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Aliases for EIF1AX Gene

Aliases for EIF1AX Gene

  • Eukaryotic Translation Initiation Factor 1A, X-Linked 2 3 5
  • Eukaryotic Translation Initiation Factor 1A, X Chromosome 2 3
  • Eukaryotic Translation Initiation Factor 4C 3 4
  • EIF-1A X Isoform 3 4
  • EIF-4C 3 4
  • EIF1A 3 4
  • EIF4C 3 4
  • Putative Eukaryotic Translation Initiation Factor 1A 3
  • EIF1AP1 3
  • EIF-1A 3

External Ids for EIF1AX Gene

Previous HGNC Symbols for EIF1AX Gene

  • EIF4C
  • EIF1A

Previous GeneCards Identifiers for EIF1AX Gene

  • GC0XU990358
  • GC0XM019505
  • GC0XM019902
  • GC0XM017884

Summaries for EIF1AX Gene

Entrez Gene Summary for EIF1AX Gene

  • This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for EIF1AX Gene

EIF1AX (Eukaryotic Translation Initiation Factor 1A, X-Linked) is a Protein Coding gene. Diseases associated with EIF1AX include differentiated thyroid carcinoma and uveal melanoma. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity. An important paralog of this gene is EIF1AY.

UniProtKB/Swiss-Prot for EIF1AX Gene

  • Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

Gene Wiki entry for EIF1AX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1AX Gene

Genomics for EIF1AX Gene

Regulatory Elements for EIF1AX Gene

Promoters for EIF1AX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF1AX on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF1AX Gene

Chromosome:
X
Start:
20,124,518 bp from pter
End:
20,141,848 bp from pter
Size:
17,331 bases
Orientation:
Minus strand

Genomic View for EIF1AX Gene

Genes around EIF1AX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1AX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1AX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AX Gene

Proteins for EIF1AX Gene

  • Protein details for EIF1AX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47813-IF1AX_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 1A, X-chromosomal
    Protein Accession:
    P47813
    Secondary Accessions:
    • B2R5U5
    • Q0VGC2
    • Q5JPS5
    • Q5JPS6

    Protein attributes for EIF1AX Gene

    Size:
    144 amino acids
    Molecular mass:
    16460 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI40551.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF1AX Gene

neXtProt entry for EIF1AX Gene

Proteomics data for EIF1AX Gene at MOPED

Post-translational modifications for EIF1AX Gene

  • Ubiquitination at Lys 56
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF1AX Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EIF1AX Gene

Domains & Families for EIF1AX Gene

Suggested Antigen Peptide Sequences for EIF1AX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47813

UniProtKB/Swiss-Prot:

IF1AX_HUMAN :
  • Contains 1 S1-like domain.
  • Belongs to the eIF-1A family.
Domain:
  • Contains 1 S1-like domain.
Family:
  • Belongs to the eIF-1A family.
genes like me logo Genes that share domains with EIF1AX: view

No data available for Gene Families for EIF1AX Gene

Function for EIF1AX Gene

Molecular function for EIF1AX Gene

GENATLAS Biochemistry:
eukaryotic initiation factor 1A on chromosome X,escaping inactivation,ubiquitous
UniProtKB/Swiss-Prot Function:
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

Gene Ontology (GO) - Molecular Function for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21139563
genes like me logo Genes that share ontologies with EIF1AX: view
genes like me logo Genes that share phenotypes with EIF1AX: view

Human Phenotype Ontology for EIF1AX Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for EIF1AX

miRNA for EIF1AX Gene

miRTarBase miRNAs that target EIF1AX

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AX Gene

Localization for EIF1AX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF1AX Gene COMPARTMENTS Subcellular localization image for EIF1AX gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EIF1AX Gene

Pathways & Interactions for EIF1AX Gene

genes like me logo Genes that share pathways with EIF1AX: view

Pathways by source for EIF1AX Gene

1 KEGG pathway for EIF1AX Gene
2 Qiagen pathways for EIF1AX Gene

Gene Ontology (GO) - Biological Process for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA,TAS --
genes like me logo Genes that share ontologies with EIF1AX: view

No data available for SIGNOR curated interactions for EIF1AX Gene

Drugs & Compounds for EIF1AX Gene

No Compound Related Data Available

Transcripts for EIF1AX Gene

mRNA/cDNA for EIF1AX Gene

Unigene Clusters for EIF1AX Gene

Eukaryotic translation initiation factor 1A, X-linked:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AX Gene

No ASD Table

Relevant External Links for EIF1AX Gene

GeneLoc Exon Structure for
EIF1AX
ECgene alternative splicing isoforms for
EIF1AX

Expression for EIF1AX Gene

mRNA expression in normal human tissues for EIF1AX Gene

Protein differential expression in normal tissues from HIPED for EIF1AX Gene

This gene is overexpressed in Islet of Langerhans (9.1) and Pancreas (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF1AX Gene



SOURCE GeneReport for Unigene cluster for EIF1AX Gene Hs.522590

genes like me logo Genes that share expression patterns with EIF1AX: view

Protein tissue co-expression partners for EIF1AX Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF1AX Gene

Orthologs for EIF1AX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF1AX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia EIF1AX 36
  • 100 (a)
OneToOne
EIF1AX 35
  • 90.74 (n)
  • 99.31 (a)
dog
(Canis familiaris)
Mammalia LOC611715 35
  • 94.21 (n)
  • 100 (a)
EIF1AX 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif1a 35
  • 87.73 (n)
  • 98.61 (a)
Eif1ax 36
  • 100 (a)
OneToOne
Eif1a 16
oppossum
(Monodelphis domestica)
Mammalia EIF1AX 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eif1a 35
  • 85.5 (n)
  • 97.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24811 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1ax 35
  • 86.81 (n)
  • 100 (a)
Str.7119 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.679 35
zebrafish
(Danio rerio)
Actinopterygii eif1axb 36
  • 95 (a)
ManyToMany
Dr.15002 35
eif1axb 35
  • 81.48 (n)
  • 99.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta eIF-1A 36
  • 78 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-1.A 36
  • 46 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER275C 35
  • 61.32 (n)
  • 64.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF11 36
  • 61 (a)
OneToMany
TIF11 38
TIF11 35
  • 65.14 (n)
  • 65.65 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11287g 35
  • 66.16 (n)
  • 66.41 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8105 35
soybean
(Glycine max)
eudicotyledons Gma.5683 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G04520 35
  • 65.9 (n)
  • 74.81 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12801 35
corn
(Zea mays)
Liliopsida Zm.16531 35
rice
(Oryza sativa)
Liliopsida Os.4711 35
Os06g0342200 35
  • 63.61 (n)
  • 77.1 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14227 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07437 35
  • 67.94 (n)
  • 83.21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif11 35
  • 67.18 (n)
  • 77.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10045 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11104 36
  • 52 (a)
OneToMany
Species with no ortholog for EIF1AX:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF1AX Gene

ENSEMBL:
Gene Tree for EIF1AX (if available)
TreeFam:
Gene Tree for EIF1AX (if available)

Paralogs for EIF1AX Gene

Paralogs for EIF1AX Gene

(1) SIMAP similar genes for EIF1AX Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EIF1AX Gene

genes like me logo Genes that share paralogs with EIF1AX: view

Variants for EIF1AX Gene

Sequence variations from dbSNP and Humsavar for EIF1AX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs14141 -- 20,125,916(-) CATCT(A/G)GCCCC utr-variant-3-prime
rs1043014 -- 20,126,287(-) TTCTT(C/T)TACTA utr-variant-3-prime
rs5955884 -- 20,124,442(+) TTAAA(A/T)ACAGC downstream-variant-500B
rs5955885 -- 20,133,400(+) cccca(C/G)ttgtg intron-variant
rs6418734 -- 20,126,792(+) GAATA(C/T)GTACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF1AX Gene

Variant ID Type Subtype PubMed ID
esv25136 CNV Gain+Loss 19812545
nsv820390 CNV Duplication 20802225

Variation tolerance for EIF1AX Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF1AX Gene

HapMap Linkage Disequilibrium report
EIF1AX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1AX Gene

Disorders for EIF1AX Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF1AX Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
uveal melanoma
  • melanoma of uvea
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EIF1AX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF1AX
genes like me logo Genes that share disorders with EIF1AX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF1AX Gene

Publications for EIF1AX Gene

  1. Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing. (PMID: 8106356) Dever T.E. … Hershey J.W.B. (J. Biol. Chem. 1994) 2 3 4 67
  2. Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. (PMID: 12514125) Olsen D.S. … Hinnebusch A.G. (EMBO J. 2003) 3 23
  3. Importin 13: a novel mediator of nuclear import and export. (PMID: 11447110) Mingot J.-M. … Goerlich D. (EMBO J. 2001) 3 23
  4. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for EIF1AX Gene

Sources for EIF1AX Gene

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