Aliases for EPHA2 Gene
Aliases for EPHA2 Gene
External Ids for EPHA2 Gene
- HGNC: 3386
- Entrez Gene: 1969
- Ensembl: ENSG00000142627
- OMIM: 176946
- UniProtKB: P29317
Previous HGNC Symbols for EPHA2 Gene
- ECK
Previous GeneCards Identifiers for EPHA2 Gene
- GC01M015783
- GC01M015564
- GC01M015679
- GC01M015831
- GC01M016323
- GC01M016450
- GC01M014968
Summaries for EPHA2 Gene
-
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
GeneCards Summary for EPHA2 Gene
EPHA2 (EPH Receptor A2) is a Protein Coding gene. Diseases associated with EPHA2 include Cataract 6, Multiple Types and Early-Onset Posterior Subcapsular Cataract. Among its related pathways are Axon guidance and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA3.
UniProtKB/Swiss-Prot for EPHA2 Gene
-
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA2 Gene
Genomics for EPHA2 Gene
Regulatory Elements for EPHA2 Gene
Enhancers for EPHA2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around EPHA2 on UCSC Golden Path with GeneCards custom track
Promoters for EPHA2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around EPHA2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for EPHA2 Gene
- Chromosome:
- 1
- Start:
- 16,124,337 bp from pter
- End:
- 16,156,087 bp from pter
- Size:
- 31,751 bases
- Orientation:
- Minus strand
Genomic View for EPHA2 Gene
Genes around EPHA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.13 by Ensembl
- 1p36 by Entrez Gene
- 1p36 by HGNC
EPHA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EPHA2 Gene
Proteins for EPHA2 Gene
-
Protein details for EPHA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29317-EPHA2_HUMAN
- Recommended name:
- Ephrin type-A receptor 2
- Protein Accession:
- P29317
- B5A968
- Q8N3Z2
Protein attributes for EPHA2 Gene
- Size:
- 976 amino acids
- Molecular mass:
- 108266 Da
- Quaternary structure:
-
- Homodimer. Interacts with SLA. Interacts (phosphorylated form) with VAV2, VAV3 and PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3); critical for the EFNA1-induced activation of RAC1 which stimulates cell migration (By similarity). Interacts with INPPL1; regulates activated EPHA2 endocytosis and degradation. Interacts (inactivated form) with PTK2/FAK1 and interacts (EFNA1 ligand-activated form) with PTPN11; regulates integrin-mediated adhesion. Interacts with ARHGEF16, DOCK4 and ELMO2; mediates ligand-independent activation of RAC1 which stimulates cell migration. Interacts with CLDN4; phosphorylates CLDN4 and may regulate tight junctions. Interacts with ACP1. Interacts (via SAM domain) with ANKS1A (via SAM domain). Interacts with human herpes virus 8/HHV-8 glycoprotein L/gL and glycoprotein H/gH heterodimer; this interaction triggers EPHA2 phosphorylation and endocytosis, allowing virus entry. Interacts with CEMIP. Interacts with NCK1; may regulate EPHA2 activity in cell migration and adhesion.
Three dimensional structures from OCA and Proteopedia for EPHA2 Gene
Protein Expression for EPHA2 Gene
Selected DME Specific Peptides for EPHA2 Gene
Post-translational modifications for EPHA2 Gene
- Autophosphorylates. Phosphorylated on tyrosine upon binding and activation by EFNA1. Phosphorylated residues Tyr-588 and Tyr-594 are required for binding VAV2 and VAV3 while phosphorylated residues Tyr-735 and Tyr-930 are required for binding PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3). These phosphorylated residues are critical for recruitment of VAV2 and VAV3 and PI3-kinase p85 subunit which transduce downstream signaling to activate RAC1 GTPase and cell migration. Dephosphorylation of Tyr-930 by PTPRF prevents the interaction of EPHA2 with NCK1. Phosphorylated at Ser-897 by PKB; serum-induced phosphorylation which targets EPHA2 to the cell leading edge and stimulates cell migration. Phosphorylation by PKB is inhibited by EFNA1-activated EPHA2 which regulates PKB activity via a reciprocal regulatory loop. Dephosphorylated by ACP1.
- Ubiquitinated by CHIP/STUB1. Ubiquitination is regulated by the HSP90 chaperone and regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity).
- Ubiquitination at Lys 578
- Glycosylation at Asn 407 and Asn 435
- Modification sites at PhosphoSitePlus
Other Protein References for EPHA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top EPHA2 Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for EPHA2
- R&D Systems Antibodies for EPHA2 (EphA2)
- Cell Signaling Technology (CST) Antibodies for EPHA2 (EphA2)
- Novus Biologicals Antibodies for EPHA2
- Abcam antibodies for Eph receptor A2
- Abcam antibodies for Eph receptor A2+A3+A4
- Invitrogen Antibodies for EPHA2
- antibodies-online Antibodies for EPHA2: See all 238
- GeneTex EPHA2 antibody for EPHA2
-
Santa Cruz Biotechnology (SCBT) Antibodies for EPHA2
Protein Products
- EMD Millipore Purified and/or Recombinant EPHA2 Protein
- R&D Systems Proteins and Enzymes for EPHA2 (EphA2)
- Enzo Life Sciences proteins for EPHA2
- Search Origene for MassSpec and Protein Over-expression Lysates for EPHA2
- Origene Custom Protein Services for EPHA2
- Sino Biological Cell Lysates for EPHA2
- Browse Sino Biological Proteins
- antibodies-online Proteins for EPHA2: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for EPHA2
- Abcam proteins for Eph receptor A2
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for EPHA2 (EphA2)
- antibodies-online Kits for EPHA2: See all 2
- Abcam assays for Eph receptor A2
Domains & Families for EPHA2 Gene
Gene Families for EPHA2 Gene
Protein Domains for EPHA2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EPHA2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P29317UniProtKB/Swiss-Prot:
EPHA2_HUMAN :- Contains 1 Eph LBD (Eph ligand-binding) domain.
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
- Domain:
-
- Contains 1 Eph LBD (Eph ligand-binding) domain.
- Contains 2 fibronectin type-III domains.
- Contains 1 protein kinase domain.
- Contains 1 SAM (sterile alpha motif) domain.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Function for EPHA2 Gene
Molecular function for EPHA2 Gene
- GENATLAS Biochemistry:
- EPH related tyrosine kinase receptor,binding ephrins A,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance,highly expressed in metastatic melanoma cells
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot Function:
- Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by UV irradiation via a TP53-independent, MAPK-dependent mechanism.
Enzyme Numbers (IUBMB) for EPHA2 Gene
- EC 2.7.10.1 63 4
- EC 2.7.10 63
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | IEA | -- |
| GO:0005003 | ephrin receptor activity | IEA | -- |
Phenotypes for EPHA2 Gene
- MGI mutant phenotypes for EPHA2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for EPHA2:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability
- Decreased cell migration
- Increased cell death HMECs cells
- Increased shRNA abundance
- Increased mitotic index
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
Animal Models for EPHA2 Gene
- MGI Knock Outs for EPHA2:
-
- Epha2 tm1Jrui
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for EPHA2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPHA2 gene
- Search ViGene Biosciences for EPHA2
CRISPR Products
-
OriGene CRISPR knockouts for EPHA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPHA2
- GenScript: Design CRISPR guide RNA sequences for EPHA2
miRNA for EPHA2 Gene
- miRTarBase miRNAs that target EPHA2
-
- hsa-mir-26b-5p (MIRT005508)
- hsa-mir-193b-3p (MIRT016375)
- hsa-mir-34a-5p (MIRT025420)
- hsa-mir-16-5p (MIRT031603)
- hsa-mir-940 (MIRT036589)
- hsa-mir-520d-3p (MIRT054131)
- hsa-mir-3187-3p (MIRT477316)
- hsa-mir-1227-5p (MIRT477317)
- hsa-mir-4435 (MIRT477318)
- hsa-mir-588 (MIRT477319)
- hsa-mir-4701-5p (MIRT477320)
- hsa-mir-548s (MIRT477321)
- hsa-mir-5187-5p (MIRT477322)
- hsa-mir-3605-5p (MIRT477323)
- hsa-mir-3679-5p (MIRT477324)
- hsa-mir-1185-5p (MIRT477325)
- hsa-mir-605-3p (MIRT477326)
- hsa-mir-4509 (MIRT477327)
- hsa-mir-4744 (MIRT477328)
- hsa-mir-6754-5p (MIRT477329)
- hsa-mir-4270 (MIRT477330)
- hsa-mir-4441 (MIRT477331)
- hsa-mir-211-3p (MIRT477332)
- hsa-mir-6757-5p (MIRT477333)
- hsa-mir-1182 (MIRT477334)
- hsa-mir-2392 (MIRT477335)
- hsa-mir-3133 (MIRT477336)
- hsa-mir-186-5p (MIRT477337)
- hsa-mir-124-3p (MIRT477338)
- hsa-mir-302c-5p (MIRT502523)
- hsa-mir-302d-5p (MIRT502524)
- hsa-mir-302b-5p (MIRT502525)
- hsa-mir-4526 (MIRT502526)
- hsa-mir-8063 (MIRT502527)
- hsa-mir-3660 (MIRT502528)
- hsa-mir-888-3p (MIRT502529)
- hsa-mir-200a-3p (MIRT502530)
- hsa-mir-141-3p (MIRT502531)
- hsa-mir-1255b-5p (MIRT537664)
- hsa-mir-1255a (MIRT537665)
miRNA Products
- Search ViGene Biosciences for EPHA2
Clone Products
- OriGene clones in human for EPHA2
- OriGene ORF clones in human,mouse,rat for EPHA2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EPHA2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EPHA2
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for EPHA2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EPHA2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPHA2 gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for EPHA2 Gene
Localization for EPHA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EPHA2 Gene
- Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). {ECO:0000269 PubMed:18794797, ECO:0000269 PubMed:19573808, ECO:0000269 PubMed:20861311}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 2 |
| chloroplast | 1 |
| cytosol | 1 |
| endoplasmic reticulum | 1 |
| extracellular | 1 |
| nucleus | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005887 | integral component of plasma membrane | IEA,IDA | 10655584 |
| GO:0005925 | focal adhesion | IDA | 10655584 |
| GO:0031258 | lamellipodium membrane | IEA | -- |
Pathways & Interactions for EPHA2 Gene
More details on SuperPathways for EPHA2| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | GPCR Pathway |
.73
.62
|
.55
|
| 2 | ERK Signaling |
.61
.58
|
.49
|
| 3 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 4 | EPHA forward signaling | ||
| 5 | Actin Nucleation by ARP-WASP Complex |
.41
|
Pathways by source for EPHA2 Gene
2 Cell Signaling Technology pathways for EPHA2 Gene
6 BioSystems pathways for EPHA2 Gene
5 Reactome pathways for EPHA2 Gene
4 KEGG pathways for EPHA2 Gene
3 GeneGo (Thomson Reuters) pathways for EPHA2 Gene
Interacting Proteins for EPHA2 Gene
Selected Interacting proteins:
P29317-EPHA2_HUMAN
ENSP00000351209
for EPHA2 Gene via
MINT
STRING
I2D
UniProtKB
SIGNOR curated interactions for EPHA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001568 | blood vessel development | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007155 | cell adhesion | IEA | -- |
Drugs & Compounds for EPHA2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dasatinib | Approved, Investigational | Pharma | Inhibition, inhibitor, Target, antagonist | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 271 | |
| regorafenib | Approved | Pharma | inhibitor, Target | Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Sprycel | Approved June 2006 | Pharma | 0 | |||
| Stivarga | Approved February 2013/ Approved September 2012 | Pharma | 0 | |||
| Adenosine triphosphate | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Drug Products
- Enzo Life Sciences drugs & compounds for EPHA2
Transcripts for EPHA2 Gene
mRNA/cDNA for EPHA2 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (215) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for EPHA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPHA2
- GenScript: Design CRISPR guide RNA sequences for EPHA2
miRNA Products
- Search ViGene Biosciences for EPHA2
Clone Products
- OriGene clones in human for EPHA2
- OriGene ORF clones in human,mouse,rat for EPHA2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EPHA2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EPHA2
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for EPHA2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Early Floor Plate Cells Mesencephalic Floor Plate
- Hypothalamus
- Hippocampus
- Thalamus
- Cerebellum
- Inner Cell Mass (Early Embryonic Tissues)
-
Neural Tube (Nervous System)
- Early Floor Plate Cells Mesencephalic Floor Plate
- Late Floor Plate Cells Mesencephalic Floor Plate
- Endothelium (Cardiovascular System)
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Spinal Cord (Nervous System)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for EPHA2 Gene
This gene is overexpressed in Esophagus - Mucosa (x10.7).
This gene is overexpressed in Amniocyte (33.1) and Adrenal (14.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPHA2 Gene
SOURCE GeneReport for Unigene cluster for EPHA2 Gene Hs.171596
mRNA Expression by UniProt/SwissProt for EPHA2 Gene
P29317-EPHA2_HUMAN
Tissue specificity:
Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary.
Primer Products
-
OriGene qPCR primer pairs and template standards for EPHA2
-
OriGene qPCR primer pairs for EPHA2
No data available for Protein tissue co-expression partners for EPHA2 Gene
Orthologs for EPHA2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | EPHA2 35 |
|
||
| EPHA2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | EPHA2 35 |
|
||
| EPHA2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Epha2 35 |
|
||
| Epha2 16 |
|
||||
| Epha2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | EPHA2 35 |
|
||
| EPHA2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Epha2 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EPHA2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | EPHA2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EPHA2 35 |
|
||
| EPHA2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | EPHA2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | epha2 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | epha2-A 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12568 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | EPHA2 (2 of 2) 36 |
|
OneToMany | |
| epha2a 36 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Eph 37 |
|
|
|
| hop 37 |
|
|
|||
| Eph 36 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | kin-24 37 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
ManyToMany | |
| -- 36 |
|
ManyToMany | |||
| CSA.1664 36 |
|
ManyToMany | |||
| CSA.7809 36 |
|
ManyToMany |
- Species with no ortholog for EPHA2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EPHA2 Gene
Paralogs for EPHA2 Gene
(142) SIMAP similar genes for EPHA2 Gene using alignment to 4 proteins:
- EPHA6
- EPHB2 variant protein
- EPHA4
- EPHA7
- EPHA3
- EPHB3
- EPHB1
- HCK
- BTK kinase deficient isoform 2
- EPHA5
- FYN
- FES
- TXK
- MET
- FER
- EPHB2
- SRC
- NTRK2
- LYN
- YES1
- NTRK1
- MST1R
- EPHB4
- BCR/ABL fusion
- ABL1
- EPHA1
- CSK
- EPHA8
- TEK
- TEC
- SRMS
- ROR1
- MUSK
- LCK
- FGR
- DKFZp686D1354
- BTK kinase deficient isoform 6
- BTK
- EPHA10
- tec
- ZAP70
- ROR2
- PDGFRB
- BMX
- PTK6
- TIE1
- NTRK3
- KDR
- ITK
- IGF1R
- ERBB2
- TNK2
- BLK
- lsk
- SYK
- PTK2B
- MATK
- INSR
- AXL
- FRK
- RYK
- KIT
- ERBB4
- DDR1
- EPHB6
- FGFR2
- TNK1
- PTK7
- FLT1
- FGFR4
- DKFZp434L0319
- FGFR1
- RET/PTC2
- FGFR3
- ERBB3
- DKFZp666O0110
- ABL2
- PTK2
- EGFR
- urf-ret
- TPM3-ROS1
- SLC34A2/ROS1 fusion
- SLC34A2/ROS fusion
- SLC34A2-ROS1
- SDC4-ROS1_S4
- R34
- SDC4-ROS1_S4
- R32
- SDC4-ROS1_S2
- R32
- ROS1
- RET
- LRIG3(NM_153377)-ROS1
- LRIG3(NM_001136051)-ROS1
- KIF5B-RET(NM_020975)_K23
- R12
- KIF5B-RET(NM_020975)_K22
- R12
- KIF5B-RET(NM_020975)_K16
- R12
- KIF5B-RET(NM_020975)_K15
- R12
- KIF5B-RET(NM_020630)_K24
- R11
- KIF5B-RET(NM_020630)_K23
- R12
- KIF5B-RET(NM_020630)_K22
- R12
- KIF5B-RET(NM_020630)_K16
- R12
- KIF5B-RET(NM_020630)_K15
- R12
- JAK2
- FLT4
- EZR-ROS1
- CSF1R
- CD74/ROS fusion
- CD74-ROS1_C6
- R32
- CCDC6-RETc
- CCDC6-RETa
- TYRO3
- MERTK
- MAP3K13
- MAP3K12
- JAK1
- TYK2
- TFG/ALK fusion
- SQSTM1-ALK
- PPFIBP1-ALK
- KIF5B-ALK_K17
- A20
- KIF5B-ALK
- EML4/ALK fusion
- EML4-ALK variant 7
- EML4-ALK variant 6
- EML4-ALK
- ALK
- FLT3
- PDGFRA
- JAK3
- LTK
Variants for EPHA2 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs34192549 | - | 16,137,994(+) | CAGTC(C/T)GTGAG | reference, missense | |
| rs55747232 | - | 16,135,086(+) | CCTGC(A/G)TCAGT | reference, missense | |
| rs56198600 | - | 16,133,895(+) | ACTGG(C/T)GGGCA | reference, missense | |
| VAR_042124 | A gastric adenocarcinoma sample | ||||
| rs35903225 | - | 16,130,268(+) | GGGCA(C/T)GAATG | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv508936 | CNV | Insertion | 20534489 |
| dgv174n71 | CNV | Loss | 21882294 |
| nsv833758 | CNV | Gain+Loss | 17160897 |
| nsv520148 | CNV | Loss | 19592680 |
| nsv871485 | CNV | Loss | 21882294 |
| nsv524045 | CNV | Loss | 19592680 |
| dgv177n71 | CNV | Loss | 21882294 |
| nsv870801 | CNV | Loss | 21882294 |
| nsv833869 | CNV | Loss | 17160897 |
| nsv871825 | CNV | Loss | 21882294 |
| nsv870978 | CNV | Loss | 21882294 |
| nsv470699 | CNV | Loss | 18288195 |
Residual Variation Intolerance Score:
29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.17;
61.68% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for EPHA2 Gene
- Human Gene Mutation Database (HGMD)
- EPHA2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA2 Gene
Disorders for EPHA2 Gene
(14) MalaCards diseases for EPHA2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cataract 6, multiple types |
|
|
| early-onset posterior subcapsular cataract |
|
|
| early-onset nuclear cataract |
|
|
| early-onset posterior polar cataract |
|
|
| total early-onset cataract |
|
|
Search EPHA2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
EPHA2_HUMAN- Cataract 6, multiple types (CTRCT6) [MIM:116600]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT6 includes posterior polar and age-related cortical cataracts, among others. Posterior polar cataract is a subcapsular opacity, usually disk-shaped, located at the back of the lens. Age-related cortical cataract is a developmental punctate opacity restricted to the cortex. The cataract is white or cerulean, increases in number with age, but rarely affects vision. {ECO:0000269 PubMed:19005574, ECO:0000269 PubMed:19306328, ECO:0000269 PubMed:19649315}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=Overexpressed in several cancer types and promotes malignancy. {ECO:0000269 PubMed:19573808}.
Relevant External Links for EPHA2
No data available for Genatlas for EPHA2 Gene
Publications for EPHA2 Gene
- The EPHA2 gene is associated with cataracts linked to chromosome 1p. (PMID: 19005574) Shiels A. … Hejtmancik J.F. (Mol. Vis. 2008) 3 4 48 67
- EFNA1 ligand and its receptor EphA2: potential biomarkers for hepatocellular carcinoma. (PMID: 19642143) Cui X.D. … Kim D.G. (Int. J. Cancer 2010) 3 23
- Cell adhesion and EGFR activation regulate EphA2 expression in cancer. (PMID: 19948216) Larsen A.B. … Poulsen H.S. (Cell. Signal. 2010) 3 23
- Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. (PMID: 20028874) Zhuang G. … Chen J. (Cancer Res. 2010) 3 23
- Left-handed dimer of EphA2 transmembrane domain: Helix packing diversity among receptor tyrosine kinases. (PMID: 20197042) Bocharov E.V. … Arseniev A.S. (Biophys. J. 2010) 3 23
Products for EPHA2 Gene
- R&D Systems Antibodies for EPHA2 (EphA2)
- R&D Systems Proteins and Enzymes for EPHA2 (EphA2)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for EPHA2 (EphA2)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for EPHA2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for EPHA2
- Origene Custom Protein Services for EPHA2
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for EPHA2
- Browse OriGene Inhibitory RNA Products For EPHA2
- OriGene qPCR primer pairs for EPHA2
- OriGene qPCR primer pairs and template standards for EPHA2
- OriGene CRISPR knockouts for EPHA2
- OriGene clones in human for EPHA2
- OriGene ORF clones in human,mouse,rat for EPHA2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for EPHA2
- GenScript Custom Assay Services for EPHA2
- GenScript Custom overexpressing Cell Line Services for EPHA2
- GenScript: Design CRISPR guide RNA sequences for EPHA2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for EPHA2
- Cell Signaling Technology (CST) Antibodies for EPHA2 (EphA2)
- Search for Antibodies & Assays
- Enzo Life Sciences proteins for EPHA2
- Browse Enzo Life Sciences for kits & assays
- Enzo Life Sciences drugs & compounds for EPHA2
- Search Enzo Life Sciences for proteins, assays, substrates, inhibitors & antibodies
- Novus Biologicals Antibodies for EPHA2
- Novus Biologicals proteins and lysates for EPHA2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for Eph receptor A2
- Abcam antibodies for Eph receptor A2+A3+A4
- Abcam proteins for Eph receptor A2
- Abcam assays for Eph receptor A2
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Addgene plasmids for EPHA2
- antibodies-online Antibodies for EPHA2: See all 238
- antibodies-online Kits for EPHA2: See all 2
- antibodies-online Proteins for EPHA2: See all 11
- Search antibodies-online for peptides
- GeneTex EPHA2 antibody for EPHA2
- Search GeneTex for Proteins for EPHA2
- ViGene Biosciences adenoviral particle packaged cDNA for EPHA2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EPHA2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EPHA2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EPHA2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EPHA2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EPHA2 gene
- Search ViGene Biosciences for EPHA2
- Search ViGene Biosciences for EPHA2
- Santa Cruz Biotechnology (SCBT) Antibodies for EPHA2
- Search Santa Cruz Biotechnology (SCBT) for EPHA2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EPHA2
Sources for EPHA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon