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Aliases for EFNA2 Gene

Aliases for EFNA2 Gene

  • Ephrin A2 2 3
  • HEK7 Ligand 3 4
  • Ephrin-A2 2 5
  • HEK7-L 3 4
  • LERK-6 3 4
  • EPLG6 3 4
  • LERK6 3 4
  • Eph-Related Receptor Tyrosine Kinase Ligand 6 3
  • EPH-Related Receptor Tyrosine Kinase Ligand 6 4
  • ELF-1 3

External Ids for EFNA2 Gene

Previous HGNC Symbols for EFNA2 Gene

  • EPLG6

Previous GeneCards Identifiers for EFNA2 Gene

  • GC19P001344
  • GC19P001226
  • GC19P001237
  • GC19P001070

Summaries for EFNA2 Gene

Entrez Gene Summary for EFNA2 Gene

  • This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]

GeneCards Summary for EFNA2 Gene

EFNA2 (Ephrin A2) is a Protein Coding gene. Among its related pathways are EphB-EphrinB Signaling and Developmental Biology. GO annotations related to this gene include ephrin receptor binding. An important paralog of this gene is EFNA3.

UniProtKB/Swiss-Prot for EFNA2 Gene

  • Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).

Gene Wiki entry for EFNA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFNA2 Gene

Genomics for EFNA2 Gene

Regulatory Elements for EFNA2 Gene

Promoters for EFNA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EFNA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EFNA2 Gene

Chromosome:
19
Start:
1,286,154 bp from pter
End:
1,301,431 bp from pter
Size:
15,278 bases
Orientation:
Plus strand

Genomic View for EFNA2 Gene

Genes around EFNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EFNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EFNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFNA2 Gene

Proteins for EFNA2 Gene

  • Protein details for EFNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43921-EFNA2_HUMAN
    Recommended name:
    Ephrin-A2
    Protein Accession:
    O43921
    Secondary Accessions:
    • O76020

    Protein attributes for EFNA2 Gene

    Size:
    213 amino acids
    Molecular mass:
    23878 Da
    Quaternary structure:
    • Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8.

    Three dimensional structures from OCA and Proteopedia for EFNA2 Gene

neXtProt entry for EFNA2 Gene

Proteomics data for EFNA2 Gene at MOPED

Post-translational modifications for EFNA2 Gene

  • Glycosylation at Asn 42, Asn 174, and Asn 188
  • Modification sites at PhosphoSitePlus

Other Protein References for EFNA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EFNA2 Gene

Domains & Families for EFNA2 Gene

Gene Families for EFNA2 Gene

Protein Domains for EFNA2 Gene

Suggested Antigen Peptide Sequences for EFNA2 Gene

Graphical View of Domain Structure for InterPro Entry

O43921

UniProtKB/Swiss-Prot:

EFNA2_HUMAN :
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
  • Belongs to the ephrin family.
Domain:
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
Family:
  • Belongs to the ephrin family.
genes like me logo Genes that share domains with EFNA2: view

Function for EFNA2 Gene

Molecular function for EFNA2 Gene

GENATLAS Biochemistry:
ephrin A2,EPH-related receptor tyrosine kinase,class A,ligand expressed in fetal brain and intestin,in adult lung and intestine
UniProtKB/Swiss-Prot Function:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).
genes like me logo Genes that share phenotypes with EFNA2: view

Animal Models for EFNA2 Gene

MGI Knock Outs for EFNA2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EFNA2 Gene

Localization for EFNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EFNA2 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EFNA2 Gene COMPARTMENTS Subcellular localization image for EFNA2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0016020 membrane IEA --
GO:0031594 neuromuscular junction IEA --
genes like me logo Genes that share ontologies with EFNA2: view

Pathways & Interactions for EFNA2 Gene

genes like me logo Genes that share pathways with EFNA2: view

SIGNOR curated interactions for EFNA2 Gene

Gene Ontology (GO) - Biological Process for EFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance IEA,IBA --
GO:0030316 osteoclast differentiation IEA,ISS --
genes like me logo Genes that share ontologies with EFNA2: view

Drugs & Compounds for EFNA2 Gene

(1) Drugs for EFNA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with EFNA2: view

Transcripts for EFNA2 Gene

mRNA/cDNA for EFNA2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EFNA2 Gene

Ephrin-A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFNA2 Gene

No ASD Table

Relevant External Links for EFNA2 Gene

GeneLoc Exon Structure for
EFNA2
ECgene alternative splicing isoforms for
EFNA2

Expression for EFNA2 Gene

mRNA expression in normal human tissues for EFNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EFNA2 Gene

This gene is overexpressed in Colon - Transverse (x15.1), Liver (x12.6), and Small Intestine - Terminal Ileum (x7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EFNA2 Gene



SOURCE GeneReport for Unigene cluster for EFNA2 Gene Hs.741510

genes like me logo Genes that share expression patterns with EFNA2: view

Protein tissue co-expression partners for EFNA2 Gene

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EFNA2 Gene

Orthologs for EFNA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EFNA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EFNA2 35
  • 92.18 (n)
  • 96.24 (a)
EFNA2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efna2 35
  • 86.12 (n)
  • 90.91 (a)
Efna2 16
Efna2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EFNA2 35
  • 99.6 (n)
  • 100 (a)
EFNA2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efna2 35
  • 85.49 (n)
  • 90.91 (a)
oppossum
(Monodelphis domestica)
Mammalia EFNA2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EFNA2 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves EFNA2 35
  • 80.48 (n)
  • 80.66 (a)
lizard
(Anolis carolinensis)
Reptilia EFNA2 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia efna2 35
  • 69.33 (n)
  • 78.86 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100332852 35
  • 66.27 (n)
  • 68.05 (a)
efna2 36
  • 56 (a)
OneToMany
EFNA2 (2 of 2) 36
  • 58 (a)
OneToMany
Species with no ortholog for EFNA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EFNA2 Gene

ENSEMBL:
Gene Tree for EFNA2 (if available)
TreeFam:
Gene Tree for EFNA2 (if available)

Paralogs for EFNA2 Gene

Paralogs for EFNA2 Gene

(4) SIMAP similar genes for EFNA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EFNA2: view

Variants for EFNA2 Gene

Sequence variations from dbSNP and Humsavar for EFNA2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1057270 -- 1,299,888(+) CCGGG(C/T)GGCTG reference, synonymous-codon
rs1557831 -- 1,298,902(+) atcac(A/G)ccact intron-variant
rs724421 -- 1,294,200(+) CTAAT(A/T)AGCCC intron-variant
rs1974563 -- 1,301,725(+) gggag(G/T)tggag downstream-variant-500B
rs1989952 -- 1,293,357(+) CCGGC(C/T)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EFNA2 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv1055e1 CNV Complex 17122850
dgv3575n71 CNV Loss 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3586n71 CNV Loss 21882294
nsv470104 CNV Loss 18288195
dgv3587n71 CNV Loss 21882294
nsv910442 CNV Gain+Loss 21882294
dgv3588n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3591n71 CNV Loss 21882294
dgv3592n71 CNV Loss 21882294
dgv3594n71 CNV Loss 21882294
nsv910471 CNV Loss 21882294
dgv3595n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
nsv910475 CNV Loss 21882294
nsv910476 CNV Loss 21882294

Variation tolerance for EFNA2 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EFNA2 Gene

HapMap Linkage Disequilibrium report
EFNA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFNA2 Gene

Disorders for EFNA2 Gene

Relevant External Links for EFNA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EFNA2

No disorders were found for EFNA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFNA2 Gene

Publications for EFNA2 Gene

  1. Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure. (PMID: 9465306) Cerretti D.P. … Nelson N. (Genomics 1998) 3 4 23 67
  2. Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression. (PMID: 17878388) Juang Y.T. … Tsokos G.C. (J. Immunol. 2007) 3 23
  3. Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus. (PMID: 12421992) Juang Y.T. … Tsokos G.C. (J. Immunol. 2002) 3 23
  4. Regulated cleavage of a contact-mediated axon repellent. (PMID: 10958785) Hattori M. … Flanagan J.G. (Science 2000) 3 23
  5. Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. (PMID: 9751130) Ciossek T. … Drescher U. (Eur. J. Neurosci. 1998) 3 23

Products for EFNA2 Gene

Sources for EFNA2 Gene

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