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Aliases for EFNB2 Gene

Aliases for EFNB2 Gene

  • Ephrin-B2 2 3
  • HTK Ligand 2 3 4
  • EPLG5 3 4 6
  • LERK5 3 4 6
  • HTKL 3 4 6
  • Eph-Related Receptor Tyrosine Kinase Ligand 5 2 3
  • Ligand Of Eph-Related Kinase 5 2 3
  • LERK-5 3 4
  • Htk-L 3 4
  • EPH-Related Receptor Tyrosine Kinase Ligand 5 4

External Ids for EFNB2 Gene

Previous HGNC Symbols for EFNB2 Gene

  • EPLG5

Previous GeneCards Identifiers for EFNB2 Gene

  • GC13M105503
  • GC13M101530
  • GC13M105980
  • GC13M104840
  • GC13M105940
  • GC13M107142
  • GC13M087733

Summaries for EFNB2 Gene

Entrez Gene Summary for EFNB2 Gene

  • This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for EFNB2 Gene

EFNB2 (Ephrin-B2) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors and Angiogenesis (CST). GO annotations related to this gene include ephrin receptor binding. An important paralog of this gene is EFNB1.

UniProtKB/Swiss-Prot for EFNB2 Gene

  • Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

Gene Wiki entry for EFNB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFNB2 Gene

Genomics for EFNB2 Gene

Regulatory Elements for EFNB2 Gene

Genomic Location for EFNB2 Gene

Start:
106,489,731 bp from pter
End:
106,535,114 bp from pter
Size:
45,384 bases
Orientation:
Minus strand

Genomic View for EFNB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EFNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFNB2 Gene

Proteins for EFNB2 Gene

  • Protein details for EFNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52799-EFNB2_HUMAN
    Recommended name:
    Ephrin-B2
    Protein Accession:
    P52799
    Secondary Accessions:
    • Q5JV56

    Protein attributes for EFNB2 Gene

    Size:
    333 amino acids
    Molecular mass:
    36923 Da
    Quaternary structure:
    • Interacts with PDZRN3 (By similarity). Binds to the receptor tyrosine kinases EPHA4, EPHB4 and EPHA3. Binds to Hendra virus and Nipah virus G protein.

    Three dimensional structures from OCA and Proteopedia for EFNB2 Gene

neXtProt entry for EFNB2 Gene

Proteomics data for EFNB2 Gene at MOPED

Post-translational modifications for EFNB2 Gene

  • Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
  • Glycosylation at Asn36, Asn139, Thr180, and Thr189
  • Modification sites at PhosphoSitePlus

Other Protein References for EFNB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EFNB2 Gene

Domains for EFNB2 Gene

Gene Families for EFNB2 Gene

HGNC:

Protein Domains for EFNB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EFNB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52799

UniProtKB/Swiss-Prot:

EFNB2_HUMAN :
  • P52799
Domain:
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
Family:
  • Belongs to the ephrin family.
genes like me logo Genes that share domains with EFNB2: view

Function for EFNB2 Gene

Molecular function for EFNB2 Gene

GENATLAS Biochemistry: ephrin B-2,eph-related receptor tyrosine kinase,class B,ligand,high affinity,involved in short-range contact-mediated axonal guidance,also involved in angiogenesis by marking arterial but not venous endothelial cells
UniProtKB/Swiss-Prot Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

Gene Ontology (GO) - Molecular Function for EFNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005515 protein binding IPI 12606549
GO:0046875 ephrin receptor binding IPI 16867992
genes like me logo Genes that share ontologies with EFNB2: view
genes like me logo Genes that share phenotypes with EFNB2: view

Animal Models for EFNB2 Gene

MGI Knock Outs for EFNB2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EFNB2 Gene

Localization for EFNB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EFNB2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EFNB2 Gene COMPARTMENTS Subcellular localization image for EFNB2 gene
Compartment Confidence
plasma membrane 4
peroxisome 2
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for EFNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8660976
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane --
genes like me logo Genes that share ontologies with EFNB2: view

Pathways for EFNB2 Gene

genes like me logo Genes that share pathways with EFNB2: view

Pathways by source for EFNB2 Gene

2 Qiagen pathways for EFNB2 Gene
2 Cell Signaling Technology pathways for EFNB2 Gene
1 KEGG pathway for EFNB2 Gene

Gene Ontology (GO) - Biological Process for EFNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001945 lymph vessel development IEA --
GO:0002042 cell migration involved in sprouting angiogenesis IDA 12734395
GO:0007155 cell adhesion IDA 12734395
GO:0007267 cell-cell signaling TAS 8559144
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with EFNB2: view

Compounds for EFNB2 Gene

(1) Drugbank Compounds for EFNB2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target

(3) Novoseek inferred chemical compound relationships for EFNB2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 56 5
vegf 26.6 6
retinoic acid 0 1
genes like me logo Genes that share compounds with EFNB2: view

Transcripts for EFNB2 Gene

mRNA/cDNA for EFNB2 Gene

(9) Additional mRNA sequences :
(200) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EFNB2 Gene

Ephrin-B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFNB2 Gene

No ASD Table

Relevant External Links for EFNB2 Gene

GeneLoc Exon Structure for
EFNB2
ECgene alternative splicing isoforms for
EFNB2

Expression for EFNB2 Gene

mRNA expression in normal human tissues for EFNB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EFNB2 Gene

SOURCE GeneReport for Unigene cluster for EFNB2 Gene Hs.149239

mRNA Expression by UniProt/SwissProt for EFNB2 Gene

P52799-EFNB2_HUMAN
Tissue specificity: Lung and kidney
genes like me logo Genes that share expressions with EFNB2: view

No data available for mRNA differential expression in normal tissues for EFNB2 Gene

Orthologs for EFNB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EFNB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFNB2 35
  • 99.7 (n)
  • 100 (a)
EFNB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EFNB2 35
  • 93.52 (n)
  • 95.9 (a)
EFNB2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EFNB2 35
  • 93.19 (n)
  • 96.7 (a)
EFNB2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efnb2 35
  • 93.03 (n)
  • 96.97 (a)
Efnb2 16
Efnb2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EFNB2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EFNB2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efnb2 35
  • 93.03 (n)
  • 97.27 (a)
chicken
(Gallus gallus)
Aves EFNB2 35
  • 83.33 (n)
  • 90 (a)
EFNB2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EFNB2 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68890 35
tropical clawed frog
(Silurana tropicalis)
Amphibia efnb2 35
  • 75.89 (n)
  • 82.07 (a)
Str.10046 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
efnb2a 35
  • 66.06 (n)
  • 66.36 (a)
efnb2a 36
  • 65 (a)
OneToMany
efnb2b 36
  • 56 (a)
OneToMany
efnb2b 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ephrin 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efn-2 36
  • 29 (a)
ManyToMany
efn-3 36
  • 28 (a)
ManyToMany
vab-2 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7000 36
  • 24 (a)
OneToMany
Species with no ortholog for EFNB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EFNB2 Gene

ENSEMBL:
Gene Tree for EFNB2 (if available)
TreeFam:
Gene Tree for EFNB2 (if available)

Paralogs for EFNB2 Gene

Paralogs for EFNB2 Gene

Selected SIMAP similar genes for EFNB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EFNB2: view

Variants for EFNB2 Gene

Sequence variations from dbSNP and Humsavar for EFNB2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs942332 -- 106,532,066(+) aaaaa(A/C)aaaaa intron-variant
rs1046755 -- 106,512,709(-) AATAT(C/T)ATAAA missense, reference
rs1046901 -- 106,491,644(-) TGGAG(C/G)CTGCA utr-variant-3-prime
rs1046903 -- 106,491,604(-) ACATA(C/T)GGCAG utr-variant-3-prime
rs1804788 -- 106,491,261(-) GAGCC(C/G)CACAG utr-variant-3-prime

Relevant External Links for EFNB2 Gene

HapMap Linkage Disequilibrium report
EFNB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EFNB2 Gene

Disorders for EFNB2 Gene

(1) University of Copenhagen DISEASES for EFNB2 Gene

(11) Novoseek inferred disease relationships for EFNB2 Gene

Disease -log(P) Hits PubMed IDs
neovascularization 50.3 7
endometrial carcinoma 16.5 3
tumors 15.8 6
thyroid cancer 14.1 1
hepatocellular carcinoma 9.1 2

Relevant External Links for EFNB2

Genetic Association Database (GAD)
EFNB2
Human Genome Epidemiology (HuGE) Navigator
EFNB2
genes like me logo Genes that share disorders with EFNB2: view

No data available for UniProtKB/Swiss-Prot for EFNB2 Gene

Publications for EFNB2 Gene

  1. Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas. (PMID: 9533549) Vogt T. … McClelland M. (Clin. Cancer Res. 1998) 3 4 23
  2. Structural basis of Nipah and Hendra virus attachment to their cell- surface receptor ephrin-B2. (PMID: 18488039) Bowden T.A. … Stuart D.I. (Nat. Struct. Mol. Biol. 2008) 3 4 23
  3. Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease. (PMID: 18580054) Hicks P.J. … Freedman B.I. (Am. J. Nephrol. 2008) 3 23 48
  4. Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. (PMID: 19875447) Qin H. … Song J. (J. Biol. Chem. 2010) 3 4 23
  5. Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes. (PMID: 19664212) Kwan Tat S. … Martel-Pelletier J. (Arthritis Res. Ther. 2009) 3 23

Products for EFNB2 Gene

Sources for EFNB2 Gene

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