Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLPP4 Gene

Aliases for PLPP4 Gene

  • Phospholipid Phosphatase 4 2 3 5
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 1A 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1A 2 3
  • Diacylglycerol Pyrophosphate Phosphatase-Like 2 2 3
  • PPAPDC1A 3 4
  • PPAPDC1 3 4
  • DPPL2 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1 2
  • Diacylglycerol Pyrophosphate Like 2 3
  • Phosphatidate Phosphatase PPAPDC1A 3
  • EC 3.1.3.4 4

External Ids for PLPP4 Gene

Previous HGNC Symbols for PLPP4 Gene

  • PPAPDC1
  • PPAPDC1A

Summaries for PLPP4 Gene

GeneCards Summary for PLPP4 Gene

PLPP4 (Phospholipid Phosphatase 4) is a Protein Coding gene. Among its related pathways are Immune System and triacylglycerol biosynthesis. An important paralog of this gene is PLPP5.

UniProtKB/Swiss-Prot for PLPP4 Gene

  • Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.

Gene Wiki entry for PLPP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP4 Gene

Genomics for PLPP4 Gene

Regulatory Elements for PLPP4 Gene

Promoters for PLPP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLPP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLPP4 Gene

Chromosome:
10
Start:
120,456,954 bp from pter
End:
120,589,855 bp from pter
Size:
132,902 bases
Orientation:
Plus strand

Genomic View for PLPP4 Gene

Genes around PLPP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP4 Gene

Proteins for PLPP4 Gene

  • Protein details for PLPP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZY2-PLPP4_HUMAN
    Recommended name:
    Phospholipid phosphatase 4
    Protein Accession:
    Q5VZY2
    Secondary Accessions:
    • A2RU82
    • Q08EQ2
    • Q0IIP2
    • Q495B4
    • Q5VZY1

    Protein attributes for PLPP4 Gene

    Size:
    271 amino acids
    Molecular mass:
    30395 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH70333.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PLPP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP4 Gene

Proteomics data for PLPP4 Gene at MOPED

Post-translational modifications for PLPP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPP4 Gene

No data available for DME Specific Peptides for PLPP4 Gene

Domains & Families for PLPP4 Gene

Gene Families for PLPP4 Gene

Protein Domains for PLPP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VZY2

UniProtKB/Swiss-Prot:

PLPP4_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP4: view

Function for PLPP4 Gene

Molecular function for PLPP4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=104 uM for diacylglycerol pyrophosphate {ECO:0000269 PubMed:17590538}; KM=506 uM for phosphatidate {ECO:0000269 PubMed:17590538}; KM=580 uM for lysophosphatidate {ECO:0000269 PubMed:17590538};
UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide.
UniProtKB/Swiss-Prot Function:
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.

Enzyme Numbers (IUBMB) for PLPP4 Gene

genes like me logo Genes that share phenotypes with PLPP4: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLPP4 Gene

Localization for PLPP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP4 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PLPP4: view

No data available for Subcellular locations from COMPARTMENTS for PLPP4 Gene

Pathways & Interactions for PLPP4 Gene

genes like me logo Genes that share pathways with PLPP4: view

Pathways by source for PLPP4 Gene

Gene Ontology (GO) - Biological Process for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA --
GO:0007165 signal transduction IBA --
GO:0046839 phospholipid dephosphorylation IDA 17590538
genes like me logo Genes that share ontologies with PLPP4: view

No data available for SIGNOR curated interactions for PLPP4 Gene

Drugs & Compounds for PLPP4 Gene

(14) Additional Compounds for PLPP4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with PLPP4: view

Transcripts for PLPP4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP4 Gene

No ASD Table

Relevant External Links for PLPP4 Gene

GeneLoc Exon Structure for
PLPP4
ECgene alternative splicing isoforms for
PLPP4

Expression for PLPP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for PLPP4 Gene

Q5VZY2-PLPP4_HUMAN
Tissue specificity: Expressed mainly to the brain, kidney and testis, and to a lesser extent the bone marrow, thymus, prostate, liver and uterus.
genes like me logo Genes that share expression patterns with PLPP4: view

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PLPP4 Gene

Orthologs for PLPP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLPP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPAPDC1A 35
  • 93.48 (n)
  • 99.26 (a)
PPAPDC1A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPAPDC1A 35
  • 94.75 (n)
  • 98.43 (a)
PPAPDC1A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppapdc1a 35
  • 92 (n)
  • 99.26 (a)
Plpp4 16
Ppapdc1a 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPAPDC1A 35
  • 99.75 (n)
  • 100 (a)
PPAPDC1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppapdc1a 35
  • 92.5 (n)
  • 99.63 (a)
oppossum
(Monodelphis domestica)
Mammalia PPAPDC1A 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPAPDC1A 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPAPDC1A 35
  • 84.13 (n)
  • 94.1 (a)
PPAPDC1A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPAPDC1A 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487728 35
  • 73.43 (n)
  • 83.03 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334794 35
  • 73.87 (n)
  • 79.6 (a)
ppapdc1a 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001941 35
  • 53.49 (n)
  • 51.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12746 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPP1 36
  • 27 (a)
OneToMany
DPP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons LPP2 35
  • 49.09 (n)
  • 41 (a)
rice
(Oryza sativa)
Liliopsida Os08g0359200 35
  • 47.85 (n)
  • 40.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for PLPP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLPP4 Gene

ENSEMBL:
Gene Tree for PLPP4 (if available)
TreeFam:
Gene Tree for PLPP4 (if available)

Paralogs for PLPP4 Gene

Paralogs for PLPP4 Gene

genes like me logo Genes that share paralogs with PLPP4: view

Variants for PLPP4 Gene

Sequence variations from dbSNP and Humsavar for PLPP4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs755938 -- 120,576,726(+) AAGAG(G/T)GTCAC intron-variant
rs755939 -- 120,576,847(+) AAACA(A/G)AGGCA intron-variant
rs755940 -- 120,577,425(-) GGCCA(C/T)GTTAC intron-variant
rs755941 -- 120,577,321(-) CAAAG(A/G)CTCTT intron-variant
rs878879 -- 120,572,295(-) TGGTT(C/T)GAGGT intron-variant

Variation tolerance for PLPP4 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPP4 Gene

HapMap Linkage Disequilibrium report
PLPP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLPP4 Gene

Disorders for PLPP4 Gene

Relevant External Links for PLPP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP4

No disorders were found for PLPP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP4 Gene

Publications for PLPP4 Gene

  1. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (PMID: 17590538) Takeuchi M. … Kamatani N. (Gene 2007) 2 3 4 67
  2. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PLPP4 Gene

Sources for PLPP4 Gene

Back to Top

Content