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Aliases for DCP1B Gene

Aliases for DCP1B Gene

  • Decapping MRNA 1B 2 3 5
  • DCP1 Decapping Enzyme Homolog B (S. Cerevisiae) 2
  • DCP1 Decapping Enzyme Homolog B 3
  • Decapping Enzyme HDcp1b 3
  • EC 3.-.-.- 4
  • DCP1 3

External Ids for DCP1B Gene

Previous GeneCards Identifiers for DCP1B Gene

  • GC12M001940
  • GC12M001925
  • GC12M002055

Summaries for DCP1B Gene

Entrez Gene Summary for DCP1B Gene

  • This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for DCP1B Gene

DCP1B (Decapping MRNA 1B) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Translational Control. GO annotations related to this gene include hydrolase activity and enzyme regulator activity. An important paralog of this gene is DCP1A.

UniProtKB/Swiss-Prot for DCP1B Gene

  • May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP (By similarity).

Gene Wiki entry for DCP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCP1B Gene

Genomics for DCP1B Gene

Regulatory Elements for DCP1B Gene

Enhancers for DCP1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCP1B on UCSC Golden Path with GeneCards custom track

Promoters for DCP1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCP1B on UCSC Golden Path with GeneCards custom track

Genomic Location for DCP1B Gene

Chromosome:
12
Start:
1,946,048 bp from pter
End:
2,004,535 bp from pter
Size:
58,488 bases
Orientation:
Minus strand

Genomic View for DCP1B Gene

Genes around DCP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP1B Gene

Proteins for DCP1B Gene

  • Protein details for DCP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZD4-DCP1B_HUMAN
    Recommended name:
    mRNA-decapping enzyme 1B
    Protein Accession:
    Q8IZD4
    Secondary Accessions:
    • B4DRD1
    • Q86XH9
    • Q96BP8
    • Q96MZ8

    Protein attributes for DCP1B Gene

    Size:
    617 amino acids
    Molecular mass:
    67723 Da
    Quaternary structure:
    • Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and CNOT6.
    SequenceCaution:
    • Sequence=AAH15368.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP1B Gene

Proteomics data for DCP1B Gene at MOPED

Post-translational modifications for DCP1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCP1B Gene

No data available for DME Specific Peptides for DCP1B Gene

Domains & Families for DCP1B Gene

Protein Domains for DCP1B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IZD4

UniProtKB/Swiss-Prot:

DCP1B_HUMAN :
  • Belongs to the DCP1 family.
Family:
  • Belongs to the DCP1 family.
genes like me logo Genes that share domains with DCP1B: view

No data available for Gene Families for DCP1B Gene

Function for DCP1B Gene

Molecular function for DCP1B Gene

UniProtKB/Swiss-Prot Function:
May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP (By similarity).

Enzyme Numbers (IUBMB) for DCP1B Gene

Gene Ontology (GO) - Molecular Function for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DCP1B: view
genes like me logo Genes that share phenotypes with DCP1B: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCP1B Gene

Localization for DCP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP1B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCP1B Gene COMPARTMENTS Subcellular localization image for DCP1B gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DCP1B: view

Pathways & Interactions for DCP1B Gene

genes like me logo Genes that share pathways with DCP1B: view

Pathways by source for DCP1B Gene

1 Cell Signaling Technology pathway for DCP1B Gene
1 KEGG pathway for DCP1B Gene

Gene Ontology (GO) - Biological Process for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with DCP1B: view

No data available for SIGNOR curated interactions for DCP1B Gene

Drugs & Compounds for DCP1B Gene

No Compound Related Data Available

Transcripts for DCP1B Gene

Unigene Clusters for DCP1B Gene

DCP1 decapping enzyme homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCP1B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for DCP1B Gene

GeneLoc Exon Structure for
DCP1B
ECgene alternative splicing isoforms for
DCP1B

Expression for DCP1B Gene

mRNA expression in normal human tissues for DCP1B Gene

Protein differential expression in normal tissues from HIPED for DCP1B Gene

This gene is overexpressed in Testis (22.6), CD8 Tcells (8.5), and Prostate (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCP1B Gene



SOURCE GeneReport for Unigene cluster for DCP1B Gene Hs.130934

genes like me logo Genes that share expression patterns with DCP1B: view

Protein tissue co-expression partners for DCP1B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCP1B Gene

Orthologs for DCP1B Gene

This gene was present in the common ancestor of animals.

Orthologs for DCP1B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DCP1B 35
  • 87.67 (n)
  • 84.94 (a)
DCP1B 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcp1b 35
  • 76.2 (n)
  • 67.94 (a)
Dcp1b 16
Dcp1b 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCP1B 35
  • 99.41 (n)
  • 99.19 (a)
DCP1B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcp1b 35
  • 76.93 (n)
  • 68.17 (a)
cow
(Bos Taurus)
Mammalia DCP1B 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCP1B 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCP1B 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCP1B 35
  • 74.02 (n)
  • 73.63 (a)
DCP1B 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCP1B 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcp1b 35
  • 63.59 (n)
  • 62.48 (a)
zebrafish
(Danio rerio)
Actinopterygii dcp1b 35
  • 58.27 (n)
  • 58.43 (a)
dcp1b 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dcp1 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dcap-1 36
  • 25 (a)
OneToMany
Species with no ortholog for DCP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCP1B Gene

ENSEMBL:
Gene Tree for DCP1B (if available)
TreeFam:
Gene Tree for DCP1B (if available)

Paralogs for DCP1B Gene

Paralogs for DCP1B Gene

genes like me logo Genes that share paralogs with DCP1B: view

Variants for DCP1B Gene

Sequence variations from dbSNP and Humsavar for DCP1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12423058 - 1,955,500(+) GAGAT(C/T)TGGAT reference, missense
rs34730825 - 1,955,436(-) GCCCA(A/G)CCAGG reference, missense
rs2470449 - 1,953,038(-) CAGGA(A/C/G)CGCAG reference, missense
rs715146 - 1,952,909(+) CACCA(C/G/T)GAGAA reference, missense
rs2041134 -- 1,955,841(+) AAAGG(C/T)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCP1B Gene

Variant ID Type Subtype PubMed ID
nsv898598 CNV Gain 21882294
nsv898600 CNV Loss 21882294
nsv521838 CNV Gain 19592680
nsv525455 CNV Loss 19592680
esv2661228 CNV Deletion 23128226
esv271845 CNV Insertion 20981092
esv273343 CNV Insertion 20981092
nsv574 CNV Insertion 18451855

Variation tolerance for DCP1B Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCP1B Gene

HapMap Linkage Disequilibrium report
DCP1B
Human Gene Mutation Database (HGMD)
DCP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCP1B Gene

Disorders for DCP1B Gene

Relevant External Links for DCP1B

Genetic Association Database (GAD)
DCP1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCP1B

No disorders were found for DCP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCP1B Gene

Publications for DCP1B Gene

  1. Cytoplasmic foci are sites of mRNA decay in human cells. (PMID: 15067023) Cougot N. … Seraphin B. (J. Cell Biol. 2004) 2 3 4 67
  2. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PMID: 12417715) Lykke-Andersen J. (Mol. Cell. Biol. 2002) 2 3
  3. Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex. (PMID: 26826132) Ziemniak M. … Jemielity J. (RNA 2016) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for DCP1B Gene

Sources for DCP1B Gene

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