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Aliases for EIF4E Gene

Aliases for EIF4E Gene

  • Eukaryotic Translation Initiation Factor 4E 2 3 5
  • MRNA Cap-Binding Protein 3 4
  • EIF-4F 25 KDa Subunit 3 4
  • EIF4EL1 3 4
  • EIF-4E 3 4
  • EIF4F 3 4
  • Eukaryotic Translation Initiation Factor 4E-Like 1 3
  • AUTS19 3
  • EIF4E1 3
  • EIF4E 4
  • CBP 3

External Ids for EIF4E Gene

Previous HGNC Symbols for EIF4E Gene

  • EIF4EL1
  • EIF4F

Previous GeneCards Identifiers for EIF4E Gene

  • GC04M100046
  • GC04M100193
  • GC04M100259
  • GC04M100158
  • GC04M099799
  • GC04M095536

Summaries for EIF4E Gene

Entrez Gene Summary for EIF4E Gene

  • The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for EIF4E Gene

EIF4E (Eukaryotic Translation Initiation Factor 4E) is a Protein Coding gene. Diseases associated with EIF4E include Autism 19 and Pervasive Developmental Disorder. Among its related pathways are Transport of the SLBP independent Mature mRNA and Akt Signaling. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity. An important paralog of this gene is EIF4E1B.

UniProtKB/Swiss-Prot for EIF4E Gene

  • Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

Gene Wiki entry for EIF4E Gene

Additional gene information for EIF4E Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF4E Gene

Genomics for EIF4E Gene

Regulatory Elements for EIF4E Gene

Enhancers for EIF4E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H098994 1.3 Ensembl ENCODE 16.1 -66.3 -66252 5.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ENSG00000272777 LOC100507053 EIF4E ADH5 RNU7-149P ADH1A ADH4 METAP1 MIR3684
GH04H098933 1.2 FANTOM5 Ensembl ENCODE 12.9 -2.3 -2264 1 JUN ELF1 ETV6 SPI1 GABPA EIF4E ENSG00000272777 LOC100507053 FAM177A1P1
GH04H098927 1.4 FANTOM5 ENCODE 6.3 +1.5 1505 4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ENSG00000272777 ADH5 EIF4E LOC100507053 RAP1GDS1 ENSG00000263923
GH04H099022 1.1 Ensembl ENCODE 5.8 -93.8 -93820 3.3 HDAC1 HDGF ARNT CHAMP1 TCF12 CBX5 ATF7 NCOA1 NFIC MTA1 ENSG00000272777 LOC100507053 EIF4E ADH5 ABT1P1
GH04H099013 1 Ensembl ENCODE 5.9 -83.1 -83104 0.9 SOX5 SOX13 TBP KLF6 NFYC CEBPG DMAP1 ZNF644 NR2F2 CC2D1A ENSG00000272777 EIF4E ABT1P1 MIR3684
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF4E on UCSC Golden Path with GeneCards custom track

Promoters for EIF4E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for EIF4E Gene

Genomic Locations for EIF4E Gene
58,954 bases
Minus strand

Genomic View for EIF4E Gene

Genes around EIF4E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF4E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF4E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF4E Gene

Proteins for EIF4E Gene

  • Protein details for EIF4E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Eukaryotic translation initiation factor 4E
    Protein Accession:
    Secondary Accessions:
    • B7Z6V1
    • D6RCQ6
    • Q96E95

    Protein attributes for EIF4E Gene

    217 amino acids
    Molecular mass:
    25097 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Hypophosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:24207126, PubMed:25533957, PubMed:21661078). Rapamycin can attenuate insulin stimulation, mediated by FKBPs. Interacts mutually exclusive with EIF4A1 or EIF4A2. Interacts with NGDN and PIWIL2. Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1. Interacts with CLOCK (By similarity). Interacts with Lassa virus Z protein. Binds to MKNK2 in nucleus. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with LARP1. Interacts with METTL3 (PubMed:27117702).

    Three dimensional structures from OCA and Proteopedia for EIF4E Gene

    Alternative splice isoforms for EIF4E Gene


neXtProt entry for EIF4E Gene

Post-translational modifications for EIF4E Gene

  • Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
  • Ubiquitination at isoforms=2, 336
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF4E Gene

Domains & Families for EIF4E Gene

Gene Families for EIF4E Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic initiation factor 4E family.
  • Belongs to the eukaryotic initiation factor 4E family.
genes like me logo Genes that share domains with EIF4E: view

Function for EIF4E Gene

Molecular function for EIF4E Gene

GENATLAS Biochemistry:
eukaryotic translation initiation factor 4E,amplified in head and neck squamous cell carcinomas
UniProtKB/Swiss-Prot Function:
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

Phenotypes From GWAS Catalog for EIF4E Gene

Gene Ontology (GO) - Molecular Function for EIF4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 3469651
GO:0000340 RNA 7-methylguanosine cap binding IDA 19750007
GO:0003723 RNA binding IDA 22681889
GO:0003743 translation initiation factor activity TAS,ISS --
GO:0005515 protein binding IPI 7651417
genes like me logo Genes that share ontologies with EIF4E: view
genes like me logo Genes that share phenotypes with EIF4E: view

Animal Model Products

miRNA for EIF4E Gene

miRTarBase miRNAs that target EIF4E

Clone Products

  • Addgene plasmids for EIF4E

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF4E Gene

Localization for EIF4E Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF4E Gene

Cytoplasm, P-body. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF4E gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (4)
  • Cytosol (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA,IDA 20616046
GO:0005737 cytoplasm IDA 19393246
GO:0005829 cytosol TAS --
GO:0005845 mRNA cap binding complex IDA,IEA 16271312
GO:0010494 cytoplasmic stress granule IDA 21883093
genes like me logo Genes that share ontologies with EIF4E: view

Pathways & Interactions for EIF4E Gene

genes like me logo Genes that share pathways with EIF4E: view

Pathways by source for EIF4E Gene

SIGNOR curated interactions for EIF4E Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EIF4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 14673156
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0001662 behavioral fear response IEA --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with EIF4E: view

Drugs & Compounds for EIF4E Gene

(45) Drugs for EIF4E Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
7-Methyl-Gpppa Experimental Pharma Target 0
7-Methyl-Guanosine-5'-Triphosphate Experimental Pharma Target 0
7n-Methyl-8-Hydroguanosine-5'-Diphosphate Experimental Pharma Target 0
S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate Experimental Pharma Target 0
LY2275796 Investigational Pharma antisense, Target 0

(36) Additional Compounds for EIF4E Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for EIF4E Gene

Compound Action Cas Number
4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 328998-25-0
4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 315706-13-9
genes like me logo Genes that share compounds with EIF4E: view

Drug Products

Transcripts for EIF4E Gene

Unigene Clusters for EIF4E Gene

Eukaryotic translation initiation factor 4E:
Representative Sequences:

Clone Products

  • Addgene plasmids for EIF4E

Alternative Splicing Database (ASD) splice patterns (SP) for EIF4E Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - -
SP4: - -

Relevant External Links for EIF4E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EIF4E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF4E Gene

Protein differential expression in normal tissues from HIPED for EIF4E Gene

This gene is overexpressed in Skin (7.0) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EIF4E Gene

Protein tissue co-expression partners for EIF4E Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF4E Gene:


SOURCE GeneReport for Unigene cluster for EIF4E Gene:


Evidence on tissue expression from TISSUES for EIF4E Gene

  • Nervous system(5)
  • Intestine(4.5)
  • Lung(3)
  • Kidney(2.8)
  • Muscle(2.5)
  • Liver(2.3)
  • Blood(2.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with EIF4E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF4E Gene

Orthologs for EIF4E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF4E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EIF4E 34 33
  • 99.85 (n)
(Canis familiaris)
Mammalia EIF4E 34 33
  • 97.08 (n)
(Bos Taurus)
Mammalia EIF4E 33 34
  • 96.93 (n)
(Rattus norvegicus)
Mammalia Eif4e 33
  • 95.08 (n)
(Mus musculus)
Mammalia Eif4e 16 34 33
  • 94.01 (n)
(Ornithorhynchus anatinus)
Mammalia EIF4E 34
  • 92 (a)
(Monodelphis domestica)
Mammalia EIF4E 34
  • 88 (a)
(Gallus gallus)
Aves EIF4E 34 33
  • 91.67 (n)
(Anolis carolinensis)
Reptilia EIF4E 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eif4e 33
  • 86.46 (n)
Str.1980 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.59 33
(Danio rerio)
Actinopterygii eif4ea 34
  • 84 (a)
eif4eb 34 33
  • 76.41 (n)
eif4e-1 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2851 33
fruit fly
(Drosophila melanogaster)
Insecta eIF-4E 35 33 34
  • 56.34 (n)
CG1442 35
  • 48 (a)
EG:BACR42I17.1 35
  • 48 (a)
CG8277 35
  • 46 (a)
CG10124 35
  • 45 (a)
eIF4E-4 34
  • 42 (a)
eIF4E-6 34
  • 42 (a)
CG8023 35
  • 41 (a)
eIF4E-5 34
  • 36 (a)
eIF4E-3 34
  • 34 (a)
eIF4E-7 34
  • 23 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007172 33
  • 54.85 (n)
(Caenorhabditis elegans)
Secernentea ife-3 33 34
  • 54.01 (n)
B0348.6c 35
  • 51 (a)
ife-5 35
  • 41 (a)
F53A2.6 35
  • 38 (a)
ife-2 35
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC33 34 36
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF4E 33
  • 53.56 (n)
(Oryza sativa)
Liliopsida Os01g0970400 33
  • 51.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6167 34
  • 53 (a)
Species where no ortholog for EIF4E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF4E Gene

Gene Tree for EIF4E (if available)
Gene Tree for EIF4E (if available)

Paralogs for EIF4E Gene

Paralogs for EIF4E Gene

(4) SIMAP similar genes for EIF4E Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EIF4E: view

Variants for EIF4E Gene

Sequence variations from dbSNP and Humsavar for EIF4E Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000054757 -- 98,905,927(+) TATAG(A/T)GGTAA intron-variant
rs1000102685 -- 98,887,546(+) CTCTA(C/G)CAACT intron-variant
rs1000276458 -- 98,905,447(+) GGATG(C/G)TGCTG intron-variant
rs1000323107 -- 98,911,740(+) AACAT(C/T)CTTAA intron-variant
rs1000399511 -- 98,917,691(+) GGGCC(A/G)AAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF4E Gene

Variant ID Type Subtype PubMed ID
nsv966299 CNV duplication 23825009
nsv956318 CNV deletion 24416366
nsv950363 CNV duplication 24416366
nsv950362 CNV duplication 24416366
nsv822666 CNV loss 20364138
nsv821288 CNV duplication 20802225
nsv819967 CNV loss 19587683
nsv594943 CNV gain 21841781
esv997164 CNV insertion 20482838
esv3601546 CNV loss 21293372
esv3303064 CNV tandem duplication 20981092
esv2861680 CNV duplication 24192839
esv27868 CNV loss 19812545
esv1000667 CNV gain 20482838
dgv1018e214 CNV gain 21293372

Variation tolerance for EIF4E Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.00; 0.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF4E Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF4E Gene

Disorders for EIF4E Gene

MalaCards: The human disease database

(7) MalaCards diseases for EIF4E Gene - From: HGMD, OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autism 19
  • auts19
pervasive developmental disorder
  • pervasive development disorder
skin squamous cell carcinoma
  • epidermoid skin carcinoma
fragile x syndrome
  • fragile x mental retardation syndrome
squamous cell carcinoma, head and neck
  • squamous cell carcinoma, head and neck, somatic
- elite association - COSMIC cancer census association via MalaCards
Search EIF4E in MalaCards View complete list of genes associated with diseases


  • Autism 19 (AUTS19) [MIM:615091]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269 PubMed:19556253}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A heterozygous single-nucleotide insertion has been found in families affected by autism. The variant results in increased promoter activity and is involved in disease pathogenesis through EIF4E deregulation (PubMed:19556253). {ECO:0000269 PubMed:19556253}.
  • Note=A chromosomal aberration involving EIF4E has been found in a patient with classic autism. Translocation t(45)(q23q31.3). The breakpoint on chromosome 4 is located 56 kb downstream of EIF4E (PubMed:19556253). {ECO:0000269 PubMed:19556253}.

Relevant External Links for EIF4E

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EIF4E: view

No data available for Genatlas for EIF4E Gene

Publications for EIF4E Gene

  1. Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives. (PMID: 17631896) Brown CJ … Walkinshaw MD (Journal of molecular biology 2007) 3 4 22 60
  2. Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. (PMID: 16271312) Tomoo K … Ishida T (Biochimica et biophysica acta 2005) 3 4 22 60
  3. Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region. (PMID: 11879179) Tomoo K … Miura K (The Biochemical journal 2002) 3 4 22 60
  4. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PMID: 9878069) Pyronnet S … Sonenberg N (The EMBO journal 1999) 3 4 22 60
  5. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. (PMID: 8521827) Haghighat A … Sonenberg N (The EMBO journal 1995) 3 4 22 60

Products for EIF4E Gene

Sources for EIF4E Gene

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