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Aliases for AHSG Gene

Aliases for AHSG Gene

  • Alpha-2-HS-Glycoprotein 2 3
  • Ba-Alpha-2-Glycoprotein 3 4
  • Alpha-2-Z-Globulin 3 4
  • Fetuin-A 3 4
  • FETUA 3 4
  • A2HS 3
  • HSGA 3
  • AHS 3

External Ids for AHSG Gene

Previous GeneCards Identifiers for AHSG Gene

  • GC03P183102
  • GC03P187587
  • GC03P187732
  • GC03P187651
  • GC03P187813
  • GC03P186330
  • GC03P183739

Summaries for AHSG Gene

Entrez Gene Summary for AHSG Gene

  • Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]

GeneCards Summary for AHSG Gene

AHSG (Alpha-2-HS-Glycoprotein) is a Protein Coding gene. Diseases associated with AHSG include uremia and liver cirrhosis. Among its related pathways are Glucose / Energy Metabolism and Signaling by BMP. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity and kinase inhibitor activity. An important paralog of this gene is FETUB.

UniProtKB/Swiss-Prot for AHSG Gene

  • Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions

Gene Wiki entry for AHSG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHSG Gene

Genomics for AHSG Gene

Regulatory Elements for AHSG Gene

Genomic Location for AHSG Gene

186,612,923 bp from pter
186,621,318 bp from pter
8,396 bases
Plus strand

Genomic View for AHSG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AHSG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHSG Gene

Proteins for AHSG Gene

  • Protein details for AHSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K9N6
    • B2R7G1
    • O14961
    • O14962
    • Q9P152

    Protein attributes for AHSG Gene

    367 amino acids
    Molecular mass:
    39325 Da
    Quaternary structure:
    • Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond

neXtProt entry for AHSG Gene

Proteomics data for AHSG Gene at MOPED

Post-translational modifications for AHSG Gene

  • O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).
  • Phosphorylation sites are present in the extracellular medium.
  • Glycosylation at Asn156, Asn176, Thr256, Thr270, and Ser346
  • Modification sites at PhosphoSitePlus

Other Protein References for AHSG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AHSG (FETUA)

No data available for DME Specific Peptides for AHSG Gene

Domains for AHSG Gene

Gene Families for AHSG Gene

Protein Domains for AHSG Gene

Suggested Antigen Peptide Sequences for AHSG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 cystatin fetuin-A-type domains.
  • Belongs to the fetuin family.
  • Contains 2 cystatin fetuin-A-type domains.
  • Belongs to the fetuin family.
genes like me logo Genes that share domains with AHSG: view

Function for AHSG Gene

Molecular function for AHSG Gene

GENATLAS Biochemistry:
HS-glycoprotein,alpha-2-,inhibitor of the insulin-receptor tyrosine kinase,pp63 (cystatin superfamily)
UniProtKB/Swiss-Prot Function:
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions

Gene Ontology (GO) - Molecular Function for AHSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0019210 kinase inhibitor activity NAS 12203945
genes like me logo Genes that share ontologies with AHSG: view
genes like me logo Genes that share phenotypes with AHSG: view

Animal Models for AHSG Gene

MGI Knock Outs for AHSG:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AHSG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for AHSG Gene

Localization for AHSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHSG Gene


Subcellular locations from

Jensen Localization Image for AHSG Gene COMPARTMENTS Subcellular localization image for AHSG gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AHSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space NAS 11922920
GO:0070062 extracellular exosome IDA 19056867
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with AHSG: view

Pathways for AHSG Gene

genes like me logo Genes that share pathways with AHSG: view

Pathways by source for AHSG Gene

1 Cell Signaling Technology pathway for AHSG Gene
1 BioSystems pathway for AHSG Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for AHSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development NAS 12153747
GO:0001503 ossification IEA --
GO:0006907 pinocytosis NAS 12773197
GO:0006953 acute-phase response IDA 12153747
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with AHSG: view

Drugs for AHSG Gene

(1) HMDB Compounds for AHSG Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(16) Novoseek inferred chemical compound relationships for AHSG Gene

Compound -log(P) Hits PubMed IDs
saci 71.6 3
kininogen 58.1 3
apai 43.2 2
polyacrylamide 40.4 8
xbai 31.6 2
genes like me logo Genes that share compounds with AHSG: view

Transcripts for AHSG Gene

mRNA/cDNA for AHSG Gene

Unigene Clusters for AHSG Gene

Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AHSG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AHSG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: -
SP3: -
SP4: -
SP6: -

Relevant External Links for AHSG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AHSG Gene

mRNA expression in normal human tissues for AHSG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AHSG Gene

This gene is overexpressed in Liver (52.7).

Protein differential expression in normal tissues for AHSG Gene

This gene is overexpressed in Serum (13.6), Lavage (12.3), Plasma (9.8), Synovial fluid (9.1), and Monocytes (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AHSG Gene

SOURCE GeneReport for Unigene cluster for AHSG Gene Hs.324746

mRNA Expression by UniProt/SwissProt for AHSG Gene

Tissue specificity: Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins
genes like me logo Genes that share expressions with AHSG: view

Expression partners for AHSG Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for AHSG Gene

This gene was present in the common ancestor of chordates.

Orthologs for AHSG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AHSG 35
  • 75.49 (n)
  • 65.92 (a)
  • 64 (a)
(Canis familiaris)
Mammalia AHSG 35
  • 79.09 (n)
  • 69.59 (a)
  • 68 (a)
(Mus musculus)
Mammalia Ahsg 35
  • 73.08 (n)
  • 63.27 (a)
Ahsg 16
Ahsg 36
  • 59 (a)
(Pan troglodytes)
Mammalia AHSG 35
  • 98.91 (n)
  • 97.55 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Ahsg 35
  • 72.81 (n)
  • 63.69 (a)
(Monodelphis domestica)
Mammalia AHSG 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia AHSG 36
  • 48 (a)
(Gallus gallus)
Aves AHSG 35
  • 52.22 (n)
  • 44 (a)
  • 37 (a)
(Anolis carolinensis)
Reptilia AHSG 36
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ahsg 35
  • 50.94 (n)
  • 42.86 (a)
(Danio rerio)
Actinopterygii ahsg 35
  • 47.66 (n)
  • 35.96 (a)
  • 26 (a)
Species with no ortholog for AHSG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AHSG Gene

Gene Tree for AHSG (if available)
Gene Tree for AHSG (if available)

Paralogs for AHSG Gene

Paralogs for AHSG Gene

genes like me logo Genes that share paralogs with AHSG: view

Variants for AHSG Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for AHSG Gene

There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256

Sequence variations from dbSNP and Humsavar for AHSG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4831 -- 186,613,180(+) CAGCT(C/G)TGGGG reference, synonymous-codon
rs4917 other, - 186,619,924(+) CTGCA(C/T)GGTGT missense, reference
rs4918 other, - 186,620,593(+) CGTGA(C/G)CTCAC missense, reference
rs1029353 -- 186,620,444(+) TACTT(A/G)GGTAG intron-variant
rs1071592 -- 186,620,636(+) CCCAC(A/C)CCCGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for AHSG Gene

Variant ID Type Subtype PubMed ID
nsv508974 CNV Insertion 20534489
dgv1541e1 CNV Complex 17122850

Relevant External Links for AHSG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for AHSG Gene

(26) Novoseek inferred disease relationships for AHSG Gene

Disease -log(P) Hits PubMed IDs
calcification 52.2 16
endometriosis 42.2 22
response acute phase 41.8 3
insulin sensitivity 27.6 4
insulin resistance 26.8 7

Relevant External Links for AHSG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AHSG: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for AHSG Gene

Publications for AHSG Gene

  1. Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). (PMID: 9322749) Osawa M. … Takeichi S. (Gene 1997) 2 3 4 23
  2. Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass. (PMID: 16117875) Dvornyk V. … Deng H.W. (Chin. Med. J. 2005) 3 23 48
  3. Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis. (PMID: 17062776) Lehtinen A.B. … Bowden D.W. (J. Clin. Endocrinol. Metab. 2007) 3 23 48
  4. AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families. (PMID: 17557141) Yang Y.J. … Deng H.W. (Eur. J. Epidemiol. 2007) 3 23 48
  5. Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study. (PMID: 20031641) Fisher E. … Weikert C. (Circ Cardiovasc Genet 2009) 3 23 48

Products for AHSG Gene

  • Addgene plasmids for AHSG

Sources for AHSG Gene

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