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AHSG Gene(Protein Coding)

Alpha-2-HS-Glycoprotein

GCID:
GC03P186612
GIFtS:
65
Genes Participants
UDN Logo

Aliases for AHSG Gene

Aliases for AHSG Gene

  • Alpha-2-HS-Glycoprotein 2 3 5
  • Ba-Alpha-2-Glycoprotein 3 4
  • Alpha-2-Z-Globulin 3 4
  • Fetuin-A 3 4
  • FETUA 3 4
  • A2HS 3
  • HSGA 3
  • AHS 3

External Ids for AHSG Gene

Previous GeneCards Identifiers for AHSG Gene

  • GC03P183102
  • GC03P187587
  • GC03P187732
  • GC03P187651
  • GC03P187813
  • GC03P186330
  • GC03P183739

Summaries for AHSG Gene

Entrez Gene Summary for AHSG Gene

  • Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]

GeneCards Summary for AHSG Gene

AHSG (Alpha-2-HS-Glycoprotein) is a Protein Coding gene. Diseases associated with AHSG include Epstein-Barr Virus Hepatitis and Eccrine Papillary Adenocarcinoma. Among its related pathways are Glucose / Energy Metabolism and Platelet activation, signaling and aggregation. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity and kinase inhibitor activity. An important paralog of this gene is FETUB.

UniProtKB/Swiss-Prot for AHSG Gene

  • Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.

Gene Wiki entry for AHSG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHSG Gene

Genomics for AHSG Gene

Products:

  1. Regulatory Element

Regulatory Elements for AHSG Gene

Enhancers for AHSG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AHSG on UCSC Golden Path with GeneCards custom track

Promoters for AHSG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AHSG on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the AHSG gene promoter:

Genomic Location for AHSG Gene

Chromosome:
3
Start:
186,612,923 bp from pter
End:
186,621,318 bp from pter
Size:
8,396 bases
Orientation:
Plus strand

Genomic View for AHSG Gene

Genes around AHSG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AHSG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AHSG Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AHSG Gene

Proteins for AHSG Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for AHSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02765-FETUA_HUMAN
    Recommended name:
    Alpha-2-HS-glycoprotein
    Protein Accession:
    P02765
    Secondary Accessions:
    • A8K9N6
    • B2R7G1
    • O14961
    • O14962
    • Q9P152

    Protein attributes for AHSG Gene

    Size:
    367 amino acids
    Molecular mass:
    39325 Da
    Quaternary structure:
    • Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond.

neXtProt entry for AHSG Gene

Proteomics data for AHSG Gene at MOPED

Protein Expression for AHSG Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for AHSG Gene

  • O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).
  • Phosphorylated by FAM20C in the extracellular medium.
  • Glycosylation at Asn 156, Asn 176, Thr 256, Thr 270, Thr 339, and Ser 346
  • Modification sites at PhosphoSitePlus

Other Protein References for AHSG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AHSG (FETUA)

No data available for DME Specific Peptides for AHSG Gene

Domains & Families for AHSG Gene

Gene Families for AHSG Gene

HGNC:

Protein Domains for AHSG Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AHSG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02765

UniProtKB/Swiss-Prot:

FETUA_HUMAN :
  • Contains 2 cystatin fetuin-A-type domains.
  • Belongs to the fetuin family.
Domain:
  • Contains 2 cystatin fetuin-A-type domains.
Family:
  • Belongs to the fetuin family.
genes like me logo Genes that share domains with AHSG: view

Function for AHSG Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for AHSG Gene

GENATLAS Biochemistry:
HS-glycoprotein,alpha-2-,inhibitor of the insulin-receptor tyrosine kinase,pp63 (cystatin superfamily)
UniProtKB/Swiss-Prot Function:
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.

Phenotypes for AHSG Gene

MGI mutant phenotypes for AHSG:
inferred from 2 alleles
GenomeRNAi human phenotypes for AHSG:
genes like me logo Genes that share phenotypes with AHSG: view

Animal Models for AHSG Gene

MGI Knock Outs for AHSG:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for AHSG Gene

Localization for AHSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHSG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AHSG Gene COMPARTMENTS Subcellular localization image for AHSG gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
cytoskeleton 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for AHSG Gene

Pathways & Interactions for AHSG Gene

genes like me logo Genes that share pathways with AHSG: view

Pathways by source for AHSG Gene

1 Cell Signaling Technology pathway for AHSG Gene
1 BioSystems pathway for AHSG Gene

Gene Ontology (GO) - Biological Process for AHSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0002576 platelet degranulation TAS --
GO:0006953 acute-phase response IDA 12153747
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030502 negative regulation of bone mineralization IEA,ISS --
genes like me logo Genes that share ontologies with AHSG: view

No data available for SIGNOR curated interactions for AHSG Gene

Drugs & Compounds for AHSG Gene

Products:

  1. Drug

(7) Drugs for AHSG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(9) Additional Compounds for AHSG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AHSG: view

Transcripts for AHSG Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for AHSG Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(533) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AHSG Gene

Alpha-2-HS-glycoprotein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AHSG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6: -

Relevant External Links for AHSG Gene

GeneLoc Exon Structure for
AHSG
ECgene alternative splicing isoforms for
AHSG

Expression for AHSG Gene

Products:

  1. Primer

mRNA expression in normal human tissues for AHSG Gene

mRNA expression in normal human tissues for AHSG Gene
mRNA expression by BioGPS for AHSG GenemRNA expression by GTEx for AHSG Gene

mRNA differential expression in normal tissues according to GTEx for AHSG Gene

This gene is overexpressed in Liver (x52.7).

Protein differential expression in normal tissues from HIPED for AHSG Gene

This gene is overexpressed in Serum (13.6), Lavage (12.3), Plasma (9.8), Synovial fluid (9.1), and Monocytes (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AHSG Gene



SOURCE GeneReport for Unigene cluster for AHSG Gene Hs.324746

mRNA Expression by UniProt/SwissProt for AHSG Gene

P02765-FETUA_HUMAN
Tissue specificity: Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins.
genes like me logo Genes that share expression patterns with AHSG: view

Protein tissue co-expression partners for AHSG Gene

- Elite partner

Primer Products

Orthologs for AHSG Gene

This gene was present in the common ancestor of chordates.

Orthologs for AHSG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia AHSG 35
  • 75.49 (n)
  • 65.92 (a)
AHSG 36
  • 64 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia AHSG 35
  • 79.09 (n)
  • 69.59 (a)
AHSG 36
  • 68 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ahsg 35
  • 73.08 (n)
  • 63.27 (a)
Ahsg 16
Ahsg 36
  • 59 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia AHSG 35
  • 98.91 (n)
  • 97.55 (a)
AHSG 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Ahsg 35
  • 72.81 (n)
  • 63.69 (a)
oppossum
(Monodelphis domestica)
 Mammalia AHSG 36
  • 49 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia AHSG 36
  • 48 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves AHSG 35
  • 52.22 (n)
  • 44 (a)
AHSG 36
  • 37 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia AHSG 36
  • 36 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ahsg 35
  • 50.94 (n)
  • 42.86 (a)
zebrafish
(Danio rerio)
 Actinopterygii ahsg 35
  • 47.66 (n)
  • 35.96 (a)
AHSG 36
  • 26 (a)
 OneToOne
Species with no ortholog for AHSG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AHSG Gene

ENSEMBL:
Gene Tree for AHSG (if available)
TreeFam:
Gene Tree for AHSG (if available)

Paralogs for AHSG Gene

Paralogs for AHSG Gene

genes like me logo Genes that share paralogs with AHSG: view

Variants for AHSG Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for AHSG Gene

FETUA_HUMAN-P02765
There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256.

Sequence variations from dbSNP and Humsavar for AHSG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4917 - 186,619,924(+) CTGCA(C/T)GGTGT reference, missense
rs4918 - 186,620,593(+) CGTGA(C/G)CTCAC reference, missense
rs70961709 - 186,620,652(+) ACCCA(A/G)ATGCA reference, missense
rs35457250 - 186,620,775(-) GTGGC(A/G)CAGGT reference, missense
rs7633550 - 186,617,201(+) AGGAC(A/G/T)TGCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AHSG Gene

Variant ID Type Subtype PubMed ID
nsv508974 CNV Insertion 20534489
dgv1541e1 CNV Complex 17122850

Variation tolerance for AHSG Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 39.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AHSG Gene

Human Gene Mutation Database (HGMD)
AHSG

Disorders for AHSG Gene

MalaCards: The human disease database

(9) MalaCards diseases for AHSG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epstein-barr virus hepatitis
eccrine papillary adenocarcinoma
  • digital papillary adenocarcinoma
eccrine adenocarcinoma
calcinosis
  • pathologic calcification
acute retinal necrosis syndrome
  • acute retinal necrosis
- elite association - COSMIC cancer census association via MalaCards
Search AHSG in MalaCards View complete list of genes associated with diseases

Relevant External Links for AHSG

Genetic Association Database (GAD)
AHSG
Human Genome Epidemiology (HuGE) Navigator
AHSG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AHSG
genes like me logo Genes that share disorders with AHSG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AHSG Gene

Publications for AHSG Gene

  1. Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). (PMID: 9322749) Osawa M. … Takeichi S. (Gene 1997) 2 3 4 23 67
  2. Three members of the human cystatin gene superfamily, AHSG, HRG, and KNG, map within one megabase of genomic DNA at 3q27. (PMID: 7736783) Rizzu P. … Baldini A. (Cytogenet. Cell Genet. 1995) 2 3 23
  3. Preeclampsia is associated with decreased serum alpha(2)-HS glycoprotein (fetuin-A) concentration. (PMID: 19478814) Molvarec A. … RigA^ J. (Hypertens. Res. 2009) 3 23
  4. High glucose induces transactivation of the alpha2-HS glycoprotein gene through the ERK1/2 signaling pathway. (PMID: 19672022) Takata H. … Terada Y. (J. Atheroscler. Thromb. 2009) 3 23
  5. Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study. (PMID: 20031641) Fisher E. … Weikert C. (Circ Cardiovasc Genet 2009) 3 23

Products for AHSG Gene

  • Addgene plasmids for AHSG

Sources for AHSG Gene

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