Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCP1B Gene

Aliases for DCP1B Gene

  • Decapping MRNA 1B 2 3
  • DCP1 3 6
  • DCP1 Decapping Enzyme Homolog B (S. Cerevisiae) 2
  • DCP1 Decapping Enzyme Homolog B 3
  • MRNA-Decapping Enzyme 1B 3
  • Decapping Enzyme HDcp1b 3
  • EC 3.-.-.- 4
  • HDcp1b 3

External Ids for DCP1B Gene

Summaries for DCP1B Gene

Entrez Gene Summary for DCP1B Gene

  • DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002 [PubMed 12417715]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DCP1B Gene

DCP1B (Decapping MRNA 1B) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for DCP1B Gene

  • May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP (By similarity).

Gene Wiki entry for DCP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCP1B Gene

Genomics for DCP1B Gene

Genomic Location for DCP1B Gene

Start:
1,946,048 bp from pter
End:
2,004,545 bp from pter
Size:
58,498 bases
Orientation:
Minus strand

Genomic View for DCP1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP1B Gene

Regulatory Elements for DCP1B Gene

Proteins for DCP1B Gene

  • Protein details for DCP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZD4-DCP1B_HUMAN
    Recommended name:
    mRNA-decapping enzyme 1B
    Protein Accession:
    Q8IZD4
    Secondary Accessions:
    • B4DRD1
    • Q86XH9
    • Q96BP8
    • Q96MZ8

    Protein attributes for DCP1B Gene

    Size:
    617 amino acids
    Molecular mass:
    67723 Da
    Quaternary structure:
    • Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and CNOT6
    SequenceCaution:
    • Sequence=AAH15368.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP1B Gene

Proteomics data for DCP1B Gene at MOPED

Post-translational modifications for DCP1B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys12

Other Protein References for DCP1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DCP1B Gene

Domains for DCP1B Gene

Protein Domains for DCP1B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DCP1B_HUMAN
Family:
  • Belongs to the DCP1 family.:
    • Q8IZD4
genes like me logo Genes that share domains with DCP1B: view

No data available for Gene Families for DCP1B Gene

Function for DCP1B Gene

Molecular function for DCP1B Gene

UniProtKB/Swiss-Prot Function: May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP (By similarity).

Enzyme Numbers (IUBMB) for DCP1B Gene

Gene Ontology (GO) - Molecular Function for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000340 RNA 7-methylguanosine cap binding IBA --
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 15231747
GO:0016787 hydrolase activity IEA --
GO:0030234 enzyme regulator activity IBA --
genes like me logo Genes that share ontologies with DCP1B: view

Phenotypes for DCP1B Gene

GenomeRNAi human phenotypes for DCP1B:
genes like me logo Genes that share phenotypes with DCP1B: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DCP1B Gene

Localization for DCP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP1B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCP1B Gene COMPARTMENTS Subcellular localization image for DCP1B gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IBA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DCP1B: view

Pathways for DCP1B Gene

genes like me logo Genes that share pathways with DCP1B: view

Pathways by source for DCP1B Gene

1 KEGG pathway for DCP1B Gene

Gene Ontology (GO) - Biological Process for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA --
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IBA --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
genes like me logo Genes that share ontologies with DCP1B: view

Transcripts for DCP1B Gene

Unigene Clusters for DCP1B Gene

DCP1 decapping enzyme homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCP1B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for DCP1B Gene

GeneLoc Exon Structure for
DCP1B
ECgene alternative splicing isoforms for
DCP1B

Expression for DCP1B Gene

mRNA expression in normal human tissues for DCP1B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCP1B Gene

SOURCE GeneReport for Unigene cluster for DCP1B Gene Hs.130934

genes like me logo Genes that share expressions with DCP1B: view

Orthologs for DCP1B Gene

This gene was present in the common ancestor of animals.

Orthologs for DCP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCP1B 36
  • 99.41 (n)
  • 99.19 (a)
DCP1B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCP1B 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCP1B 36
  • 87.67 (n)
  • 84.94 (a)
DCP1B 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcp1b 36
  • 76.2 (n)
  • 67.94 (a)
Dcp1b 16
Dcp1b 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCP1B 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCP1B 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcp1b 36
  • 76.93 (n)
  • 68.17 (a)
chicken
(Gallus gallus)
Aves DCP1B 36
  • 74.02 (n)
  • 73.63 (a)
DCP1B 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCP1B 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcp1b 36
  • 63.59 (n)
  • 62.48 (a)
zebrafish
(Danio rerio)
Actinopterygii dcp1b 36
  • 58.27 (n)
  • 58.43 (a)
dcp1b 37
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dcp1 37
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dcap-1 37
  • 25 (a)
OneToMany
Species with no ortholog for DCP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCP1B Gene

ENSEMBL:
Gene Tree for DCP1B (if available)
TreeFam:
Gene Tree for DCP1B (if available)

Paralogs for DCP1B Gene

No data available for Paralogs for DCP1B Gene

Variants for DCP1B Gene

Sequence variations from dbSNP and Humsavar for DCP1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7222 -- 1,946,100(-) TAAAA(A/G)AAAAG utr-variant-3-prime
rs715146 - 1,952,909(+) CACCA(C/T)GAGAA missense, reference
rs1044950 -- 1,952,816(-) ACCAG(C/T)ACCTG reference, missense
rs1860047 -- 1,946,948(+) ACTTT(A/G)GCCTC intron-variant
rs1860048 -- 1,949,529(+) GTATC(A/G)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCP1B Gene

Variant ID Type Subtype PubMed ID
nsv898598 CNV Gain 21882294
nsv898600 CNV Loss 21882294
nsv521838 CNV Gain 19592680
nsv525455 CNV Loss 19592680
esv2661228 CNV Deletion 23128226
esv271845 CNV Insertion 20981092
esv273343 CNV Insertion 20981092
nsv574 CNV Insertion 18451855

Relevant External Links for DCP1B Gene

HapMap Linkage Disequilibrium report
DCP1B
Human Gene Mutation Database (HGMD)
DCP1B

Disorders for DCP1B Gene

Relevant External Links for DCP1B

Genetic Association Database (GAD)
DCP1B
genes like me logo Genes that share disorders with DCP1B: view

No data available for UniProtKB/Swiss-Prot for DCP1B Gene

Publications for DCP1B Gene

  1. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PMID: 12417715) Lykke-Andersen J. (Mol. Cell. Biol. 2002) 2 3 4
  2. Cytoplasmic foci are sites of mRNA decay in human cells. (PMID: 15067023) Cougot N. … Seraphin B. (J. Cell Biol. 2004) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4

Products for DCP1B Gene

Sources for DCP1B Gene

Back to Top

Content