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Aliases for EFNB2 Gene

Aliases for EFNB2 Gene

  • Ephrin-B2 2 3
  • HTK Ligand 2 3 4
  • Eph-Related Receptor Tyrosine Kinase Ligand 5 2 3
  • Ligand Of Eph-Related Kinase 5 2 3
  • LERK-5 3 4
  • Htk-L 3 4
  • EPLG5 3 4
  • LERK5 3 4
  • HTKL 3 4
  • EPH-Related Receptor Tyrosine Kinase Ligand 5 4

External Ids for EFNB2 Gene

Previous HGNC Symbols for EFNB2 Gene

  • EPLG5

Previous GeneCards Identifiers for EFNB2 Gene

  • GC13M105503
  • GC13M101530
  • GC13M105980
  • GC13M104840
  • GC13M105940
  • GC13M107142
  • GC13M087733

Summaries for EFNB2 Gene

Entrez Gene Summary for EFNB2 Gene

  • This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for EFNB2 Gene

EFNB2 (Ephrin-B2) is a Protein Coding gene. Diseases associated with EFNB2 include nodular regenerative hyperplasia. Among its related pathways are Developmental Biology and Tyrosine Kinases / Adaptors. GO annotations related to this gene include receptor binding and ephrin receptor binding. An important paralog of this gene is EFNB1.

UniProtKB/Swiss-Prot for EFNB2 Gene

  • Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

  • (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.

Gene Wiki entry for EFNB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFNB2 Gene

Genomics for EFNB2 Gene

Regulatory Elements for EFNB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EFNB2 Gene

Chromosome:
13
Start:
106,489,731 bp from pter
End:
106,535,114 bp from pter
Size:
45,384 bases
Orientation:
Minus strand

Genomic View for EFNB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EFNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFNB2 Gene

Proteins for EFNB2 Gene

  • Protein details for EFNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52799-EFNB2_HUMAN
    Recommended name:
    Ephrin-B2
    Protein Accession:
    P52799
    Secondary Accessions:
    • Q5JV56

    Protein attributes for EFNB2 Gene

    Size:
    333 amino acids
    Molecular mass:
    36923 Da
    Quaternary structure:
    • Interacts with PDZRN3 (By similarity). Binds to the receptor tyrosine kinases EPHA4, EPHB4 and EPHA3. (Microbial infection) Interacts with Hendra virus and Nipah virus G protein (PubMed:16007075, PubMed:16477309, PubMed:17376907, PubMed:15998730).

    Three dimensional structures from OCA and Proteopedia for EFNB2 Gene

neXtProt entry for EFNB2 Gene

Proteomics data for EFNB2 Gene at MOPED

Post-translational modifications for EFNB2 Gene

  • Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
  • Glycosylation at Asn 36, Asn 139, Thr 180, and Thr 189
  • Modification sites at PhosphoSitePlus

Other Protein References for EFNB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EFNB2 (EFNB2)

No data available for DME Specific Peptides for EFNB2 Gene

Domains & Families for EFNB2 Gene

Gene Families for EFNB2 Gene

Protein Domains for EFNB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EFNB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52799

UniProtKB/Swiss-Prot:

EFNB2_HUMAN :
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
  • Belongs to the ephrin family.
Domain:
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
Family:
  • Belongs to the ephrin family.
genes like me logo Genes that share domains with EFNB2: view

Function for EFNB2 Gene

Molecular function for EFNB2 Gene

GENATLAS Biochemistry:
ephrin B-2,eph-related receptor tyrosine kinase,class B,ligand,high affinity,involved in short-range contact-mediated axonal guidance,also involved in angiogenesis by marking arterial but not venous endothelial cells
UniProtKB/Swiss-Prot Function:
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.

Gene Ontology (GO) - Molecular Function for EFNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005102 receptor binding --
GO:0005515 protein binding IPI 12606549
GO:0046875 ephrin receptor binding IPI 16867992
genes like me logo Genes that share ontologies with EFNB2: view
genes like me logo Genes that share phenotypes with EFNB2: view

Animal Models for EFNB2 Gene

MGI Knock Outs for EFNB2:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EFNB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for EFNB2 Gene

Localization for EFNB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EFNB2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EFNB2 Gene COMPARTMENTS Subcellular localization image for EFNB2 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2
extracellular 2
mitochondrion 2
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for EFNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8660976
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane --
genes like me logo Genes that share ontologies with EFNB2: view

Pathways & Interactions for EFNB2 Gene

genes like me logo Genes that share pathways with EFNB2: view

Pathways by source for EFNB2 Gene

2 Qiagen pathways for EFNB2 Gene
2 Cell Signaling Technology pathways for EFNB2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for EFNB2 Gene

Activates:

Gene Ontology (GO) - Biological Process for EFNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001945 lymph vessel development IEA --
GO:0002042 cell migration involved in sprouting angiogenesis IDA 12734395
GO:0007155 cell adhesion IDA 12734395
GO:0007267 cell-cell signaling TAS 8559144
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with EFNB2: view

Drugs & Compounds for EFNB2 Gene

(1) Drugs for EFNB2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tyrosine Nutra 547

(2) Additional Compounds for EFNB2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
retinoic acid
302-79-4
VEGF
genes like me logo Genes that share compounds with EFNB2: view

Transcripts for EFNB2 Gene

mRNA/cDNA for EFNB2 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(200) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EFNB2 Gene

Ephrin-B2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EFNB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EFNB2 Gene

No ASD Table

Relevant External Links for EFNB2 Gene

GeneLoc Exon Structure for
EFNB2
ECgene alternative splicing isoforms for
EFNB2

Expression for EFNB2 Gene

mRNA expression in normal human tissues for EFNB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EFNB2 Gene

This gene is overexpressed in Amniocyte (23.1), Cerebrospinal fluid (17.8), and Breast (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EFNB2 Gene



SOURCE GeneReport for Unigene cluster for EFNB2 Gene Hs.149239

mRNA Expression by UniProt/SwissProt for EFNB2 Gene

P52799-EFNB2_HUMAN
Tissue specificity: Lung and kidney
genes like me logo Genes that share expression patterns with EFNB2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for EFNB2 Gene

Orthologs for EFNB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EFNB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EFNB2 35
  • 93.52 (n)
  • 95.9 (a)
EFNB2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EFNB2 35
  • 93.19 (n)
  • 96.7 (a)
EFNB2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efnb2 35
  • 93.03 (n)
  • 96.97 (a)
Efnb2 16
Efnb2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EFNB2 35
  • 99.7 (n)
  • 100 (a)
EFNB2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efnb2 35
  • 93.03 (n)
  • 97.27 (a)
oppossum
(Monodelphis domestica)
Mammalia EFNB2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EFNB2 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves EFNB2 35
  • 83.33 (n)
  • 90 (a)
EFNB2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EFNB2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia efnb2 35
  • 75.89 (n)
  • 82.07 (a)
Str.10046 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68890 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
efnb2a 35
  • 66.06 (n)
  • 66.36 (a)
efnb2a 36
  • 65 (a)
OneToMany
efnb2b 36
  • 56 (a)
OneToMany
efnb2b 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ephrin 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efn-2 36
  • 29 (a)
ManyToMany
efn-3 36
  • 28 (a)
ManyToMany
vab-2 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7000 36
  • 24 (a)
OneToMany
Species with no ortholog for EFNB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EFNB2 Gene

ENSEMBL:
Gene Tree for EFNB2 (if available)
TreeFam:
Gene Tree for EFNB2 (if available)

Paralogs for EFNB2 Gene

Paralogs for EFNB2 Gene

(2) SIMAP similar genes for EFNB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EFNB2: view

Variants for EFNB2 Gene

Variation tolerance for EFNB2 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EFNB2 Gene

HapMap Linkage Disequilibrium report
EFNB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for EFNB2 Gene

Disorders for EFNB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EFNB2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nodular regenerative hyperplasia
  • miliary hepatocellular adenomatosis
- elite association
Search EFNB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EFNB2

Genetic Association Database (GAD)
EFNB2
Human Genome Epidemiology (HuGE) Navigator
EFNB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EFNB2
genes like me logo Genes that share disorders with EFNB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EFNB2 Gene

Publications for EFNB2 Gene

  1. Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. (PMID: 19875447) Qin H. … Song J. (J. Biol. Chem. 2010) 23 67
  2. Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding. (PMID: 20233847) Bochenek M.L. … Nobes C.D. (J. Cell. Sci. 2010) 23 67
  3. The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion. (PMID: 19728339) Nakada M. … Berens M.E. (Int. J. Cancer 2010) 23 67
  4. Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia. (PMID: 20061560) Kuang S.Q. … Garcia-Manero G. (Blood 2010) 23 67
  5. Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy. (PMID: 20431808) Guttula S.V. … Rao P.V. (Int J Diabetes Dev Ctries 2010) 23 67

Products for EFNB2 Gene

Sources for EFNB2 Gene

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