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Aliases for ARID2 Gene

Aliases for ARID2 Gene

  • AT Rich Interactive Domain 2 (ARID, RFX-Like) 2 3
  • Zinc Finger Protein With Activation Potential 3 4
  • ARID Domain-Containing Protein 2 3 4
  • BRG1-Associated Factor 200 3 4
  • Zipzap/P200 3 4
  • BAF200 3 4
  • AT-Rich Interactive Domain-Containing Protein 2 3
  • KIAA1557 4
  • Zipzap 3
  • P200 3

External Ids for ARID2 Gene

Summaries for ARID2 Gene

Entrez Gene Summary for ARID2 Gene

  • ARID2 is a subunit of the PBAF chromatin-remodeling complex (see BAF180; MIM 606083), which facilitates ligand-dependent transcriptional activation by nuclear receptors (Yan et al., 2005 [PubMed 15985610]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARID2 Gene

ARID2 (AT Rich Interactive Domain 2 (ARID, RFX-Like)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ARID2 Gene

  • Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.

Gene Wiki entry for ARID2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID2 Gene

Genomics for ARID2 Gene

Genomic Location for ARID2 Gene

Start:
45,729,665 bp from pter
End:
45,908,040 bp from pter
Size:
178,376 bases
Orientation:
Plus strand

Genomic View for ARID2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARID2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID2 Gene

Regulatory Elements for ARID2 Gene

Transcription factor binding sites by QIAGEN in the ARID2 gene promoter:

Proteins for ARID2 Gene

  • Protein details for ARID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CP9-ARID2_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 2
    Protein Accession:
    Q68CP9
    Secondary Accessions:
    • Q15KG9
    • Q5EB51
    • Q645I3
    • Q6ZRY5
    • Q7Z3I5
    • Q86T28
    • Q96SJ6
    • Q9HCL5

    Protein attributes for ARID2 Gene

    Size:
    1835 amino acids
    Molecular mass:
    197391 Da
    Quaternary structure:
    • Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Interacts with SRF. Forms complexes with SRF and SRF cofactors MYOCD, NKX2-5 and SRFBP1.
    SequenceCaution:
    • Sequence=AAU20329.2; Type=Miscellaneous discrepancy; Note=Differs from position 1094 onward for unknown reason.; Evidence={ECO:0000305}; Sequence=BAB55320.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87171.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARID2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARID2 Gene

Proteomics data for ARID2 Gene at MOPED

Post-translational modifications for ARID2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys7, Lys15, Lys62, Lys1731, and Lys1777

Other Protein References for ARID2 Gene

No data available for DME Specific Peptides for ARID2 Gene

Domains for ARID2 Gene

Suggested Antigen Peptide Sequences for ARID2 Gene

Graphical View of Domain Structure for InterPro Entry

Q68CP9

UniProtKB/Swiss-Prot:

ARID2_HUMAN
Domain:
  • Contains 1 ARID domain.:
    • Q68CP9
  • Contains 1 RFX-type winged-helix DNA-binding domain.:
    • Q68CP9
Similarity:
  • Contains 1 C2H2-type zinc finger.:
    • Q68CP9
genes like me logo Genes that share domains with ARID2: view

No data available for Gene Families for ARID2 Gene

Function for ARID2 Gene

Molecular function for ARID2 Gene

UniProtKB/Swiss-Prot Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.

Gene Ontology (GO) - Molecular Function for ARID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 15985610
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARID2: view

Phenotypes for ARID2 Gene

genes like me logo Genes that share phenotypes with ARID2: view

miRNA for ARID2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARID2 Gene

Localization for ARID2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID2 Gene COMPARTMENTS Subcellular localization image for ARID2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ARID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ARID2: view

Pathways for ARID2 Gene

SuperPathways for ARID2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006337 nucleosome disassembly IDA 8895581
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with ARID2: view

No data available for Pathways by source for ARID2 Gene

Transcripts for ARID2 Gene

Unigene Clusters for ARID2 Gene

AT rich interactive domain 2 (ARID, RFX-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5: - - - - - - - - - - - - - - - -
SP6:
SP7:

ExUns: 20 ^ 21 ^ 22 ^ 23
SP1: -
SP2: -
SP3:
SP4: -
SP5: -
SP6:
SP7:

Relevant External Links for ARID2 Gene

GeneLoc Exon Structure for
ARID2
ECgene alternative splicing isoforms for
ARID2

Expression for ARID2 Gene

mRNA expression in normal human tissues for ARID2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARID2 Gene

SOURCE GeneReport for Unigene cluster for ARID2 Gene Hs.317304

mRNA Expression by UniProt/SwissProt for ARID2 Gene

Q68CP9-ARID2_HUMAN
Tissue specificity: Highly expressed in heart and testis.
genes like me logo Genes that share expressions with ARID2: view

No data available for mRNA differential expression in normal tissues for ARID2 Gene

Orthologs for ARID2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID2 35
  • 99.04 (n)
  • 98.96 (a)
ARID2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARID2 35
  • 94.91 (n)
  • 96.78 (a)
ARID2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID2 35
  • 94.71 (n)
  • 95.97 (a)
ARID2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arid2 35
  • 88.98 (n)
  • 92.45 (a)
Arid2 16
Arid2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARID2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arid2 35
  • 88.15 (n)
  • 91.23 (a)
chicken
(Gallus gallus)
Aves ARID2 35
  • 84.65 (n)
  • 85.52 (a)
ARID2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARID2 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6507 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arid2 35
  • 76.65 (n)
  • 77.89 (a)
Str.6901 35
zebrafish
(Danio rerio)
Actinopterygii arid2 35
  • 63.15 (n)
  • 64.86 (a)
arid2 36
  • 62 (a)
OneToOne
wufi45a01 35
fruit fly
(Drosophila melanogaster)
Insecta Bap170 36
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea swsn-7 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5262 36
  • 29 (a)
OneToOne
Species with no ortholog for ARID2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID2 Gene

ENSEMBL:
Gene Tree for ARID2 (if available)
TreeFam:
Gene Tree for ARID2 (if available)

Paralogs for ARID2 Gene

Pseudogenes.org Pseudogenes for ARID2 Gene

genes like me logo Genes that share paralogs with ARID2: view

No data available for Paralogs for ARID2 Gene

Variants for ARID2 Gene

Sequence variations from dbSNP and Humsavar for ARID2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs15852 -- 45,907,298(+) ACAAC(A/G)TTTAT utr-variant-3-prime
rs35113 -- 45,866,159(-) ATATA(C/T)ATAGT intron-variant
rs35114 -- 45,856,258(-) aaccc(A/C)gtctc intron-variant
rs35115 -- 45,855,644(-) CAACA(A/G)CCTTC intron-variant
rs35116 -- 45,853,385(-) GGAGA(C/T)TAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID2 Gene

Variant ID Type Subtype PubMed ID
nsv899052 CNV Loss 21882294
nsv899053 CNV Loss 21882294
dgv508e1 CNV Complex 17122850
nsv832396 CNV Loss 17160897
esv2516965 CNV Insertion 19546169
esv268062 CNV Insertion 20981092
esv273302 CNV Insertion 20981092
nsv832397 CNV Loss 17160897

Relevant External Links for ARID2 Gene

HapMap Linkage Disequilibrium report
ARID2
Human Gene Mutation Database (HGMD)
ARID2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID2 Gene

Disorders for ARID2 Gene

Relevant External Links for ARID2

Genetic Association Database (GAD)
ARID2
genes like me logo Genes that share disorders with ARID2: view

No data available for UniProtKB/Swiss-Prot for ARID2 Gene

Publications for ARID2 Gene

  1. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin S.G. … Macciardi F. (PLoS ONE 2009) 3 48
  2. Recent advances in understanding chromatin remodeling by SWI/SNF complexes. (PMID: 12672490) Martens J.A. … Winston F. (Curr. Opin. Genet. Dev. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARID2 Gene

Sources for ARID2 Gene

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