Aliases for AHSG Gene
Aliases for AHSG Gene
External Ids for AHSG Gene
- HGNC: 349
- Entrez Gene: 197
- Ensembl: ENSG00000145192
- OMIM: 138680
- UniProtKB: P02765
Previous GeneCards Identifiers for AHSG Gene
- GC03P183102
- GC03P187587
- GC03P187732
- GC03P187651
- GC03P187813
- GC03P186330
- GC03P183739
Summaries for AHSG Gene
-
The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cause of susceptibility to leanness. [provided by RefSeq, Aug 2017]
GeneCards Summary for AHSG Gene
AHSG (Alpha 2-HS Glycoprotein) is a Protein Coding gene. Diseases associated with AHSG include Alopecia-Mental Retardation Syndrome 1 and Alopecia-Intellectual Disability Syndrome. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity and kinase inhibitor activity. An important paralog of this gene is FETUB.
UniProtKB/Swiss-Prot for AHSG Gene
-
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Additional gene information for AHSG Gene
- Monarch Initiative
- Search for AHSG at DataMed
- Search for AHSG at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHSG Gene
Genomics for AHSG Gene
GeneHancer (GH) Regulatory Elements for AHSG Gene
- Top Transcription factor binding sites by QIAGEN in the AHSG gene promoter:
Regulatory Element Products
Genomic Locations for AHSG Gene
- chr3:186,612,923-186,621,318
- (GRCh38/hg38)
- Size:
- 8,396 bases
- Orientation:
- Plus strand
- chr3:186,330,712-186,339,107
- (GRCh37/hg19)
Genomic View for AHSG Gene
- Cytogenetic band:
-
- 3q27.3 by Ensembl
- 3q27.3 by Entrez Gene
- 3q27.3 by HGNC


RefSeq DNA sequence for AHSG Gene
Proteins for AHSG Gene
-
Protein details for AHSG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P02765-FETUA_HUMAN
- Recommended name:
- Alpha-2-HS-glycoprotein
- Protein Accession:
- P02765
- A8K9N6
- B2R7G1
- O14961
- O14962
- Q9P152
Protein attributes for AHSG Gene
- Size:
- 367 amino acids
- Molecular mass:
- 39325 Da
- Quaternary structure:
-
- Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond.
Protein Expression for AHSG Gene
Post-translational modifications for AHSG Gene
- O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).
- Phosphorylated by FAM20C in the extracellular medium.
- Glycosylation at posLast=156156, posLast=176176, Thr256, posLast=270270, Thr339, and Ser346
Other Protein References for AHSG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for AHSG (Fetuin A/AHSG)
- Cell Signaling Technology (CST) Antibodies for AHSG (FETUA)
-
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-
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-
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Protein Products
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-
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Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for AHSG
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-
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-
Abcam assays for AHSG
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No data available for DME Specific Peptides for AHSG Gene
Domains & Families for AHSG Gene
Gene Families for AHSG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for AHSG Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AHSG Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P02765- Family:
-
- Belongs to the fetuin family.
Function for AHSG Gene
Molecular function for AHSG Gene
- GENATLAS Biochemistry:
- HS-glycoprotein,alpha-2-,inhibitor of the insulin-receptor tyrosine kinase,pp63 (cystatin superfamily)
- UniProtKB/Swiss-Prot Function:
- Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Phenotypes From GWAS Catalog for AHSG Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004866 | endopeptidase inhibitor activity | IBA | -- |
GO:0004869 | cysteine-type endopeptidase inhibitor activity | IEA | -- |
GO:0019210 | kinase inhibitor activity | NAS | 12203945 |
Phenotypes for AHSG Gene
- MGI mutant phenotypes for AHSG:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for AHSG:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for AHSG gene
-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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Inhibitory RNA Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AHSG
- Applied Biological Materials Clones for AHSG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for AHSG (Fetuin A/AHSG)
Cell Line Products
-
Horizon Cell Lines for AHSG
-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for AHSG Gene
Localization for AHSG Gene
Subcellular locations from UniProtKB/Swiss-Prot for AHSG Gene
- Secreted.
- Golgi apparatus (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS,IDA | -- |
GO:0005615 | extracellular space | NAS,IEA | 11922920 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0005794 | Golgi apparatus | IDA | -- |
GO:0031012 | extracellular matrix | IBA,IDA | 27559042 |
Pathways & Interactions for AHSG Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
2 | Innate Immune System |
.61
|
|
3 | Glucose / Energy Metabolism | ||
4 | Signaling by BMP |
Pathways by source for AHSG Gene
1 Cell Signaling Technology pathway for AHSG Gene
1 BioSystems pathway for AHSG Gene
7 Reactome pathways for AHSG Gene
Interacting Proteins for AHSG Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001501 | skeletal system development | NAS | 12153747 |
GO:0001503 | ossification | IEA | -- |
GO:0002576 | platelet degranulation | TAS | -- |
GO:0006907 | pinocytosis | NAS | 12773197 |
GO:0006953 | acute-phase response | IDA | 12153747 |
No data available for SIGNOR curated interactions for AHSG Gene
Transcripts for AHSG Gene
mRNA/cDNA for AHSG Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (533) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AHSG Gene
CRISPR Products
-
OriGene CRISPR knockouts for AHSG
- genomics-online: gRNA clones - Search results for 138 available Fetuin A gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AHSG
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miRNA Products
- Search ViGene Biosciences for AHSG
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for AHSG
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-
ViGene Biosciences ready-to-package AAV shRNAs for AHSG gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AHSG
- Applied Biological Materials Clones for AHSG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for AHSG (Fetuin A/AHSG)
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||
SP5: | |||||||||||||||||||||||
SP6: | - |
Expression for AHSG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
- Left Ventricle
- Right Ventricle
- Left Atrium
- Right Atrium
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Autopod
- Zeugopod
- Bone (Muscoskeletal System)
- NULL (Uncategorized)
- Liver (Hepatobiliary System)
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Gut Tube (Gastrointestinal Tract)
- Smooth Muscle (Muscoskeletal System)
- Epithelial Cells (Uncategorized)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for AHSG Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AHSG Gene
NURSA nuclear receptor signaling pathways regulating expression of AHSG Gene:
AHSGSOURCE GeneReport for Unigene cluster for AHSG Gene:
Hs.324746mRNA Expression by UniProt/SwissProt for AHSG Gene:
P02765-FETUA_HUMANEvidence on tissue expression from TISSUES for AHSG Gene
- Liver(5)
- Blood(4.7)
- Nervous system(4.4)
- Bone marrow(4.2)
- Saliva(4.2)
- Lung(2.5)
- Kidney(2.3)
- Heart(2.2)
- Bone(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for AHSG
-
OriGene qPCR primer pairs for AHSG
- genomics-online: primer clones - Search results for 138 available Fetuin A gene related products
- Overview of 138 available Fetuin A gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AHSG Gene
Orthologs for AHSG Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | AHSG 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | AHSG 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | AHSG 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Ahsg 16 34 33 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ahsg 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | AHSG 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | AHSG 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | AHSG 34 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | AHSG 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | ahsg 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ahsg 33 |
|
||
AHSG 34 |
|
OneToOne |
- Species where no ortholog for AHSG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for AHSG Gene
Variants for AHSG Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for AHSG Gene
- FETUA_HUMAN-P02765
- There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256.
SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2070634 | association, Calcium oxalate urolithiasis | 186,618,238(+) | T/G | intron_variant | |
rs2070635 | association, Calcium oxalate urolithiasis | 186,618,387(+) | A/G | intron_variant | |
rs4917 | risk-factor, Leanness, susceptibility to | 186,619,924(+) | T/C | coding_sequence_variant, intron_variant, missense_variant | |
rs4918 | risk-factor, Leanness, susceptibility to | 186,620,593(+) | G/A/C | coding_sequence_variant, missense_variant | |
rs1000277790 | -- | 186,611,694(+) | C/T | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759206 | CNV | loss | 17122850 |
nsv508974 | CNV | insertion | 20534489 |
Additional Variant Information for AHSG Gene
Disorders for AHSG Gene

(15) MalaCards diseases for AHSG Gene - From: HGMD, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
alopecia-mental retardation syndrome 1 |
|
|
alopecia-intellectual disability syndrome |
|
|
epstein-barr virus hepatitis |
|
|
testicular yolk sac tumor |
|
|
eccrine papillary adenocarcinoma |
|
|
Additional Disease Information for AHSG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for AHSG Gene
Publications for AHSG Gene
- Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). (PMID: 9322749) Osawa M … Takeichi S (Gene 1997) 2 3 4 22 58
- Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study. (PMID: 20031641) Fisher E … Weikert C (Circulation. Cardiovascular genetics 2009) 3 22 44 58
- AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects. (PMID: 18316360) Andersen G … Pedersen O (Diabetes 2008) 3 22 44 58
- Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease? (PMID: 18337634) Axelsson J … Stenvinkel P (American journal of nephrology 2008) 3 22 44 58
- Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis. (PMID: 17062776) Lehtinen AB … Bowden DW (The Journal of clinical endocrinology and metabolism 2007) 3 22 44 58
Products for AHSG Gene
- R&D Systems Antibodies for AHSG (Fetuin A/AHSG)
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AHSG
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AHSG
- antibodies-online: Search results for 213 available Fetuin A Antibodies ranked by validation data
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- GeneTex AHSG antibody for AHSG
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Sources for AHSG Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew