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Aliases for EIF4E Gene

Aliases for EIF4E Gene

  • Eukaryotic Translation Initiation Factor 4E 2 3 5
  • MRNA Cap-Binding Protein 3 4
  • EIF-4F 25 KDa Subunit 3 4
  • EIF4EL1 3 4
  • EIF-4E 3 4
  • EIF4F 3 4
  • Eukaryotic Translation Initiation Factor 4E-Like 1 3
  • AUTS19 3
  • EIF4E1 3
  • EIF4E 4
  • CBP 3

External Ids for EIF4E Gene

Previous HGNC Symbols for EIF4E Gene

  • EIF4EL1
  • EIF4F

Previous GeneCards Identifiers for EIF4E Gene

  • GC04M100046
  • GC04M100193
  • GC04M100259
  • GC04M100158
  • GC04M099799
  • GC04M095536

Summaries for EIF4E Gene

Entrez Gene Summary for EIF4E Gene

  • The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for EIF4E Gene

EIF4E (Eukaryotic Translation Initiation Factor 4E) is a Protein Coding gene. Diseases associated with EIF4E include autism 19 and skin squamous cell carcinoma. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity. An important paralog of this gene is EIF4E1B.

UniProtKB/Swiss-Prot for EIF4E Gene

  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

Gene Wiki entry for EIF4E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4E Gene

Genomics for EIF4E Gene

Regulatory Elements for EIF4E Gene

Promoters for EIF4E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF4E on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF4E Gene

Chromosome:
4
Start:
98,871,684 bp from pter
End:
98,930,637 bp from pter
Size:
58,954 bases
Orientation:
Minus strand

Genomic View for EIF4E Gene

Genes around EIF4E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4E Gene

Proteins for EIF4E Gene

  • Protein details for EIF4E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06730-IF4E_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 4E
    Protein Accession:
    P06730
    Secondary Accessions:
    • B7Z6V1
    • D6RCQ6
    • Q96E95

    Protein attributes for EIF4E Gene

    Size:
    217 amino acids
    Molecular mass:
    25097 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Hypophosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:24207126, PubMed:25533957, PubMed:21661078). Rapamycin can attenuate insulin stimulation, mediated by FKBPs. Interacts mutually exclusive with EIF4A1 or EIF4A2. Interacts with NGDN and PIWIL2. Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1. Interacts with CLOCK (By similarity). Interacts with Lassa virus Z protein. Binds to MKNK2 in nucleus. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with LARP1.

    Three dimensional structures from OCA and Proteopedia for EIF4E Gene

    Alternative splice isoforms for EIF4E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF4E Gene

Proteomics data for EIF4E Gene at MOPED

Post-translational modifications for EIF4E Gene

  • Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
  • Ubiquitination at Lys 36
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF4E (EIF4E)

No data available for DME Specific Peptides for EIF4E Gene

Domains & Families for EIF4E Gene

Protein Domains for EIF4E Gene

Graphical View of Domain Structure for InterPro Entry

P06730

UniProtKB/Swiss-Prot:

IF4E_HUMAN :
  • Belongs to the eukaryotic initiation factor 4E family.
Family:
  • Belongs to the eukaryotic initiation factor 4E family.
genes like me logo Genes that share domains with EIF4E: view

No data available for Gene Families for EIF4E Gene

Function for EIF4E Gene

Molecular function for EIF4E Gene

GENATLAS Biochemistry:
eukaryotic translation initiation factor 4E,amplified in head and neck squamous cell carcinomas
UniProtKB/Swiss-Prot Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

Gene Ontology (GO) - Molecular Function for EIF4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 7651417
genes like me logo Genes that share ontologies with EIF4E: view
genes like me logo Genes that share phenotypes with EIF4E: view

Animal Model Products

miRNA for EIF4E Gene

miRTarBase miRNAs that target EIF4E

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4E Gene

Localization for EIF4E Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF4E Gene

Cytoplasm, P-body. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF4E Gene COMPARTMENTS Subcellular localization image for EIF4E gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EIF4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033391 chromatoid body IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with EIF4E: view

Pathways & Interactions for EIF4E Gene

genes like me logo Genes that share pathways with EIF4E: view

SIGNOR curated interactions for EIF4E Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EIF4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 14673156
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0001662 behavioral fear response IEA --
GO:0019827 stem cell population maintenance IEA --
genes like me logo Genes that share ontologies with EIF4E: view

Drugs & Compounds for EIF4E Gene

(42) Drugs for EIF4E Gene - From: Novoseek, DrugBank, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL Experimental Pharma Target 0
7-Methyl-Gpppa Experimental Pharma Target 0
7-Methyl-Guanosine-5'-Triphosphate Experimental Pharma Target 0
7n-Methyl-8-Hydroguanosine-5'-Diphosphate Experimental Pharma Target 0
LY2275796 Investigational Pharma antisense, Target 0

(39) Additional Compounds for EIF4E Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for EIF4E Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 315706-13-9
genes like me logo Genes that share compounds with EIF4E: view

Drug Products

Transcripts for EIF4E Gene

Unigene Clusters for EIF4E Gene

Eukaryotic translation initiation factor 4E:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - -
SP3:
SP4: - -

Relevant External Links for EIF4E Gene

GeneLoc Exon Structure for
EIF4E
ECgene alternative splicing isoforms for
EIF4E

Expression for EIF4E Gene

mRNA expression in normal human tissues for EIF4E Gene

Protein differential expression in normal tissues from HIPED for EIF4E Gene

This gene is overexpressed in Skin (7.0) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EIF4E Gene



SOURCE GeneReport for Unigene cluster for EIF4E Gene Hs.249718

genes like me logo Genes that share expression patterns with EIF4E: view

Protein tissue co-expression partners for EIF4E Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF4E Gene

Orthologs for EIF4E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF4E 35
  • 96.93 (n)
  • 99.08 (a)
EIF4E 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4E 35
  • 97.08 (n)
  • 99.54 (a)
EIF4E 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4e 35
  • 94.01 (n)
  • 98.16 (a)
Eif4e 16
Eif4e 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF4E 35
  • 99.85 (n)
  • 100 (a)
EIF4E 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif4e 35
  • 95.08 (n)
  • 98.16 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF4E 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF4E 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF4E 35
  • 91.67 (n)
  • 97.4 (a)
EIF4E 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4E 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4e 35
  • 86.46 (n)
  • 91.88 (a)
Str.1980 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.59 35
zebrafish
(Danio rerio)
Actinopterygii eif4e-1 35
eif4eb 35
  • 76.41 (n)
  • 89.23 (a)
eif4ea 36
  • 84 (a)
OneToMany
eif4eb 36
  • 85 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2851 35
fruit fly
(Drosophila melanogaster)
Insecta CG10124 37
  • 45 (a)
CG1442 37
  • 48 (a)
CG8023 37
  • 41 (a)
CG8277 37
  • 46 (a)
EG:BACR42I17.1 37
  • 48 (a)
eIF-4E 37
  • 52 (a)
eIF-4E 35
  • 56.34 (n)
  • 53.26 (a)
eIF-4E 36
  • 41 (a)
ManyToMany
eIF4E-3 36
  • 34 (a)
ManyToMany
eIF4E-4 36
  • 42 (a)
ManyToMany
eIF4E-5 36
  • 36 (a)
ManyToMany
eIF4E-6 36
  • 42 (a)
ManyToMany
eIF4E-7 36
  • 23 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007172 35
  • 54.85 (n)
  • 55.56 (a)
worm
(Caenorhabditis elegans)
Secernentea B0348.6c 37
  • 51 (a)
F53A2.6 37
  • 38 (a)
ife-2 37
  • 38 (a)
ife-5 37
  • 41 (a)
ife-3 35
  • 54.01 (n)
  • 50.27 (a)
ife-3 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC33 36
  • 33 (a)
OneToMany
CDC33 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF4E 35
  • 53.56 (n)
  • 43.93 (a)
rice
(Oryza sativa)
Liliopsida Os01g0970400 35
  • 51.21 (n)
  • 47.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6167 36
  • 53 (a)
OneToMany
Species with no ortholog for EIF4E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4E Gene

ENSEMBL:
Gene Tree for EIF4E (if available)
TreeFam:
Gene Tree for EIF4E (if available)

Paralogs for EIF4E Gene

Paralogs for EIF4E Gene

(4) SIMAP similar genes for EIF4E Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EIF4E: view

Variants for EIF4E Gene

Sequence variations from dbSNP and Humsavar for EIF4E Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs994636 -- 98,887,721(+) TTTTA(C/T)AAACA intron-variant
rs1237658 -- 98,930,331(+) ACAAC(G/T)GCAGC upstream-variant-2KB, utr-variant-5-prime
rs1052438 -- 98,929,688(-) GGGGA(C/T)GTGGG upstream-variant-2KB, utr-variant-5-prime
rs1052440 -- 98,929,685(-) GACGT(G/T)GGAGG upstream-variant-2KB, utr-variant-5-prime
rs1063526 -- 98,879,875(-) TCATA(A/T)ATATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF4E Gene

Variant ID Type Subtype PubMed ID
nsv879654 CNV Loss 21882294
nsv879655 CNV Loss 21882294
nsv822666 CNV Loss 20364138
nsv821288 CNV Duplication 20802225
nsv819967 CNV Loss 19587683
esv27868 CNV Loss 19812545
esv1000667 CNV Gain 20482838
esv260038 OTHER Complex 20981092
esv997164 CNV Insertion 20482838

Variation tolerance for EIF4E Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.00; 0.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4E Gene

HapMap Linkage Disequilibrium report
EIF4E
Human Gene Mutation Database (HGMD)
EIF4E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4E Gene

Disorders for EIF4E Gene

MalaCards: The human disease database

(7) MalaCards diseases for EIF4E Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autism 19
  • autism, susceptibility to, 19
skin squamous cell carcinoma
  • epidermoid skin carcinoma
pervasive developmental disorder
  • pervasive development disorder
fragile x syndrome
  • fragile x mental retardation syndrome
pharyngoconjunctival fever
  • adenoviral pharyngoconjunctivitis
- elite association - COSMIC cancer census association via MalaCards
Search EIF4E in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IF4E_HUMAN
  • Autism 19 (AUTS19) [MIM:615091]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269 PubMed:19556253}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A heterozygous single-nucleotide insertion has been found in families affected by autism. The variant results in increased promoter activity and is involved in disease pathogenesis through EIF4E deregulation (PubMed:19556253). {ECO:0000269 PubMed:19556253}.
  • Note=A chromosomal aberration involving EIF4E has been found in a patient with classic autism. Translocation t(45)(q23q31.3). The breakpoint on chromosome 4 is located 56 kb downstream of EIF4E (PubMed:19556253). {ECO:0000269 PubMed:19556253}.

Relevant External Links for EIF4E

Genetic Association Database (GAD)
EIF4E
Human Genome Epidemiology (HuGE) Navigator
EIF4E
Tumor Gene Database (TGDB):
EIF4E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF4E
genes like me logo Genes that share disorders with EIF4E: view

No data available for Genatlas for EIF4E Gene

Publications for EIF4E Gene

  1. Structural basis for mRNA cap-binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. (PMID: 16271312) Tomoo K. … Ishida T. (Biochim. Biophys. Acta 2005) 3 4 23 67
  2. Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20. (PMID: 1916814) Pelletier J. … Housman D.E. (Genomics 1991) 2 3 23
  3. Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E. (PMID: 20101233) Andrieu C. … Rocchi P. (Oncogene 2010) 3 23
  4. Sumoylation of eIF4E activates mRNA translation. (PMID: 20224576) Xu X. … Hu J. (EMBO Rep. 2010) 3 23
  5. Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. (PMID: 20347422) Bidinosti M. … Sonenberg N. (Mol. Cell 2010) 3 23

Products for EIF4E Gene

  • Addgene plasmids for EIF4E

Sources for EIF4E Gene

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