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Aliases for PLPP4 Gene

Aliases for PLPP4 Gene

  • Phospholipid Phosphatase 4 2 3 5
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 1A 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1A 2 3
  • Diacylglycerol Pyrophosphate Phosphatase-Like 2 2 3
  • PPAPDC1A 3 4
  • PPAPDC1 3 4
  • DPPL2 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1 2
  • Diacylglycerol Pyrophosphate Like 2 3
  • Phosphatidate Phosphatase PPAPDC1A 3
  • EC 3.1.3.4 4

External Ids for PLPP4 Gene

Previous HGNC Symbols for PLPP4 Gene

  • PPAPDC1
  • PPAPDC1A

Summaries for PLPP4 Gene

GeneCards Summary for PLPP4 Gene

PLPP4 (Phospholipid Phosphatase 4) is a Protein Coding gene. Among its related pathways are Role of phospholipids in phagocytosis and Innate Immune System. An important paralog of this gene is PLPP5.

UniProtKB/Swiss-Prot for PLPP4 Gene

  • Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.

Gene Wiki entry for PLPP4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP4 Gene

Genomics for PLPP4 Gene

Regulatory Elements for PLPP4 Gene

Enhancers for PLPP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G120422 1.2 Ensembl ENCODE 11.1 -33.4 -33427 2.9 ELF3 PKNOX1 FOXA2 KLF17 ARID4B SIN3A ZSCAN9 RAD21 RARA ZNF143 PLPP4 GC10M120361 ENSG00000234522
GH10G120555 0.4 ENCODE 27.6 +99.0 99030 0.2 PRDM10 MAFK PLPP4 PIR43908 LINC01561
GH10G120503 0.9 ENCODE 11.1 +49.8 49805 5.7 NFIB ZNF76 SIN3A KLF17 ARID4B DMAP1 FEZF1 RAD21 GLIS2 GATA2 LINC01561 PLPP4 PIR43908
GH10G120458 0.8 ENCODE 7.7 +3.4 3379 2.8 PKNOX1 TAL1 JUN SIN3A RAD21 FOSL1 TCF12 NCOR1 GATA2 FOS PLPP4 PIR43908
GH10G121036 0.5 ENCODE 5.6 +579.6 579573 0.6 ZNF680 ZNF366 PRDM10 ATF2 TRIM28 PLPP4 GC10P121065 GC10P121066 LOC105378520
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLPP4 on UCSC Golden Path with GeneCards custom track

Promoters for PLPP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000034381 146 601 MXI1 SUZ12 SIN3A ZIC2 HIC1 ZBTB48 ZBTB20 EZH2 MAZ CBX2

Genomic Location for PLPP4 Gene

Chromosome:
10
Start:
120,456,954 bp from pter
End:
120,589,855 bp from pter
Size:
132,902 bases
Orientation:
Plus strand

Genomic View for PLPP4 Gene

Genes around PLPP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP4 Gene

Proteins for PLPP4 Gene

  • Protein details for PLPP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZY2-PLPP4_HUMAN
    Recommended name:
    Phospholipid phosphatase 4
    Protein Accession:
    Q5VZY2
    Secondary Accessions:
    • A2RU82
    • Q08EQ2
    • Q0IIP2
    • Q495B4
    • Q5VZY1

    Protein attributes for PLPP4 Gene

    Size:
    271 amino acids
    Molecular mass:
    30395 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH70333.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PLPP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP4 Gene

Post-translational modifications for PLPP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLPP4 Gene

Domains & Families for PLPP4 Gene

Gene Families for PLPP4 Gene

Protein Domains for PLPP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VZY2

UniProtKB/Swiss-Prot:

PLPP4_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP4: view

Function for PLPP4 Gene

Molecular function for PLPP4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=104 uM for diacylglycerol pyrophosphate {ECO:0000269 PubMed:17590538}; KM=506 uM for phosphatidate {ECO:0000269 PubMed:17590538}; KM=580 uM for lysophosphatidate {ECO:0000269 PubMed:17590538};
UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide.
UniProtKB/Swiss-Prot Function:
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.

Enzyme Numbers (IUBMB) for PLPP4 Gene

Gene Ontology (GO) - Molecular Function for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008195 phosphatidate phosphatase activity EXP,IDA 17590538
GO:0016787 hydrolase activity IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with PLPP4: view
genes like me logo Genes that share phenotypes with PLPP4: view

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLPP4 Gene

Localization for PLPP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP4 gene
Compartment Confidence
plasma membrane 5
nucleus 3
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP4: view

Pathways & Interactions for PLPP4 Gene

genes like me logo Genes that share pathways with PLPP4: view

Pathways by source for PLPP4 Gene

Gene Ontology (GO) - Biological Process for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA --
GO:0007165 signal transduction IBA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0046839 phospholipid dephosphorylation IDA 17590538
genes like me logo Genes that share ontologies with PLPP4: view

No data available for SIGNOR curated interactions for PLPP4 Gene

Drugs & Compounds for PLPP4 Gene

(2) Drugs for PLPP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(12) Additional Compounds for PLPP4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with PLPP4: view

Transcripts for PLPP4 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP4 Gene

No ASD Table

Relevant External Links for PLPP4 Gene

GeneLoc Exon Structure for
PLPP4
ECgene alternative splicing isoforms for
PLPP4

Expression for PLPP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PLPP4 Gene:

PLPP4

mRNA Expression by UniProt/SwissProt for PLPP4 Gene:

Q5VZY2-PLPP4_HUMAN
Tissue specificity: Expressed mainly to the brain, kidney and testis, and to a lesser extent the bone marrow, thymus, prostate, liver and uterus.

Evidence on tissue expression from TISSUES for PLPP4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PLPP4: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP4 Gene

Orthologs for PLPP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLPP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAPDC1A 34 35
  • 99.75 (n)
oppossum
(Monodelphis domestica)
Mammalia PPAPDC1A 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPAPDC1A 34 35
  • 94.75 (n)
cow
(Bos Taurus)
Mammalia PPAPDC1A 34 35
  • 93.48 (n)
rat
(Rattus norvegicus)
Mammalia Ppapdc1a 34
  • 92.5 (n)
mouse
(Mus musculus)
Mammalia Ppapdc1a 34 35
  • 92 (n)
Plpp4 16
platypus
(Ornithorhynchus anatinus)
Mammalia PPAPDC1A 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPAPDC1A 34 35
  • 84.13 (n)
lizard
(Anolis carolinensis)
Reptilia PPAPDC1A 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487728 34
  • 73.43 (n)
zebrafish
(Danio rerio)
Actinopterygii ppapdc1a 35
  • 75 (a)
OneToOne
LOC100334794 34
  • 73.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001941 34
  • 53.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12746 35
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPP1 35 37
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LPP2 34
  • 49.09 (n)
rice
(Oryza sativa)
Liliopsida Os08g0359200 34
  • 47.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for PLPP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLPP4 Gene

ENSEMBL:
Gene Tree for PLPP4 (if available)
TreeFam:
Gene Tree for PLPP4 (if available)

Paralogs for PLPP4 Gene

Paralogs for PLPP4 Gene

genes like me logo Genes that share paralogs with PLPP4: view

Variants for PLPP4 Gene

Sequence variations from dbSNP and Humsavar for PLPP4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000017278 -- 120,540,141(+) CTTCC(-/A)AAAAA intron-variant
rs1000034138 -- 120,476,224(+) TGCAG(G/T)CCTTG intron-variant
rs1000034605 -- 120,503,353(+) TCTTC(C/G)CCCCA intron-variant
rs1000046609 -- 120,545,922(+) GGCAG(A/G)TGAAC intron-variant
rs1000070581 -- 120,533,481(+) ACTCT(C/G)ATGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLPP4 Gene

Variant ID Type Subtype PubMed ID
dgv1402n54 CNV gain 21841781
dgv1403n54 CNV gain 21841781
dgv1404n54 CNV gain+loss 21841781
dgv174n67 CNV loss 20364138
dgv17e180 CNV gain 20482838
esv2546781 CNV deletion 19546169
esv26675 CNV gain 19812545
esv2669932 CNV deletion 23128226
esv2676968 CNV deletion 23128226
esv2741940 CNV deletion 23290073
esv3260274 CNV deletion 24192839
esv3546941 CNV deletion 23714750
esv3624729 CNV loss 21293372
esv3624730 CNV loss 21293372
esv995047 CNV deletion 20482838
nsv1119840 CNV deletion 24896259
nsv1119841 CNV deletion 24896259
nsv1121823 CNV deletion 24896259
nsv436106 CNV deletion 17901297
nsv498743 CNV loss 21111241
nsv508610 CNV deletion 20534489
nsv511435 CNV loss 21212237
nsv512187 CNV loss 21212237
nsv528787 CNV gain 19592680
nsv552222 CNV loss 21841781
nsv552223 CNV gain 21841781
nsv7572 CNV deletion 18451855
nsv821211 CNV deletion 20802225
nsv955610 CNV deletion 24416366

Variation tolerance for PLPP4 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPP4 Gene

Disorders for PLPP4 Gene

Relevant External Links for PLPP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP4

No disorders were found for PLPP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP4 Gene

Publications for PLPP4 Gene

  1. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (PMID: 17590538) Takeuchi M. … Kamatani N. (Gene 2007) 2 3 4 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64

Products for PLPP4 Gene

Sources for PLPP4 Gene

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