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Aliases for ELAVL3 Gene

Aliases for ELAVL3 Gene

  • ELAV Like Neuron-Specific RNA Binding Protein 3 2 3
  • Paraneoplastic Cerebellar Degeneration-Associated Antigen 2 3 4
  • Paraneoplastic Limbic Encephalitis Antigen 21 2 3 4
  • PLE21 3 4 6
  • HUC 3 4 6
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 3 (Hu Antigen C) 2 3
  • ELAV-Like Protein 3 2 3
  • Hu Antigen C 2 3
  • Hu-Antigen C 3 4
  • HUCL 3

External Ids for ELAVL3 Gene

Previous GeneCards Identifiers for ELAVL3 Gene

  • GC19M011694
  • GC19M011786
  • GC19M011409
  • GC19M011425
  • GC19M011562
  • GC19M011140

Summaries for ELAVL3 Gene

Entrez Gene Summary for ELAVL3 Gene

  • A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELAVL3 Gene

ELAVL3 (ELAV Like Neuron-Specific RNA Binding Protein 3) is a Protein Coding gene. Diseases associated with ELAVL3 include encephalitis and limbic encephalitis. GO annotations related to this gene include nucleotide binding and AU-rich element binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for ELAVL3 Gene

  • Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.

Gene Wiki entry for ELAVL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL3 Gene

Genomics for ELAVL3 Gene

Regulatory Elements for ELAVL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ELAVL3 Gene

11,451,326 bp from pter
11,481,046 bp from pter
29,721 bases
Minus strand

Genomic View for ELAVL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELAVL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL3 Gene

Proteins for ELAVL3 Gene

  • Protein details for ELAVL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ELAV-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q16135
    • Q96CL8
    • Q96QS9

    Protein attributes for ELAVL3 Gene

    367 amino acids
    Molecular mass:
    39547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ELAVL3 Gene


neXtProt entry for ELAVL3 Gene

Proteomics data for ELAVL3 Gene at MOPED

Post-translational modifications for ELAVL3 Gene

  • Ubiquitination at Lys111
  • Modification sites at PhosphoSitePlus

Other Protein References for ELAVL3 Gene

Antibody Products

No data available for DME Specific Peptides for ELAVL3 Gene

Domains for ELAVL3 Gene

Gene Families for ELAVL3 Gene

  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for ELAVL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q14576
  • RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).
  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL3: view

Function for ELAVL3 Gene

Molecular function for ELAVL3 Gene

GENATLAS Biochemistry:
Drosophila Elav-like 3 (embryonic,lethal,abnormal vision),onconeural specific,expressed at an early stage of neural development,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded,required for neuronal differentiation in the mammalian nervous system
UniProtKB/Swiss-Prot Function:
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.

Gene Ontology (GO) - Molecular Function for ELAVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0017091 AU-rich element binding IDA 10710437
genes like me logo Genes that share ontologies with ELAVL3: view

Phenotypes for ELAVL3 Gene

genes like me logo Genes that share phenotypes with ELAVL3: view

Animal Models for ELAVL3 Gene

MGI Knock Outs for ELAVL3:

Animal Model Products

CRISPR Products

miRNA for ELAVL3 Gene

miRTarBase miRNAs that target ELAVL3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELAVL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ELAVL3 Gene

Localization for ELAVL3 Gene

Subcellular locations from

Jensen Localization Image for ELAVL3 Gene COMPARTMENTS Subcellular localization image for ELAVL3 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ELAVL3 Gene

Pathways for ELAVL3 Gene

SuperPathways for ELAVL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELAVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ELAVL3: view

No data available for Pathways by source for ELAVL3 Gene

Transcripts for ELAVL3 Gene

Unigene Clusters for ELAVL3 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELAVL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL3 Gene

No ASD Table

Relevant External Links for ELAVL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ELAVL3 Gene

mRNA expression in normal human tissues for ELAVL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELAVL3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.7), Brain - Cerebellum (7.6), and Brain - Spinal cord (cervical c-1) (4.6).

Protein differential expression in normal tissues for ELAVL3 Gene

This gene is overexpressed in Fetal Brain (44.0) and Brain (18.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ELAVL3 Gene

SOURCE GeneReport for Unigene cluster for ELAVL3 Gene Hs.1701

mRNA Expression by UniProt/SwissProt for ELAVL3 Gene

Tissue specificity: Brain specific
genes like me logo Genes that share expressions with ELAVL3: view

Expression partners for ELAVL3 Gene

In Situ Assay Products

Orthologs for ELAVL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ELAVL3 35
  • 93.08 (n)
  • 99.42 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ELAVL3 35
  • 93.98 (n)
  • 99.72 (a)
  • 100 (a)
(Mus musculus)
Mammalia Elavl3 35
  • 91.76 (n)
  • 99.44 (a)
Elavl3 16
Elavl3 36
  • 99 (a)
(Pan troglodytes)
Mammalia ELAVL3 35
  • 95.87 (n)
  • 93.96 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Elavl3 35
  • 91.57 (n)
  • 99.44 (a)
(Monodelphis domestica)
Mammalia ELAVL3 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia ELAVL3 36
  • 91 (a)
(Anolis carolinensis)
Reptilia ELAVL3 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl3 35
  • 76.41 (n)
  • 88.89 (a)
Str.10863 35
(Danio rerio)
Actinopterygii elavl3 35
  • 80.87 (n)
  • 89.57 (a)
elavl3 36
  • 90 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8000 35
fruit fly
(Drosophila melanogaster)
Insecta CG5213 37
  • 34 (a)
EG:132E8.1 37
  • 49 (a)
elav 37
  • 52 (a)
fne 37
  • 57 (a)
Sxl 37
  • 45 (a)
elav 36
  • 40 (a)
fne 36
  • 59 (a)
Rbp9 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea exc-7 37
  • 63 (a)
exc-7 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 36
  • 52 (a)
Species with no ortholog for ELAVL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL3 Gene

Gene Tree for ELAVL3 (if available)
Gene Tree for ELAVL3 (if available)

Paralogs for ELAVL3 Gene

Selected SIMAP similar genes for ELAVL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ELAVL3: view

Variants for ELAVL3 Gene

Sequence variations from dbSNP and Humsavar for ELAVL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs167480 -- 11,468,675(-) gctga(A/G)gcagg intron-variant
rs167516 -- 11,453,390(-) CAGAC(A/C)CTGCC utr-variant-3-prime, intron-variant
rs170172 -- 11,463,146(-) CTGTG(C/T)CTCAG intron-variant
rs170173 -- 11,463,128(-) TGGAC(C/G)TCCAA intron-variant
rs188723 -- 11,468,027(-) ggatc(A/G)ccaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL3 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV Loss 19592680
nsv911062 CNV Loss 21882294
dgv3731n71 CNV Loss 21882294
nsv911065 CNV Loss 21882294
nsv819522 CNV Loss 19587683
nsv819321 CNV Gain 19587683
nsv911066 CNV Loss 21882294

Relevant External Links for ELAVL3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL3 Gene

Disorders for ELAVL3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ELAVL3 Gene in MalaCards »

(2) Diseases for ELAVL3 Gene including...

(1) University of Copenhagen DISEASES for ELAVL3 Gene

(4) Novoseek inferred disease relationships for ELAVL3 Gene

Disease -log(P) Hits PubMed IDs
paraneoplastic encephalomyelitis 93.4 3
sensory neuropathy 67.9 1
small cell lung cancer 52.7 1
cancer lung 40.9 1
genes like me logo Genes that share disorders with ELAVL3: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for ELAVL3 Gene

Publications for ELAVL3 Gene

  1. A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma. (PMID: 7511893) Sakai K. … Steinman L. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  2. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'- untranslated regions using a novel ELISA-based assay. (PMID: 10710437) King P.H. (Nucleic Acids Res. 2000) 3 4 23
  3. Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique. (PMID: 9799595) Van Tine B.A. … King P.H. (Genomics 1998) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PMID: 12209604) Behrends U. … Mautner J.M. (Int. J. Cancer 2002) 3 23

Products for ELAVL3 Gene

Sources for ELAVL3 Gene

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