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Aliases for EIF1AX Gene

Aliases for EIF1AX Gene

  • Eukaryotic Translation Initiation Factor 1A, X-Linked 2 3
  • EIF1A 3 4 6
  • Eukaryotic Translation Initiation Factor 1A, X Chromosome 2 3
  • Eukaryotic Translation Initiation Factor 4C 3 4
  • EIF-1A X Isoform 3 4
  • EIF-4C 3 4
  • EIF4C 3 4
  • Eukaryotic Translation Initiation Factor 1A, X-Chromosomal 3
  • Putative Eukaryotic Translation Initiation Factor 1A 3
  • EIF1AP1 3
  • EIF-1A 3
  • EIF4C, 6

External Ids for EIF1AX Gene

Previous Symbols for EIF1AX Gene

  • EIF4C
  • EIF1A

Summaries for EIF1AX Gene

Entrez Gene Summary for EIF1AX Gene

  • This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for EIF1AX Gene

EIF1AX (Eukaryotic Translation Initiation Factor 1A, X-Linked) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include translation initiation factor activity and translation factor activity, RNA binding. An important paralog of this gene is EIF1AY.

UniProtKB/Swiss-Prot for EIF1AX Gene

  • Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits

Gene Wiki entry for EIF1AX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1AX Gene

Genomics for EIF1AX Gene

Genomic Location for EIF1AX Gene

Start:
20,124,518 bp from pter
End:
20,141,848 bp from pter
Size:
17,331 bases
Orientation:
Minus strand

Genomic View for EIF1AX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF1AX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AX Gene

Regulatory Elements for EIF1AX Gene

Proteins for EIF1AX Gene

  • Protein details for EIF1AX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47813-IF1AX_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 1A, X-chromosomal
    Protein Accession:
    P47813
    Secondary Accessions:
    • B2R5U5
    • Q0VGC2
    • Q5JPS5
    • Q5JPS6

    Protein attributes for EIF1AX Gene

    Size:
    144 amino acids
    Molecular mass:
    16460 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI40551.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF1AX Gene

neXtProt entry for EIF1AX Gene

Proteomics data for EIF1AX Gene at MOPED

Post-translational modifications for EIF1AX Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys40, Lys56, Lys88, Lys94, and Lys104

Other Protein References for EIF1AX Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF1AX Gene

Domains for EIF1AX Gene

Suggested Antigen Peptide Sequences for EIF1AX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47813

UniProtKB/Swiss-Prot:

IF1AX_HUMAN
Domain:
  • Contains 1 S1-like domain.:
    • P47813
Family:
  • Belongs to the eIF-1A family.:
    • P47813
genes like me logo Genes that share domains with EIF1AX: view

No data available for Gene Families for EIF1AX Gene

Function for EIF1AX Gene

Molecular function for EIF1AX Gene

GENATLAS Biochemistry: eukaryotic initiation factor 1A on chromosome X,escaping inactivation,ubiquitous
UniProtKB/Swiss-Prot Function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits

Gene Ontology (GO) - Molecular Function for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 21139563
GO:0008135 translation factor activity, RNA binding TAS 8106356
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with EIF1AX: view
genes like me logo Genes that share phenotypes with EIF1AX: view

miRNA for EIF1AX Gene

miRTarBase miRNAs that target EIF1AX

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF1AX Gene

Localization for EIF1AX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF1AX Gene COMPARTMENTS Subcellular localization image for EIF1AX gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EIF1AX: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF1AX Gene

Pathways for EIF1AX Gene

genes like me logo Genes that share pathways with EIF1AX: view

Pathways by source for EIF1AX Gene

2 Qiagen pathways for EIF1AX Gene
1 BioSystems pathway for EIF1AX Gene

Gene Ontology (GO) - Biological Process for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0010467 gene expression TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with EIF1AX: view

Transcripts for EIF1AX Gene

mRNA/cDNA for EIF1AX Gene

Unigene Clusters for EIF1AX Gene

Eukaryotic translation initiation factor 1A, X-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AX Gene

No ASD Table

Relevant External Links for EIF1AX Gene

GeneLoc Exon Structure for
EIF1AX
ECgene alternative splicing isoforms for
EIF1AX

Expression for EIF1AX Gene

mRNA expression in normal human tissues for EIF1AX Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF1AX Gene

SOURCE GeneReport for Unigene cluster for EIF1AX Gene Hs.522590

genes like me logo Genes that share expressions with EIF1AX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF1AX Gene

Orthologs for EIF1AX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF1AX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia EIF1AX 35
  • 90.74 (n)
  • 99.31 (a)
EIF1AX 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF1AX 36
  • 100 (a)
OneToOne
LOC611715 35
  • 94.21 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Eif1a 35
  • 87.73 (n)
  • 98.61 (a)
Eif1a 16
Eif1ax 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF1AX 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eif1a 35
  • 85.5 (n)
  • 97.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24811 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1ax 35
  • 86.81 (n)
  • 100 (a)
Str.7119 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.679 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15002 35
eif1axb 35
  • 81.48 (n)
  • 99.31 (a)
eif1axb 36
  • 95 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta eIF-1A 36
  • 78 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-1.A 36
  • 46 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER275C 35
  • 61.32 (n)
  • 64.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF11 35
  • 65.14 (n)
  • 65.65 (a)
TIF11 36
  • 61 (a)
OneToMany
TIF11 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11287g 35
  • 66.16 (n)
  • 66.41 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8105 35
soybean
(Glycine max)
eudicotyledons Gma.5683 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G04520 35
  • 65.9 (n)
  • 74.81 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12801 35
corn
(Zea mays)
Liliopsida Zm.16531 35
rice
(Oryza sativa)
Liliopsida Os.4711 35
Os06g0342200 35
  • 63.61 (n)
  • 77.1 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14227 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07437 35
  • 67.94 (n)
  • 83.21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif11 35
  • 67.18 (n)
  • 77.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10045 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11104 36
  • 52 (a)
OneToMany
Species with no ortholog for EIF1AX:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF1AX Gene

ENSEMBL:
Gene Tree for EIF1AX (if available)
TreeFam:
Gene Tree for EIF1AX (if available)

Paralogs for EIF1AX Gene

Paralogs for EIF1AX Gene

Selected SIMAP similar genes for EIF1AX Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EIF1AX Gene

genes like me logo Genes that share paralogs with EIF1AX: view

Variants for EIF1AX Gene

Sequence variations from dbSNP and Humsavar for EIF1AX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs13179 -- 20,125,252(+) GGGGG(G/T)AATAA utr-variant-3-prime
rs14141 -- 20,125,916(-) CATCT(A/G)GCCCC utr-variant-3-prime
rs1043014 -- 20,126,287(-) TTCTT(C/T)TACTA utr-variant-3-prime
rs3182471 -- 20,125,191(-) GGAGA(A/G)CATGG utr-variant-3-prime
rs4573469 -- 20,129,472(+) TAAAA(A/G)AGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF1AX Gene

Variant ID Type Subtype PubMed ID
esv25136 CNV Gain+Loss 19812545
nsv820390 CNV Duplication 20802225

Relevant External Links for EIF1AX Gene

HapMap Linkage Disequilibrium report
EIF1AX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1AX Gene

Disorders for EIF1AX Gene

No disorders were found for EIF1AX Gene.

No data available for UniProtKB/Swiss-Prot for EIF1AX Gene

Publications for EIF1AX Gene

  1. Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing. (PMID: 8106356) Dever T.E. … Hershey J.W.B. (J. Biol. Chem. 1994) 2 3 4
  2. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 2 3
  3. The eIF1A solution structure reveals a large RNA-binding surface important for scanning function. (PMID: 10678173) Battiste J.L. … Wagner G. (Mol. Cell 2000) 3 4
  4. Importin 13: a novel mediator of nuclear import and export. (PMID: 11447110) Mingot J.-M. … Goerlich D. (EMBO J. 2001) 3 23
  5. Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. (PMID: 12514125) Olsen D.S. … Hinnebusch A.G. (EMBO J. 2003) 3 23

Products for EIF1AX Gene

Sources for EIF1AX Gene

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