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Aliases for EIF4G1 Gene

Aliases for EIF4G1 Gene

  • Eukaryotic Translation Initiation Factor 4 Gamma, 1 2 3
  • EIF4G 3 4 6
  • EIF-4-Gamma 1 3 4
  • EIF-4G1 3 4
  • PARK18 3 6
  • EIF4GI 3 4
  • EIF4F 3 4
  • P220 3 4
  • Eukaryotic Translation Initiation Factor 4 Gamma 1 3
  • Eucaryotic Translation Initiation Factor 4G 3
  • EIF4-Gamma 3
  • EIF-4G 1 4

External Ids for EIF4G1 Gene

Previous Symbols for EIF4G1 Gene

  • EIF4G
  • EIF4F

Summaries for EIF4G1 Gene

Entrez Gene Summary for EIF4G1 Gene

  • The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

GeneCards Summary for EIF4G1 Gene

EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma, 1) is a Protein Coding gene. Diseases associated with EIF4G1 include parkinson disease 18 and young adult-onset parkinsonism. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include translation initiation factor activity and translation factor activity, RNA binding. An important paralog of this gene is EIF4G2.

UniProtKB/Swiss-Prot for EIF4G1 Gene

  • Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome

Gene Wiki entry for EIF4G1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4G1 Gene

Genomics for EIF4G1 Gene

Genomic Location for EIF4G1 Gene

Start:
184,314,495 bp from pter
End:
184,335,358 bp from pter
Size:
20,864 bases
Orientation:
Plus strand

Genomic View for EIF4G1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF4G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4G1 Gene

Regulatory Elements for EIF4G1 Gene

Transcription factor binding sites by QIAGEN in the EIF4G1 gene promoter:

Proteins for EIF4G1 Gene

  • Protein details for EIF4G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04637-IF4G1_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4 gamma 1
    Protein Accession:
    Q04637
    Secondary Accessions:
    • D3DNT2
    • D3DNT4
    • D3DNT5
    • E9PFM1
    • G5E9S1
    • O43177
    • O95066
    • Q5HYG0
    • Q6ZN21
    • Q8N102

    Protein attributes for EIF4G1 Gene

    Size:
    1599 amino acids
    Molecular mass:
    175491 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. Interacts with RBM4. Interacts with HNRNPD/AUF1; the interaction requires RNA.
    SequenceCaution:
    • Sequence=AAC78444.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC82471.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA02185.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAD18554.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF4G1 Gene

    Alternative splice isoforms for EIF4G1 Gene

neXtProt entry for EIF4G1 Gene

Proteomics data for EIF4G1 Gene at MOPED

Post-translational modifications for EIF4G1 Gene

  • Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
  • Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys580, Lys593, Lys597, Lys602, Lys770, Lys795, Lys832, Lys900, and Lys1059

No data available for DME Specific Peptides for EIF4G1 Gene

Domains for EIF4G1 Gene

Gene Families for EIF4G1 Gene

HGNC:
  • PARK :Parkinson disease

UniProtKB/Swiss-Prot:

IF4G1_HUMAN
Domain:
  • Contains 1 MI domain.:
    • Q04637
  • Contains 1 MIF4G domain.:
    • Q04637
  • Contains 1 W2 domain.:
    • Q04637
Family:
  • Belongs to the eukaryotic initiation factor 4G family.:
    • Q04637
genes like me logo Genes that share domains with EIF4G1: view

Function for EIF4G1 Gene

Molecular function for EIF4G1 Gene

GENATLAS Biochemistry: eukaryotic translation initiation factor 4 gamma 1,p220 (154kDa),complexing with other EIF,involved in the binding of mRNA cap structure to ribosome,also interacting with the poly (A)-binding protein (PABPx) and increasing its RNA binding activity
UniProtKB/Swiss-Prot Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome

Gene Ontology (GO) - Molecular Function for EIF4G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003743 translation initiation factor activity TAS 8961935
GO:0005488 binding --
GO:0005515 protein binding IPI 10523622
GO:0008135 translation factor activity, RNA binding TAS 10880459
genes like me logo Genes that share ontologies with EIF4G1: view

Phenotypes for EIF4G1 Gene

genes like me logo Genes that share phenotypes with EIF4G1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF4G1 Gene

Localization for EIF4G1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4G1 Gene COMPARTMENTS Subcellular localization image for EIF4G1 gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EIF4G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0016281 eukaryotic translation initiation factor 4F complex TAS 9857202
genes like me logo Genes that share ontologies with EIF4G1: view

Pathways for EIF4G1 Gene

SuperPathways for EIF4G1 Gene

Superpath Contained pathways
1 Insulin receptor signalling cascade
2 Influenza Viral RNA Transcription and Replication
3 Interferon Signaling
4 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
5 Translation Insulin regulation of translation
genes like me logo Genes that share pathways with EIF4G1: view

Pathways by source for EIF4G1 Gene

Gene Ontology (GO) - Biological Process for EIF4G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with EIF4G1: view

Compounds for EIF4G1 Gene

(24) Novoseek inferred chemical compound relationships for EIF4G1 Gene

Compound -log(P) Hits PubMed IDs
m7gtp 78.8 3
rapamycin 65.1 10
adenylate 51.4 28
phosphatidylinositol 24.3 3
mg 132 22.5 5
genes like me logo Genes that share compounds with EIF4G1: view

Transcripts for EIF4G1 Gene

Unigene Clusters for EIF4G1 Gene

Eukaryotic translation initiation factor 4 gamma, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4G1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^
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ExUns: 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^
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ExUns: 23a · 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c · 29d ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^
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ExUns: 38a · 38b ^ 39 ^ 40a · 40b · 40c ·
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Relevant External Links for EIF4G1 Gene

GeneLoc Exon Structure for
EIF4G1
ECgene alternative splicing isoforms for
EIF4G1

Expression for EIF4G1 Gene

mRNA expression in normal human tissues for EIF4G1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EIF4G1 Gene

This gene is overexpressed in Muscle - Skeletal (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF4G1 Gene

SOURCE GeneReport for Unigene cluster for EIF4G1 Gene Hs.433750

genes like me logo Genes that share expressions with EIF4G1: view

Orthologs for EIF4G1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF4G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF4G1 36
  • 99.71 (n)
  • 99.69 (a)
EIF4G1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF4G1 36
  • 90.8 (n)
  • 93.73 (a)
EIF4G1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4G1 36
  • 91.64 (n)
  • 93.85 (a)
EIF4G1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4g1 36
  • 88.09 (n)
  • 91.12 (a)
Eif4g1 16
Eif4g1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 78 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4G1 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4g1 36
  • 87.91 (n)
  • 90.91 (a)
chicken
(Gallus gallus)
Aves EIF4G1 36
  • 74.49 (n)
  • 82.65 (a)
EIF4G1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4G1 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4g3 36
  • 64.68 (n)
  • 68.32 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01085054.1 37
  • 54 (a)
OneToMany
Dr.16403 36
EIF4G1 (1 of 3) 37
  • 59 (a)
OneToMany
EIF4G1 (2 of 3) 37
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta eIF4G 37
  • 22 (a)
ManyToMany
eIF4G2 37
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ifg-1 37
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF4631 37
  • 21 (a)
ManyToMany
TIF4632 37
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToMany
Species with no ortholog for EIF4G1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4G1 Gene

ENSEMBL:
Gene Tree for EIF4G1 (if available)
TreeFam:
Gene Tree for EIF4G1 (if available)

Paralogs for EIF4G1 Gene

Paralogs for EIF4G1 Gene

genes like me logo Genes that share paralogs with EIF4G1: view

Variants for EIF4G1 Gene

Sequence variations from dbSNP and Humsavar for EIF4G1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs939317 -- 184,328,011(-) GAAGC(C/T)GGTCA intron-variant
rs1879244 -- 184,328,567(-) GCAAC(A/G)TGGCA intron-variant
rs1881974 -- 184,331,183(-) acaaa(C/T)attta intron-variant
rs1881975 -- 184,328,254(-) ACGCC(C/T)GGCTA intron-variant
rs1965451 -- 184,329,460(-) agaga(C/T)ggggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4G1 Gene

Variant ID Type Subtype PubMed ID
nsv878057 CNV Loss 21882294
nsv878060 CNV Loss 21882294
nsv829813 CNV Loss 17160897
esv2422400 CNV Duplication 17116639

Relevant External Links for EIF4G1 Gene

HapMap Linkage Disequilibrium report
EIF4G1
Human Gene Mutation Database (HGMD)
EIF4G1

Disorders for EIF4G1 Gene

(1) OMIM Diseases for EIF4G1 Gene (600495)

UniProtKB/Swiss-Prot

IF4G1_HUMAN
  • Parkinson disease 18 (PARK18) [MIM:614251]: An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269 PubMed:21907011}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(14) Novoseek inferred disease relationships for EIF4G1 Gene

Disease -log(P) Hits PubMed IDs
foot-and-mouth disease 72.9 9
virus infection 43.3 11
laryngeal carcinoma 15 1
shock 4.95 9
necrosis 4.42 2
genes like me logo Genes that share disorders with EIF4G1: view

Publications for EIF4G1 Gene

  1. Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma. (PMID: 1429670) Yan R. … Rhoads R.E. (J. Biol. Chem. 1992) 2 3 4 23
  2. Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. (PMID: 9372926) Imataka H. … Sonenberg N. (Mol. Cell. Biol. 1997) 2 3 4 23
  3. A novel functional human eukaryotic translation initiation factor 4G. (PMID: 9418880) Gradi A. … Sonenberg N. (Mol. Cell. Biol. 1998) 3 4 23
  4. A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases. (PMID: 8961935) Lamphear B.J. … Rhoads R.E. (Biochemistry 1996) 3 4 23
  5. Mapping the cleavage site in protein synthesis initiation factor eIF- 4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus. (PMID: 8396129) Lamphear B.J. … Rhoads R.E. (J. Biol. Chem. 1993) 3 4 23

Products for EIF4G1 Gene

Sources for EIF4G1 Gene

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