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Aliases for EGR4 Gene

Aliases for EGR4 Gene

  • Early Growth Response 4 2 3 5
  • AT133 3 4
  • EGR-4 3 4
  • Early Growth Response Protein 4 3
  • NGFI-C 3
  • PAT133 3
  • NGFIC 3

External Ids for EGR4 Gene

Previous GeneCards Identifiers for EGR4 Gene

  • GC02M073527
  • GC02M073728
  • GC02M073493
  • GC02M073494
  • GC02M073430
  • GC02M073253
  • GC02M073518

Summaries for EGR4 Gene

GeneCards Summary for EGR4 Gene

EGR4 (Early Growth Response 4) is a Protein Coding gene. Among its related pathways are Downstream signaling in naive CD8+ T cells and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is EGR2.

UniProtKB/Swiss-Prot for EGR4 Gene

  • Transcriptional regulator. Recognizes and binds to the DNA sequence 5-GCGGGGGCG-3 (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).

Gene Wiki entry for EGR4 Gene

Additional gene information for EGR4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR4 Gene

Genomics for EGR4 Gene

GeneHancer (GH) Regulatory Elements for EGR4 Gene

Promoters and enhancers for EGR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I073293 Promoter/Enhancer 1.3 EPDnew ENCODE 550.8 0.0 -15 0.2 ATF1 RB1 ARID4B SIN3A RFX5 ZNF335 ELK1 ATF7 RUNX3 CREM EGR4 RNU6-111P
GH02I073175 Enhancer 1.6 FANTOM5 Ensembl ENCODE 1.4 +117.1 117051 3.2 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF213 E2F8 SMYD5 ALMS1 DUSP11 SFXN5 PRADC1 NOTO SPR ENSG00000273245 EMX1 CCT7
GH02I073291 Enhancer 0.9 ENCODE 0.8 +2.4 2397 0.2 ELF3 MLX ARID4B SIN3A DNMT3B ZNF48 ZSCAN9 RARA ZEB1 CHAMP1 EGR4 FBXO41
GH02I073283 Promoter/Enhancer 1.4 Ensembl ENCODE 0.4 +9.2 9168 2.7 HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF48 NCOA2 GLIS2 RUNX3 ZNF263 FBXO41 EGR4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EGR4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EGR4 gene promoter:

Genomic Locations for EGR4 Gene

Genomic Locations for EGR4 Gene
chr2:73,290,929-73,293,705
(GRCh38/hg38)
Size:
2,777 bases
Orientation:
Minus strand
chr2:73,518,057-73,520,833
(GRCh37/hg19)

Genomic View for EGR4 Gene

Genes around EGR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR4 Gene

Proteins for EGR4 Gene

  • Protein details for EGR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05215-EGR4_HUMAN
    Recommended name:
    Early growth response protein 4
    Protein Accession:
    Q05215
    Secondary Accessions:
    • B2RAE3
    • G3V1T5
    • Q2Z1P5

    Protein attributes for EGR4 Gene

    Size:
    589 amino acids
    Molecular mass:
    61623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88903.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36840.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA42698.1; Type=Frameshift; Positions=66; Evidence={ECO:0000305}; Sequence=CAA49214.1; Type=Frameshift; Positions=66; Evidence={ECO:0000305};

neXtProt entry for EGR4 Gene

Post-translational modifications for EGR4 Gene

No Post-translational modifications

Other Protein References for EGR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EGR4 Gene

Domains & Families for EGR4 Gene

Gene Families for EGR4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for EGR4 Gene

Suggested Antigen Peptide Sequences for EGR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05215

UniProtKB/Swiss-Prot:

EGR4_HUMAN :
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with EGR4: view

Function for EGR4 Gene

Molecular function for EGR4 Gene

GENATLAS Biochemistry:
immediate early growth response,gene 4 (pAT133),nerve growth factor induced clone C
UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Recognizes and binds to the DNA sequence 5-GCGGGGGCG-3 (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).
UniProtKB/Swiss-Prot Induction:
By PHA/PMA or by serum.

Gene Ontology (GO) - Molecular Function for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 1584812
GO:0043565 sequence-specific DNA binding IDA 23332764
genes like me logo Genes that share ontologies with EGR4: view
genes like me logo Genes that share phenotypes with EGR4: view

Animal Models for EGR4 Gene

MGI Knock Outs for EGR4:

Transcription Factor Targets for EGR4 Gene

Selected GeneGlobe predicted Target genes for EGR4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA and HOMER Transcription for EGR4 Gene

Localization for EGR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EGR4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EGR4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EGR4 Gene

Pathways & Interactions for EGR4 Gene

genes like me logo Genes that share pathways with EGR4: view

Pathways by source for EGR4 Gene

Gene Ontology (GO) - Biological Process for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0008284 positive regulation of cell proliferation TAS 1658795
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 12560487
genes like me logo Genes that share ontologies with EGR4: view

No data available for SIGNOR curated interactions for EGR4 Gene

Drugs & Compounds for EGR4 Gene

No Compound Related Data Available

Transcripts for EGR4 Gene

mRNA/cDNA for EGR4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EGR4 Gene

Early growth response 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EGR4 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for EGR4 Gene

GeneLoc Exon Structure for
EGR4
ECgene alternative splicing isoforms for
EGR4

Expression for EGR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EGR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EGR4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.8), Brain - Cerebellum (x7.0), Brain - Putamen (basal ganglia) (x6.3), Brain - Nucleus accumbens (basal ganglia) (x4.8), and Brain - Caudate (basal ganglia) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of EGR4 Gene:

EGR4

SOURCE GeneReport for Unigene cluster for EGR4 Gene:

Hs.3052

Evidence on tissue expression from TISSUES for EGR4 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with EGR4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EGR4 Gene

Orthologs for EGR4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EGR4 33 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia EGR4 33 34
  • 86.88 (n)
cow
(Bos Taurus)
Mammalia EGR4 33 34
  • 86.86 (n)
rat
(Rattus norvegicus)
Mammalia Egr4 33
  • 85.05 (n)
mouse
(Mus musculus)
Mammalia Egr4 16 34 33
  • 84.98 (n)
oppossum
(Monodelphis domestica)
Mammalia EGR4 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves EGR4 34 33
  • 60.64 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egr4 33
  • 52.2 (n)
zebrafish
(Danio rerio)
Actinopterygii EGR4 (1 of 2) 34
  • 34 (a)
OneToMany
EGR4 (2 of 2) 34
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sr 34
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27C12.2 35
  • 75 (a)
Y55F3AM.7 35
  • 68 (a)
egrh-3 34
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG1 34
  • 10 (a)
ManyToMany
MIG2 34
  • 9 (a)
ManyToMany
MIG3 34
  • 9 (a)
ManyToMany
Species where no ortholog for EGR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR4 Gene

ENSEMBL:
Gene Tree for EGR4 (if available)
TreeFam:
Gene Tree for EGR4 (if available)

Paralogs for EGR4 Gene

Paralogs for EGR4 Gene

genes like me logo Genes that share paralogs with EGR4: view

Variants for EGR4 Gene

Sequence variations from dbSNP and Humsavar for EGR4 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000417794 -- 73,293,529(-) T/G coding_sequence_variant, missense_variant
rs1000659971 -- 73,294,056(-) A/G upstream_transcript_variant
rs1000711853 -- 73,293,856(-) G/A upstream_transcript_variant
rs1002407715 -- 73,290,947(-) A/C 3_prime_UTR_variant
rs1002417252 -- 73,291,283(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for EGR4 Gene

Variant ID Type Subtype PubMed ID
nsv1013190 CNV loss 25217958

Variation tolerance for EGR4 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EGR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EGR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR4 Gene

Disorders for EGR4 Gene

Additional Disease Information for EGR4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for EGR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EGR4 Gene

Publications for EGR4 Gene

  1. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PMID: 20144677) Liu BC … He G (Progress in neuro-psychopharmacology & biological psychiatry 2010) 3 44 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. (PMID: 8504297) Holst C … Zipfel PF (Human molecular genetics 1993) 3 4 58
  4. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. (PMID: 1584812) Crosby SD … Milbrandt J (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 58
  5. Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains. (PMID: 1658795) Müller HJ … Zipfel PF (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 58

Products for EGR4 Gene

Sources for EGR4 Gene

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