Aliases for AIF1 Gene
External Ids for AIF1 Gene
Previous GeneCards Identifiers for AIF1 Gene
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for AIF1 Gene
AIF1 (Allograft Inflammatory Factor 1) is a Protein Coding gene. Diseases associated with AIF1 include chronic inflammatory demyelinating polyneuropathy and blue color blindness. Among its related pathways are Spinal Cord Injury. GO annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is AIF1L.
UniProtKB/Swiss-Prot for AIF1 Gene
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.