Aliases for PHC1 Gene
External Ids for PHC1 Gene
Previous HGNC Symbols for PHC1 Gene
Previous GeneCards Identifiers for PHC1 Gene
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for PHC1 Gene
PHC1 (Polyhomeotic Homolog 1) is a Protein Coding gene. Diseases associated with PHC1 include microcephaly 11, primary, autosomal recessive and autosomal recessive primary microcephaly. Among its related pathways are Chromatin Regulation / Acetylation and Cellular Senescence. GO annotations related to this gene include chromatin binding. An important paralog of this gene is SAMD7.
UniProtKB/Swiss-Prot for PHC1 Gene
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.