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Aliases for AHR Gene

Aliases for AHR Gene

  • Aryl Hydrocarbon Receptor 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 76 3 4
  • Ah Receptor 3 4
  • BHLHe76 3 4
  • Aromatic Hydrocarbon Receptor 3
  • AH-Receptor 3
  • AhR 4

External Ids for AHR Gene

Previous GeneCards Identifiers for AHR Gene

  • GC07P016982
  • GC07P017082
  • GC07P017111
  • GC07P017304

Summaries for AHR Gene

Entrez Gene Summary for AHR Gene

  • The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]

GeneCards Summary for AHR Gene

AHR (Aryl Hydrocarbon Receptor) is a Protein Coding gene. Diseases associated with AHR include toxic oil syndrome and eosinophilic fasciitis. Among its related pathways are Integrated Breast Cancer Pathway and Innate Lymphoid Cell Differentiation Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is AHRR.

UniProtKB/Swiss-Prot for AHR Gene

  • Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Tocris Summary for AHR Gene

  • Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state. Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize and alter transcription of target genes.

Gene Wiki entry for AHR Gene

PharmGKB "VIP" Summary for AHR Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for AHR Gene

Genomics for AHR Gene

Regulatory Elements for AHR Gene

Promoters for AHR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AHR on UCSC Golden Path with GeneCards custom track

Genomic Location for AHR Gene

Chromosome:
7
Start:
17,298,622 bp from pter
End:
17,346,152 bp from pter
Size:
47,531 bases
Orientation:
Plus strand

Genomic View for AHR Gene

Genes around AHR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AHR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AHR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHR Gene

Proteins for AHR Gene

  • Protein details for AHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35869-AHR_HUMAN
    Recommended name:
    Aryl hydrocarbon receptor
    Protein Accession:
    P35869
    Secondary Accessions:
    • A4D130
    • Q13728
    • Q13803
    • Q13804

    Protein attributes for AHR Gene

    Size:
    848 amino acids
    Molecular mass:
    96147 Da
    Quaternary structure:
    • Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1.

neXtProt entry for AHR Gene

Proteomics data for AHR Gene at MOPED

Post-translational modifications for AHR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AHR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AHR (AHR)

No data available for DME Specific Peptides for AHR Gene

Domains & Families for AHR Gene

Gene Families for AHR Gene

Suggested Antigen Peptide Sequences for AHR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35869

UniProtKB/Swiss-Prot:

AHR_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 PAC (PAS-associated C-terminal) domain.
  • Contains 2 PAS (PER-ARNT-SIM) domains.
genes like me logo Genes that share domains with AHR: view

Function for AHR Gene

Molecular function for AHR Gene

GENATLAS Biochemistry:
aryl hydrocarbon receptor,unliganded,retained in cytoplasm in resting state in association with HSP90,and with AIP (AH receptor associated protein 9),released after exposure to xenobiotics,dimerizing with ARNT and translocated to the nucleus interacting with pRB1 to induce G1 arrest
UniProtKB/Swiss-Prot Function:
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
UniProtKB/Swiss-Prot Induction:
Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA).

Gene Ontology (GO) - Molecular Function for AHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004874 aryl hydrocarbon receptor activity IEA --
GO:0005515 protein binding IEA,IPI 9079689
GO:0044212 transcription regulatory region DNA binding IDA 15681594
GO:0046982 protein heterodimerization activity TAS 19538249
genes like me logo Genes that share ontologies with AHR: view
genes like me logo Genes that share phenotypes with AHR: view

Animal Models for AHR Gene

MGI Knock Outs for AHR:

Animal Model Products

  • Taconic Biosciences Mouse Models for AHR

miRNA for AHR Gene

miRTarBase miRNAs that target AHR

Transcription Factor Targets for AHR Gene

Selected GeneGlobe predicted Target genes for AHR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for AHR Gene

Localization for AHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for AHR Gene

Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AHR Gene COMPARTMENTS Subcellular localization image for AHR gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for AHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10395741
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with AHR: view

Pathways & Interactions for AHR Gene

genes like me logo Genes that share pathways with AHR: view

Pathways by source for AHR Gene

3 BioSystems pathways for AHR Gene
1 GeneGo (Thomson Reuters) pathway for AHR Gene
1 R&D Systems pathway for AHR Gene
1 Qiagen pathway for AHR Gene

SIGNOR curated interactions for AHR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for AHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 10395741
GO:0006366 transcription from RNA polymerase II promoter IDA 10395741
GO:0006805 xenobiotic metabolic process TAS 19538249
GO:0006915 apoptotic process TAS 12213388
genes like me logo Genes that share ontologies with AHR: view

Drugs & Compounds for AHR Gene

(55) Drugs for AHR Gene - From: Novoseek, DrugBank, Tocris, ApexBio, PharmGKB, HMDB, ClinicalTrials, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Leflunomide Approved, Investigational Pharma Target, agonist AHR agonist,immunosuppressive agent 62
Flutamide Approved Pharma Target, agonist 60
Mexiletine Approved Pharma Target, agonist 19
Nimodipine Approved Pharma Potentiation, Activator, Target, agonist 20
atorvastatin Approved Pharma Competitive, Inhibitor, Target, agonist 0

(70) Additional Compounds for AHR Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Nebivolol hydrochloride
152520-56-4
Salbutamol hemisulfate
51022-70-9

(3) Tocris Compounds for AHR Gene

Compound Action Cas Number
Metoprolol tartrate Selective beta1 antagonist 56392-17-7
Nebivolol hydrochloride Highly selective beta1-adrenoceptor antagonist 152520-56-4
Salbutamol hemisulfate beta agonist (beta2 > beta1) 51022-70-9

(3) ApexBio Compounds for AHR Gene

Compound Action Cas Number
Leflunomide AHR agonist,immunosuppressive agent 75706-12-6
StemRegenin 1 (SR1) AhR antagonist 1227633-49-9
UM 729 Enhancer of AhR antagonists 1448723-60-1
genes like me logo Genes that share compounds with AHR: view

Drug Products

Transcripts for AHR Gene

Unigene Clusters for AHR Gene

Aryl hydrocarbon receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AHR Gene

No ASD Table

Relevant External Links for AHR Gene

GeneLoc Exon Structure for
AHR
ECgene alternative splicing isoforms for
AHR

Expression for AHR Gene

mRNA expression in normal human tissues for AHR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AHR Gene

This gene is overexpressed in Nerve - Tibial (x4.5).

Protein differential expression in normal tissues from HIPED for AHR Gene

This gene is overexpressed in Placenta (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AHR Gene



SOURCE GeneReport for Unigene cluster for AHR Gene Hs.171189

mRNA Expression by UniProt/SwissProt for AHR Gene

P35869-AHR_HUMAN
Tissue specificity: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.
genes like me logo Genes that share expression patterns with AHR: view

Protein tissue co-expression partners for AHR Gene

Primer Products

In Situ Assay Products

Orthologs for AHR Gene

This gene was present in the common ancestor of animals.

Orthologs for AHR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AHR 35
  • 84.39 (n)
  • 80.93 (a)
AHR 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AHR 35
  • 87.78 (n)
  • 84.93 (a)
AHR 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ahr 35
  • 79.17 (n)
  • 74.62 (a)
Ahr 16
Ahr 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AHR 35
  • 98.9 (n)
  • 98.58 (a)
AHR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ahr 35
  • 77.84 (n)
  • 73.15 (a)
oppossum
(Monodelphis domestica)
Mammalia AHR 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AHR 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves AHR 35
  • 71.87 (n)
  • 67.39 (a)
AHR 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ahr 35
  • 65.53 (n)
  • 60.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia AHR 35
zebrafish
(Danio rerio)
Actinopterygii ahr1 35
ahr1b 35
  • 60.47 (n)
  • 60.41 (a)
ahr1a 36
  • 41 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11494 35
fruit fly
(Drosophila melanogaster)
Insecta ss 37
  • 45 (a)
ss 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ahr-1 37
  • 34 (a)
ahr-1 36
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12569 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for AHR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AHR Gene

ENSEMBL:
Gene Tree for AHR (if available)
TreeFam:
Gene Tree for AHR (if available)

Paralogs for AHR Gene

Paralogs for AHR Gene

Pseudogenes.org Pseudogenes for AHR Gene

genes like me logo Genes that share paralogs with AHR: view

Variants for AHR Gene

Sequence variations from dbSNP and Humsavar for AHR Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2066853 - 17,339,486(+) CATCA(A/G)ACACA reference, missense
rs4986826 - 17,339,533(+) GTGAG(A/G)TTGAC reference, missense
rs72552768 - 17,339,374(+) ACCAG(C/T)CTCAG reference, missense
rs72552769 - 17,340,181(+) GTCAG(A/G)TGCAG reference, missense
rs1476080 -- 17,318,249(-) ATATC(A/C/T)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AHR Gene

Variant ID Type Subtype PubMed ID
dgv7217n71 CNV Gain 21882294
nsv464398 CNV Gain 19166990
dgv2066e1 CNV Complex 17122850
nsv464399 CNV Gain 19166990
dgv7220n71 CNV Gain 21882294
nsv8064 CNV Gain 18304495
essv2917 CNV CNV 17122850
esv34717 CNV Gain 17911159
esv2422294 CNV Duplication 17116639
nsv887792 CNV Loss 21882294
nsv887793 CNV Loss 21882294

Variation tolerance for AHR Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.78; 73.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AHR Gene

HapMap Linkage Disequilibrium report
AHR
Human Gene Mutation Database (HGMD)
AHR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHR Gene

Disorders for AHR Gene

MalaCards: The human disease database

(7) MalaCards diseases for AHR Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
toxic oil syndrome
eosinophilic fasciitis
  • ef
seborrheic dermatitis
  • other seborrheic dermatitis
eosinophilia-myalgia syndrome
  • eosinophilia myalgia syndrome
peanut allergy
  • allergy to peanuts
- elite association - COSMIC cancer census association via MalaCards
Search AHR in MalaCards View complete list of genes associated with diseases

Relevant External Links for AHR

Genetic Association Database (GAD)
AHR
Human Genome Epidemiology (HuGE) Navigator
AHR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AHR
genes like me logo Genes that share disorders with AHR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AHR Gene

Publications for AHR Gene

  1. Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PMID: 11698344) Cauchi S. … Massaad-Massade L. (Carcinogenesis 2001) 3 4 48 67
  2. Chromosomal localization of the human AHR locus encoding the structural gene for the Ah receptor to 7p21-->p15. (PMID: 8125016) Le Beau M.M. … Bradfield C.A. (Cytogenet. Cell Genet. 1994) 2 3 23
  3. Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by upregulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer. (PMID: 19755661) Ishida M. … Oya M. (Carcinogenesis 2010) 3 23
  4. Four and a half LIM domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity. (PMID: 19815066) Kollara A. … Brown T.J. (J. Steroid Biochem. Mol. Biol. 2010) 3 23
  5. The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. (PMID: 20000589) Schroeder J.C. … Perdew G.H. (Biochemistry 2010) 3 23

Products for AHR Gene

Sources for AHR Gene

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