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Aliases for EGR4 Gene

Aliases for EGR4 Gene

  • Early Growth Response 4 2 3
  • NGFIC 3 6
  • AT133 3 4
  • EGR-4 3 4
  • Early Growth Response Protein 4 3
  • NGFI-C 3
  • PAT133 3

External Ids for EGR4 Gene

Summaries for EGR4 Gene

GeneCards Summary for EGR4 Gene

EGR4 (Early Growth Response 4) is a Protein Coding gene. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Downstream signaling in naive CD8+ T cells. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is WT1.

UniProtKB/Swiss-Prot for EGR4 Gene

  • Transcriptional regulator. Recognizes and binds to the DNA sequence 5-GCGGGGGCG-3 (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).

Gene Wiki entry for EGR4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR4 Gene

Genomics for EGR4 Gene

Genomic Location for EGR4 Gene

Start:
73,290,929 bp from pter
End:
73,293,705 bp from pter
Size:
2,777 bases
Orientation:
Minus strand

Genomic View for EGR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EGR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR4 Gene

Regulatory Elements for EGR4 Gene

Proteins for EGR4 Gene

  • Protein details for EGR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05215-EGR4_HUMAN
    Recommended name:
    Early growth response protein 4
    Protein Accession:
    Q05215
    Secondary Accessions:
    • B2RAE3
    • G3V1T5
    • Q2Z1P5

    Protein attributes for EGR4 Gene

    Size:
    589 amino acids
    Molecular mass:
    61623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88903.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36840.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA42698.1; Type=Frameshift; Positions=66; Evidence={ECO:0000305}; Sequence=CAA49214.1; Type=Frameshift; Positions=66; Evidence={ECO:0000305};

neXtProt entry for EGR4 Gene

Proteomics data for EGR4 Gene at MOPED

Post-translational modifications for EGR4 Gene

No Post-translational modifications

Other Protein References for EGR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EGR4 Gene

Domains for EGR4 Gene

Gene Families for EGR4 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for EGR4 Gene

Suggested Antigen Peptide Sequences for EGR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05215

UniProtKB/Swiss-Prot:

EGR4_HUMAN
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.:
    • Q05215
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q05215
genes like me logo Genes that share domains with EGR4: view

Function for EGR4 Gene

Molecular function for EGR4 Gene

GENATLAS Biochemistry: immediate early growth response,gene 4 (pAT133),nerve growth factor induced clone C
UniProtKB/Swiss-Prot Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5-GCGGGGGCG-3 (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).
UniProtKB/Swiss-Prot Induction: By PHA/PMA or by serum

Gene Ontology (GO) - Molecular Function for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 1584812
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with EGR4: view
genes like me logo Genes that share phenotypes with EGR4: view

Animal Models for EGR4 Gene

MGI Knock Outs for EGR4:

Transcription Factor Targeting for EGR4 Gene

Selected GeneGlobe predicted Target genes for EGR4

No data available for Enzyme Numbers (IUBMB) , miRNA and HOMER Transcription for EGR4 Gene

Localization for EGR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EGR4 Gene COMPARTMENTS Subcellular localization image for EGR4 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with EGR4: view

Pathways for EGR4 Gene

genes like me logo Genes that share pathways with EGR4: view

Pathways by source for EGR4 Gene

Gene Ontology (GO) - Biological Process for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation TAS 1658795
GO:0043066 negative regulation of apoptotic process IBA --
GO:0071320 cellular response to cAMP IBA --
genes like me logo Genes that share ontologies with EGR4: view

Transcripts for EGR4 Gene

mRNA/cDNA for EGR4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EGR4 Gene

Early growth response 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EGR4 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for EGR4 Gene

GeneLoc Exon Structure for
EGR4
ECgene alternative splicing isoforms for
EGR4

Expression for EGR4 Gene

mRNA expression in normal human tissues for EGR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EGR4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (8.8), Brain - Cerebellum (7.0), Brain - Putamen (basal ganglia) (6.3), Brain - Nucleus accumbens (basal ganglia) (4.8), and Brain - Caudate (basal ganglia) (4.5).

SOURCE GeneReport for Unigene cluster for EGR4 Gene Hs.3052

genes like me logo Genes that share expressions with EGR4: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for EGR4 Gene

Orthologs for EGR4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EGR4 35
  • 99.49 (n)
  • 99.32 (a)
EGR4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EGR4 35
  • 86.86 (n)
  • 89.21 (a)
EGR4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EGR4 35
  • 86.88 (n)
  • 86.03 (a)
EGR4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Egr4 35
  • 84.98 (n)
  • 86.37 (a)
Egr4 16
Egr4 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EGR4 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Egr4 35
  • 85.05 (n)
  • 86.58 (a)
chicken
(Gallus gallus)
Aves EGR4 35
  • 60.64 (n)
  • 54.01 (a)
EGR4 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egr4 35
  • 52.2 (n)
  • 45.37 (a)
zebrafish
(Danio rerio)
Actinopterygii EGR4 (1 of 2) 36
  • 34 (a)
OneToMany
EGR4 (2 of 2) 36
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sr 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea egrh-3 36
  • 21 (a)
ManyToMany
Y55F3AM.7 37
  • 68 (a)
C27C12.2 37
  • 75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG1 36
  • 10 (a)
ManyToMany
MIG2 36
  • 9 (a)
ManyToMany
MIG3 36
  • 9 (a)
ManyToMany
Species with no ortholog for EGR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR4 Gene

ENSEMBL:
Gene Tree for EGR4 (if available)
TreeFam:
Gene Tree for EGR4 (if available)

Paralogs for EGR4 Gene

Paralogs for EGR4 Gene

genes like me logo Genes that share paralogs with EGR4: view

Variants for EGR4 Gene

Sequence variations from dbSNP and Humsavar for EGR4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs533641 -- 73,291,844(-) CGACG(A/C)AAGGG synonymous-codon, reference
rs2229294 -- 73,291,405(-) GAGTT(C/T)CGGGC utr-variant-3-prime
rs6718289 -- 73,294,038(+) AACCA(C/T)AGAGA upstream-variant-2KB
rs6719622 -- 73,294,877(+) TGGCT(G/T)CAGAA upstream-variant-2KB
rs6723073 -- 73,295,518(+) TCACA(A/G)AATAT upstream-variant-2KB

Relevant External Links for EGR4 Gene

HapMap Linkage Disequilibrium report
EGR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EGR4 Gene

Disorders for EGR4 Gene

Relevant External Links for EGR4

Genetic Association Database (GAD)
EGR4
Human Genome Epidemiology (HuGE) Navigator
EGR4
genes like me logo Genes that share disorders with EGR4: view

No data available for UniProtKB/Swiss-Prot for EGR4 Gene

Publications for EGR4 Gene

  1. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. (PMID: 1584812) Crosby S.D. … Milbrandt J. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3
  2. Clone pAT133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains. (PMID: 1658795) Mueller H.-J. … Zipfel P.F. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4
  3. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. (PMID: 8504297) Holst C. … Zipfel P.F. (Hum. Mol. Genet. 1993) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PMID: 20144677) Liu B.C. … He G. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2010) 3 48

Products for EGR4 Gene

Sources for EGR4 Gene

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