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Aliases for EGF Gene

Aliases for EGF Gene

  • Epidermal Growth Factor 2 3
  • HOMG4 3 6
  • URG 3 6
  • Epidermal Growth Factor (Beta-Urogastrone) 2
  • Pro-Epidermal Growth Factor 3
  • Beta-Urogastrone 3

External Ids for EGF Gene

Previous GeneCards Identifiers for EGF Gene

  • GC04P111240
  • GC04P111104
  • GC04P111292
  • GC04P111191
  • GC04P110834
  • GC04P106566

Summaries for EGF Gene

Entrez Gene Summary for EGF Gene

  • This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for EGF Gene

EGF (Epidermal Growth Factor) is a Protein Coding gene. Diseases associated with EGF include hypomagnesemia 4, renal and hypomagnesemia 6. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include calcium ion binding and epidermal growth factor receptor binding. An important paralog of this gene is LRP1B.

UniProtKB/Swiss-Prot for EGF Gene

  • EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).

Tocris Summary for EGF Gene

  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for EGF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGF Gene

Genomics for EGF Gene

Regulatory Elements for EGF Gene

Genomic Location for EGF Gene

109,912,884 bp from pter
110,012,962 bp from pter
100,079 bases
Plus strand

Genomic View for EGF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGF Gene

Proteins for EGF Gene

  • Protein details for EGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pro-epidermal growth factor
    Protein Accession:
    Secondary Accessions:
    • B4DRK7
    • E7EVD2
    • E9PBF0
    • Q52LZ6

    Protein attributes for EGF Gene

    1207 amino acids
    Molecular mass:
    133994 Da
    Quaternary structure:
    • Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD).
    • Sequence=AAR84237.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EGF Gene

    Alternative splice isoforms for EGF Gene


neXtProt entry for EGF Gene

Proteomics data for EGF Gene at MOPED

Post-translational modifications for EGF Gene

  • O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor).
  • Glycosylation at Asn38, Asn104, Asn117, Asn148, Asn324, Asn404, Asn596, Asn815, Asn926, Ser954, and Thr955
  • Modification sites at PhosphoSitePlus

Other Protein References for EGF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EGF (EGF)

Protein Products

No data available for DME Specific Peptides for EGF Gene

Domains for EGF Gene

Suggested Antigen Peptide Sequences for EGF Gene

Graphical View of Domain Structure for InterPro Entry



  • P01133
  • Contains 9 EGF-like domains.
  • Contains 9 LDL-receptor class B repeats.
genes like me logo Genes that share domains with EGF: view

No data available for Gene Families for EGF Gene

Function for EGF Gene

Molecular function for EGF Gene

GENATLAS Biochemistry: epidermal growth factor,6kDa,synthesized as a large preprotein,EGF membrane glycoprotein also containing nine EGF repeats and urogastrone
UniProtKB/Swiss-Prot Function: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).

LifeMap Function Summary for EGF Gene

EGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for EGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding TAS 15611079
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 12297050
GO:0008083 growth factor activity IDA 15611079
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity TAS 9712850
genes like me logo Genes that share ontologies with EGF: view
genes like me logo Genes that share phenotypes with EGF: view

Animal Models for EGF Gene

MGI Knock Outs for EGF:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for EGF Gene

Localization for EGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGF Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for EGF Gene COMPARTMENTS Subcellular localization image for EGF gene
Compartment Confidence
extracellular 4
plasma membrane 4
endoplasmic reticulum 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for EGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EGF: view

Pathways for EGF Gene

SuperPathways for EGF Gene

Superpath Contained pathways
1 Signaling by FGFR
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI-3K cascade
4 GPCR Pathway
5 TGF-Beta Pathway
genes like me logo Genes that share pathways with EGF: view

PCR Array Products

Gene Ontology (GO) - Biological Process for EGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0001525 angiogenesis IDA 15611079
GO:0002576 platelet degranulation TAS --
GO:0006260 DNA replication TAS 9482941
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with EGF: view

Compounds for EGF Gene

Compound Products

(5) Tocris Compounds for EGF Gene

Compound Action Cas Number
AG 1478 hydrochloride Highly potent EGFR-kinase inhibitor [170449-18-0]
AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
AG 825 Selective ErbB2 inhibitor [149092-50-2]
Iressa Orally active, selective EGFR inhibitor [184475-35-2]
PD 153035 hydrochloride EGFR-kinase inhibitor [183322-45-4]

(31) ApexBio Compounds for EGF Gene

Compound Action Cas Number
AC480 (BMS-599626) orally bioavailable inhibitor of the HER1, HER2 and HER4 [714971-09-2]
AEE788 (NVP-AEE788) novel multitargeted HER 1/2 and VEGFR 1/2 [497839-62-0]
Afatinib (BIBW2992) Irreversible EGFR and HER2 inhibitor [439081-18-2]
AG-18 Inhibits EGFR,PDGFR [118409-57-7]
AG-490 inhibitor of EGFR [133550-30-8]
AP26113 Dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). [1197958-12-5]
ARRY-380 orally bioavailable inhibitor of the human EGFR tyrosine kinase ErbB-2. [937265-83-3]
AZD8931 (Sapitinib) ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3. [848942-61-0]
BMS-690514 potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4 [859853-30-8]
Butein a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-kinase beta [487-52-5]
Canertinib (CI-1033) Potent and selective inhibitor of tyrosine residue phosphorylation of EGFR [267243-28-7]
CO-1686 novel, irreversible and orally delivered kinase inhibitor [1374640-70-6]
Compound 56 Cell-permeable, reversible, and ATP-competitive inhibitor of tyrosine kinase activity of EGFR [171745-13-4]
CP-724714 marked selectively against EGFR [537705-08-1]
CUDC-101 Multitargeted HDAC inhibitor [1012054-59-9]
Dacomitinib (PF299804, PF299) Highly selective and irreversible pan-EGFR family inhibitor [1110813-31-4]
Erlotinib potent and orally-bioavailable inhibitor of EGFR tyrosine kinase. [183321-74-6]
Gefitinib (ZD1839) Selective EGFR inhibitor [184475-35-2]
Gefitinib hydrochloride EGFR inhibitor [184475-55-6]
Icotinib Hydrochloride orally available quinazoline-based inhibitor of EGFR [1204313-51-8]
Lapatinib Dual inhibitor of EGFR and HER2 [231277-92-2]
Lapatinib Ditosylate Dual inhibitor of EGFR and HER2 [388082-78-8]
Neratinib (HKI-272) Potent HER2 and EGFR inhibitor [698387-09-6]
PD153035 HCl potent and specific inhibitor of EGFR [183322-45-4]
PD153035 hydrochloride Selective and extremely potent EGFR inhibitor, inhibits its tyrosine kinase activity, ATP competitive, reversible [153436-54-5]
PD168393 potent, irreversible, cell-permeable and selective inhibitor of EGFR [194423-15-9]
Pelitinib (EKB-569) Covalently binds to EGFR, inhibiting receptor phosphorylation and thus inhibiting signal transduction from EGFR. [257933-82-7]
Varlitinib (ARRY334543) orally bioavailable inhibitor of the EGFR family [845272-21-1]
WZ3146 Potent and mutant-selective EGFR phosphorylation inhibitor [1214265-56-1]
WZ4002 Mutant-selective EGFR inhibitor(L858R,T790M) [1213269-23-8]
WZ8040 Irreversible inhibitor of mutated EGFR T790M [1214265-57-2]

(2) HMDB Compounds for EGF Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Magnesium

(2) Drugbank Compounds for EGF Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Aminobutyric Acid
54182-58-0 target inducer

(133) Novoseek inferred chemical compound relationships for EGF Gene

Compound -log(P) Hits PubMed IDs
tyrosine 89.9 268
ag 1478 89.1 82
pd153035 81.2 16
gefitinib 78.8 99
thymidine 74.8 135

(1) PharmGKB related drug/compound annotations for EGF Gene

Drug/compound Annotation
cetuximab CA
genes like me logo Genes that share compounds with EGF: view

Transcripts for EGF Gene

Unigene Clusters for EGF Gene

Epidermal growth factor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EGF

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EGF Gene

No ASD Table

Relevant External Links for EGF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EGF Gene

mRNA expression in normal human tissues for EGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EGF Gene

This gene is overexpressed in Muscle - Skeletal (18.0), Pancreas (15.0), and Kidney - Cortex (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EGF Gene

SOURCE GeneReport for Unigene cluster for EGF Gene Hs.419815

mRNA Expression by UniProt/SwissProt for EGF Gene

Tissue specificity: Expressed in kidney, salivary gland, cerebrum and prostate.
genes like me logo Genes that share expressions with EGF: view

In Situ Assay Products

Orthologs for EGF Gene

This gene was present in the common ancestor of animals.

Orthologs for EGF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EGF 35
  • 99.14 (n)
  • 98.59 (a)
EGF 36
  • 99 (a)
(Bos Taurus)
Mammalia EGF 35
  • 80.85 (n)
  • 69.87 (a)
(Canis familiaris)
Mammalia EGF 35
  • 85.8 (n)
  • 79.4 (a)
EGF 36
  • 78 (a)
(Mus musculus)
Mammalia Egf 35
  • 76.73 (n)
  • 67.48 (a)
Egf 16
Egf 36
  • 66 (a)
(Monodelphis domestica)
Mammalia EGF 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia EGF 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Egf 35
  • 76.67 (n)
  • 67.67 (a)
(Gallus gallus)
Aves EGF 35
  • 65.75 (n)
  • 55.4 (a)
EGF 36
  • 50 (a)
(Anolis carolinensis)
Reptilia EGF 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia egf 35
  • 58.85 (n)
  • 49.03 (a)
(Danio rerio)
Actinopterygii Dr.27130 35
egf 35
  • 53.87 (n)
  • 44.41 (a)
egf 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta LRP1 36
  • 6 (a)
yl 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea egg-1 36
  • 16 (a)
egg-2 36
  • 18 (a)
lrp-2 36
  • 7 (a)
rme-2 36
  • 17 (a)
ZC101.1 36
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for EGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGF Gene

Gene Tree for EGF (if available)
Gene Tree for EGF (if available)

Paralogs for EGF Gene

Paralogs for EGF Gene

Selected SIMAP similar genes for EGF Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EGF: view

Variants for EGF Gene

Sequence variations from dbSNP and Humsavar for EGF Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs881841 -- 109,977,769(-) TCAAC(A/C)TCCCA intron-variant
rs881878 -- 109,914,892(+) CTAGA(A/G)TTGGG intron-variant
rs882405 -- 109,929,980(-) CACCA(C/T)TGGGG intron-variant
rs882471 -- 109,983,817(-) GTCCT(A/G)TGTTT intron-variant
rs882481 -- 109,995,282(-) ACTTT(G/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EGF Gene

Variant ID Type Subtype PubMed ID
esv2672203 CNV Deletion 23128226
nsv290769 CNV Loss 16902084
esv22936 CNV Loss 19812545
esv2618042 CNV Insertion 19546169
nsv820232 CNV Loss 19587683

Relevant External Links for EGF Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGF Gene

Disorders for EGF Gene

(1) OMIM Diseases for EGF Gene (131530)


  • Hypomagnesemia 4 (HOMG4) [MIM:611718]: A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. {ECO:0000269 PubMed:17671655}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(97) Novoseek inferred disease relationships for EGF Gene

Disease -log(P) Hits PubMed IDs
tumors 73.5 282
breast cancer 69.4 203
carcinoma squamous cell 69.1 126
cancer 64.3 148
carcinoma 60.5 134

Relevant External Links for EGF

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
genes like me logo Genes that share disorders with EGF: view

Publications for EGF Gene

  1. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. (PMID: 12620237) Ferguson K.M. … Lemmon M.A. (Mol. Cell 2003) 3 4 23
  2. Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population. (PMID: 15663953) Lim Y.J. … Park Y.H. (Neurosci. Lett. 2005) 3 23 48
  3. A single nucleotide polymorphism in the 5' untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer. (PMID: 15860930) Hamai Y. … Yasui W. (Pathobiology 2005) 3 23 48
  4. No association between EGF gene polymorphism and gastric cancer. (PMID: 16214932) Goto Y. … Hamajima N. (Cancer Epidemiol. Biomarkers Prev. 2005) 3 23 48
  5. Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab. (PMID: 16788380) Zhang W. … Lenz H.J. (Pharmacogenet. Genomics 2006) 3 23 48

Products for EGF Gene

Sources for EGF Gene

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