNA Expression by UniProt/SwissProt for ELAVL4 Gene

P26378-ELAV4_HUMAN
Tissue specificity: Brain.
genes like me logo Genes that share expression patterns with ELAVL4: view

Protein tissue co-expression partners for ELAVL4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ELAVL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ELAVL4 35
  • 96.36 (n)
  • 99.73 (a)
ELAVL4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELAVL4 35
  • 95.35 (n)
  • 98.68 (a)
ELAVL4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elavl4 35
  • 94.08 (n)
  • 99.18 (a)
Elavl4 16
Elavl4 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELAVL4 35
  • 99.36 (n)
  • 99.45 (a)
ELAVL4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elavl4 35
  • 94.91 (n)
  • 99.73 (a)
oppossum
(Monodelphis domestica)
Mammalia ELAVL4 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELAVL4 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELAVL4 35
  • 87.7 (n)
  • 97.81 (a)
ELAVL4 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELAVL4 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl4 35
  • 84.88 (n)
  • 98.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia elrD 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
elavl4 35
  • 82.23 (n)
  • 95.88 (a)
elavl4 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5213 37
  • 37 (a)
EG:132E8.1 37
  • 43 (a)
elav 37
  • 52 (a)
fne 37
  • 57 (a)
Sxl 37
  • 46 (a)
Rbp9 35
  • 62.2 (n)
  • 65.01 (a)
elav 36
  • 40 (a)
ManyToMany
fne 36
  • 59 (a)
ManyToMany
Rbp9 36
  • 50 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea exc-7 37
  • 65 (a)
exc-7 35
  • 54.05 (n)
  • 57.73 (a)
exc-7 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 36
  • 55 (a)
OneToMany
Species with no ortholog for ELAVL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL4 Gene

ENSEMBL:
Gene Tree for ELAVL4 (if available)
TreeFam:
Gene Tree for ELAVL4 (if available)

Paralogs for ELAVL4 Gene

(7) SIMAP similar genes for ELAVL4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ELAVL4: view

Variants for ELAVL4 Gene

Sequence variations from dbSNP and Humsavar for ELAVL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2494876 - 50,200,843(+) CTTGT(C/T)CCCCC intron-variant, reference, missense
rs17853533 - 50,193,907(+) GGTTG(A/G)TCAAG reference, missense
rs17853531 - 50,201,101(+) CCATC(A/G)CCAGC reference, missense
rs967582 -- 50,116,500(-) TACTT(G/T)AGAAG intron-variant
rs967583 -- 50,116,417(-) CACAC(A/G)CACGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL4 Gene

Variant ID Type Subtype PubMed ID
nsv810 CNV Loss 18451855
esv2665070 CNV Deletion 23128226
nsv498670 CNV Loss 21111241
nsv829826 CNV Gain 17160897

Variation tolerance for ELAVL4 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELAVL4 Gene

HapMap Linkage Disequilibrium report
ELAVL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL4 Gene

Disorders for ELAVL4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ELAVL4 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ELAVL4

Genetic Association Database (GAD)
ELAVL4
Human Genome Epidemiology (HuGE) Navigator
ELAVL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELAVL4
genes like me logo Genes that share disorders with ELAVL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAVL4 Gene

Publications for ELAVL4 Gene

  1. CARM1 regulates proliferation of PC12 cells by methylating HuD. (PMID: 16508003) Fujiwara T. … Tohyama M. (Mol. Cell. Biol. 2006) 3 4 23 67
  2. Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34. (PMID: 8222755) Muresu R. … Siniscalco M. (Cytogenet. Cell Genet. 1994) 2 3 23
  3. Molecular analysis of the HuD gene in neuroendocrine lung cancers. (PMID: 19410329) D'Alessandro V. … Vendemiale G. (Lung Cancer 2010) 3 23
  4. Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. (PMID: 18218628) Ratti A. … Silani V. (J. Biol. Chem. 2008) 3 23
  5. Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD. (PMID: 18493953) Tanner D.C. … Perrone-Bizzozero N.I. (Hippocampus 2008) 3 23

Products for ELAVL4 Gene

Sources for ELAVL4 Gene

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