Aliases for EIF4E Gene
External Ids for EIF4E Gene
Previous HGNC Symbols for EIF4E Gene
Previous GeneCards Identifiers for EIF4E Gene
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for EIF4E Gene
EIF4E (Eukaryotic Translation Initiation Factor 4E) is a Protein Coding gene. Diseases associated with EIF4E include autism 19 and hypopharynx cancer. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include translation initiation factor activity and eukaryotic initiation factor 4G binding. An important paralog of this gene is EIF4E1B.
UniProtKB/Swiss-Prot for EIF4E Gene
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.