Aliases for EIF4G1 Gene
External Ids for EIF4G1 Gene
Previous Symbols for EIF4G1 Gene
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
GeneCards Summary for EIF4G1 Gene
EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma, 1) is a Protein Coding gene. Diseases associated with EIF4G1 include parkinson disease 18 and young adult-onset parkinsonism. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include translation initiation factor activity and translation factor activity, RNA binding. An important paralog of this gene is EIF4G2.
UniProtKB/Swiss-Prot for EIF4G1 Gene
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure and recruitment of mRNA to the ribosome