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Aliases for PHC2 Gene

Aliases for PHC2 Gene

  • Polyhomeotic Homolog 2 (Drosophila) 2 3
  • Early Development Regulator 2 (Homolog Of Polyhomeotic 2) 2 3
  • Early Development Regulatory Protein 2 3 4
  • HPH2 3 4
  • EDR2 3 4
  • PH2 3 4
  • Polyhomeotic-Like 2 (Drosophila) 2
  • Polyhomeotic-Like Protein 2 3
  • Polyhomeotic-Like 2 3
  • Polyhomeotic 2 3

External Ids for PHC2 Gene

Previous HGNC Symbols for PHC2 Gene

  • EDR2

Previous GeneCards Identifiers for PHC2 Gene

  • GC01M032845
  • GC01M033215
  • GC01M033291
  • GC01M033458
  • GC01M033561
  • GC01M033789
  • GC01M031905

Summaries for PHC2 Gene

Entrez Gene Summary for PHC2 Gene

  • In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PHC2 Gene

PHC2 (Polyhomeotic Homolog 2 (Drosophila)) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cellular Senescence. An important paralog of this gene is SAMD7.

UniProtKB/Swiss-Prot for PHC2 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility

Gene Wiki entry for PHC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHC2 Gene

Genomics for PHC2 Gene

Regulatory Elements for PHC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PHC2 Gene

Start:
33,323,623 bp from pter
End:
33,431,052 bp from pter
Size:
107,430 bases
Orientation:
Minus strand

Genomic View for PHC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHC2 Gene

Proteins for PHC2 Gene

  • Protein details for PHC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXK0-PHC2_HUMAN
    Recommended name:
    Polyhomeotic-like protein 2
    Protein Accession:
    Q8IXK0
    Secondary Accessions:
    • A1L4Q1
    • A8KA40
    • D3DPR2
    • Q2TAL3
    • Q5T0C1
    • Q6NUJ6
    • Q6ZQR1
    • Q8N306
    • Q8TAG8
    • Q96BL4
    • Q9Y4Y7

    Protein attributes for PHC2 Gene

    Size:
    858 amino acids
    Molecular mass:
    90713 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2. Interacts with CHTOP (By similarity). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2.
    Miscellaneous:
    • The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes
    SequenceCaution:
    • Sequence=AAH68573.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH92492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI13956.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PHC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHC2 Gene

Proteomics data for PHC2 Gene at MOPED

Post-translational modifications for PHC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PHC2 Gene

Domains for PHC2 Gene

Gene Families for PHC2 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for PHC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IXK0

UniProtKB/Swiss-Prot:

PHC2_HUMAN :
  • Q8IXK0
Domain:
  • HD1 motif interacts with SAM domain of PHC1
  • Contains 1 SAM (sterile alpha motif) domain.
Similarity:
  • Contains 1 FCS-type zinc finger.
genes like me logo Genes that share domains with PHC2: view

Function for PHC2 Gene

Molecular function for PHC2 Gene

UniProtKB/Swiss-Prot Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility

Gene Ontology (GO) - Molecular Function for PHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 10976766
GO:0008270 zinc ion binding IEA --
GO:0042802 identical protein binding IPI 16169070
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with PHC2: view
genes like me logo Genes that share phenotypes with PHC2: view

Animal Models for PHC2 Gene

MGI Knock Outs for PHC2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PHC2 Gene

Localization for PHC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHC2 Gene COMPARTMENTS Subcellular localization image for PHC2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IDA 21282530
GO:0005654 nucleoplasm TAS --
GO:0031519 PcG protein complex IDA 21282530
GO:0035102 PRC1 complex IDA 12167701
genes like me logo Genes that share ontologies with PHC2: view

Pathways for PHC2 Gene

genes like me logo Genes that share pathways with PHC2: view

Pathways by source for PHC2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for PHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0016925 protein sumoylation TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PHC2: view

Transcripts for PHC2 Gene

Unigene Clusters for PHC2 Gene

Polyhomeotic homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PHC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - -
SP7:
SP8:
SP9:
SP10: - -
SP11: -
SP12: -
SP13:
SP14:
SP15: - -

ExUns: 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25a · 25b
SP1: - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PHC2 Gene

GeneLoc Exon Structure for
PHC2
ECgene alternative splicing isoforms for
PHC2

Expression for PHC2 Gene

mRNA expression in normal human tissues for PHC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PHC2 Gene

This gene is overexpressed in Whole Blood (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHC2 Gene

SOURCE GeneReport for Unigene cluster for PHC2 Gene Hs.524271

genes like me logo Genes that share expressions with PHC2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PHC2 Gene

Orthologs for PHC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHC2 35
  • 99.69 (n)
  • 99.77 (a)
PHC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHC2 35
  • 90.91 (n)
  • 91.92 (a)
PHC2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHC2 35
  • 91.01 (n)
  • 90.74 (a)
PHC2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phc2 35
  • 86.75 (n)
  • 87.1 (a)
Phc2 16
Phc2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHC2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHC2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phc2 35
  • 87.48 (n)
  • 88.39 (a)
chicken
(Gallus gallus)
Aves PHC2 35
  • 76.94 (n)
  • 79.11 (a)
PHC2 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHC2 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii edr2 35
phc2a 35
  • 58.79 (n)
  • 54.66 (a)
phc2a 36
  • 49 (a)
OneToMany
phc2b 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ph-d 36
  • 13 (a)
ManyToMany
ph-p 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for PHC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHC2 Gene

ENSEMBL:
Gene Tree for PHC2 (if available)
TreeFam:
Gene Tree for PHC2 (if available)

Paralogs for PHC2 Gene

Paralogs for PHC2 Gene

Selected SIMAP similar genes for PHC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PHC2: view

Variants for PHC2 Gene

Sequence variations from dbSNP and Humsavar for PHC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5861 -- 33,323,919(+) CTTAG(A/C)AGTTC utr-variant-3-prime
rs7264 -- 33,323,781(+) GCCCT(C/T)GCCCT utr-variant-3-prime
rs11061 -- 33,324,069(-) CTCCC(C/T)GCACT utr-variant-3-prime
rs942485 -- 33,390,222(-) TTCAC(A/G)GAATT intron-variant
rs1016905 -- 33,396,678(+) AAGTG(C/T)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHC2 Gene

Variant ID Type Subtype PubMed ID
nsv522364 CNV Loss 19592680
nsv871813 CNV Loss 21882294
nsv516693 CNV Loss 19592680
nsv834613 CNV Gain 17160897
esv2658876 CNV Deletion 23128226
esv1384773 CNV Insertion 17803354

Relevant External Links for PHC2 Gene

HapMap Linkage Disequilibrium report
PHC2
Human Gene Mutation Database (HGMD)
PHC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHC2 Gene

Disorders for PHC2 Gene

Relevant External Links for PHC2

Genetic Association Database (GAD)
PHC2
Human Genome Epidemiology (HuGE) Navigator
PHC2
genes like me logo Genes that share disorders with PHC2: view

No data available for UniProtKB/Swiss-Prot for PHC2 Gene

Publications for PHC2 Gene

  1. Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. (PMID: 9121482) Gunster M.J. … Otte A.P. (Mol. Cell. Biol. 1997) 2 3 4 23
  2. Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family. (PMID: 12384788) Tonkin E. … Strachan T. (Hum. Genet. 2002) 2 3 4 23
  3. Role of Bmi1 in H2A ubiquitylation and Hox gene silencing. (PMID: 16751658) Wei J. … Wang H. (J. Biol. Chem. 2006) 3 23
  4. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. (PMID: 9199346) Satijn D.P.E. … Otte A.P. (Mol. Cell. Biol. 1997) 3 4
  5. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. (PMID: 10976766) Gunther M. … Brison O. (Mol. Cell. Biochem. 2000) 3 4

Products for PHC2 Gene

Sources for PHC2 Gene

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