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Aliases for EDNRA Gene

Aliases for EDNRA Gene

  • Endothelin Receptor Type A 2 3
  • HET-AR 3 4
  • ETA-R 3 4
  • ET-A 3 4
  • ETRA 3 4
  • ETA 3 4
  • Endothelin-1-Specific Receptor 3
  • Endothelin Receptor Subtype A 3
  • G Protein-Coupled Receptor 3
  • Endothelin-1 Receptor 3
  • Endothelin A Receptor 4
  • ETAR 3

External Ids for EDNRA Gene

Summaries for EDNRA Gene

Entrez Gene Summary for EDNRA Gene

  • This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for EDNRA Gene

EDNRA (Endothelin Receptor Type A) is a Protein Coding gene. Diseases associated with EDNRA include staphylococcal scarlet fever and scarlet fever. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and endothelin receptor activity. An important paralog of this gene is EDNRB.

UniProtKB/Swiss-Prot for EDNRA Gene

  • Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3

Tocris Summary for EDNRA Gene

  • The endothelin A receptor (ETA receptor) is a member of the endothelin receptor group of G-protein-coupled receptors that also includes ETB. They are located primarily in the vascular smooth muscle where they play a role in vasoconstriction and cell proliferation. The human ETA receptor gene has been localized to chromosome 4 (4q31.22).

Gene Wiki entry for EDNRA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EDNRA Gene

Genomics for EDNRA Gene

Genomic Location for EDNRA Gene

Start:
147,480,917 bp from pter
End:
147,544,954 bp from pter
Size:
64,038 bases
Orientation:
Plus strand

Genomic View for EDNRA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EDNRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EDNRA Gene

Regulatory Elements for EDNRA Gene

Proteins for EDNRA Gene

  • Protein details for EDNRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25101-EDNRA_HUMAN
    Recommended name:
    Endothelin-1 receptor
    Protein Accession:
    P25101
    Secondary Accessions:
    • B2R723
    • B4E2V6
    • B7Z9G6
    • D3DP03
    • E7ER36
    • O43441
    • Q16432
    • Q16433
    • Q8TBH2

    Protein attributes for EDNRA Gene

    Size:
    427 amino acids
    Molecular mass:
    48722 Da
    Quaternary structure:
    • Interacts with HDAC7 and KAT5.

    Alternative splice isoforms for EDNRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EDNRA Gene

Proteomics data for EDNRA Gene at MOPED

Post-translational modifications for EDNRA Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn29 and Asn62

Other Protein References for EDNRA Gene

No data available for DME Specific Peptides for EDNRA Gene

Domains for EDNRA Gene

Gene Families for EDNRA Gene

HGNC:
  • EDNR :GPCR / Class A : Endothelin receptors
IUPHAR :

UniProtKB/Swiss-Prot:

EDNRA_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.:
    • P25101
genes like me logo Genes that share domains with EDNRA: view

Function for EDNRA Gene

Molecular function for EDNRA Gene

GENATLAS Biochemistry: endothelin receptor A,with higher affinity to EDN1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3

Gene Ontology (GO) - Molecular Function for EDNRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 8702836
GO:0004930 G-protein coupled receptor activity --
GO:0004962 endothelin receptor activity NAS 8611157
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with EDNRA: view
genes like me logo Genes that share phenotypes with EDNRA: view

Animal Models for EDNRA Gene

MGI Knock Outs for EDNRA:

miRNA for EDNRA Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EDNRA Gene

Localization for EDNRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for EDNRA Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EDNRA Gene COMPARTMENTS Subcellular localization image for EDNRA gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for EDNRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1326535
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030315 T-tubule IEA --
genes like me logo Genes that share ontologies with EDNRA: view

Pathways for EDNRA Gene

genes like me logo Genes that share pathways with EDNRA: view

Gene Ontology (GO) - Biological Process for EDNRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 patterning of blood vessels IEA --
GO:0001666 response to hypoxia IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001821 histamine secretion IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
genes like me logo Genes that share ontologies with EDNRA: view

Compounds for EDNRA Gene

(5) Tocris Compounds for EDNRA Gene

Compound Action Cas Number
BMS 182874 hydrochloride Highly selective, orally active non-peptide ETA antagonist [153042-42-3]
BQ-123 Selective ETA antagonist [136553-81-6]
CI 1020 Highly selective, orally active ETA antagonist [162256-50-0]
FR 139317 Highly potent, selective ETA antagonist [142375-60-8]
Sulfisoxazole Endothelin ETA antagonist [127-69-5]

(1) HMDB Compounds for EDNRA Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Drugbank Compounds for EDNRA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-HYDROXY-3,5-DIIODOBENZOIC ACID
target
Bosentan
147536-97-8 target antagonist
Sitaxentan
  • Sitaxsentan
210421-64-0 target antagonist

(20) IUPHAR Ligand for EDNRA Gene

Ligand Type Action Affinity Pubmed IDs
[125I]ET-1 Agonist Full agonist 10.5
A127722 Antagonist Antagonist 10.5
[125I]PD164333 Antagonist Antagonist 9.8
[125I]sarafotoxin S6b Agonist Full agonist 9.8
PD-156707 Antagonist Antagonist 9.2
[3H]S0139 Antagonist Antagonist 9.2
[125I]ET-2 Agonist Full agonist 9.1
[125I]PD151242 Antagonist Antagonist 9.1
SB234551 Antagonist Antagonist 9
darusentan Antagonist Antagonist 8.9
endothelin-1 Agonist Full agonist 8.5
[3H]BQ123 Antagonist Antagonist 8.5
zibotentan Antagonist Antagonist 8.3
endothelin-2 Agonist Full agonist 8.2
[18F]ET-1 Agonist Full agonist 8.2
sarafotoxin S6b Agonist Full agonist 8.1
sitaxsentan Antagonist Antagonist 8
FR139317 Antagonist Inverse agonist 7.9
BQ123 Antagonist Antagonist 7.4
ambrisentan Antagonist Antagonist 7.1

(107) Novoseek inferred chemical compound relationships for EDNRA Gene

Compound -log(P) Hits PubMed IDs
bq123 93.9 75
sitaxsentan 91.5 29
sarafotoxin 91.3 26
atrasentan 91.1 33
bq788 88.1 24
genes like me logo Genes that share compounds with EDNRA: view

Transcripts for EDNRA Gene

Unigene Clusters for EDNRA Gene

Endothelin receptor type A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EDNRA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - -
SP7: - -

Relevant External Links for EDNRA Gene

GeneLoc Exon Structure for
EDNRA
ECgene alternative splicing isoforms for
EDNRA

Expression for EDNRA Gene

mRNA expression in normal human tissues for EDNRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EDNRA Gene

This gene is overexpressed in Cervix - Ectocervix (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EDNRA Gene

SOURCE GeneReport for Unigene cluster for EDNRA Gene Hs.183713

mRNA Expression by UniProt/SwissProt for EDNRA Gene

P25101-EDNRA_HUMAN
Tissue specificity: Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.
genes like me logo Genes that share expressions with EDNRA: view

Orthologs for EDNRA Gene

This gene was present in the common ancestor of chordates.

Orthologs for EDNRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EDNRA 36
  • 99.77 (n)
  • 100 (a)
EDNRA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EDNRA 36
  • 91.26 (n)
  • 94.61 (a)
EDNRA 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EDNRA 36
  • 92.88 (n)
  • 94.84 (a)
EDNRA 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ednra 36
  • 85.4 (n)
  • 92.27 (a)
Ednra 16
Ednra 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EDNRA 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EDNRA 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ednra 36
  • 85.92 (n)
  • 92.72 (a)
chicken
(Gallus gallus)
Aves EDNRA 36
  • 76.48 (n)
  • 78.38 (a)
EDNRA 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EDNRA 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ednra-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ednra 36
  • 71.64 (n)
  • 74.08 (a)
Str.12889 36
zebrafish
(Danio rerio)
Actinopterygii ednraa 36
  • 68.08 (n)
  • 73.45 (a)
ednraa 37
  • 64 (a)
OneToMany
ednrab 37
  • 63 (a)
OneToMany
Species with no ortholog for EDNRA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EDNRA Gene

ENSEMBL:
Gene Tree for EDNRA (if available)
TreeFam:
Gene Tree for EDNRA (if available)

Paralogs for EDNRA Gene

Paralogs for EDNRA Gene

Selected SIMAP similar genes for EDNRA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EDNRA: view

Variants for EDNRA Gene

Sequence variations from dbSNP and Humsavar for EDNRA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs5333 -- 147,539,885(+) CTTCA(C/T)TTAAG synonymous-codon, reference, nc-transcript-variant
rs5334 -- 147,539,921(+) AACGA(A/G)ATGGA synonymous-codon, reference, nc-transcript-variant
rs5335 -- 147,542,688(+) TGTGA(C/G)TCCGG utr-variant-3-prime, nc-transcript-variant
rs5336 -- 147,542,755(+) TTTCC(A/G)AAACC utr-variant-3-prime, nc-transcript-variant
rs5337 -- 147,543,084(+) GCTCA(A/G)GTCAC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for EDNRA Gene

Variant ID Type Subtype PubMed ID
nsv830109 CNV Loss 17160897
nsv880241 CNV Loss 21882294
nsv830110 CNV Loss 17160897
esv2274849 CNV Deletion 18987734
esv2728508 CNV Deletion 23290073

Relevant External Links for EDNRA Gene

HapMap Linkage Disequilibrium report
EDNRA
Human Gene Mutation Database (HGMD)
EDNRA

Disorders for EDNRA Gene

(1) OMIM Diseases for EDNRA Gene (131243)

(5) University of Copenhagen DISEASES for EDNRA Gene

(96) Novoseek inferred disease relationships for EDNRA Gene

Disease -log(P) Hits PubMed IDs
staphylococcal scalded skin syndrome 79.5 7
hypertension arterial 66 22
staphylococcal scarlet fever 65.6 1
hypertension pulmonary 64.1 13
bullous impetigo 59.5 2

Relevant External Links for EDNRA

Genetic Association Database (GAD)
EDNRA
Human Genome Epidemiology (HuGE) Navigator
EDNRA
genes like me logo Genes that share disorders with EDNRA: view

No data available for UniProtKB/Swiss-Prot for EDNRA Gene

Publications for EDNRA Gene

  1. Cloning and characterization of cDNA encoding human A-type endothelin receptor. (PMID: 1719979) Adachi M. … Miyamoto C. (Biochem. Biophys. Res. Commun. 1991) 3 4 23
  2. Molecular characterization and regulation of the human endothelin receptors. (PMID: 8440682) Elshourbagy N.A. … Nambi P. (J. Biol. Chem. 1993) 3 4 23
  3. Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts. (PMID: 8611157) Miyamoto Y. … Nakao K. (Biochem. J. 1996) 3 4 23
  4. Association between migraine and endothelin type A receptor (ETA -231 A/G) gene polymorphism. (PMID: 11376172) Tzourio C. … AlpAcrovitch A. (Neurology 2001) 3 23 49
  5. A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy. (PMID: 11601839) Herrmann S. … Osterziel K.J. (Eur. Heart J. 2001) 3 23 49

Products for EDNRA Gene

Sources for EDNRA Gene

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