Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ELAVL3 Gene

Aliases for ELAVL3 Gene

  • ELAV Like Neuron-Specific RNA Binding Protein 3 2 3 5
  • Paraneoplastic Cerebellar Degeneration-Associated Antigen 2 3 4
  • Paraneoplastic Limbic Encephalitis Antigen 21 2 3 4
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 3 (Hu Antigen C) 2 3
  • Hu Antigen C 2 3
  • Hu-Antigen C 3 4
  • PLE21 3 4
  • HUC 3 4
  • ELAV-Like Protein 3 2
  • HUCL 3

External Ids for ELAVL3 Gene

Previous GeneCards Identifiers for ELAVL3 Gene

  • GC19M011694
  • GC19M011786
  • GC19M011409
  • GC19M011425
  • GC19M011562
  • GC19M011140

Summaries for ELAVL3 Gene

Entrez Gene Summary for ELAVL3 Gene

  • A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELAVL3 Gene

ELAVL3 (ELAV Like Neuron-Specific RNA Binding Protein 3) is a Protein Coding gene. Diseases associated with ELAVL3 include Paraneoplastic Cerebellar Degeneration and Limbic Encephalitis. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC1L2A.

UniProtKB/Swiss-Prot for ELAVL3 Gene

  • Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.

Gene Wiki entry for ELAVL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL3 Gene

Genomics for ELAVL3 Gene

Regulatory Elements for ELAVL3 Gene

Enhancers for ELAVL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ELAVL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELAVL3 Gene

11,451,326 bp from pter
11,481,046 bp from pter
29,721 bases
Minus strand

Genomic View for ELAVL3 Gene

Genes around ELAVL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAVL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAVL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL3 Gene

Proteins for ELAVL3 Gene

  • Protein details for ELAVL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ELAV-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q16135
    • Q96CL8
    • Q96QS9

    Protein attributes for ELAVL3 Gene

    367 amino acids
    Molecular mass:
    39547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ELAVL3 Gene


neXtProt entry for ELAVL3 Gene

Proteomics data for ELAVL3 Gene at MOPED

Post-translational modifications for ELAVL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELAVL3 Gene

No data available for DME Specific Peptides for ELAVL3 Gene

Domains & Families for ELAVL3 Gene

Gene Families for ELAVL3 Gene

Suggested Antigen Peptide Sequences for ELAVL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).
  • Belongs to the RRM elav family.
  • RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).
  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL3: view

Function for ELAVL3 Gene

Molecular function for ELAVL3 Gene

GENATLAS Biochemistry:
Drosophila Elav-like 3 (embryonic,lethal,abnormal vision),onconeural specific,expressed at an early stage of neural development,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded,required for neuronal differentiation in the mammalian nervous system
UniProtKB/Swiss-Prot Function:
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.

Gene Ontology (GO) - Molecular Function for ELAVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0017091 AU-rich element binding IDA 10710437
genes like me logo Genes that share ontologies with ELAVL3: view
genes like me logo Genes that share phenotypes with ELAVL3: view

Animal Models for ELAVL3 Gene

MGI Knock Outs for ELAVL3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELAVL3 Gene

Localization for ELAVL3 Gene

Subcellular locations from

Jensen Localization Image for ELAVL3 Gene COMPARTMENTS Subcellular localization image for ELAVL3 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ELAVL3 Gene

Pathways & Interactions for ELAVL3 Gene

SuperPathways for ELAVL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELAVL3 Gene


No data available for Pathways by source and SIGNOR curated interactions for ELAVL3 Gene

Drugs & Compounds for ELAVL3 Gene

No Compound Related Data Available

Transcripts for ELAVL3 Gene

Unigene Clusters for ELAVL3 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL3 Gene

No ASD Table

Relevant External Links for ELAVL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ELAVL3 Gene

mRNA expression in normal human tissues for ELAVL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELAVL3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.7), Brain - Cerebellum (x7.6), and Brain - Spinal cord (cervical c-1) (x4.6).

Protein differential expression in normal tissues from HIPED for ELAVL3 Gene

This gene is overexpressed in Fetal Brain (44.0) and Brain (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ELAVL3 Gene

SOURCE GeneReport for Unigene cluster for ELAVL3 Gene Hs.1701

mRNA Expression by UniProt/SwissProt for ELAVL3 Gene

Tissue specificity: Brain specific.
genes like me logo Genes that share expression patterns with ELAVL3: view

Protein tissue co-expression partners for ELAVL3 Gene

- Elite partner

Primer Products

Orthologs for ELAVL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ELAVL3 35
  • 93.08 (n)
  • 99.42 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ELAVL3 35
  • 93.98 (n)
  • 99.72 (a)
  • 100 (a)
(Mus musculus)
Mammalia Elavl3 35
  • 91.76 (n)
  • 99.44 (a)
Elavl3 16
Elavl3 36
  • 99 (a)
(Pan troglodytes)
Mammalia ELAVL3 35
  • 95.87 (n)
  • 93.96 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Elavl3 35
  • 91.57 (n)
  • 99.44 (a)
(Monodelphis domestica)
Mammalia ELAVL3 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia ELAVL3 36
  • 91 (a)
(Anolis carolinensis)
Reptilia ELAVL3 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl3 35
  • 76.41 (n)
  • 88.89 (a)
Str.10863 35
(Danio rerio)
Actinopterygii elavl3 35
  • 80.87 (n)
  • 89.57 (a)
elavl3 36
  • 90 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8000 35
fruit fly
(Drosophila melanogaster)
Insecta CG5213 37
  • 34 (a)
EG:132E8.1 37
  • 49 (a)
elav 37
  • 52 (a)
fne 37
  • 57 (a)
Sxl 37
  • 45 (a)
elav 36
  • 40 (a)
fne 36
  • 59 (a)
Rbp9 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea exc-7 37
  • 63 (a)
exc-7 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 36
  • 52 (a)
Species with no ortholog for ELAVL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL3 Gene

Gene Tree for ELAVL3 (if available)
Gene Tree for ELAVL3 (if available)

Paralogs for ELAVL3 Gene

(4) SIMAP similar genes for ELAVL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ELAVL3: view

Variants for ELAVL3 Gene

Sequence variations from dbSNP and Humsavar for ELAVL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7257898 -- 11,469,791(+) agtga(C/T)ttacg intron-variant
rs7259600 -- 11,473,041(+) cagcc(C/T)gggtg intron-variant
rs12983107 -- 11,464,169(+) TATAt(A/T)ttttt intron-variant
rs12985007 -- 11,481,045(+) GCGCT(A/C)TGGAC nc-transcript-variant, upstream-variant-2KB
rs13346717 -- 11,475,811(+) CGTTT(C/T)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL3 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV Loss 19592680
nsv911062 CNV Loss 21882294
dgv3731n71 CNV Loss 21882294
nsv911065 CNV Loss 21882294
nsv819522 CNV Loss 19587683
nsv819321 CNV Gain 19587683
nsv911066 CNV Loss 21882294

Variation tolerance for ELAVL3 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ELAVL3 Gene

Disorders for ELAVL3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ELAVL3 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ELAVL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ELAVL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAVL3 Gene

Publications for ELAVL3 Gene

  1. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'- untranslated regions using a novel ELISA-based assay. (PMID: 10710437) King P.H. (Nucleic Acids Res. 2000) 3 4 23 67
  2. Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PMID: 12209604) Behrends U. … Mautner J.M. (Int. J. Cancer 2002) 3 23
  3. Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique. (PMID: 9799595) Van Tine B.A. … King P.H. (Genomics 1998) 2 3
  4. A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma. (PMID: 7511893) Sakai K. … Steinman L. (Biochem. Biophys. Res. Commun. 1994) 3 23
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for ELAVL3 Gene

Sources for ELAVL3 Gene