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Aliases for PPAPDC1A Gene

Aliases for PPAPDC1A Gene

  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1A 2 3
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 1A 3 4
  • PPAPDC1 3 4
  • DPPL2 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1 2
  • Diacylglycerol Pyrophosphate Like 2 3
  • Phosphatidate Phosphatase PPAPDC1A 3
  • EC 3.1.3.4 4

External Ids for PPAPDC1A Gene

Previous HGNC Symbols for PPAPDC1A Gene

  • PPAPDC1

Previous GeneCards Identifiers for PPAPDC1A Gene

  • GC10P122207
  • GC10P115845

Summaries for PPAPDC1A Gene

GeneCards Summary for PPAPDC1A Gene

PPAPDC1A (Phosphatidic Acid Phosphatase Type 2 Domain Containing 1A) is a Protein Coding gene. Among its related pathways are Fcgamma receptor (FCGR) dependent phagocytosis and triacylglycerol biosynthesis. GO annotations related to this gene include phosphatidate phosphatase activity. An important paralog of this gene is PPAPDC1B.

UniProtKB/Swiss-Prot for PPAPDC1A Gene

  • Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.

Gene Wiki entry for PPAPDC1A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPAPDC1A Gene

Genomics for PPAPDC1A Gene

Regulatory Elements for PPAPDC1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPAPDC1A Gene

Start:
120,456,954 bp from pter
End:
120,589,855 bp from pter
Size:
132,902 bases
Orientation:
Plus strand

Genomic View for PPAPDC1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPAPDC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPAPDC1A Gene

Proteins for PPAPDC1A Gene

  • Protein details for PPAPDC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZY2-PPC1A_HUMAN
    Recommended name:
    Phosphatidate phosphatase PPAPDC1A
    Protein Accession:
    Q5VZY2
    Secondary Accessions:
    • A2RU82
    • Q08EQ2
    • Q0IIP2
    • Q495B4
    • Q5VZY1

    Protein attributes for PPAPDC1A Gene

    Size:
    271 amino acids
    Molecular mass:
    30395 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH70333.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PPAPDC1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPAPDC1A Gene

Proteomics data for PPAPDC1A Gene at MOPED

Post-translational modifications for PPAPDC1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPAPDC1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PPAPDC1A Gene

Domains for PPAPDC1A Gene

Protein Domains for PPAPDC1A Gene

Graphical View of Domain Structure for InterPro Entry

Q5VZY2

UniProtKB/Swiss-Prot:

PPC1A_HUMAN :
  • Q5VZY2
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PPAPDC1A: view

No data available for Gene Families for PPAPDC1A Gene

Function for PPAPDC1A Gene

Molecular function for PPAPDC1A Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=104 uM for diacylglycerol pyrophosphate {ECO:0000269 PubMed:17590538}; KM=506 uM for phosphatidate {ECO:0000269 PubMed:17590538}; KM=580 uM for lysophosphatidate {ECO:0000269 PubMed:17590538};
UniProtKB/Swiss-Prot CatalyticActivity: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by N-ethylmaleimide.
UniProtKB/Swiss-Prot Function: Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.

Enzyme Numbers (IUBMB) for PPAPDC1A Gene

Gene Ontology (GO) - Molecular Function for PPAPDC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0008195 phosphatidate phosphatase activity IDA 17590538
genes like me logo Genes that share ontologies with PPAPDC1A: view

Animal Model Products

CRISPR Products

miRNA for PPAPDC1A Gene

miRTarBase miRNAs that target PPAPDC1A

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPAPDC1A Gene

Localization for PPAPDC1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPAPDC1A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPAPDC1A Gene COMPARTMENTS Subcellular localization image for PPAPDC1A gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PPAPDC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PPAPDC1A: view

Pathways for PPAPDC1A Gene

genes like me logo Genes that share pathways with PPAPDC1A: view

Pathways by source for PPAPDC1A Gene

1 BioSystems pathway for PPAPDC1A Gene

Gene Ontology (GO) - Biological Process for PPAPDC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
GO:0046839 phospholipid dephosphorylation IDA 17590538
genes like me logo Genes that share ontologies with PPAPDC1A: view

Compounds for PPAPDC1A Gene

(12) HMDB Compounds for PPAPDC1A Gene

Compound Synonyms Cas Number PubMed IDs
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
PA(16:0/18:2(9Z,12Z))
  • PA(34:2)
Not Available
PA(16:0e/18:0)
  • 2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
Not Available
genes like me logo Genes that share compounds with PPAPDC1A: view

Transcripts for PPAPDC1A Gene

Unigene Clusters for PPAPDC1A Gene

Phosphatidic acid phosphatase type 2 domain containing 1A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPAPDC1A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PPAPDC1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPAPDC1A Gene

No ASD Table

Relevant External Links for PPAPDC1A Gene

GeneLoc Exon Structure for
PPAPDC1A
ECgene alternative splicing isoforms for
PPAPDC1A

Expression for PPAPDC1A Gene

mRNA expression in normal human tissues for PPAPDC1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPAPDC1A Gene

This gene is overexpressed in Brain - Hypothalamus (8.2), Brain - Hippocampus (5.2), Brain - Substantia nigra (5.0), and Brain - Spinal cord (cervical c-1) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPAPDC1A Gene

SOURCE GeneReport for Unigene cluster for PPAPDC1A Gene Hs.40479

mRNA Expression by UniProt/SwissProt for PPAPDC1A Gene

Q5VZY2-PPC1A_HUMAN
Tissue specificity: Expressed mainly to the brain, kidney and testis, and to a lesser extent the bone marrow, thymus, prostate, liver and uterus.
genes like me logo Genes that share expressions with PPAPDC1A: view

In Situ Assay Products

Orthologs for PPAPDC1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPAPDC1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAPDC1A 35
  • 99.75 (n)
  • 100 (a)
PPAPDC1A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPAPDC1A 35
  • 93.48 (n)
  • 99.26 (a)
PPAPDC1A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPAPDC1A 35
  • 94.75 (n)
  • 98.43 (a)
PPAPDC1A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppapdc1a 35
  • 92 (n)
  • 99.26 (a)
Ppapdc1a 16
Ppapdc1a 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPAPDC1A 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPAPDC1A 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppapdc1a 35
  • 92.5 (n)
  • 99.63 (a)
chicken
(Gallus gallus)
Aves PPAPDC1A 35
  • 84.13 (n)
  • 94.1 (a)
PPAPDC1A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPAPDC1A 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487728 35
  • 73.43 (n)
  • 83.03 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334794 35
  • 73.87 (n)
  • 79.6 (a)
ppapdc1a 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001941 35
  • 53.49 (n)
  • 51.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12746 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPP1 36
  • 27 (a)
OneToMany
DPP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons LPP2 35
  • 49.09 (n)
  • 41 (a)
rice
(Oryza sativa)
Liliopsida Os08g0359200 35
  • 47.85 (n)
  • 40.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for PPAPDC1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPAPDC1A Gene

ENSEMBL:
Gene Tree for PPAPDC1A (if available)
TreeFam:
Gene Tree for PPAPDC1A (if available)

Paralogs for PPAPDC1A Gene

Paralogs for PPAPDC1A Gene

Selected SIMAP similar genes for PPAPDC1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PPAPDC1A: view

Variants for PPAPDC1A Gene

Sequence variations from dbSNP and Humsavar for PPAPDC1A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs713088 -- 120,503,689(-) GACAG(G/T)CCCTG intron-variant
rs716453 -- 120,581,594(+) tgatt(A/G)catcg intron-variant
rs716725 -- 120,473,896(+) agtta(A/C)acctc intron-variant
rs716862 -- 120,503,430(-) GGAGT(A/G)ACTGG intron-variant
rs729370 -- 120,589,078(-) CCGGT(G/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPAPDC1A Gene

Variant ID Type Subtype PubMed ID
nsv508610 CNV Loss 20534489
nsv7572 CNV Loss 18451855
nsv436106 CNV Deletion 17901297
esv995047 CNV Deletion 20482838
nsv511435 CNV Loss 21212237
esv2546781 CNV Deletion 19546169
nsv512187 CNV Loss 21212237
esv2741940 CNV Deletion 23290073
esv2676968 CNV Deletion 23128226
nsv498743 CNV Loss 21111241
dgv17e180 CNV Gain 20482838
dgv174n67 CNV Loss 20364138
nsv821211 CNV Deletion 20802225
esv26675 CNV Gain 19812545
esv2669932 CNV Deletion 23128226
nsv528787 CNV Gain 19592680

Relevant External Links for PPAPDC1A Gene

HapMap Linkage Disequilibrium report
PPAPDC1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPAPDC1A Gene

Disorders for PPAPDC1A Gene

Relevant External Links for PPAPDC1A

Genetic Association Database (GAD)
PPAPDC1A
Human Genome Epidemiology (HuGE) Navigator
PPAPDC1A
genes like me logo Genes that share disorders with PPAPDC1A: view

No data available for UniProtKB/Swiss-Prot for PPAPDC1A Gene

Publications for PPAPDC1A Gene

  1. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (PMID: 17590538) Takeuchi M. … Kamatani N. (Gene 2007) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PMID: 20235792) Uhl G.R. … MunafA^ M.R. (Pharmacogenomics 2010) 48

Products for PPAPDC1A Gene

Sources for PPAPDC1A Gene

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